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Biomedical and Environmental Sciences 2020年第2期33卷 114-122页

作者： GUO Peng Bo ZHU Bing Qing XU Li gao wan ying gao Yuan LIANG Hao ZHANG Mao Jun SHAO Zhu Jun State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003ZhejiangChina

Objective To compare the pathogenicity of isolates of sequence type 7(ST-7)Neisseria meningitidis(***)belonging to four different serogroups(A,B,C,and X).Methods Four ST-7 *** isolates serogrouped as A,B,C,and X and characterized by different capsule structures,were examined for their adhesion and invasion properties,and their ability to induce cytokine release and apoptosis in the host cell(the A549 cell line).Results Among the four ST-7 *** isolates,the serogroup A isolate possessed the strongest adhesion and invasion *** isolate also induced the release of the highest levels of the proinflammatory mediators interleukin-6,interleukin-1β,and interferon,and the highest apoptosis rate in the host ***,there was no significant difference in interleukin-8 and tumor necrosis factor-αsecretion between the four *** on the findings,the serogroup X *** isolate had the weakest pathogenicity,whereas there was almost no difference in the pathogenicity of the isolates from serogroups B and *** The differences in the capsular structure of the four isolates of ST-7 *** affected their pathogenic *** findings also imply that the hyperinvasive ST-7 *** lineage may include hypoinvasive isolates.

关键词： ST-7 N.meningitidis Capsule Pathogenicity Adaptation

Visualizing charge transfer and nuclear quantum effects in the hydrogen bond network of water

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Science China Chemistry 2025年

作者： ying gao Haotian wang Bin Zhang Department of Chemistry School of Science Tianjin University

Water, one of the most common and important solvents on earth, is widely used in biology, physics, chemistry, and other fields [1]. The hydrogen bond interactions between water molecules form a highly dynamic and syne...

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透明质酸钠关节腔内注射治疗髋关节骨性关节炎的临床观察

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中国现代应用药学 2005年第6期22卷 507-508页

作者：高宛英孙太存开滦集团有限责任公司医院骨科河北唐山063000

目的观察透明质酸钠关节腔内注射对髋关节骨性关节炎的治疗作用.方法对20例髋关节骨性关节炎患者行透明质酸钠关节腔内注射,每周1次,连续5次.观察治疗前后关节疼痛、肿胀以及关节活动度等改善情况.结果20例患者获得2～6月随访,临床缓解7... 详细信息

目的观察透明质酸钠关节腔内注射对髋关节骨性关节炎的治疗作用.方法对20例髋关节骨性关节炎患者行透明质酸钠关节腔内注射,每周1次,连续5次.观察治疗前后关节疼痛、肿胀以及关节活动度等改善情况.结果20例患者获得2～6月随访,临床缓解7例,显效8例,有效2例,无效3例.总有效率为85%.未见明显不良反应和感染发生.结论透明质酸钠关节腔内注射是一种安全、有效的髋关节骨性关节炎治疗方法.

关键词：骨性关节炎髋关节透明质酸钠关节腔内注射

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng wang Zhou ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen Yang Peng gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

大数据背景下的国土空间规划和智慧城市建设探讨

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智能建筑与智慧城市 2024年第7期 65-67页

作者：高婉莹广州市番禺城市规划勘测设计院有限公司

在国土空间规划中,大数据技术可以对海量数据进行综合处理,同时也能够提取关键性决策数据,使城市空间规划更加合理,推动智慧城市的建设。文章结合国土空间规划和智慧城市建设现状展开了深入分析,结合大数据时代背景分析了国土空间规划... 详细信息

在国土空间规划中,大数据技术可以对海量数据进行综合处理,同时也能够提取关键性决策数据,使城市空间规划更加合理,推动智慧城市的建设。文章结合国土空间规划和智慧城市建设现状展开了深入分析,结合大数据时代背景分析了国土空间规划和智慧城市建设的具体内容,最后从加快数字资源整合、推动数字规划创新、落实可持续发展等三个方面,探讨了国土空间规划与智慧城市建设的保障措施。

关键词：国土空间规划大数据智慧城市建设

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国土空间规划传导体系与实施机制探讨

智能建筑与智慧城市 2024年第4期 21-23页

作者：高婉莹广州市番禺城市规划勘测设计院有限公司

文章以新时代、新形势背景下,国土空间规划体系的建设工作为背景,以市县一级国土空间规划传导体系作为研究主体,尝试从组织架构的优化与保障机制与实施路径的落实两个方面探讨了新时代市县一级国土空间规划传导体系的构建思路与实施策... 详细信息

