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Artificial intelligence in the anterior segment of eye diseases

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1743-1751页

作者： Yao-Hong Liu Lin-Yu Li Si-Jia Liu Li-Xiong gao Yong Tang Zhao-Hui Li zi Ye School of Medicine Nankai UniversityTianjin 300071China Medical School of Chinese PLA Beijing 100039China Department of Ophthalmology Chinese PLA General HospitalBeijing 100039China Chinese PLA General Hospital Medicine Innovation Research Department Beijing 100039China

Ophthalmology is a subject that highly depends on imaging *** intelligence(AI)technology has great potential in medical imaging analysis,including image diagnosis,classification,grading,guiding treatment and evaluating *** combination of the two can realize mass screening of grass-roots eye health,making it possible to seek medical treatment in the mode of“first treatment at the grass-roots level,two-way referral,emergency and slow treatment,and linkage between the upper and lower levels”.On the basis of summarizing the AI technology carried out by scholars and their teams all over the world in the field of ophthalmology,quite a lot of studies have confirmed that machine learning can assist in diagnosis,grading,providing optimal treatment plans and evaluating prognosis in corneal and conjunctival diseases,ametropia,lens diseases,glaucoma,iris diseases,*** paper systematically shows the application and progress of AI technology in common anterior segment ocular diseases,the current limitations,and prospects for the future.

关键词： artificial intelligence anterior segment ocular disease ametropia glaucoma

Engineering CuMn Prussian blue analog-shelled nanobox for efficient electrochemical reduction of nitrate to ammonia

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Tungsten 2024年第4期6卷 833-844页

作者： zi-Yi Yang Yu-Dong Li Dan Liu Mao-Sen Song Yang gao Qing-Ping Wu En-Shan Han Yan-Zhen He Xiao-Hui Yang School of Chemical Engineering and Technology Hebei University of Technology Key Laboratory of Bio-Based Material Science and Technology Northeast Forestry University Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie Chongqing Institute of Green and Intelligent Technology Chinese Academy of Sciences

Electrocatalytic nitrate reduction reaction（ENRR） for ammonia synthesis is a promising strategy to relieve nitration contamination,as well as an alternative to the Haber-Bosch *** blue analogs（PBAs） are expected to be an electrocatalytic material with superior performance owing to their abundant active sites and open channel ***,most reported PBA materials possess low nitrate conversion and ammonia yield rates,which has led to a hindrance in their research of ***,CuMn-PBA-shelled nanoboxes（CuMn-PBA SNBs） synthesized through tannic acid etching and cation exchange approaches are demonstrated for efficient ammonia *** optimal CuMn-PBA SNBs electrode achieves a high nitrate conversion of 91.33% and ammonia selectivity of 98.87% in a 0.2 mol·L-1Na2SO4solution with100×10-6NO3--N at-1.4 V ***,the CuMn-PBA SNB s electrode exhibits exceptional stability throughout a 30 h electrocatalytic *** outstanding electrochemical performance is attributed to the unique hollow nanobox structure with abundant active sites and high-throughput transport pathways for ions' aspects.

关键词： Acid etching Ammonia synthesis Cation exchange Electrocatalytic nitrate reduction Nanobox Prussian blue analogs

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弹性需求下网络设计问题和电子路票问题研究

管理科学学报 2015年第4期18卷 38-48页

作者：王广民高自友徐猛孙会君中国地质大学经济管理学院武汉430074 北京交通大学交通运输学院系统科学所北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044

应用双(二)层规划模型研究弹性需求下网络设计问题与电子路票收取问题,其中只考虑在部分路段进行路段能力扩充和收取电子路票.上层决策者(网络规划者)选择路段能力增加和收取电子路票的数量来获得最优的社会总福利.下层决策者(网络用户... 详细信息

应用双(二)层规划模型研究弹性需求下网络设计问题与电子路票收取问题,其中只考虑在部分路段进行路段能力扩充和收取电子路票.上层决策者(网络规划者)选择路段能力增加和收取电子路票的数量来获得最优的社会总福利.下层决策者(网络用户)选择路径来最小化他们的出行成本(路径出行时间与所付出电子路票的价值的和).应用下层规划问题的Karush-Kuhn-Tucker(KKT)条件,将双层规划模型转化为单层规划模型.为了解决互补条件所造成的求解困难,本文构造了松弛算法进行求解,并用数值试验研究了模型和算法的可行性.数值结果表明,本文的模型在缓解交通拥挤方面可以得到更好的效果,而且只在部分路段进行路段能力扩充和收取电子路票更加方便实用.在可交易电子路票方案中,更多出行的用户需要购买电子路票来为他们的额外出行付费,而减少出行的用户则可以卖出多余电子路票得到补偿,同时电子路票的交易价格是在完全竞争的市场上形成的,因此本文中的可交易电子路票机制是收入中性的.

关键词：双(二)层规划模型连续均衡网络设计可交易电子路票松弛算法

Allelic reprogramming of chromatin states in human early embryos

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National Science Review 2024年第3期11卷 58-71页

作者： Shenli Yuan Lei gao Wenrong Tao Jianhong Zhan Gang Lu Jingye Zhang Chuanxin Zhang Lizhi Yi Zhenbo Liu Zhenzhen Hou Min Dai Han Zhao zi-Jiang Chen Jiang Liu Keliang Wu Center for Reproductive Medicine Shandong University CAS Key Laboratory of Genome Sciences and Information Collaborative Innovation Center of Genetics and Development Beijing Institute of Genomicsand China National Center for BioinformationChinese Academy of Sciences University of Chinese Academy of Sciences CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical Sciences the Chinese University of Hong Kong Key Laboratory of Reproductive Endocrinology of the Ministry of Education Shandong University Center for Reproductive Medicine Ren Ji Hospital School of Medicine Shanghai Jiao Tong University CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

The reprogramming of parental epigenomes in human early embryos remains elusive. To what extent the characteristics of parental epigenomes are conserved between humans and mice is currently unknown. Here,we mapped parental haploid epigenomes using human parthenogenetic and androgenetic embryos. Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse *** allelic patterns of epigenetic states for orthologous regions are not conserved between humans and mice. Nevertheless, it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in humans and mice. In addition, for DNA-methylation-dependent imprinting, we report 19 novel imprinted genes and their associated germline differentially methylated regions. Unlike in mice, H3K27me3-dependent imprinting is not observed in human early ***, allele-specific epigenomic reprogramming is different in humans and mice.

