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Cutaneous Hypersensitivity as an Indicator of Visceral Inflammation via C-Nociceptor Axon Bifurcation

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Neuroscience Bulletin 2021年第1期37卷 45-54页

作者： Yehong Fang Shu Han Xiaoxue Li Yikuan Xie Bing Zhu xinyan gao Chao Ma Institute of Basic Medical Sciences Department of Human AnatomyHistology and EmbryologyNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Joint Laboratory of Anesthesia and Pain Peking Union Medical CollegeBeijing 100730China

Pain on the body surface can accompany disorders in the deep tissue or internal organs. However, the anatomical and physiological mechanisms are ***, we provided direct evidence of axon bifurcation in primary C-nociceptive neurons that innervate both the skin and a visceral organ. Double-labeled dorsal root ganglion(DRG) neurons and Evans blue extravasation were observed in 3 types of chemically-induced visceral inflammation(colitis, urocystitis, and acute gastritis) rat *** the colitis model, mechanical hypersensitivity and spontaneous activity were recorded in vivo from doublelabeled C-nociceptive neurons in S1 or L6 DRGs. These neurons showed significantly enhanced responses to both somatic stimulation and colorectal distension. Our findings suggest that the branching of C-nociceptor axons contribute to cutaneous hypersensitivity in visceral inflammation. Cutaneous hypersensitivity on certain locations of the body surface might serve as an indicator of pathological conditions in the corresponding visceral organ.

关键词： Visceral inflammation Cutaneous hypersensitivity Axon bifurcation C-nociceptor

Neuro-and immuno-modulation mediated by the cardiac sympathetic nerve:a novel insight into the anti-ischemic efficacy of acupuncture

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1058-1066页

作者： XI Hanqing LI Xia ZHANG Ziyi CUI Xiang JING Xianghong ZHU Bing gao xinyan Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijing 100700China

Communication between sympathetic nerves and the immune system is a crucial and active process during myocardial ischemia(MI),as myocardial damage and inflammatory stimuli concurrently *** nerves undergo structural and functional changes after MI,leading to adverse left ventricular(LV)remodeling and heart failure(HF).The complex inflammatory response to MI,including local myocardial anti-inflammatory repair and systemic immune reactions,plays a key role in adverse LV ***,we review the progressive structural and electrophysiological remodeling of the LV and the involvement of sympathetic tone in complex and dynamic processes that are susceptible to MI pathological *** has been reported to effectively improve cardiac function,eliminate arrhythmia,and mitigate adverse LV remodeling via somatosensory regulation after ***,acupuncture has an anti-inflammatory effect on the pathological process of myocardial *** this Review,we aim to summarize the involvement of sympathetic nerve activation in the neuro-immune modulation of structural and functional cardiac changes after *** a noninvasive method for sympathetic regulation,acupuncture is an ideal option because of its anti-ischemic efficacy.A better understanding of the neural circuitry that regulates cardiac function and immune responses following MI could reveal novel targets for acupuncture treatment.

关键词： neuroinflammatory diseases sympathetic nerves myocardial ischemia acupuncture review

Effect of scraping therapy on weightlifting ability

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Journal of Traditional Chinese Medicine 2014年第1期34卷 52-56页

作者： Xingze Wang Wichai Eungpinichpong Jinsheng Yang Uraiwan Chatchawan Saowanee Nakmareong Yingying Wang xinyan gao Back Neck and Other Joint Pain Research Group Khon Kaen University Research and Training Center for Enhancing Quality of Life of Working Age People Khon Kaen University Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Faculty of Associated Medical Sciences Khon Kaen University

OBJECTIVE:To verify the effects of scraping therapy on the weightlifting ability by measuring the subjective sensation,and changes of ***:Five students,who have been trained for 3 years in a sport school in China were participated in this study.A course of scraping therapy was applied to intervene during the normal 7-week of weightlifting training *** ability of weightlifting,the scale of rating perceived exertion and serum biochemical markers were measured before and after the ***:Scraping therapy caused a significant increase in weightlifting ability(P<0.05).The level of rating perceived exertion remained stable with the increase in the training ***-globulinA was significantly increased(P<0.05),and creatine kinase and blood urea nitrogen were significantly decreased(P<0.05).No significant changes were observed in white blood cell,neutrophil,and ***:Scraping therapy may facilitate weightlifting ability mainly by decreasing weight sensation and improving serum biochemical parameters.

