NDI-induced Topological Conversion of Human Telomeric G-Quadruplexes from Hybrid-2 to Parallel Form

作     者：HAO Xueyu LI Chunjie WANG Yu ZHANG Feng HOU Jingwei KANG Chunqing GAO Lianxun HAO Xueyu;LI Chunjie;WANG Yu;ZHANG Feng;HOU Jingwei;KANG Chunqing;GAO Lianxun

作者机构：Laboratory of Polymer Composite and EngineeringChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022P.R.China University of Science and Technology of ChinaHefei230026P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2021年第37卷第3期

页      面：795-800页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Changchun Institute of Applied Chemistry  CIAC 

主　　题：G-Quadruplex Naphthalene diimide Topological conversion Telomeric DNA 

摘      要：G-Quadruplexes(GQs),which are formed by G-rich DNA sequences in human telomeres,have become an attractive target for cancer *** ligands to stabilize the conformation of human telomeric GQs in vivo are particularly important for structure-based ligand design and drug development targeting the noncanonical DNA *** we report the conformational conversion of Tel26 induced by a naphthalene diimide(NDI)ligand in K^(+)buffer,even at cellular physiological temperature(37℃)and under mimetic cellular crowding conditions created by Ficoll *** provide an insight into the dynamic conversion from initial hybrid-2 GQ topology to final parallel GQ *** results are helpful for the design of ligands with GQ conformation regulation.