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Dual-targeting AAV9P1.mediated neuronal reprogramming in a mouse model of traumatic brain injury

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Neural Regeneration Research 2024年第3期19卷 629-635页

作者： Jingzhou Liu Xin Xin Jiejie Sun Yueyue Fan Xun Zhou Wei Gong Meiyan yang Zhiping Li Yuli {1. yang yang Chunsheng gao State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina Academy of Medical Engineering and Translational Medicine Medical CollegeTianjin UniversityTianjinChina

Traumatic brain injury results in neuronal loss and glial scar *** neurons and eliminating the consequences of glial scar formation are essential for treating traumatic brain *** reprogramming is a promising strategy to convert glial scars to neural ***,previous studies have reported inconsistent *** this study,an AAV9P1.vector incorporating an astrocyte-targeting P1.peptide and glial fibrillary acidic protein promoter was used to achieve dual-targeting of astrocytes and the glial scar while minimizing off-target *** results demonstrate that AAV9P1.provides high selectivity of astrocytes and reactive ***,neuronal reprogramming was induced by downregulating the polypyrimidine tract-binding protein 1.gene via systemic administration of AAV9P1.in a mouse model of traumatic brain *** summary,this approach provides an improved gene delivery vehicle to study neuronal programming and evidence of its applications for traumatic brain injury.

关键词： AAV9P1 astrocytes astrocyte-to-neuron conversion GFAP promoter glial scar induced neurons neuronal reprogramming P1.peptide PTBP1 traumatic brain injury

New advances of adiponectin in regulating obesity and related metabolic syndromes

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Journal of Pharmaceutical Analysis 2024年第5期14卷 623-638页

作者： Yanqi Han Qianwen Sun Wei Chen Yue gao Jun Ye Yanmin Chen Tingting {1. Lili gao Yuling Liu Yanfang yang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking UnionMedical CollegeBeijing100050China beijing Key Laboratoryof Drug Delivery Technology and NovelFormulation Institute of Materia MedicaChinese Academyof Medical Sciences&Peking UnionMedical CollegeBeijing100050China

Obesity and related metabolic syndromes have been recognized as important disease risks,in which the role of adipokines cannot be ***(ADP)is one of the key adipokines with various beneficial effects,including improving glucose and lipid metabolism,enhancing insulin sensitivity,reducing oxidative stress and inflammation,promoting ceramides degradation,and stimulating adipose tissue *** on those,it can serve as a positive regulator in many metabolic syndromes,such as type 2 diabetes(T2D),cardiovascular diseases,non-alcoholic fatty liver disease(NAFLD),sarcopenia,neurodegenerative diseases,and certain ***,a promising therapeutic approach for treating various metabolic diseases may involve elevating ADP levels or activating ADP *** modulation of ADP genes,multimerization,and secretion covers the main processes of ADP generation,providing a comprehensive orientation for the development of more appropriate therapeutic *** order to have a deeper understanding of ADP,this paper will provide an all-encompassing review of ADP.

关键词： Adiponectin Obesity Metabolic syndrome Regulation

A novel function for the cellulose binding module of cellobiohydrolase I

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science{1.(Life sciences) 2008年第7期51卷 620-629页

作者： wang LuShan 1.2 ,ZHANG YuZhong 1.&{1. PeiJi 1.1.tate Key Laboratory of Microbial Technology,Shandong University,Jinan 2501.0,china 2beijing Laboratory of Nanoscale Physics&Devices,Chinese Academy of sciences,beijing 1.0080,china 1. State Key Laboratory of Microbial Technology Shandong University Jinan 250100 China 2. beijing Laboratory of Nanoscale Physics & Devices Chinese Academy of Sciences Beijing 100080 China

A homogeneous cellulose-binding module(CBM)of cellobiohydrolase I(CBHI)from Trichoderma pseudokoningii S-38 was obtained by the limited proteolysis with papain and a series of chromatographs *** of FT-IR spectra demonstrated that the structural changes result from a weakening and splitting of the hydrogen bond network in cellulose by the action of CBMCBHI at 40℃for 24 *** results of molecular dynamic simulations are consistent with the experimental conclusions, and provide a nanoscopic view of the mechanism that strong and medium H-bonds decreased dramatically when CBM was bound to the cellulose *** function of CBMCBHI is not only limited to locating intact CBHI in close proximity with cellulose fibrils,but also is involved in the structural disruption at the fibre *** present studies provided considerable evidence for the model of the intramolecular synergy between the catalytic domain and their CBMs.

