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Novel process for facile preparation of mesoporous silica-based materials with controllable pore structure from coal fly ash Author links open overlay panel

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Particuology 2024年第8期91卷 128-137页

作者： jian-ming gao Zhen Li Shujia Ma Yuanyuan Zhang Fangqin Cheng Institute of Resources and Environment Engineering State Environmental Protection Key Laboratory of Efficient Utilization Technology of Coal Waste ResourcesShanxi Collaborative Innovation Center of High Value-added Utilization of Coal-related WastesShanxi UniversityTaiyuan 030006China

Extraction of silica from fly ash to produce mesoporous silica materials is one of the most important utilization *** silica could not be synthesized on a large-scale by conventional sol-gel *** this paper,facile preparation of mesoporous silica with controllable pore structure from fly ash by the template-free process via two steps of mineral phase transformation and selective acid etching was *** influence of crystalline structure and acid etching degree on structure of as-synthesized mesoporous silica materials was revealed,as well as mechanism of crystalline structure transformation and pore structure *** results show that mullite and quartz could be transformed into acid-soluble kaliophilite when fly ash reacted with K_(2)CO_(3)at temperature of 800-1100℃.The hexagonal kaliophilite would be transformed into orthorhombic KAlSiO_(4)-O1 phase when the temperature is controlled at 1100℃.Mesoporous silica with specific surface area of 475.93 m^(2)/g and 642.57 m^(2)/g could be synthesized from activated fly ash with kaliophilite and KAlSiO_(4)-O1 phase crystalline *** controlling the degree of acid etching,mesoporous silica materials with different pore structures can be *** paper provides a cost-effective and large-scale process for the preparation of mesoporous silica materials with controllable pore structure from solid waste fly ash.

关键词： Fly ash Mesoporous silica Crystal transformation Acid etching Controllable pore structure

Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： Fan Yang ming-Han Cheng Hai-Feng Pan jian gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

Amorphous high-entropy phosphoxides for efficient overall alkaline water/seawater splitting

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Journal of Materials Science & Technology 2024年第6期173卷 1-10页

作者： Han-ming Zhang Lihao Zuo Yuhang gao Junxia Guo Caizhen Zhu jian Xu Jinfeng Sun School of Materials Science and Engineering Hebei University of Science and TechnologyShijiazhuangHebei 050018China Hebei Key Laboratory of Flexible Functional Materials ShijiazhuangHebei 0500180China Institute of Low-dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhenGuangdong 518060China

Designing and synthesizing cost-effective bifunctional catalysts for overall alkaline water/seawater splitting is still a huge challenge for hydrogen ***,Co/Ni/Fe/Mn based-amorphous high-entropy phosphoxide self-standing electrode(CNFMPO)is synthesized by the facile and fast electrodeposition *** exhibits excellent bifunctional electrocatalytic performances on alkaline water/seawater *** hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of CNFMPO in alkaline water/seawater are as low as 43/73 and 252/282 mV to reach a current density of 10 mA cm^(-2),***,two-electrode electrolyzers with CNFMPO||CNFMPO successfully achieve the current density of 10 mA cm^(-2) at low voltages of 1.54 and 1.56 V for overall alkaline water/seawater splitting,*** exhibits satisfactory long-term stability on overall alkaline water/seawater splitting for the surface reconstruction into active metal hydroxide/(oxy)hydroxide,phosphite,and ***,no hypochlorite is detected during seawater electrolysis for the beneficial chlorite oxidation inhibition of the reconstructed phosphite and *** excellent catalytic performances of CNFMPO are due to the unique amorphous structure,multi-component synergistic effect,beneficial electronic structure modulation,and surface reconstruction during the catalytic reaction ***,CNFMPO has shown potential promotion to the development of the water/seawater splitting industry as a promising substituent for noble-metal *** work provides new insights into the design of efficient bifunctional catalysts for overall water/seawater splitting.

关键词： Amorphous high-entropy phosphoxides Water/seawater splitting Synergistic effect Surface reconstruction Electronic structure modulation Inhibition of chloride oxidation reaction

A Novel Predictive Model for Edge Computing Resource Scheduling Based on Deep Neural Network

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 259-277页

作者： ming gao Weiwei Cai Yizhang jiang Wenjun Hu jian Yao Pengjiang Qian School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China The Center for Intelligent Systems and Applications Research School of Artificial Intelligence and Computer ScienceJiangnan UniversityWuxi214122China School of Information Engineering Huzhou UniversityHuzhou313000China

Currently,applications accessing remote computing resources through cloud data centers is the main mode of operation,but this mode of operation greatly increases communication latency and reduces overall quality of service(QoS)and quality of experience(QoE).Edge computing technology extends cloud service functionality to the edge of the mobile network,closer to the task execution end,and can effectivelymitigate the communication latency ***,the massive and heterogeneous nature of servers in edge computing systems brings new challenges to task scheduling and resource management,and the booming development of artificial neural networks provides us withmore powerfulmethods to alleviate this ***,in this paper,we proposed a time series forecasting model incorporating Conv1D,LSTM and GRU for edge computing device resource scheduling,trained and tested the forecasting model using a small self-built dataset,and achieved competitive experimental results.