关键词： Scraping therapy Weight lifting Rating perceived exertion

Referred Somatic Hyperalgesia Mediates Cardiac Regulation by the Activation of Sympathetic Nerves in a Rat Model of Myocardial Ischemia

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Neuroscience Bulletin 2022年第4期38卷 386-402页

作者： Xiang Cui Guang Sun Honglei Cao Qun Liu Kun Liu Shuya Wang Bing Zhu xinyan gao Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Research Center of Traditional Chinese Medicine The Affiliated Hospital of Changchun University of Chinese MedicineChangchunJilin 130021China Department of Cardiology Jining No.1 People’s HospitalJining 272100ShandongChina Department of Needling Manipulation Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China

Myocardial ischemia(MI)causes somatic referred pain and sympathetic hyperactivity,and the role of sensory inputs from referred areas in cardiac function and sympathetic hyperactivity remain ***,in a rat model,we showed that MI not only led to referred mechanical hypersensitivity on the forelimbs and upper back,but also elicited sympathetic sprouting in the skin of the referred area and C8–T6 dorsal root ganglia,and increased cardiac sympathetic tone,indicating sympathetic-sensory ***,intensifying referred hyperalgesic inputs with noxious mechanical,thermal,and electro-stimulation(ES)of the forearm augmented sympathetic hyperactivity and regulated cardiac function,whereas deafferentation of the left brachial plexus diminished *** injection of the α_(2) adrenoceptor(α_(2)AR)antagonist yohimbine and agonist dexmedetomidine in the forearm attenuated the cardiac adjustment by ***,these findings suggest that sensory inputs from the referred pain area contribute to cardiac functional adjustment via peripheral α_(2)AR-mediated sympathetic-sensory coupling.

关键词： Sympathetic-sensory coupling Neuromodulation Referred pain α_(2)adrenoceptor Cardioprotectio

Mechanism of acupuncture regulating visceral sensation and mobility

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Frontiers of Medicine 2011年第2期5卷 151-156页

作者： Peijing Rong Bing Zhu Yuqing Li xinyan gao Hui Ben Yanhua Li Liang Li Wei He Rupeng Liu Lingling Yu Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China

Chinese ancient medical scientists have long focused on the internal and external contacts between acupoints on the surface of the body and the *** Miraculous Pivot(it is one of the earliest medical classics in China)stated,“Twelve regular channels belong to the zang-fu organs internally,and connect to the extremities and joints externally.”Traditional Chinese medicine considers acupoints as defined areas where the Qi of viscera and meridians are *** include the reaction points of visceral diseases on the body surface as well as the acupuncture trigger points that promote the flow of Qi and blood,and regulate visceral *** ancient medical scientists classified the specificity of the main acupoints in the body based on the meridian doctrine,which has been instructing clinical application for about 2000 *** on the domino effect of acupoints have mainly focused on conclusions to clinical *** of some acupoints exceed the practical paradigm since the excessive extension occurred during theory *** current research direction on acupuncture focuses on three aspects:the effectiveness of acupuncture and moxibustion;the relevances and associations between meridians and viscera;and the physical and chemical properties and relevant physical basis of *** relevance between meridians and viscera is the central theory in the meridian doctrine,and acupoints are regarded as an important link in the relationship between meridians and *** relationships between acupoints and target organs *** different acupoints on the body surface can help deal with different diseases,especially visceral *** addition,acupoints have a dual function of reflecting and treating visceral *** is no systemic research available on acupoint specificity,despite current knowledge and clinical experiences,which results in a weak foundation for acupuncture *** study focuses on the re

