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A special type of endovascular stent repair with complicated thoracic aneurysm and chronic type B dissection aligned in tandem： double perfusion in true and false distal aorta lumen

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Chinese Medical Journal 2008年第15期121卷 1484-1486页

作者： gan hui-li ZHANG Jian-qun Cardiac Surgery Department Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 100029 China

Aortic dissection and aortic aneurysm are two of the most common catastrophic events involving the aorta. Thoracic endovascular aortic repair is now considered as a promising alternative to open surgical graft replacement. The aim of endovascular repair of a thoracic aneurysm is to exclude, and thus depressurize, the aneurismal wall and the aim of the endovascular repair of type B aortic dissection is to obliterate all of the false lumen through thrombosis after sealing the primary entry tears, thus to ensure the true lumen perfusion. But in some special pathologies, such as when the aneurysm and chronic type B dissection are aligned in tandem, or when a visceral branch originates from the false lumen, how should the endovascular repair strategy proceed in this situation？ For the endovascular stent repair of some special chronic type B aortic dissection, the false lumen cannot be obliterated, and the true and false lumens in the dissected but with a normal diameter distal aorta need to be perfused at the same time, as practiced in the surgery treatment. In this report, we present a case of endovascular stent repair for a special thoracic aneurysm and chronic type B aortic dissection aligned in tandem.

关键词： aortic aneurysm aortic dissection stent

Pulmonary oligemia maneuver can alleviate pulmonary artery injury during pulmonary thromboendarterectomy procedure

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Chinese Medical Journal 2013年第5期126卷 828-833页

作者： gan hui-li ZHANG Jian-qun LU Jia-kai DONG Xiu-hua Hou Xiao-tong GAO Yuan-ming ZHU Guang-fa Cardiac Surgery Department Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 100029 China Anaesthesiology Department Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 100029 China Cardiopulmonary Bypass Department Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 100029 China Respiratory Department Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing 100029 China

Background Pulmonary thromboendarterectomy （PTE） has evolved as a treatment of choice for chronic thromboembolic pulmonary hypertension （CTEPH）. This study aimed to characterize if pulmonary oligemia maneuver （POM） can alleviate pulmonary artery injury during PTE procedure. Methods A total of 112 cases of CTEPH admitted to Beijing Anzhen Hospital from March 2002 to August 2011 received PTE procedure. They were retrospectively classified as non-POM group （group A, n=55） or POM group （group B, n=57）. Members from group B received POM during rewarming period, whereas members from group A did not. Results There were three （5.45%） early deaths in group A, no death in group B （0）（Fisher＇s exact test, P=0.118）. Six patients in group A needed extracorporeal membrane oxygenation （ECMO） as life support after the PTE procedure, no patients in group B needed ECMO （Fisher＇s exact test, P=0.013）. The patients in group B had a shorter intubation and ICU stay, lower mean pulmonary arterial pressure （mPAP） and pulmonary vascular resistance （PVR）, higher partial pressure of oxygen in artery （PaO2） and arterial oxygen saturation （SaO2） and less medical expenditure than patients in group A. With a mean follow-up time of （58.3 ± 30.6） months, two patients in group A and one patient in group B died. The difference of the actuarial survival after the procedure between the two groups did not reach statistical significance. Three months post the PTE procedure, the difference of residual occluded pulmonary segment between the two groups did not reach statistical significance （P=0.393）. Conclusion POM can alleviate pulmonary artery injury, shorten ICU stay and intubation time, and lower down the rate of ECMO after PTE procedure.

关键词： chronic thromboembolic pulmonary hypertension pulmonary thromboendarterectomy pulmonary artery injury

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin gan Kun ling Mingfang He Jianshu li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

High volume practice proved the safety of off-pump coronary artery bypass surgery in left main coronary artery lesions： a two-year single center experience

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Chinese Medical Journal 2012年第21期125卷 3861-3867页

作者： liU Tong LU Jia-kai gan hui-li ZHANG Jian-qun HUANG Fang-jong GU Cheng-xiong KONG Qing-yu CAO Xiang-rong BO Ping LU Chun-shan Department of Cardiology Beijing Anzhen Hospital Capital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseaseBeijing 100029China Department of Anesthesiology Beijing Anzhen Hospital Capital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseaseBeijing 100029China Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseaseBeijing 100029China

Background Left main coronary artery （LMCA） stenosis has been recognized as a risk factorfor early death among patients undergoing coronary artery bypass grafting （CABG）. This study aimed to assess if LMCA lesions pose an additional risk of early or mid-term mortality and/or a major adverse cardiac and cerebrovascular event （MACCE） after off-pump coronary artery bypass grafting （OPCABG）, compared with non-left main coronary artery stenosis （non-mainstem disease）.