关键词： cellulose cellulase cellobiohydrolase cellulose binding module hydrogen bonds molecular dynamics simulation

Level Set interface treatment and its application in Euler method

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science{1.(Physics,Mechanics & Astronomy) 2010年第2期53卷 227-236页

作者： WU KaiTeng1.2,HAO Li3,wang Cheng4 & ZHANG Li1.2 1.Numerical Simulation Sichuan Higher School Key Laboratory,Neijiang Normal University,Neijiang 641.1.,{1. 2 college of Mathematics and Information science,Neijiang Normal University,Neijiang 641.1.,{1. 3 college of science,beijing University of Civil Engineering and Architecture,beijing 1.0044,{1. 4 State Key Laboratory of Explosion science and Technology,beijing Institute of Technology,beijing 1.0081.{1. 1. Numerical Simulation Sichuan Higher School Key Laboratory Neijiang Normal University Neijiang 641112 China2. College of Mathematics and Information Science Neijiang Normal University Neijiang 641112 China3. College of Science Beijing University of Civil Engineering and Architecture Beijing 100044 China4. State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing 100081 China

Level Set interface treatment method is introduced into Euler method,which is employed for interface treatment method for multi-materials. Combined with the ghost fluid method,the moving interface is tracked. Fifth-order WENO spatial discretization and third-order TVD Runge-Kutta time discretization methods are used. Shock-wave action on bubble,implosion and velocity field Shock effect bubbles; implosion and velocity field are simulated by means of LS-MMIC3D programmed by C++. Nu-merical results show that the Level Set interface treatment method is effective and feasible for multi-material interface treatment in comparison with the WENO method.

关键词： Euler method Level Set method shock-wave action on bubble implosion numerical simulation

The distribution rule and seepage effect of the fractures in the ultra-low permeability sandstone reservoir in east Gansu Province,Ordos Basin

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science{1. Earth sciences 2008年第S2期51卷 44-52页

作者： ZENG LianBo1.gao ChunYu2,QI JiaFu1.{1. YongKang2,LI Liang2 & QU XueFeng2 1.State Key Laboratory of Petroleum Resource and Prospecting,china University of Petroleum,beijing 1.2249,china 2 Changqing Oilfield Branch,Petrochina,Xi’an 1.351.,china china Univ Petr State Key Lab Petr Resource & Prospecting Beijing 102249 Peoples R China Petrochina Changqing Oilfield Branch Xian 163517 Peoples R China

To study the impact of the fractures on development in the ultra-low permeability sandstone reservoir of the yangchang Formation of the Upper Triassic in the Ordos Basin,data on outcrops,cores,slices,well logging and experiments are utilized to analyze the cause of the formation of the fractures,their distribution rules and the control factors and discuss the seepage flow effect of the fractures. In the studied area developed chiefly high-angle tectonic fractures and horizontal bedding fractures,inter-granular fractures and grain boundary fractures as well. Grain boundary fractures and intragranular fractures serve as vital channels linking intragranular pores and intergranular solution pores in the reservoir matrix,thus providing a good connectivity between the pores in the ultra-low perme-ability sandstone reservoir. The formation of fractures and their distribution are influenced by such external and internal factors as the palaeo-tectonic stress field,the reservoir lithological character,the thickness of the rock layer and the anisotropy of a layer. The present-day stress field influences the preservative state of fractures and their seepage flow effect. Under the tec-tonic effect of both the Yanshan and Himalayan periods,in this region four sets of fractures are distributed,respectively assuming the NE-SW,NW-SE,nearly E-W and nearly S-N orientations,but,due to the effect of the rock anisotropy of the rock formation,in some part of it two groups of nearly orthogonal fractures are chiefly distributed. Under the effect of the present-day stress field,the fractures that assume the NE-SW direction have a good connectivity,big apertures,a high permeability and a minimum starting pressure,all of which are main advantages of the seepage fractures in this region. With the development of oilfields,the permeability of the fractures of dif-ferent directions will have a dynamic change.

关键词： fracture genetic type distribution characteristic seepage flow effect ultra-low permeability sandstone reservoir Ordos Basin

Suppressing the multimodal size distribution of InAs/GaAs quantum dots through flattening the surface fluctuation

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science{1.(Physics,Mechanics & Astronomy) 2010年第5期53卷 788-792页

作者： wang Lu1.2,LI MeiCheng1.wang WenXin2,gao HanChao2,TIAN HaiTao2,XIONG Min1.& ZHAO LianCheng1.1.School of Material science and Technology,Harbin Institute of Technology,Harbin 1.0001.china 2 National Laboratory for Condensed Matter Physics,Institute of Physics,Chinese Academy of sciences,beijing 1.01.0,china 1. School of Material science and Technology Harbin Institute of Technology Harbin 150001 China2. National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

A method of suppressing the multimodal size distribution of InAs/GaAs quantum dots(QDs) using molecular beam epitaxy through flattening the substrate surface is reported in this *** is found that the surface roughness plays an important role in the growth of QDs through continuous surface evolution(SEQDs).SEQDs are the main components of small QD ensemble in QDs with multimodal size *** is suggested that most of the SEQDs are very likely to nucleate during the growth interruption rather than during the *** growth of QDs on a smoother surface has largely reduced the density of *** photoluminescence line width of uniform QDs is found to be only 1. meV at a low temperature.

