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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第2期15卷 779-794页

作者： Mingkun gao Chaoyong Liao Jianyang fu Zhonghua Ning Zengpeng Lv Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Baicalin and probiotic cocktails are promising feed additives with broad application *** probiotic cocktails are known to enhance intestinal health,the potential synergistic impact of combining baicalin with probiotic cocktails on the gut health of broiler chickens remains largely ***,this study aims to investigate the influence of the combined administration of baicalin and probiotic cocktails on the composition of ileal and cecal microbiota in broiler chickens to elucidate the underlying mechanisms responsible for the healthpromoting *** A total of 3201-day-old male Arbor Acres broilers were divided into 4 groups,each with 8 replicates of 10 chicks per *** a period of 42 d,the birds were fed a basal diet or the same diet supplemented with 37.5 g/t baicalin(BC),1,000 g/t probiotic cocktails(PC),or a combination of both BC(37.5 g/t)and PC(1,000 g/t).The results demonstrated that BC+PC exhibited positive synergistic effects,enhancing intestinal morphology,immune function,and barrier *** was evidenced by increased VH/CD ratio,sIgA levels,and upregulated expression of occludin and claudin-1(P<0.05).16S rRNA analysis indicated that PC potentiated the effects of BC,particularly in the ileum,where BC+PC significantly increased theα-diversity of the ileal microbiota,altered itsβ-diversity,and increased the relative abundance of Flavonifractor(P<0.05),a flavonoid-metabolizing ***,Flavonifractor positively correlated with chicken ileum crypt depth(P<0.05).While BC+PC had a limited effect on cecal microbiota structure,the PC group had a very similar microbial composition to BC+PC,suggesting that the effect of PC at the distal end of the gut overshadowed those of *** We demonstrated the synergistic enhancement of gut health regulation in broiler chickens by combining baicalin and probiotic *** cocktails enhanced the effects of baicalin and accelerated its metab

关键词： Baicalin Gut health Ileal microbiota Probiotic cocktails Synergistic effects

A green cross-linking method for the preparation of renewable threedimensional graphene sponges for efficient adsorption of Congo red dye

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Chinese Journal of Chemical Engineering 2024年第2期66卷 84-93页

作者： Zhuang Liu Bo gao Haoyuan Han Yuling Li Haiyang fu Donghui Wei Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China

Graphene-based materials possess significant potential for the treatment of dye wastewater due to their exceptional adsorption properties toward stubborn ***,their utilization is hindered by high preparation costs,low yields,environmental pollution during synthesis,and challenges in regenerating the *** study proposes a novel approach to address these limitations by developing nitrogen-doped three-dimensional(3D)polyvinyl alcohol(PVA)crosslinked graphene sponges(N-PGA)using a cross-linking method with ammonium *** method offers a relatively mild,environmentally friendly *** carbonate serves as both a reducing and modifying agent,facilitating the formation of the intrinsic structure of N-PGA and acting as a nitrogen ***,PVA is utilized as the cross-linking *** results demonstrate that N-PGA exhibits a favorable internal 3D hierarchical porous structure and possesses robust mechanical *** measured specific surface area(BET)of N-PGA was as high as406.538 m^(2)·g^(-1),which was favorable for its efficient adsorption of Congo red(CR)dye *** an initial concentration of 50 mg·L^(-1),N-PGA achieved an impressive removal rate of 89.6%and an adsorption capacity of 112 mg·g^(-1)for CR ***,it retained 79%of its initial adsorption capacity after 10 cycles,demonstrating excellent regeneration *** summary,the synthesized N-PGA displays remarkable efficacy in the adsorption of CR dye in wastewater,opening up new possibilities for utilizing 3D porous graphene nanomaterials as efficient adsorbents in wastewater treatment.

关键词： Green chemistry Graphene sponge Adsorbents Adsorption Congo red Regeneration

Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1236-1247页

作者： Kun-Peng Ma Jin-Xin fu Feng Duan Mao-qiang Wang Department of Interventional Radiology The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Chinese People's Liberation Army Medical School Beijing 100853China

BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to *** To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable *** This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April *** survival(OS)and progression-free survival(PFS)were *** objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid ***,the prognostic factors affecting the clinical outcome were *** One hundred and two patients were enrolled with a median follow-up duration of 12.63 *** median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,*** patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their *** This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable *** patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy.

