检索结果-南通市图书馆

Ethnopharmacology,chemodiversity,and bioactivity of Cephalotaxus medicinal plants

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第5期19卷 321-338页

作者： HAO Da-Cheng HOU Xu-Dong GU Xiao-Jie XIAO Pei-gen ge guang-bo Biotechnology Institute School of Environment and Chemical EngineeringDalian Jiaotong UniversityDalian 116028China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China

Cephalotaxus is the only genus of Cephalotaxaceae family,and its natural resources are declining due to habitat fragmentation,excessive exploitation and *** many areas of China,folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison,many of which are *** only among Han people,but also among minority ethnic groups,Cephalotaxus is used to treat various diseases,e.g.,cough,internal bleeding and cancer in Miao medicine,bruises,rheumatism and pain in Yao medicine,and ascariasis,hookworm disease,scrofula in She medicine,*** values of some Cephalotaxus species and compounds are acknowledged ***,there is a lack of comprehensive review summarizing the ethnomedicinal knowledge o f Cephalotaxus,relevant medicinal phytometabolites and their *** research progresses in ethnopharmacology,chemodiversity,and bioactivities of Cephalotaxus medicinal plants are reviewed and commented *** gaps are pinpointed and future research directions are *** medicinal books,folk medicine books,herbal manuals and ethnomedicinal publications were reviewed for the genus Cephalotaxus(Sanjianshan in Chinese).The relevant data about ethnobotany,phytochemistry,and pharmacology were collected as comprehensively as possible from online databases including Scopus,NCBI PubMed,Bing Scholar,and China National Knowledge Infrastructure(CNKI).44 Cephalotaxus"',and the respective species name were used as keywords in database *** obtained articles of the past six decades were collated and *** Cephalotaxus species are listed in the official medicinal book in *** are used as ethnomedicines by many ethnic groups such as Miao,Yao,Dong,She and *** are obtained from traditional applications,and Cephalotaxus phytometabolites are developed into anticancer ***-type alkaloids,homoerythrina-type alkaloids and homoharringtonine(HHT)are abundant in Cephalo

关键词： Cephalotaxus Ethnomedicine Chemodiversity Alkaloids Bioactivity Pharmacology

Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第11期17卷 858-870页

作者： ZHOU Qi-Hang ZHU Ya-Di ZHANG Feng SONG Yun-Qing JIA Shou-Ning ZHU Liang FANG Sheng-Quan ge guang-bo Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 200000China Translational Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200000China Qinghai Hospital of Traditional Chinese Medicine Xining 810000China

Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions(HDI) or herb-endobiotic interactions(HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus;the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes(DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.

关键词： Psoraleae Fructus Cytochrome P450 enzymes(CYPs) Uridine diphosphate-glucuronosyltransferases(UGTs) Herb-drug interactions(HDI) Herb-endobiotic interactions(HEI)

Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第1期18卷 75-80页

作者： XIA Gui-Yang WANG Ling-Yan ZHANG Jing-Fang WU Yu-Zhuo ge guang-bo WANG Ya-Nan LIN Peng-Cheng LIN Sheng State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 1Q0050China Institute of Interdisciplinaty Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China

Purpurolides D–F(1–3),three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system,were isolated from the endophytic fungus Penicillium purpurogenum IMM *** structures were unambiguously elucidated based on extensive spectroscopic data analyses,13 C NMR chemical shifts calculations coupled with the DP4+probability method,and the calculated and experimental electronic circular dichroism(ECD)*** 1–3 showed significant inhibitory activity against pancreatic lipase(PL).The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.

关键词： Penicillium purpurogenum Sesquiterpene lactones Pancreatic lipase inhibitors

Transcriptional profiling and network pharmacology analysis identify the potential biomarkers from Chinese herbal formula Huosu Yangwei Formula treated gastric cancer in vivo

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第12期19卷 944-953页

作者： FANG Sheng-Quan LIU Yue-Han ZHAO Kun-Peng ZHANG Hui-Xing WANG Hong-Wei DENG Yu-Hai ZHOU Yu-Xuan ge guang-bo NI Hong-Mei CHEN Qi-Long Department of Gastroenterology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China

Huosu Yangwei(HSYW) Formula is a traditioanl Chinese herbal medicine that has been extensively used to treat chronic atrophic gastritis, precancerous lesions of gastric cancer and advanced gastric cancer. However, the effective compounds of HSYW and its related anti-tumor mechanisms are not completely understood. In the current study, 160 ingredients of HSYW were identified and 64 effective compounds were screened by the ADMET evaluation. Furthermore, 64 effective compounds and 2579 potential targets were mapped based on public databases. Animal experiments demonstrated that HSYW significantly inhibited tumor growth in vivo. Transcriptional profiles revealed that 81 mRNAs were differentially expressed in HSYW-treated N87-bearing Balb/c mice. Network pharmacology and PPI network showed that 12 core genes acted as potential markers to evaluate the curative effects of HSYW. Bioinformatics and qRT-PCR results suggested that HSYW might regulate the mRNA expression of DNAJB4, CALD,AKR1C1, CST1, CASP1, PREX1, SOCS3 and PRDM1 against tumor growth in N87-bearing Balb/c mice.

