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23例妊娠并发结核病患者的临床分析

中国防痨杂志 2016年第7期38卷 564-568页

作者：刘荣梅马丽萍孔忠顺黄麦玲陈红梅宋艳华高孟秋首都医科大学附属北京胸科医院结核二科 101149

目的探讨妊娠并发结核病患者的临床特点。方法回顾性分析首都医科大学附属北京胸科医院2012年5月至2015年8月收治的23例妊娠并发结核病患者的临床资料，包括一般资料、临床症状及体征，胸部CT、头颅MRI等影像学资料，痰标本染色镜检、... 详细信息

目的探讨妊娠并发结核病患者的临床特点。方法回顾性分析首都医科大学附属北京胸科医院2012年5月至2015年8月收治的23例妊娠并发结核病患者的临床资料，包括一般资料、临床症状及体征，胸部CT、头颅MRI等影像学资料，痰标本染色镜检、液体培养及血γ-干扰素释放试验等检测结果，经菌种鉴定确定为结核分枝杆菌感染，并归纳总结其临床诊治特点。结果23例妊娠并发结核病患者中，并发肺结核8例、结核性胸膜炎2例、肺结核＋结核性脑膜脑炎或结核性脑膜炎10例、继发性肺结核＋结核性胸膜炎3例。患者临床表现为全身中毒症状突出，发热、纳差分别占78．3％（18／23％和73．9％（17／23）；呼吸道症状以咳嗽为主，占73．9％（17／23）。早期妊娠11例（47．8％），中期妊娠5例（21．8％），晚期妊娠3例（13．0％），产褥期4例（17．4％）；其中，先患结核病后发现妊娠者6例（26．1％），妊娠后发现罹患结核病者17例（73．9％）。23例妊娠并发结核病患者3例试管婴儿均自然流产，12例行人工流产术，3例发生新生儿死亡，5例分娩健康婴儿。23例患者诊断明确后均给予合理的联合抗结核药物治疗，20例患者经抗结核药物治疗好转，3例重症结核病患者死亡。结论妊娠并发结核病患者临床全身中毒症状重，多并发中枢系统结核而危及生命。早中期妊娠患者及时终止妊娠是必须面对的选择；对晚期妊娠患者进行积极治疗，转归较理想。

关键词：妊娠并发症,感染性结核治疗结果数据说明,统计结果与过程评价(卫生保健)

Robustly Tuning Bandgaps in Two-Dimensional Soft Phononic Crystals with Criss-Crossed Elliptical Holes

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Acta Mechanica Solida Sinica 2018年第5期31卷 573-588页

作者： Nan gao Yi-lan Huang Rong-hao Bao Wei-qiu Chen Department of Engineering Mechanics Zhejiang University Hangzhou 310027 China State Key Lab of CAD & CG Zhejiang University Hangzhou 310058 China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University Hangzhou 310027 China Soft Matter Research Center Zhejiang University Hangzhou 310027 China

Tuning band gaps in soft materials by post-buckling deformation is becoming an appealing means to manipulate elastic waves. As one of the most favorable topologies, two- dimensional soft structures with circular holes have been extensively studied. Based on the contrarian thinking, this paper starts from the two-dimensional soft structures with criss-crossed elliptical holes, which is close to the post-buckling configuration of soft structures with circular holes, and then proposes to tune the band gaps through elongating or stretching rather than compressing. Influences of the loading magnitude and loading pattern （i.e., uniaxial and biaxial elongations） on the band gaps are studied via the nonlinear finite element simulations. Effects of the geometric parameters （the major-to-minor half-axis ratio and the porosity of the structure） are also discussed. It is shown that, compared with the traditional circular hole case, the band gaps of the unloaded structure with criss-crossed elliptical holes are much richer, and they could be reversely and continuously tuned by tensile loadings. In particular, the deformation is very robust and is insensitive to small geometric imperfections, which is always necessary for triggering the post-buckling deformations. The present work provides a useful reference to the manipula- tion of elastic waves in periodic structures as well as the design of soft phononic crystals/acoustic devices.