关键词： Edge computing resource scheduling predictive models

Establishment of a Stable PrP^(Sc) Panel from Brain Tissues of Experimental Hamsters with Scrapie Strain 263K

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Biomedical and Environmental Sciences 2009年第2期22卷 151-156页

作者： BAO-YUN ZHANG CHAN TIAN JUN HAN CHEN gao QI SHI jian-ming CHEN HUI-YING jianG WEI ZHOU AND XIAO-PING DONG State Key Laboratory for Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China

Objective To establish a stable PrP^Sc panel from brain tissues of experimental hamsters infected with scrapie agent 263K for evaluating diagnostic techniques of human and animals＇ prion diseases. Methods Thirty brain tissue samples from hamsters intracerebrally infected with scrapie strain 263K and another 30 samples from normal hamsters were selected to prepare 10%, 1%, and 0.5% brain homogenates, which were aliquoted into stocks. PrP^Sc in each brain homogenate was determined by proteinase K digestions followed by Western blot assay and partially by immunohistochemistry. Stability and glycoforms of PrP^Sc were repeatedly detected by prp^SC-specific Western blots in half a year and 3 years later. Results PrPsc signals were observed in all 10% brain homogenates of infected hamsters. Twenty out of 30 stocks and 19 out of 30 stocks were PrPsc positive in 1% and 0.5% brain homogenatesof infected hamsters, respectively. TWenty-seven out of 30 stocks presented three positive bands in 10% brain homogenates, whereas none of 1% and 0.5% homogenates contained 3 bands. The detection of prpSc-specific signals stored in half a year and 3 years later demonstrated that the ratio of PrPsc positive samples and glycoforms was almost unchanged. All normal hamsters＇ brain homogenates were PrP^Sc negative. Conclusion A PrP^Sc panel of prion disease can be established, which displays reliably stable prp^Sc-specific signals and glycoforms.

关键词： TSE prp^Sc Panel Glycoforms Stability

维普期刊数据库

Relationships Between Icariin and Anti-Apoptotic miRNA-21 in Mouse Blastocyst Development In vitro

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Journal of Integrative Agriculture 2013年第4期12卷 663-669页

作者： SHI Ya-ran WANG Zhan-he CAO Yong-chun LU Yan TIAN Jin-ling ZhANG Chao JIA Zi-ye CHEN Wu gao jian-ming Animal Science and Technology College Beijing University of Agriculture

In this study, the effect of icariin, a flavonoid from the Chinese traditional medicine epimedium, on miRNA-21 of mouse developmental blastocysts in vitro and the development of preimplantation embryos were studied. The possible effective targets of icariin promoting preimplantation embryo development in vitro and anti-apoptosis were determined. The embryos were cultured in modified CZB medium （mCZB） as control group. The experimental group （Ica group） was supplemented with 0.6 μg mL-1 icariin. Mouse pronuclear embryos were cultured in vitro until blastocysts. The development rates of preimplantation embryos were observed. The total cell number, apoptotic cell number and the rate of apoptotic cells in blastocysts were analysed by the staining of Hoechst33342 and labeling of TUNEL and detected under a laser confocal scanning microscope. The miRNA-21 expression, the mRNA levels of pro-apoptotic Caspase3, and the target genes of miRNA-21： pro-apoptotic PTEN, anti-apoptotic Bcl-2 were detected by real-time RT-PCR. The results showed that percentages of morulaes and blastocysts in Ica group were both extremely higher than control group （（85.14±6.57）% vs. （72.04±11.58）%; （82.50±7.11）% vs. （66.80±11.70）%, respectively, P〈0.01）. The total cell number ofblastocysts had extreme difference between Ica group and control group （（61.40±9.64） vs. （46.23±4.50）, P〈0.01）. The apoptotic cell number and rate of apoptotic cells of blastocysts were both reduced in Ica group （（1.47±0.51） vs. （2.94±0.66）; （2.40±0.27）% vs. （6.25±0.62）%, respectively, P〈0.01）. Compared to control group, addition of icariin into mCZB extremely increased the expression of anti-apoptotic miRNA-21 （P〈0.01）, down-regulated pro-apoptotic Caspase3 （P〈0.05） and PTEN （P〈0.01）, up-regulated anti-apoptotic Bcl-2 （P〈0.01）. In conclusion, icariin could reduce the apoptosis, promote the embryo development in vitro by enhancing miRNA-21 expression to up-regulated anti-apoptotic genes and down-regulated pro- apoptotic genes

关键词： blastocysts icariin miRNA-21 anti-apoptosis mice

维普期刊数据库

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

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Petroleum Science 2024年第4期21卷 2625-2637页