关键词： acupuncture somite visceral pain somato-visceral connection meridian

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中西医结合新病名"耳眩晕"的衍生与确立

中华医史杂志 2020年第5期50卷 286-289页

作者：高新颜中国中医科学院中国医史文献研究所北京100700

"耳眩晕"是现代中医新病名,相当于现代医学的耳源性眩晕。中医很早就观察到眩晕症状,耳眩晕包含于中医古籍"眩冒""掉眩""眩晕""风眩""真眩晕"等病症内,其中"真眩晕"与现今耳源性眩晕较为接近。"耳眩晕"是中医耳鼻喉科专家在中西医结合... 详细信息

"耳眩晕"是现代中医新病名,相当于现代医学的耳源性眩晕。中医很早就观察到眩晕症状,耳眩晕包含于中医古籍"眩冒""掉眩""眩晕""风眩""真眩晕"等病症内,其中"真眩晕"与现今耳源性眩晕较为接近。"耳眩晕"是中医耳鼻喉科专家在中西医结合背景下创造的新病名,它诞生于中医学全国统编教材《中医耳鼻喉科学》第4版和第5版,现已成为中医规范术语,其定义和对应西医病名均已基本统一。现代中医内科疾病眩晕定义宽泛,耳眩晕亦包含在内。

关键词：耳眩晕眩晕中医病名中医术语

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软件工程经济的研究及发展趋势

计算机工程 2006年第18期32卷 3-5页

作者：方海光高新岩陈澎四川师范大学计算机软件实验室成都610068 中国科学院成都计算机应用研究所成都610041

软件工程经济是近年来出现的崭新的研究方向,是软件工程和经济学相互融合深入的产物。该文从总体上讨论了软件工程经济的概念、软件工程经济在软件产品价值中的关系以及和经济学研究的关系,描述了当前应用的模型分类和具有代表性的模型... 详细信息

软件工程经济是近年来出现的崭新的研究方向,是软件工程和经济学相互融合深入的产物。该文从总体上讨论了软件工程经济的概念、软件工程经济在软件产品价值中的关系以及和经济学研究的关系,描述了当前应用的模型分类和具有代表性的模型,以及关于软件工程经济的未来研究内容、研究趋势整体框架和分层结构。

关键词：软件工程经济评估模型未来框架分层结构

场所精神视域下图书馆的空间营造研究——以IFLA年度公共图书馆奖为例

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图书馆 2023年第12期 90-96页

作者：祁宁高欣妍沈阳建筑大学图书馆沈阳110168 沈阳建筑大学计算机科学与工程学院沈阳110168

图书馆作为城市的建筑地标、风景地标和文化地标,其场所功能与职责正在发生转变。文章以场所精神为理论基础,探讨其与图书馆的内在联系,并以IFLA年度公共图书馆奖为例,从场所的特征、意义和价值等视角出发,分析各馆是如何从景观、建筑... 详细信息

图书馆作为城市的建筑地标、风景地标和文化地标,其场所功能与职责正在发生转变。文章以场所精神为理论基础,探讨其与图书馆的内在联系,并以IFLA年度公共图书馆奖为例,从场所的特征、意义和价值等视角出发,分析各馆是如何从景观、建筑、空间、文化、功能、信息、服务等方面诠释其场所精神,以期从提升公众审美感知、提高空间表现力、传承历史文脉、创建多元智慧场所、提高服务效能等方面,为我国图书馆的空间营造提供启示和借鉴。

关键词：场所精神图书馆空间营造 IFLA 年度公共图书馆奖

Cutaneous hypersensitivity as an indicator of visceral inflammation via C-nociceptor's axon bifurcation

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Cutaneous hypersensitivity as an indicator of visceral infla...