关键词： Soft phononic crystal Criss-crossed elliptical holes Band gap Tunability

Adsorption of humic acid from aqueous solution on bilayer hexadecyltrimethyl ammonium bromide-modified zeolite

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Frontiers of Environmental Science & Engineering 2011年第1期5卷 65-75页

作者： Yanhui ZHAN Jianwei LIN Yanling qiu Naiyun gao Zhiliang ZHU State Key Laboratory of Pollution Control and Resource Reuse Tongji UniversityShanghai 200092China College of Marine Science Shanghai Ocean UniversityShanghai 201306China

Surfactant-modified natural zeolites(SMNZ)with different coverage types were prepared by loading hexadecyltrimethyl ammonium bromide(HTAB)onto the surface of a natural *** adsorption behavior of humic acid(HA)on SMNZ was *** indicate that the adsorbent SMNZ exhibited a higher affinity toward HA than the natural *** removal efficiency by SMNZ increased with HTAB *** Ca2+in solution favored HA adsorption onto *** capacity decreased with an increasing solution *** typical SMNZ with bilayer HTAB coverage,HA adsorption process is well described by a pseudo-second-order kinetic *** experimental isotherm data fitted well with the Langmuir *** maximum HA adsorption capacities for SMNZ with bilayer HTAB coverage at pH 5.5 and 7.5 were 63 and 41 mg·g^(-1),respectively.E2/E3(absorbance at 250 nm to that at 365 nm)and E4/E6(absorbance at 465 nm to that at 665 nm)ratios of the residual HA in solution were lower than that of the original HA *** indicates that the HA fractions with high polar functional groups,low molecular weight(MW),and aromaticity had a stronger tendency for adsorption onto SMNZ with bilayer HTAB *** show that HTABmodified natural zeolite is a promising adsorbent for removal of HA from aqueous solution.

关键词： bilayer surfactant-modified zeolite hexadecyltrimethyl ammonium bromide(HTAB) adsorption humic acid(HA)

18个月化疗方案对耐多药肺结核患者的治疗效果分析

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中国防痨杂志 2019年第3期41卷 294-301页

作者：李琦姜晓颖高孟秋刘宇红杨坤云阚晓红梁建琴田明刘锦程崔文玉刘文余德美谭守勇唐神结刘玉琴梁煊邱丽华邵世峰高飞接力蔡宝云卜建玲马丽萍刘智徐麟杜娟操敏高静韬舒薇李亮首都医科大学附属北京胸科医院中国疾病预防控制中心结核病防治临床中心 101149 广州市胸科医院黑龙江省传染病防治院沈阳市第五人民医院山东省胸科医院五病区(疑难结核病) 天津市海河医院内蒙古自治区第四人民医院新疆维吾尔自治区胸科医院结核二科深圳市第三人民医院肺病三科宁夏回族自治区第四人民医院呼吸一科贵州医科大学附属医院呼吸科湖南省结核病防治所耐药专科安徽省胸科医院科教科中国人民解放军总保院第八医学中心全军结核病研究所成都市公共卫生临床中心陕西省结核病防治院长春市传染病医院枣庄市王开传染病医院西安市结核病胸部肿瘤医院结核内科

目的分析由6种药物组成、疗程为18个月的化疗方案对耐多药肺结核患者的治疗效果,为缩短耐多药肺结核患者的化疗疗程提供依据。方法纳入2009年7月至2015年12月在首都医科大学附属北京胸科医院等20家结核病专科医院确诊为耐多药肺结核的68... 详细信息

目的分析由6种药物组成、疗程为18个月的化疗方案对耐多药肺结核患者的治疗效果,为缩短耐多药肺结核患者的化疗疗程提供依据。方法纳入2009年7月至2015年12月在首都医科大学附属北京胸科医院等20家结核病专科医院确诊为耐多药肺结核的681例患者,按照所采用的化疗方案将患者分为观察组(18个月方案组,515例)和对照组(24个月方案组,166例)。收集治疗中结核分枝杆菌培养、血常规、肝肾功能、心电图检查等结果,观察药物不良反应,评估两组患者的治疗转归(治疗成功、失败、死亡、丢失等)。采用SPSS 22.0软件进行数据的统计学分析,计量资料采用t检验或Z检验,计数资料采用χ 2检验;两组患者治疗前有差异的临床指标与治疗成功率间的关系采用logistic回归分析,以P<0.05为差异有统计学意义结果观察组的治疗成功率(64.66%,333/515)高于对照组(54.22%,90/166)(χ 2=5.818, P=0.002),病死率(2.33%,12/515)低于对照组(5.42%,9/166)(χ 2=4.015, P=0.045)。而两组的失败率(17.86%,92/515;23.49%,39/166)、丢失率(11.46%,59/515;11.45%,19/166)、药物不良反应的总发生率(24.85%,128/515;25.90%,43/166)差异均无统计学意义(χ 2=2.561,P=0.109;χ 2=0.000,P=0.997;χ 2=0.095,P=0.757)。logistic回归分析显示年龄≥50岁[β=0.549,s-x=0.204,Wald χ 2=7.262,P=0.007,OR(95%CI)=1.731(1.161~2.579)]和使用乙胺丁醇[β=0.485,s-x=0.190,Wald χ 2=6.516,P=0.011,OR(95%CI)=1.625(1.119~2.359)]是影响治疗成功率的风险因素。结论采用6种药物组成、疗程为18个月的化疗方案能够达到24个月化疗方案的疗效,并获得较好的治疗成功率,且未增加药物不良反应发生率,具有临床可行性。关键词:

