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Design and Synthesis of Polyoxazole-based Macrocycles Tethered with a Phosphonate Group

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Chinese Journal of Chemistry 2014年第7期32卷 585-591页

作者： Fuling Qi lianxun gao Fushe Han Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchunJilin 130022China University of Chinese Academy of Sciences Beijing 100864China Key Lab of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring *** unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.

关键词： telomerase Telomestatin oxazole phosphonate macrocyclic compound

Cu-CatalyzedAryl C H Halogenation Using N-Halosuccinimides via Assistance of Benzoic Acid

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Chemical Research in Chinese Universities 2015年第2期31卷 167-170页

作者： DU Zhijun gao lianxun LIN Yingjie Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China University of Chinese Academy of Sciences Beijing 100864 P. R. China College of Chemistry Jilin University Changchun 130012 P. R. China

Aryl halides are a kind of extremely valuable compounds used in transition-metal-catalyzed coupling reactions, as well as important structure motifs in many natural products and manufactured drugs. The classical approach for preparation of haloarenes is electrophilic aromatic substitution（EAS） using various halogenating reagents or oxidative halogenations with halogenating reagent generated in situ from halides and oxidants, such as peroxide, oxygen and meta-cholorperoxybenzoic acid（mCPBA）. However, harsh reaction conditions are required for halogenation of less active aromatics, orthoMetalation followed by halogen quenching is another approach for halogenation of aromatics. However, there are obvious drawbacks for these methods, such as low regioselectivity, harsh conditions and even dangerous procedures. Therefore, the development of an alternative and practical way remains challenge in organic synthesis.

关键词： Arylpyridine Phenylpyrimidine Cu-Catalyzed halogenation Carboxylic acid Non-coordinating anion

NDI-induced Topological Conversion of Human Telomeric G-Quadruplexes from Hybrid-2 to Parallel Form

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Chemical Research in Chinese Universities 2021年第3期37卷 795-800页

作者： HAO Xueyu LI Chunjie WANG Yu ZHANG Feng HOU Jingwei KANG Chunqing gao lianxun Laboratory of Polymer Composite and Engineering Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022P.R.China University of Science and Technology of China Hefei230026P.R.China

G-Quadruplexes(GQs),which are formed by G-rich DNA sequences in human telomeres,have become an attractive target for cancer *** ligands to stabilize the conformation of human telomeric GQs in vivo are particularly important for structure-based ligand design and drug development targeting the noncanonical DNA *** we report the conformational conversion of Tel26 induced by a naphthalene diimide(NDI)ligand in K^(+)buffer,even at cellular physiological temperature(37℃)and under mimetic cellular crowding conditions created by Ficoll *** provide an insight into the dynamic conversion from initial hybrid-2 GQ topology to final parallel GQ *** results are helpful for the design of ligands with GQ conformation regulation.

关键词： G-Quadruplex Naphthalene diimide Topological conversion Telomeric DNA

Preparation and Properties of Imidazole-containing Polyimide/Silica Hybrid Films

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Chemical Research in Chinese Universities 2014年第6期30卷 1047-1050页

作者： MA Xiaoye MA Xiaofei QIU Xuepeng LIU Fangfang JIN Rizhe KANG Chuanqing GUO Haiquan gao lianxun Polymer Composite Engineering Laboratory Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China" CAST- Xi 'an Institute of Space Radio Technology China Academy of Space Technology Xi' an 710000 P. R. China

Imidazole-containing polyimide/silica（PI/SiO2） hybrid films were prepared from 3,3＇,4,4＇-biphenyltetra- carboxylic dianhydride（BPDA） and 2,2＇-di（p-aminophenyl）-5,5＇-bibenzimidazole in N,N-dimethylacetamide（DMAc） by sol-gel method and thermal imidization. The hybrid film with high silica mass fraction up to 40% was transparent. Scanning electron microscope（SEM） and transmission electron microscope（TEM） results of the film indicate a ho- mogeneous dispersion of silica nanoparticles in the polyimide matrix. One hybrid film PI/SiO2 with 15% SiO2 exhi- bits better mechanical properties with a tensile strength of 222 MPa, an elongation at break of 12%, and a tensile modulus of 5.66 GPa. The reinforced mechanism on mechanical Drooerties was also studied.

关键词： Polyimide Silica Benzimidazole Sol-gel method

Effect of Draw Ratio on the Morphologies and Properties of BPDA/PMDA/ODA Polyimide Fibers

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Chemical Research in Chinese Universities 2014年第1期30卷 163-167页

作者： ZHANG Chunling ZHANG Qiong XUE Yanhu LI Guomin LIU Fangfang QIU Xuepeng JI Xiangling gao lianxun College of Materials Science and Engineering Jilin University Changchun 130025 P. R. China Polymer Composite Engineering Laboratory Chinese Academy of Sciences Changchun 130022 P. R. China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 R R. China