关键词： coronary artery disease " coronary artery bypass grafting " left main coronary artery

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线型脲醛树脂的半结晶模板化作用

化学学报 2008年第8期66卷 860-866页

作者：郝志显李红李铮刘辉甘礼华徐子颉陈龙武同济大学化学系上海200092

酸性条件下硅溶胶体系中尿素和甲醛聚合反应会产生脲醛树脂-氧化硅杂化沉淀.沉淀的质量随有机组分比例的增加而增加,当尿素和甲醛物质的量比≥1.0时生成沉淀的量为恒定最大值.红外分析表明杂化材料在3348,1635,1572和784cm-1处产生了可... 详细信息

酸性条件下硅溶胶体系中尿素和甲醛聚合反应会产生脲醛树脂-氧化硅杂化沉淀.沉淀的质量随有机组分比例的增加而增加,当尿素和甲醛物质的量比≥1.0时生成沉淀的量为恒定最大值.红外分析表明杂化材料在3348,1635,1572和784cm-1处产生了可被归结为线型结构(—[NHCONHCH2]n—)的特征吸收.XRD分析表明这种线型分子可形成氢键(C=O…H—N)导向型的半结晶.微分热重和XRD结果证明结晶物种在290℃完全分解.SEM表征显示半结晶杂化沉淀以三维网络结构为特征,具有层状结晶的各向异性,其初级粒子即使在室温下干燥也容易开裂.随着反应时间的延长、酸性的增加或无机组分量的相对增加杂化粒子变得更加致密.液氮吸附结果证明沉淀焙烧后所得氧化硅材料的结构具有层状孔结构性质,其比表面积、孔尺寸和孔体积可以达到510m2/g,14.3nm和1.68cm3/g.改变反应体系的酸性和反应组分配比等条件可以方便地控制杂化材料的结构.

关键词：脲醛树脂中孔氧化硅半结晶模板剂杂化过程

HPLC结合MALDI-TOF-MS分析木聚糖水解产物

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林产化学与工业 2015年第5期35卷 10-14页

作者：黎海龙李成国秦光辉刘健甘礼惠谢茹胜龙敏南厦门大学能源学院福建生物工程职业技术学院药学系

利用HPLC结合MALDI-TOF-MS对1-苯基-3-甲基-5-吡唑啉酮(PMP)衍生化后山毛榉木聚糖水解产物进行分析,检测到了难以获得标准品对照的木聚糖水解产物。结果表明,稀硫酸水解山毛榉木聚糖的主要水解产物有木糖和4-O-甲基葡萄糖醛酸-木糖(B2)... 详细信息

利用HPLC结合MALDI-TOF-MS对1-苯基-3-甲基-5-吡唑啉酮(PMP)衍生化后山毛榉木聚糖水解产物进行分析,检测到了难以获得标准品对照的木聚糖水解产物。结果表明,稀硫酸水解山毛榉木聚糖的主要水解产物有木糖和4-O-甲基葡萄糖醛酸-木糖(B2),以及少量4-O-甲基葡萄糖醛酸(B1)。内切重组木聚糖酶An Xyn10C水解山毛榉木聚糖产生木糖、木二糖和4-O-甲基葡萄糖醛酸-木三糖(B3),而内切重组木聚糖酶Ho Xyn11A水解山毛榉木聚糖主要产生木糖、木二糖、木三糖、4-O-甲基葡萄糖醛酸-木四糖(B4)和4-O-甲基葡萄糖醛酸-木五糖(B5)。基于PMP柱前衍生化的HPLC结合MALDI-TOF-MS方法能高效地分析复杂的木聚糖水解产物。