关键词：结核,抗多种药物性药物疗法,联合方案评价疗效比较研究

cPCN-Regulated SnO_(2) Composites Enables Perovskite Solar Cell with Efficiency Beyond 23%

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Nano-Micro Letters 2021年第7期13卷 12-27页

作者： Zicheng Li Yifeng gao Zhihao Zhang qiu Xiong Longhui Deng Xiaochun Li Qin Zhou Yuanxing Fang Peng gao CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianPeople’s Republic of China College of Chemistry Fuzhou UniversityFuzhou 350116People’s Republic of China Laboratory for Advanced Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021People’s Republic of China

Efficient electron transport layers(ETLs)not only play a crucial role in promoting carrier separation and electron extraction in perovskite solar cells(PSCs)but also significantly affect the process of nucleation and growth of the perovskite ***,crystalline polymeric carbon nitrides(cPCN)are introduced to regulate the electronic properties of SnO_(2) nanocrystals,resulting in cPCN-composited SnO_(2)(SnO_(2)-cPCN)ETLs with enhanced charge transport and perovs-kite layers with decreased grain ***,SnO_(2)-cPCN ETLs show three times higher electron mobility than pristine SnO_(2) while offering better energy level alignment with the perovskite *** SnO_(2)-cPCN ETLs with decreased wettability endow the perovskite films with higher crystallinity by retarding the crystallization *** the end,the power conversion efficiency(PCE)of planar PSCs can be boosted to 23.17%with negligible hysteresis and a steady-state efficiency output of 21.98%,which is one of the highest PCEs for PSCs with modified SnO_(2) ***_(2)-cPCN based devices also showed higher stability than pristine SnO_(2),maintaining 88%of the initial PCE after 2000 h of storage in the ambient environment(with controlled RH of 30%±5%)without encapsulation.

关键词： Electron transport layer Perovskite solar cell Carbon nitride SnO_(2)

An Image Classification Method Based on Deep Neural Network with Energy Model

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Computer Modeling in Engineering & Sciences 2018年第12期117卷 555-575页

作者： Yang Yang Jinbao Duan Haitao Yu Zhipeng gao Xuesong qiu State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China.

The development of deep learning has revolutionized image recognition *** to design faster and more accurate image classification algorithms has become our research *** this paper,we propose a new algorithm called stochastic depth networks with deep energy model(SADIE),and the model improves stochastic depth neural network with deep energy model to provide attributes of images and analysis their ***,the Bernoulli distribution probability is used to select the current layer of the neural network to prevent gradient dispersion during *** in the backpropagation process,the energy function is designed to optimize the target loss function of the neural *** also explored the possibility of using Adam and SGD combination optimization in deep neural ***,we use training data to train our network based on deep energy model and testing data to verify the performance of the *** results we finally obtained in this research include the Classified labels of *** impacts of our obtained results show that our model has high accuracy and performance.

关键词： Image classification deep energy model deep neural network stochastic depth deep learning.

Synthesis of core-shell structured Au@Bi2S3 nanorod and its application as DNA immobilization matrix for electrochemical biosensor construction

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Chinese Chemical Letters 2020年第1期31卷 181-184页

作者： Feng gao Juan Song Bin Zhang Hidekazu Tanaka Fei gao Weiwei qiu Qingxiang Wang Department of Chemistry and Environment Science Minnan Normal UniversityZhangzhou 363000China Department of Chemistry Graduate School of Science and EngineeringShimane UniversityMatsueShimane 690-8504Japan Key Laboratory of Sensor Analysis of Tumor Marker Ministry of Education College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China

