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在荷兰乳腺癌筛查方面新老技师之间乳腺钼靶X线定位技术质量的比较分析

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国际医学放射学杂志 2016年第1期 89-89页

作者： C.Landsveld-Verhoeven g.j.den heeten j.Timmers M.j.M.Broeders 佟琪 Department for Health Evidence Radboud University Medical Center

摘要目的旨在比较分析荷兰初训(NR)和有经验的放射科技师(ER)在乳腺钼靶X线定位技术质量方面的差别。材料与方法在从事乳腺检查工作之前,NR必须完成所有课程,包括4天理论课,6周实践训练,以及一份作为放射科技师行50例乳腺钼靶X线检查后... 详细信息

摘要目的旨在比较分析荷兰初训(NR)和有经验的放射科技师(ER)在乳腺钼靶X线定位技术质量方面的差别。材料与方法在从事乳腺检查工作之前,NR必须完成所有课程,包括4天理论课,6周实践训练,以及一份作为放射科技师行50例乳腺钼靶X线检查后的回顾性总结报告。另外,荷兰拥有一个庞大的质量保证筛选系统,其中包括对ER乳腺钼靶X线定位质量的审核。按照预先设定的标准,如乳腺下角的描述,分析了13 520份组合意见(NR)和14 896份审查意见(ER)。结果 NR比ER整体定位更准确(头尾位:97%∶86%,P=0.00;内外侧斜位:92%∶84%,P=0.00)。NR在多数头

关键词：乳腺钼靶 ER 定位技术技师荷兰质量

乳腺数字摄影与胶片摄影筛查对于早期发现临床相关癌症的比较:多中心研究

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国际医学放射学杂志 2013年第1期 71-71页

作者： A.M.j.Bluekens R.Holland N.Karssemeijer M.j.M.Broeders g.j.den heeten 柴超 National Expert and Training Centre for Breast Cancer ScreeningPO Box 68736503 GJ Nijmegenthe Netherlands

目的比较胶片摄影与数字摄影在乳腺癌筛查中对于临床相关癌症的检出率。材料与方法研究经过地区医学伦理委员会批准,不需要知情同意书。在荷兰每两年1次的筛查项目中,全国广泛使用数字乳腺摄影之前,有3个筛查区进行了数字乳腺摄影。最... 详细信息

目的比较胶片摄影与数字摄影在乳腺癌筛查中对于临床相关癌症的检出率。材料与方法研究经过地区医学伦理委员会批准,不需要知情同意书。在荷兰每两年1次的筛查项目中,全国广泛使用数字乳腺摄影之前,有3个筛查区进行了数字乳腺摄影。最初的筛查检查中,每侧乳腺进行内外侧斜位和头尾位摄影。而在随后的检查中,常规进行内外侧斜位摄影。如果有需要才进行头尾位摄影。将最初和随后的乳腺胶片摄影和数字摄影的筛查结果,包括放射学与病理学特点进行比较。结果 2003—2007年间共进行1198493例筛查,18896例进行了复查(胶片摄影:最初的筛查为2.6%,随后的检查为1.3%;数字摄影:最初的筛查为4.4%,随后的检查为2.1%;两者P<0.001)。6410例妇女诊断为乳腺癌(胶片摄影:最初的检查每1000名妇女的检出率为5.6,随后的检出率为5.2;数字摄影:最初的检查中每1000名妇女的检出率为6.8,随后的检出率6.1;P=0.02和P<0.001)。不论哪次筛查,数字乳腺摄影均可发现更多的导管原位癌。在随后的检查中,可发现更多的浸润癌,特别是伴有微钙化者(P=0.047)。两种成像方法中发现的导管原位癌和浸润癌的组织病理学分化等级是相似的。但是,在随后的检查中数字乳腺摄影能检出更多高级别的导管原位癌(P=0.013)。结论在对人群的乳腺筛查项目中,乳腺数字摄影对于导管原位癌和浸润癌的检测显著优于胶片摄影。采用数字乳腺摄影进行筛查,低级别导管原位癌的检出并没有增加的迹象,表明有可能存在过度诊断。相反的,数字乳腺摄影似乎增加了高级别导管原位癌的检测。

关键词：胶片摄影筛查乳腺乳房数字摄影癌症

盲法和非盲法再读存在分歧的筛查乳腺钼靶:第3位阅片人对筛查结果仲裁的影响

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国际医学放射学杂志 2015年第6期 603-603页

作者： E.g.Klompenhouwer A.C.Voogd g.j.den heeten L.j.A.Strobbe V.C.Tjan-Heijnen M.j.M.Broeders 于静 Department of Radiology Catharina Hospital

摘要目的探讨额外第3位阅片人仲裁存在分歧的筛查乳腺钼靶的价值。方法本研究纳入连续性的84 927例数字化筛查乳腺钼靶,采用盲法或非盲法对钼靶进行解读。仲

关键词：乳腺钼靶盲法筛查

在乳腺摄影中应用计算机辅助检查提供诊断决策

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国际医学放射学杂志 2010年第6期 589-589页

作者： M.Samulski R.Hupse C.Boetes R.D.M.Mus g.j.den heeten N.Karssemeijer 邢志珩 Department of Radiology Radboud University Nijmegen Medical CentreGeert Grooteplein 106500 HB NijmegenThe Netherlandsm

目的对乳腺X线阅片时应用互动式计算机辅助检查(CAD)系统改善决策的效果进行评估。方法阅片者利用成熟而专业的乳腺影像工作站为CAD信息的使用进行图像定位。如果可以定位,CAD检测结果与计算机得出的病灶恶