关键词： 1-苯基-3-甲基-5-吡唑啉酮低聚木糖 4-O-甲基葡萄糖醛酸 MALDI-TOF-MS HPLC

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乙酰木聚糖酯酶研究进展

中国生物工程杂志 2016年第3期36卷 102-110页

作者：吴红丽薛勇刘健甘礼惠龙敏南厦门大学能源学院厦门361102 福建生物工程职业技术学院福州350002

半纤维素是一类丰富可再生而又亟待开发利用的生物质资源,将半纤维素降解为糖类进而生产木糖醇及其它化学品是利用生物质资源的关键一步。乙酰木聚糖酯酶是降解半纤维素的一个重要酶,它能够水解乙酰化木聚糖中的木糖残基上的2位和3位的... 详细信息

半纤维素是一类丰富可再生而又亟待开发利用的生物质资源,将半纤维素降解为糖类进而生产木糖醇及其它化学品是利用生物质资源的关键一步。乙酰木聚糖酯酶是降解半纤维素的一个重要酶,它能够水解乙酰化木聚糖中的木糖残基上的2位和3位的O乙酰基,在工业、农业及食品业具有广阔的应用前景。综述了乙酰木聚糖酯酶的分类、酶学性质、催化机制、基因克隆和协同酶解等方面的研究进展,同时对该研究进行了展望。

关键词：乙酰木聚糖酯酶酶学性质催化机制协同酶解

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木聚糖酶原位协同水解预处理大米草的研究

应用化工 2020年第1期49卷 74-77,84页

作者：杨旸刘健甘礼惠龙敏南厦门大学能源学院

用氨水与双氧水预处理大米草,与原料大米草一起进行球磨,用于木聚糖酶的协同酶解。结果表明,氨水结合双氧水预处理能有效脱除大米草中的木质素(63.81%),球磨处理能对纤维素结晶结构有所破坏,两者均可有效提高木聚糖酶的水解率。酶水解... 详细信息

用氨水与双氧水预处理大米草,与原料大米草一起进行球磨,用于木聚糖酶的协同酶解。结果表明,氨水结合双氧水预处理能有效脱除大米草中的木质素(63.81%),球磨处理能对纤维素结晶结构有所破坏,两者均可有效提高木聚糖酶的水解率。酶水解物主要成分为木糖(12.54%)、木二糖(40.38%)及少量阿拉伯糖(5.50%)。碱预处理结合球磨预处理,对木聚糖酶协同水解大米草产木寡糖具有明显的促进作用。

关键词：碱预处理球磨预处理协同水解木糖木寡糖

先天性心脏病合并重度肺动脉高压非手术与手术治疗生存分析

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中华医学杂志 2010年第17期90卷 1162-1166页

作者：甘辉立张健群伯平周其文首都医科大学附属北京安贞医院心脏外科北京心肺血管疾病研究所 100029

目的确定先天性心脏病合并重度肺动脉高压（CHDSPH）手术治疗的远期效果与其术前肺循环阻力（PVR）及肺体循环血流比（Qp/Qs）之间的关系,以探讨CHDSPH手术指征.方法 1990年2月至2008年7月,安贞医院心外科收治1212例CHDSPH进行非手术... 详细信息

目的确定先天性心脏病合并重度肺动脉高压（CHDSPH）手术治疗的远期效果与其术前肺循环阻力（PVR）及肺体循环血流比（Qp/Qs）之间的关系,以探讨CHDSPH手术指征.方法 1990年2月至2008年7月,安贞医院心外科收治1212例CHDSPH进行非手术治疗或手术治疗,本文回顾性将其分为非手术组（n=297）和手术组（n=915）.对全部病例计算归入手术治疗组的倾向分数,按相同倾向分数±0.05对两组进行配组,形成245个3人组,按PVR在120 kPa·L-1·S-1水平或Qp/Qs在1.25水平分层,分别建立Kaplan-Meier生存曲线进行统计学分析.结果全组随访（97±57）个月,非手术组有65例晚期死亡,手术组有44例晚期死亡.对245个倾向分数配对3人组生存曲线分析,当PVR≥120 kPa·L-1·S-1,两组间Log-rank检验表明x2=0.54,P=0.4611;而当PVR＜120 kPa·L-1·S-1,两组间Log-rank检验表明x2=51.68,P=0.000,差异有统计学意义.当Qp/Qs＜1.25,两组间Log-rank检验表明x2=0.97,P=0.3254;而当Qp/Qs≥1.25,两组间Logrank检验表明x2=62.77,P=0.000,差异有统计学意义.结论当PVR＜120 kPa·L-1·S-1和（或）Qp/Qs≥1.25是CHDSPH的手术指征.

关键词：先天性心脏病肺动脉高压