The core-shell structured Au@Bi2S3 nanorods have been prepared through direct in-situ growth of Bi2S3 at the surface of pre-synthesized gold *** product was characterized by X-ray diffraction,transmission electron microscopy and energy-dispersive X-ray *** the obtained Au@Bi2S3 nanorods were coated onto glassy carbon electrode to act as a scaffold for fabrication of electrochemical DNA biosensor on the basis of the coordination of-NH2 modified on 5’-end of probe DNA and Au@*** characterization assays demonstrate that the Au@Bi2S3 nanorods behave as an excellent electronic transport channel to promote the electron transfer kinetics and increase the effective surface area by their nanosize *** hybridization experiments reveal that the Au@Bi2S3 matrix-based DNA biosensor is capable of recognizing complementary DNA over a wide concentration ranging from 10 fmol/L to 1 nmol/*** limit of detection was estimated to be 2 fmol/L(S/N=3).The biosensor also presents remarkable selectivity to distinguish fully complementa ry sequences from basemismatched and non-complementary ones,showing great promising in practical application.

关键词： DNA biosensor Au@Bi2S3 nanorods Electrochemical impedance spectroscopy Core-shell structure Bi^3+-N bond Probe immobilization

Magnetic properties and structure of Ni_80Fe_20/Ni_48Fe_12Cr_40 bilayer films deposited on SiO_2/Si(100) by electron beam evaporation

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Rare Metals 2007年第2期26卷 176-181页

作者： WU Ping gao Yanqing qiu Hong PAN Liqing TIAN Yue Wang Fengping Department of Physics University of Science and Technology Beijing Beijing 100083 China

Ni80Fe20/Ni48Fe12Cr40 bilayer films and Ni80Fe20 monolayer films were deposited at room temperature on SiO2/Si（100） substrates by electron beam evaporation. The influence of the thickness of the Ni48Fe12Cr40 underlayer on the structure, magnetization, and magnetoresistance of the Ni80Fe20/Ni48Fe12Cr40 bilayer film was investigated. The thickness of the Ni48Fe12Cr40 layer varied from about 1 nm to 18 nm while the Ni80Fe20 layer thickness was fixed at 45 nm. For the as-deposited bilayer films the introducing of the Ni48Fe12Cr40 underlayer promotes both the （111） texture and grain growth in the Ni80Fe20 layer. The Ni48Fe12Cr40 underlayer has no significant influence on the magnetic moment of the Ni80Fe20/Ni48Fe12Cr40 bilayer film. However, the coercivity of the bilayer film changes with the thickness of the Ni48Fe12Cr40 undedayer. The optimum thickness of the Ni48Fe12Cr40 underlayer for improving the anisotropic magnetoresistance effect of the Ni80Fe20/Ni48Fe12Cr40 bilayer film is about 5 nm. With a decrease in temperature from 300 K to 81 K, the anisotropic magnetoresistance ratio of the Ni80Fe20 （45 nm）/Ni48Fe12Cr40 （5 nm） bilayer film increases linearly from 2.1% to 4.8% compared with that of the Ni80Fe20 monolayer film from 1.7% to 4.0%.

关键词： Ni80Fe20 films Ni48Fe12Cr4o seed layer structure magnetic properties

A Multi-module Controller for Walking Quadruped Robots

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Journal of Bionic Engineering 2019年第2期16卷 253-263页

作者： Boxing Wang Ziwei Wan Chunlin Zhou Jun Wu Yanfeng qiu Zhijun gao College of Control Science and Engineerings Zhejiang University Zhejiang 310027China Binhai Industrial Technology Research Institute of Zhejiang University Tianjin 300457China

Motion control based on biologically inspired methods,such as Central Pattern Generator(CPG)models,offers a promising technique for robot ***,for a quadruped robot which needs to maintain balance while performing flexible movements,this technique often requires a complicated nonlinear oscillator to build a controller,and it is difficult to achieve agility by merely modifying the predefined limit cycle in real *** this study,we tried to solve this problem by constructing a multi-module controller based on *** different parallel modules will ensure the dynamic stability and agility of *** the proposed controller,a specific control task is accomplished by adding basic and superposed *** basic motions decide the basic foot end trajectories,which are generated by the predefined limit cycle of the CPG *** to conventional kinematics-based design,the superposed motions are generated through different modules alter the basic foot end trajectories to maintain balance and increase *** a considerable stability margin can be achieved,different modules are designed *** proposed CPG-based controller is capable of stabilizing a walking quadruped robot and performing start and stop movements,turning,lateral movement and reversal in real *** and simulations demonstrate the effectiveness of the method.

关键词： Central Pattern Generator(CPG) open-loop stability agile locomotion control quadruped robots