关键词： quantum dots multimodal surface fluctuation

Thermal expansion properties and hygro-scopicity of Y_(2-x)Sm_xW_3O_(1.) (x=0.0-0.4) compounds

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science{1.(Technological sciences) 2008年第1期51卷 25-32页

作者： YU ZhouXiang1. PENG Jie2, wang Hui2, WU MeiMei2, CHENG YingZhi2, HU ZhongBo2 & CHEN DongFeng1.1.1. Institute of Atomic Energy, P.O. Box 275 (30), beijing 1.241.,{1. 2 college of Chemistry and Chemical Engineering, Graduate University of Chinese Academy of sciences, beijing 1.0049,{1. china Institute of Atomic Energy P.O.Box 275 (30)Beijing 102413China college of Chemistry and Chemical Engineering Graduate University of Chinese Academy of SciencesBeijing 100049China

A novel class of solid solutions of Y2-xSmxW3O1. (x = 0.0–0.4) were synthesized and studied by means of powder X-ray diffraction. All samples crystallize in an ortho- rhombic space group Pnca. The lattice parameters a, b and c of Y2-xSmxW3O1. in- crease with increasing Sm content. Since the compounds of this series hydrate at room temperature, thermogravimetric (TG) analysis was carried out. The result shows that the compound stores less water with increasing Sm content. The thermal expansion properties of Y2-xSmxW3O1. (x = 0.1. 0.3 and 0.4) were investi- gated with high temperature X-ray diffraction. Negative thermal expansion coeffi- cient αl becomes less negative from -6.644×1.-6 to -6.21.×1.-6℃-1.when x changes from 0.1.to 0.4.

关键词： rare earth tungstates negative thermal expansion hygroscopic XRD

Characterization of SH3GLB1.in the Checkfor auditory system and its potential role in updates mitophagy

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Genes & Diseases 2024年第4期11卷 61-64页

作者： Xue gao Weiqian {1. Jincao Xu Shasha Huang Kun yang Jinyuan yang Yijin Chen Guojian {1. Mingyu Han Zhendong {1. Dongyang Kang Yongyi Yuan Pu Dai college of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijing 100853China National Clinical Research Center for Otolaryngologic Diseases State Key Lab of Hearing ScienceMinistry of EducationBeijing 100853China beijing Key Lab of Hearing Impairment Prevention and Treatment Chinese PLA Medical SchoolBeijing 100853China Department of Otolaryngology PLA Rocket Force Characteristic Medical CenterBeijing 100088China

Mitochondria energize the inner ear to maintain the cochlear potential createdbythe striavascularis,assist the motility of outer hair cells,perform synaptic processes,and maintain the spontaneous and sound-driven discharges of the spiral ganglion neurons(SGNs).Mitophagy deficiencies induce the accumulation of damaged organelles and mitochondria in cells and are a primary cause of drug-induced hearing loss.

关键词： auditory maintain potential

Up-conversion emissions of Er^(3+)-Yb^(3+) codoped Al_2O_3 nanoparticles by the arc discharge synthesis method

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science{1.(Physics,Mechanics & Astronomy) 2009年第7期52卷 1043-1046页

作者： DONG Bin1. CAO BaoSheng1. FENG ZhiQing1. wang XingJun2, LI ChengRen3 & HUA RuiNian4 1.School of {1., Dalian Nationalities University, Dalian 1.6600, china 2 School of Electronics Engineering and Computer {1., Peking University, beijing 1.0871. china 3 college of Physics and Electronic Technology, Liaoning Normal University, Dalian 1.6029, china 4 college of Life {1., Dalian Nationalities University, Dalian 1.6600, china 1. School of science Dalian Nationalities University Dalian 116600 China 2. School of Electronics Engineering and Computer science Peking University Beijing 100871 China 3. college of Physics and Electronic Technology Liaoning Normal University Dalian 116029 China 4. college of Life {1. Dalian Nationalities University Dalian 116600 China

The Er3+-Yb3+ codoped Al2O3 nanoparticles with an average particle size of about 50 nm have been synthesized by an arc discharge synthesis method. The green and red up-conversion emissions centered at about 526, 547 and 677 nm, corresponding respectively to the 2H1./2→4I1./2, 4S3/2→4I1./2 and 4 F9/2→4I1./2 transitions of Er3+, were detected by a 978-nm semiconductor laser diode excitation. The Annealing has evident effect on the up-conversion emissions of the samples: The red up-conversion emission is noticeable before annealing; however, the green up-conversion emission becomes predominant after annealing. The mixture of (Er,Yb)3Al5O1. and α-(Al,Er,Yb)2O3 phases is more favorable for green up-conversion emissions due to an enhancement of the ESA (I) of 4I1./2+a photon→4F7/2 and ET (III) of 2F5/2(Yb3+)+4I1./2(Er3+)→2F7/2(Yb3+)+4F7/2(Er3+) processes. The two-photon absorption up-conversion process is involved in the green and red up-conversion emissions. The results have proved that arc discharge synthesis is a new promising preparation technology for optical materials.

关键词： up-conversion Er3+-Yb3+ codoped Al2O3 arc discharge synthesis