关键词： Transarterial chemoembolization Efficacy Lenvatinib Programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma

A novel histone methyltransferase gene Cg SDG40 positively regulates carotenoid biosynthesis during citrus fruit ripening

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Journal of Integrative Agriculture 2024年第8期23卷 2633-2648页

作者： Jialing fu Qingjiang Wu Xia Wang Juan Sun Li Liao Li Li qiang Xu National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture&Forestry ScienceHuazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Institute of Horticultural Sciences Jiangxi Academy of Agricultural SciencesNanchang 330200China Plant Breeding and Genetics Section School of Integrative Plant ScienceCornell UniversityNew York 14853USA Robert W.Holley Center for Agriculture and Health USDA-Agricultural Research ServiceCornell UniversityNew York 14853USA

The flesh color of pummelo(Citrus maxima)fruits is highly diverse and largely depends on the level of carotenoids,which are beneficial to human *** is vital to investigate the regulatory network of carotenoid biosynthesis to improve the carotenoid content in ***,the molecular mechanism underlying carotenoid accumulation in pummelo is not fully *** this study,we identified a novel histone methyltransferase gene,CgSDG40,involved in carotenoid regulation by analyzing the flesh transcriptome of typical white-fleshed pummelo,red-fleshed pummelo and extreme-colored F1 hybrids from a segregated pummelo *** of CgSDG40 corresponded to flesh color change and was highly coexpressed with ***,CgSDG40 and CgPSY1 are located physically adjacent to each other on the chromosome in opposite directions,sharing a partially overlapping promoter *** localization analysis indicated that CgSDG40 localizes to the *** of CgSDG40 significantly increased the total carotenoid content in citrus calli relative to that in wild *** addition,expression of CgPSY1 was significantly activated in overexpression lines relative to wild *** together,our findings reveal a novel histone methyltransferase regulator,CgSDG40,involved in the regulation of carotenoid biosynthesis in citrus and provide new strategies for molecular design breeding and genetic improvement of fruit color and nutritional quality.

关键词： pummelo SET domain protein epigenetic regulation PSY1 lycopene fruit quality fruit color

基于FLAC的煤巷锚杆支护设计系统开发与应用

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煤炭工程 2007年第8期39卷 104-106页

作者：高富强煤炭科学研究总院北京开采研究所

介绍了基于FLAC的煤巷锚杆支护设计系统的研究和开发,系统综合利用工程类比、理论计算及数值模拟方法进行煤巷锚杆支护设计。具备FLAC自动建模功能,极大地方便了现场技术人员使用FLAC进行煤巷锚杆支护设计。系统在铜川矿区得到广泛应用。

关键词： FLAC 数值计算锚杆支护设计系统

Molecular Ferroelastic Induced by Mono-/Double-Protonation Strategy

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Chinese Journal of Chemistry 2024年第15期42卷 1706-1712页

作者： Jia-Qi Luo Meng-Meng Lun qiang-qiang Jia Zhi-Jie Wang Hai-Feng Lu Yi Zhang Da-Wei fu Institute for Science and Applications of Molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhuaZhejiang 321004China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular FerroelectricsSoutheast UniversityNanjingJiangsu 211189China

Molecular ferroelastics with the natural features of mechanical flexibility and switchable spontaneous strain have attracted widespread attention in the scientific community due to their potential applications in tunable gratings,flexible memorizers,strain sensors,and intelligent ***,most designs of molecular ferroelastics remain in the stage of blind exploration,posing a challenge to achieve a functional ferroelastic more ***,we have successfully obtained a molecular ferroelastic,[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2)(Me_(2)NH(CH_(2))_(2)NH_(3)=N,N-dimethylethylenediammonium),under the guidance of the mono-/double-protonation ***_double-protonated[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2) undergoes a paraelastic-ferroelastic phase transition with the Aizu notation of 2/mFi at 322 ***,the theoretical calculation and experimental measurement simultaneously show that[Me_(2)NH(CH_(2))_(2)NH_(3)](ReO_(4))_(2) possesses good mechanical flexibility,because its elastic modulus(E)of 8.26 GPa and hardness(H)of 0.45 GPa are smaller than the average values of organic crystals(E of 12.05 GPa and H of 0.5 GPa),which makes it promising to apply in wearable pressure sensors,implantable medical sensors,high-precision tuners,*** work further enriches the molecular ferroelastic family and demonstrates that mono-/double-protonation is one of the effective molecular modification strategies for designing ferroelastics.