关键词： Huosu Yangwei(HSYW)Formula Network pharmacology Protein-protein interaction(PPI)network Gastric Cancer

Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第4期19卷 305-320页

作者： LIU Wei HUANG Jian ZHANG Feng ZHANG Cong-Cong LI Rong-Sheng WANG Yong-Li WANG Chao-Ran LIANG Xin-Miao ZHANG Wei-Dong YANG Ling LIU Ping ge guang-bo Key Laboratory of Liver and Kidney Diseases(Ministry of Education) Institute of Liver DiseasesShanghai Key Laboratory of Traditional Chinese Clinical MedicineShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Chinese Materia Medica Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China

Qing-Fei-Pai-Du decoction(QFPDD)is a Chinese medicine compound formula recommended for combating corona virus disease 2019(COVID-19)by National Health Commission of the People's Republic of *** latest clinical study showed that early treatment with QFPDD was associated with favorable outcomes for patient recovery,viral shedding,hospital stay,and course of the ***,the effective constituents of QFPDD remain *** this study,an UHPLC-Q-Orbitrap HRMS based method was developed to identify the chemical constituents in QFPDD and the absorbed prototypes as well as the metabolites in mice serum and tissues following oral administration of QFPDD.A total of 405 chemicals,including 40 kinds of alkaloids,162 kinds of flavonoids,44 kinds of organic acids,71 kinds of triterpene saponins and 88 kinds of other compounds in the water extract of QFPDD were tentatively identified via comparison with the retention times and MS/MS spectra of the standards or refereed by *** the help of the standards and in vitro metabolites,195 chemical components(including 104 prototypes and 91 metabolites)were identified in mice serum after oral administration of *** addition,165,177,112,120,44,53 constituents were identified in the lung,liver,heart,kidney,brain,and spleen of QFPDD-treated mice,*** findings provided key information and guidance for further investigation on the pharmacologically active substances and clinical applications of QFPDD.

关键词： Qing-Fei-Pai-Du decoction(QFPDD) Corona virus disease 2019(COVID-19) Chemical profiling Absorbed components High-Resolution Mass Spectrometry(HRMS)

Pancreatic lipase inhibitory constituents from Fructus Psoraleae

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第5期18卷 369-378页

作者： HOU Xu-Dong SONG Li-Lin CAO Yun-Feng WANG Yi-Nan ZHOU Qi FANG Sheng-Quan WU Da-Chang ZANG Shi-Zhu CHEN Lu BAI Yue ge guang-bo HOU Jie College of Basic Medical Sciences Dalian Medical UniversityDalian 116000China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116000China Translational Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western Medicine&Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 200000China Dalian Runsheng Kangtai Medical Laboratory Co.Ltd. Dalian 116000China

Pancreatic lipase(PL), a crucial enzyme in the digestive system of mammals, has been proven as a therapeutic target to prevent and treat obesity. The purpose of this study is to evaluate and characterize the PL inhibition activities of the major constituents from Fructus Psoraleae(FP), one of the most frequently used Chinese herbs with lipid-lowering activity. To this end, a total of eleven major constituents isolated from Fructus Psoraleae have been obtained and their inhibition potentials against PL have been assayed by a fluorescence-based assay. Among all tested compounds, isobavachalcone, bavachalcone and corylifol A displayed strong inhibition on PL(IC50 gen binding and hydrophobic interactions. Collectively, these finding provided solid evidence to support that Fructus Psoraleae contained bioactive compounds with lipid-lowering effects via targeting PL, and also suggested that the chalcones in Fructus Psoraleae could be used as ideal leading compounds to develop novel PL inhibitors.

关键词： Pancreatic lipase Fructus Psoraleae Inhibition potential Isobavachalcone Bavachalcone

源于临床有效中药活性成分的创新药物研发策略与挑战

在线全文

学校读者我要写书评

暂无评论

中国中药杂志 2023年第7期48卷 1705-1710页

作者：栾鑫黄敏柯博文葛广波张卫东上海中医药大学交叉科学研究院上海201203 海军军医大学药学院上海200433 中国科学院上海药物研究所上海201203 四川大学华西临床医学院四川成都610041

源于中药活性成分的新药创制是我国创新药物研发的特色和优势领域,但目前仍然存在药效物质基础不清、作用靶标和机制不明确等问题,极大阻碍了中药活性成分向新药物的临床转化。该文在分析整理当前我国创新药物研发现状及进展的基础上,... 详细信息