作者： Zhi-Qiang He He-Ping Xie Ling Chen jian-Ping Yang Bo Yu Zi-Jie Wei ming-Zhong gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and Hydropower Sichuan University Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green Energy College of Civil and Transportation Engineering Shenzhen University School of Mechanical Engineering Sichuan University College of Polymer Science and Engineering Sichuan University

Deep oil and gas reservoirs are under high-temperature conditions, but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability, resulting in distorted resource assessments. The development of in situ temperaturepreserved coring(ITP-Coring) technology for deep reservoir rock is urgent, and thermal insulation materials are key. Therefore, hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) were proposed as thermal insulation materials. The materials properties under coupled hightemperature and high-pressure(HTHP) conditions were tested. The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased; additionally,increasing temperature accelerated the process. High temperatures directly caused the thermal conductivity of the materials to increase; additionally, the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity. High temperatures weakened the matrix, and high pressures destroyed the HGM, which resulted in a decrease in the tensile mechanical properties of the materials. The materials entered the high elastic state at 150.C, and the mechanical properties were weakened more obviously, while the pressure led to a significant effect when the water absorption was above 10%. Meanwhile, the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86% at 100.C and 100 MPa, respectively, which meet the application requirements of the self-designed coring device. Finally, K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100.C and 100 MPa. To further improve the materials properties, the interface layer and EP matrix should be optimized. The results can provide references for the optimization and engineering application of materials and thus technical su

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring (ITP-Coring) Hollow glass microsphere/epoxy resin thermal insulation materials (HGM/EP materials) High-temperature and high-pressure (HTHP) Physical and mechanical properties

Exhaust hood performance and its improvement technologies in industrial buildings:A literatu rereview

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Building Simulation 2024年第1期17卷 23-40页

作者： Jing Zhang jian Wang Jun gao Weimin Zhang Architectural Engineering Institute Jinhua PolytechnicJinhua 321017China Institute of HVAC Engineering Schoolof Mechanical EngineeringTongji UniversityShanghai 200092China Tongji Architectural Design(Group)Co .LtdShanghai 200092China

The pollutant control performance of exhaust hoods plays a crucial role in the indoor air quality and energy consumption of ventilation systems in industrial *** better understand the impact of local ventilation on the industrial indoor environment,this paper presents a literature review of exhaust hood performance and its improvement *** create an index for evaluating the performance of exhaust hoods,the capture velocity,capture efficiency,flow ratio of pollutant emissions and exhaust airflow and energy consumption are first introduced.A number of factors affecting exhaust hood performance are assessed such as hood type,hood opening size,exhaust rate,installation distance,pollution source emission and environmental *** to structural improvement methods,the use of active airflow is a more effective way to improve the exhaust hood *** most commonly used methods for determining the exhaust rate are the controlled speed method and the flow ratio *** use of an exhaust hood with an appropriate exhaust rate and jet parameters(for an active air-assisted hood)can effectively improve the pollutant control performance and reduce the energy consumption that would be wasted on the redundant exhaust *** more information focused on exhaust hood performance,this work suggests more effective strategies for improving indoor air quality and reducing energy consumption in industrial buildings.

关键词： industrial ventilation exhaust hood capture efficiency exhaust rate performance improvement

Spatial distribution of supra-permafrost groundwater in the Qinghai-Tibet Engineering Corridor using inversion models

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Advances in Climate Change Research 2024年第1期15卷 31-41页

作者： Yu gao ming-Tang CHAI Wei MA Yu-Tao gao State Key Laboratory of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 73000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China School of Civil and Hydraulic Engineering Ningxia UniversityYinchuan 750021China

Supra-permafrost groundwater(SPG)is a key factor that causes damage to highways and railways in the Qinghai-Tibet Engineering Corridor(QTEC).It is difficult to monitor SPG in the field due to their complex formation mechanisms and movement *** single-site field monitoring studies limit the spatial and temporal precision of SPG spatial *** determine the moisture content of shallow soils and the SPG distribution along the QTEC,this work employed the temperature vegetation dryness index and remote sensing models for groundwater table distribution *** accuracies of the models were validated using mea-surements obtained from different sites in the *** the permafrost zones of the QTEC,72%,22%and 6%of the SPG were located at depths of 0.5-1,1 m,***,79.4%of the area along the Qinghai-Tibet Highway(QTH)(Xidatan-Tanggula)section contained *** these sections with SPG,37.9%have an SPG table at depths of 0.5-0.8 *** study preliminarily explored the SPG distribution in the QTEC with a 30 m *** findings can help improve the spatial scale of SPG research,provide a basis for the analysis of the hydrothermal mechanisms,and serve as a guide in the assessment of operational risks and road structure designs.

关键词： Dryness index Landsat Soil moisture Groundwater level Qinghai-Tibet Engineering Corridor