关键词： human embryo epigenetics reprogramming DNA methylation H3K27me3 chromatin accessibility

基于平均最小间隔的城际铁路线路运输能力计算模型

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中国管理科学 2022年第1期30卷 222-229页

作者：沈洁杨欣吴建军孙会君高自友北京交通大学轨道交通控制与安全国家重点实验室北京100044

在城市群交通一体化迅速发展的大背景下,本文针对城际铁路的运输能力计算问题提出一种与之相适应的计算模型。首先,文章在分析城际铁路运营特点基础上,基于整数线性规划建立计算模型,该模型利用平均最小间隔时间法中将两列相邻的列车组... 详细信息

在城市群交通一体化迅速发展的大背景下,本文针对城际铁路的运输能力计算问题提出一种与之相适应的计算模型。首先,文章在分析城际铁路运营特点基础上,基于整数线性规划建立计算模型,该模型利用平均最小间隔时间法中将两列相邻的列车组合为运行列车组作为运行图结构单元的思想来计算列车占用运行图总时间,并以最大化运行列车组总数为目标函数,以规定列车占用运行图总时间的有效时间范围为约束条件。最后,文章通过京津城际实际数据算例,验证了文章所提计算模型相较于传统计算方法更切合城际铁路运营实际。该模型大幅简化了城际铁路线路运输能力的计算步骤,提高了计算效率,能够助力于改善城际铁路运输能力及其运营服务水平。

关键词：运行列车组城际铁路运输能力整数线性规划

Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu gao Chen-Xia Zhou Hong-Mei Li Min Cheng Da Chen zi-Yi Li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(<7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

能力限制条件下的公交平衡配流模型和求解算法

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铁道学报 1999年第5期21卷 10-14页

作者：宋一凡高自友北方交通大学交通运输学院北京100044

利用道路网络和公交线路以产生便于公交分析的广义网络，它仅由节点和路段组成，节点代表车站和地区中心，路段代表公交线路、等车路段、步行路段及换乘或下车路段。车内出行费用由两部分组成：一部分是与乘客数量无关的公交车在路段上... 详细信息

利用道路网络和公交线路以产生便于公交分析的广义网络，它仅由节点和路段组成，节点代表车站和地区中心，路段代表公交线路、等车路段、步行路段及换乘或下车路段。车内出行费用由两部分组成：一部分是与乘客数量无关的公交车在路段上的运行时间；另一部分是与乘客数量有关的乘客感觉到的不舒适程度。乘客在车站的等车时间也分为两个部分：一部分是由公交车间隔决定的等车时间；另一部分是由于能力所限和拥挤导致一部分乘客上不了车而不得不等下一辆或换乘另一条公交线路从而造成的在车站的延误时间。以此网络为基础，为公交配流问题设计了一个基于用户平衡的模型和求解算法。

关键词：公交配流用户平衡求解算法城市运输

停车诱导信息系统条件下的城市交通网络SUE配流模型及算法

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公路交通科技 2006年第1期23卷 120-124页

作者：四兵锋高自友林兴强北京交通大学系统科学研究所北京100044 香港理工大学土木工程系

停车诱导信息系统(Parking Guidance Information System,PGIS)被认为是改善城市交通拥挤的一项有效技术,不同的PGIS市场占有率对道路交通的影响是不同的。文章将出行者分成两类:使用PGIS和不使用PGIS,考虑了PGIS对出行者道路和停车选... 详细信息

停车诱导信息系统(Parking Guidance Information System,PGIS)被认为是改善城市交通拥挤的一项有效技术,不同的PGIS市场占有率对道路交通的影响是不同的。文章将出行者分成两类:使用PGIS和不使用PGIS,考虑了PGIS对出行者道路和停车选择行为的影响以及PGIS的市场占有率,构造了随机用户均衡模型来描述PGIS条件下的道路和停车选择问题,设计了相应的算法。最后,通过一个算例对模型及算法进行了验证。

关键词：停车诱导信息系统随机用户平衡流量分配求解算法

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考虑出发时间选择的动态用户最优模型

交通运输系统工程与信息 2007年第3期7卷 83-89页

作者：任华玲高自友北京交通大学交通运输学院北京100044

建立了动态用户最优(DUO)配流问题的双层变分不等式(VI)模型,该模型能够同时选择出发时间和路径,使得乘客在任意时刻都能够选择负效用最小的出发时刻和阻抗最小的路径.文中用基于混沌优化分析的算法来求解这个双层变分不等式模型,其结... 详细信息

建立了动态用户最优(DUO)配流问题的双层变分不等式(VI)模型,该模型能够同时选择出发时间和路径,使得乘客在任意时刻都能够选择负效用最小的出发时刻和阻抗最小的路径.文中用基于混沌优化分析的算法来求解这个双层变分不等式模型,其结果不仅能够告诉出行者应该在什么时刻出发,而且还能够计算每个小时段的路段流入率、流出率及路段流量,从而达到对行人进行诱导的目的.

关键词：动态用户最优(DUO) 出发时间和路径选择双层模型