源于中药活性成分的新药创制是我国创新药物研发的特色和优势领域,但目前仍然存在药效物质基础不清、作用靶标和机制不明确等问题,极大阻碍了中药活性成分向新药物的临床转化。该文在分析整理当前我国创新药物研发现状及进展的基础上,针对中药活性成分发展前景及面临的困境,探讨实现中药活性成分高效发现,获得化学结构新颖、作用靶标/机制独特且具有自主知识产权的候选药物,以期为中国特色创新药物研发提供新策略和新模式。

关键词：临床有效中药中药活性成分创新药物作用靶标

同方期刊数据库

人细胞色素P450酶2J2的功能及其配体研究进展

在线全文

学校读者我要写书评

暂无评论

药学学报 2017年第1期52卷 26-33页

作者：马虹莹宁静葛广波杨凌郝大程大连交通大学环境化工学院/生物技术研究所辽宁大连116028 中国科学院大连化学物理研究所药用资源开发组辽宁大连116023

细胞色素酶P450 2J2(cytochrome P450 2J2,CYP2J2)广泛分布于人体多个组织,参与众多内源性化合物和外源性药物的代谢。CYP2J2可催化花生四烯酸(arachidonic acid,AA)生成具有多种生理功能的环氧化二十碳三烯甘油酸(expoxyeicosatrienoic... 详细信息

细胞色素酶P450 2J2(cytochrome P450 2J2,CYP2J2)广泛分布于人体多个组织,参与众多内源性化合物和外源性药物的代谢。CYP2J2可催化花生四烯酸(arachidonic acid,AA)生成具有多种生理功能的环氧化二十碳三烯甘油酸(expoxyeicosatrienoic acids,EETs),进而在调节心血管功能和肿瘤发生发展中发挥重要作用。此外,CYP2J2在阿司咪唑、依巴斯汀和特非那定等临床药物的肠道代谢中也发挥关键作用,是多种药物肠道首过代谢环节的重要屏障。本综述结合国内外新近研究进展,系统介绍了CYP2J2的分布、功能及催化特征,CYP2J2功能的表征方法和探针底物研究现状、药物等外源物对CYP2J2的调节作用以及CYP2J2与人类疾病间的关系等,旨在使国内医药领域的研究者更加深入地了解CYP2J2的功能及其在疾病发生发展中的作用。本文通过对近年来CYP2J2配体(底物和抑制剂)研究进展的总结,以期为以CYP2J2为靶点的新药研发提供指导和参考。

关键词： CYP2J2 代谢疾病探针底物 CYP2J2抑制剂

红景天苷对高原红细胞增多症大鼠红细胞膜结构和功能的影响

在线全文

学校读者我要写书评

暂无评论

中草药 2020年第15期51卷 3960-3967页

作者：贾守宁孙梦茹马春花马丽娟张庆光葛广波青海省中医院青海西宁810000 上海中医药大学交叉科学研究院上海201203

目的研究红景天苷对高原红细胞增多症(HAPC)大鼠红细胞膜结构与功能的影响,为红景天苷防治HAPC提供科学依据。方法40只Wistar大鼠随机分为对照组、HAPC模型组及红景天苷高、中、低剂量(200、100、50 mg/kg)组,每组8只,雌雄各半。除对照... 详细信息

目的研究红景天苷对高原红细胞增多症(HAPC)大鼠红细胞膜结构与功能的影响,为红景天苷防治HAPC提供科学依据。方法40只Wistar大鼠随机分为对照组、HAPC模型组及红景天苷高、中、低剂量(200、100、50 mg/kg)组,每组8只,雌雄各半。除对照组外,其余4组制备HAPC模型。对照组、模型组大鼠ig生理盐水,红景天苷组大鼠同时ig红景天苷,给药体积为10 mL/kg,1次/d,连续给药40 d。给药结束后,股动脉取血,采用生化、酶联免疫法测定大鼠红细胞膜脂质流动性和红细胞膜总胆固醇含量、总磷脂含量,以及磷脂成分磷脂酸(PA)、磷脂酰胆碱(PC)、磷脂酰乙醇胺(PE)、磷脂酰丝氨酸(PS)的含量,Na+,K+-ATPase和Ca2+,Mg2+-ATPase的活性,红细胞内Na+和Ca2+浓度。结果红景天苷可显著提高HAPC大鼠红细胞膜脂质流动性和红细胞膜总磷脂、PA、PC、PE、PS含量,提高Na+,K+-ATPase和Ca2+,Mg2+-ATPase的活性;显著降低红细胞膜总胆固醇含量、红细胞内Na+和Ca2+浓度。结论红景天苷可通过调控红细胞膜脂质成分,改善红细胞膜的功能和细胞代谢活动,进而缓解HAPC的相关症状。

关键词：红景天苷高原红细胞增多症红细胞膜结构和功能胆固醇磷脂