文章以新时代、新形势背景下,国土空间规划体系的建设工作为背景,以市县一级国土空间规划传导体系作为研究主体,尝试从组织架构的优化与保障机制与实施路径的落实两个方面探讨了新时代市县一级国土空间规划传导体系的构建思路与实施策略。县市一级国土空间规划的两种传达层级,一种是中心城市与新城共同规划,一种是常见的三个层级的规划模式,并对市县一级国土规划传导体系的实施机制提出了实施路径保障机制。

关键词：国土空间规划传导体系实施机制

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“互联网+”背景下,高校会计教育新思路

河北工程大学学报（社会科学版） 2018年第3期35卷 102-104页

作者：高婉莹河北工程大学管理工程与商学院河北邯郸056038

随着互联网的发展,会计行业正在经历重大的行业转型时期,对新型人才的需求与以往有所不同。文章分析了"互联网+"影响下高校教育面临的教学模式单一,课程设置尚待完善,适应新技术发展的师资不足等问题,并从创新教学模式,着重学生综合素... 详细信息

随着互联网的发展,会计行业正在经历重大的行业转型时期,对新型人才的需求与以往有所不同。文章分析了"互联网+"影响下高校教育面临的教学模式单一,课程设置尚待完善,适应新技术发展的师资不足等问题,并从创新教学模式,着重学生综合素质培养,创新课程结构,促成校企合作,优化教师团队,创办互联网会计师资方面提出了对会计教育现状的改善方案。

关键词：互联网+ 会计教育高校创新

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浅析国土空间规划存在的问题与对策

智能城市 2020年第8期6卷 147-148页

作者：高婉莹广州市番禺城市规划设计院广东广州511400

国土规划是基于现阶段国内经济和社会发展整体战略目标、方向和规划区范围内的各种因素等进行综合考虑,针对资源开发与整治保护等环节所采取的战略部署,本质上属于国土资源的综合布局。新时期背景下,国土空间的科学规划重要性不言而喻,... 详细信息

国土规划是基于现阶段国内经济和社会发展整体战略目标、方向和规划区范围内的各种因素等进行综合考虑,针对资源开发与整治保护等环节所采取的战略部署,本质上属于国土资源的综合布局。新时期背景下,国土空间的科学规划重要性不言而喻,合理规划是国土空间建设的整体布局以及环境综合治理的指导性意见,同时也是针对本地区中长期发展规划的重要参考依据。文章先对现阶段国土空间规划过程中存在的各种问题进行分析,并在此基础上就如何加强空间规划、解决实践中存在的各种矛盾和问题提出观点。

关键词：国土空间规划建设问题对策

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei wan Xiuqin Rao Yue Lin Gen Wei Jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

The Changes of Photosynthetic Properties and Cell Microstructure in Peanut Leaves during Leaf Senescence

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Agricultural Sciences in China 2002年第4期1卷 410-416页

作者： LI Xiang-dong, wanG Xiao-yun, YU Song-lie, ZHANG gao-ying, wan Yong-shan and LI Jun(’ College of Agronomy Life Science Academy, Shandong Agricultural University, Taian 271018 , P.R. China) College of Agronomy Life Science Academy Shandong Agricultural University Taian 271018 P.R. China

The changes of photosynthetic properties and cell microstructure in peanut leaves during leaf senescence were studied with two high-yielding peanut cultivars (cv. Luhuall and Fu8707). The main results showed that during the whole process of leaf growth and senescence, changes in the photosynthesis rate (Pn) and contents of chlorophyll in leaves, could be described with a parabolic function, y = A + Bx + Cx2 (where y refers to the values of the above parameters and x to the days after leaf unfolding). During peanut leaf senescence , the shape of chloroplast changed gradually from long ellipses to *** starch globule in chloroplast altered gradually from more and larger sizes to fewer and smaller, but the oil globule from fewer and smaller to more and larger. The grana lamellae varied progressively: from thinness and length to thickness and shortness; from ranking along the long axle direction of chloroplast to disorderly arrangment and finally blurring. At last, the membrane envelope of chloroplast broke, so the inclusion seeped out to the cell and the chloroplast broke up.

关键词： Peanut Leaf senescence Photosynthetic properties Cell microstructure