3,3,4,4-Biphenyltetracarboxylic dianhydride/pyromellitic dianhydride/4,4-oxydianiline（BPDA/PMDA/ODA） polyimide copolymer fibers with different draw ratios were prepared from the imidization of polyacrylic acid（PAA） fibers via a dry-jet wet-spinning *** morphologies,microcrystal orientations,thermal stabilities,and mechanical properties were investigated via scanning electron microscopy（SEM）,wide angle X-ray diffraction（WAXD）,thermogravimetric analysis（TGA）,and tensile *** order to acquire fibers with better mechanical performance,we aimed at obtaining the optimal draw *** during thermal imidization resulted in a decreased diameter of fiber from 25.8 μm to 16.9 μm corresponding to draw ratio from 1 to *** results show that the degree of the orientation of the undrawn sample is 64.1％,whereas that of the drawn sample is up to 82％.The as-spun fiber and those with different draw ratios all exhibit high thermal stabilities,i.e.,the temperature at a mass loss of 5％ can reach as high as 570 ℃.The tensile strengths and tensile modulus of the fibers increase with the draw ratios,and the maximum tensile strength and modulus are 0.90 and 12.61 GPa,respectively.

关键词： Polyimide Draw ratio Morphology Orientation Mechanical property

纤维素类手性固定相及高效液相色谱-旋光仪联用技术的研究

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分析化学 2001年第5期29卷 526-529页

作者：张欣高连勋中国科学院长春应用化学研究所!长春130022

合成了 3种纤维素衍生物并分别填充分析型色谱柱 ,研究了不同的涂敷条件对柱效的影响以及色谱柱的稳定性 ,对外消旋化合物进行了手性拆分。实现了高效液相色谱旋光仪的联用 ,获得了在线旋光曲线

关键词：手性固定相拆分高效液相色谱旋光仪联用

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阴离子-萘四酸双酰亚胺相互作用及其应用

化学进展 2018年第7期30卷 902-912页

作者：闫吉军康传清高连勋中国科学院长春应用化学研究所长春130022

萘四酸双酰亚胺(NDI)具有较大的正四极矩,是探索阴离子-π相互作用的理想π酸性芳香体系。阴离子-NDI相互作用的机制和应用受到了广泛关注,利用阴离子-NDI电子转移导致的NDI体系的颜色变化或光谱学变化实现阴离子识别,已经成为一种有效... 详细信息

萘四酸双酰亚胺(NDI)具有较大的正四极矩,是探索阴离子-π相互作用的理想π酸性芳香体系。阴离子-NDI相互作用的机制和应用受到了广泛关注,利用阴离子-NDI电子转移导致的NDI体系的颜色变化或光谱学变化实现阴离子识别,已经成为一种有效的离子识别传感器设计策略,尤其在强碱性阴离子识别方面,由于形成易于辨识的自由基阴离子相关UV谱带而展现出了独特的优势。本文综述了近年来阴离子-NDI相互作用的机制、作用模式及其在阴离子识别、对映体识别、有机催化和离子通道构建中的应用研究进展,兼顾基于孤对电子-π相互作用的中性分子-NDI相互作用研究,讨论了NDI结构与阴离子-π相互作用及应用的功能相关性。本文最后展望了阴离子-NDI体系构建及应用研究面临的挑战与未来发展趋势。

关键词：阴离子萘四酸双酰亚胺阴离子-π相互作用分子识别有机催化阴离子通道

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手性聚酰亚胺的合成、结构与性能

化学进展 2015年第1期27卷 59-69页

作者：康传清闫吉军高连勋中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022

手性聚酰亚胺逐渐成为手性高分子研究的一个重要方面,在分子识别、对映体选择性分离、不对称催化等领域有潜在的应用,日益受到研究者的重视。本文综述了近二十年手性聚酰亚胺的研究进展,将手性聚酰亚胺按照手性结构的引入方式分为侧链... 详细信息

手性聚酰亚胺逐渐成为手性高分子研究的一个重要方面,在分子识别、对映体选择性分离、不对称催化等领域有潜在的应用,日益受到研究者的重视。本文综述了近二十年手性聚酰亚胺的研究进展,将手性聚酰亚胺按照手性结构的引入方式分为侧链手性、主链中心手性和主链轴手性三种类型,并分别加以总结和阐述,介绍了具有代表性的光活性聚酰亚胺的结构、合成和性能,特别关注了手性聚酰亚胺的高次结构的形成以及与其手性光活性相关的性能与应用。最后,本文阐述了手性聚酰亚胺研究面对的挑战与未来发展前景,探索手性聚酰亚胺的合成、性质和应用,建立合理的模型和分析手段,深入探讨手性聚酰亚胺的高次结构仍然是值得深入研究的重点方向。

关键词：手性聚酰亚胺高次结构氨基酸联萘光活性圆二色

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离子液体在有机反应中的应用

有机化学 2002年第3期22卷 159-163页

作者：张所波丁孟贤高连勋中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022

室温离子液体 ,由含氮的有机阳离子和无机阴离子组成 ,可溶解各种有机、无机、金属有机化合物 .它们没有蒸气压、不易燃、容易循环使用 .近年已发现 ,离子液体可广泛地用于许多过渡金属化合物和酶催化的反应 .

关键词：有机反应离子液体溶剂过渡金属催化合成应用有机合成酶催化

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