关键词： Molecular crystal Ferroelastic Mono-/double-protonation Mechanical flexibility Phase transition Crystal engineering Computational chemistry Molecular dynamics

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尼尔基水利枢纽工程低温季节混凝土生产措施

水力发电 2005年第11期31卷 55-56页

作者：高福强中国水利水电第六工程局辽宁丹东118000

尼尔基水利枢纽骨料加工与混凝土拌和工程,是向尼尔基水利枢纽主体工程提供成品混凝土的工程,混凝土总量为105.13万m3,施工期为5a,每年仅可施工6个月。由于工期紧,混凝土生产需要在当年的4～10月间进行,为保证工程质量与工期要求,生产... 详细信息

尼尔基水利枢纽骨料加工与混凝土拌和工程,是向尼尔基水利枢纽主体工程提供成品混凝土的工程,混凝土总量为105.13万m3,施工期为5a,每年仅可施工6个月。由于工期紧,混凝土生产需要在当年的4～10月间进行,为保证工程质量与工期要求,生产采取了加防冻剂并在拌和系统中加装增温系统和骨料保温系统的低温季节混凝土技术措施,并取得了良好的效果。

关键词：混凝土低温季节生产措施性能比较尼尔基水利枢纽

Significance of Lateral Pillar in Osteonecrosis of Femoral Head:A Finite Element Analysis

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Chinese Medical Journal 2017年第21期130卷 2569-2574页

作者： Peng-Fei Wen Wan-Shou Guo Qi-Dong Zhang fu-qiang gao Ju-An Yue Zhao-Hui Liu Li-Ming Cheng Zi-Rong Li Department of Orthopaedic Surgery Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Department of Orthopaedic Surgery Center for Osteonecrosis and Joint Preserving and ReconstructionBeijing Key Laboratory of Arthritic and Rheumatic DiseasesChina-Japan Friendship HospitalBeijing 100029China Beijing University of Chinese Medicine Beijing 100029China

Background： The lateral pillar of the femoral head is an important site for disease development such as osteonecrosis of the femoral head. The femoral head consists of medial, central, and lateral pillars. This study aimed to determine the biomechanical effects of early osteonecrosis in pillars of the femoral head via a finite element （FE） analysis. Methods： A three-dimensional FE model of the intact hip joint was constructed from the image data of a healthy control. further, a set of six early osteonecrosis models was developed based on the three-pillar classification. The von Mises stress and surface displacements were calculated for all models. Results： The peak values of von Mises stress in the cortical and cancellous bones of normal model were 6.41 MPa and 0.49 MPa, respectively. In models with necrotic lesions in the cortical and cancellous bones, the von Mises stress and displacement of lateral pillar showed significant variability： the stress of cortical bone decreased from 6.41 MPa to 1.51 MPa （76.0% reduction）, while cancellous bone showed an increase from 0.49 MPa to 1.28 MPa （159.0% increase）; surface displacements of cortical and cancellous bones increased from 52.4 μm and 52.1 μm to 67.9 μm （29.5%） and 61.9 μm （18.8%）, respectively. In addition, osteonecrosis affected not only pillars but also adjacent structures in terms of the von Mises stress and surface displacement levels. Conclusions： This study suggested that the early-stage necrosis in the femoral head could increase the risk of collapse, especially in lateral pillar. On the other hand, the cortical part of lateral pillar was found to be the main biomechanical support of femoral head.

关键词： Displacement Finite Element Analysis Osteonecrosis of the Femoral Head Stress Structure Collapse

Analysis of SF6 decomposed products by fibre-enhanced Raman spectroscopy for gas-insulated switchgear diagnosis

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High Voltage 2024年第1期9卷 206-216页

作者： Jianxin Wang Weigen Chen Pinyi Wang fu Wan Zhixian Zhang Shoufei gao Yingying Wang School of Electrical Engineering Chongqing UniversityChongqingChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina Institute of Photonics Technology Jinan UniversityGuangzhouChina

Sulphur hexafluoride(SF6)decomposed products analysis is highly critical in the earlystage fault diagnosis of gas-insulated switchgear(GIS).Spectrum technology outperforms traditional methods on non-invasiveness,no sample preparation,and no ***,the authors present an improved fibre-enhanced Raman spectroscopy(FERS)as a comprehensive analytical tool to detect a suite of SF_(6)decomposed products(SO_(2)F_(2),SOF_(2),SO_(2),H_(2)S,CF_(4),OCS,CO_(2),and CO).The FERS approach is combined with two iris diaphragms for spatial filtering and a rear-end reflector for additional Raman signal *** of detection down to 1×10^(−6)–8×10^(−6)are achieved for different SF6 decompositions,and quantification of an undefined multigas,sampled from an 800 kV GIS in service,is realised utilising SF6 as the internal standard gas and with a maximum error of 5.5%.The GIS is diagnosed according to the results and confirmed by an on-site *** authors foresee that this technique will provide a route for trace gas analysis in the power industry.

关键词： SF6 diagnosis fibre