关键词：乳腺摄影乳腺癌早期检查决策计算机辅助放射成像解释

乳腺癌风险预测模型:基于普通乳腺X线检查结果的列线图

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国际医学放射学杂志 2013年第6期 593-593页

作者： j.M.H.Timmers A.L.M.Verbeek j.IntHout R.M.Pijnappel M.j.M.Broeders g.j.den heeten 时代刘倩 National Expert and Training Centre for Breast Cancer Screening PO Box 6873 6503 GJ NijmegenThe Netherlands

摘要目的确定一项以乳腺X线筛查结果为乳腺癌的预测模型方法,建立此模型目的是在分析BI-RADS时减少阅片者间的差异性。方法回顾性分析352例进行乳腺X线

关键词：乳腺癌肿块筛查乳腺摄影决策支持技术列线图

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荷兰筛查区域间乳腺体积密度的地理差异

国际医学放射学杂志 2016年第1期 90-90页

作者： D.van der Waal M.j.Emaus M.F.Bakker g.j.den heeten N.Karsse meijer R.M.Pijnappel 陈伯柱 Radboud Institute for Health Sciences (Department for Health Evidence Mailbox 133) Radboud university medical center

摘要目的人群中乳腺密度的差异可以部分解释地区间乳腺癌筛查效能的变化。本研究旨在明确荷兰筛查的人口中是否存在乳腺密度分布的地区性差异。方法作为denSE试验的一部分,使用一个完全自动化的容积法测量乳腺密度。研究在地理位置上覆... 详细信息

摘要目的人群中乳腺密度的差异可以部分解释地区间乳腺癌筛查效能的变化。本研究旨在明确荷兰筛查的人口中是否存在乳腺密度分布的地区性差异。方法作为denSE试验的一部分,使用一个完全自动化的容积法测量乳腺密度。研究在地理位置上覆盖了14个阅片单位,代表荷兰的很大一部分。采用一般线性模型进行数据分析。结果 2013年—2014年间,共48 5021名受试者参与筛查,中位年龄为60岁。不同区域中,32.5%45.7%的女性具有非均质或极致密乳腺。平均密度体积介于6.51%（95%CI:6.46%6.55%）和

关键词：乳腺密度差异筛查体积密度荷兰

Alternative Exposure Parameters and Post Process Noise Reduction Expect Considerable Dose Reduction in Single Mammography Views—Initial Experience on Mastectomy Specimens

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Advances in Breast Cancer Research 2013年第3期2卷 91-96页

作者： Adriana M. j. Bluekens Ruben Evan Engen Nico Karssemeijer Klaas H. Schuur Mireille j. M. Broeders gerard j. den heeten gerard j. den heeten Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands National Expert and Training Centre for Breast Cancer Screening Nijmegen The Netherlands St. Elisabeth Hospital Department of Radiology Tilburg The Netherlands

Objective: To experimentally indicate a lower limit of dose in mammographic imaging yielding adequate image quality for complementary diagnostic views, by evaluation of image series with different exposure parameters and additional image processing on mastectomy specimens with diverse pathology. Methods: Image series were obtained on seven specimens with different target-filter combinations at different exposure values. Three experienced radiologists assessed the lowest acceptable dose level per specimen using a relative grading technique. With the standard image as reference, fibroglandular tissue and pathological structures, including microcalcifications, were evaluated. Subsequently, a series of pixel binning processes was tested and subjectively assessed on the selected images. Results: The lowest dose level at which image quality was acceptable, and achieved with a W/Ag target-filter combination at 32 kV and 4 mAs. These images can be acquired with 10.4% to 22.4% of the average glandular dose in standard images. Post process pixel binning added to the interpretability of such low dose images. Conclusion: This specimen study suggests that dose level of mammography images might be reduced substantially by general application of a W/Ag spectrum, particularly when combined with post process noise reduction. Future studies should focus on the feasibility of this technique in clinical mammography.

关键词： Digital Mammography Dose Reduction

Spatial distribution of archaeal and bacterial ammonia oxidizers in the littoral buffer zone of a nitrogen-rich lake

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journal of Environmental Sciences 2012年第5期24卷 790-799页

作者： Huub j. M. Op den Camp Department of Microbiology IWWR Radboud University Nijmegen

The spatial distribution and diversity of archaeal and bacterial ammonia oxidizers （AOA and AOB） were evaluated targeting amoA genes in the gradient of a littoral buffer zone which has been identified as a hot spot for N cycling. Here we found high spatial heterogeneity in the nitrification rate and abundance of ammonia oxidizers in the five sampling sites. The bacterial amoA gene was numerically dominant in most of the surface soil but decreased dramatically in deep layers. Higher nitrification potentials were detected in two sites near the land/water interface at 4.4–6.1 μg NO2-N/（g dry weight soil·hr）, while only 1.0–1.7 μg NO2-N/（g dry weight soil·hr） was measured at other sites. The potential nitrification rates were proportional to the amoA gene abundance for AOB, but with no significant correlation with AOA. The NH4＋ concentration was the most determinative parameter for the abundance of AOB and potential nitrification rates in this study. Higher richness in the surface layer was found in the analysis of biodiversity. Phylogenetic analysis revealed that most of the bacterial amoA sequences in surface soil were affiliated with the genus of Nitrosopira while the archaeal sequences were almost equally affiliated with Candidatus ‘Nitrososphaera gargensis’ and Candidatus ‘Nitrosocaldus yellowstonii’. The spatial distribution of AOA and AOB indicated that bacteria may play a more important role in nitrification in the littoral buffer zone of a N-rich lake.

关键词： littoral zone ammonia oxidation archaea bacteria heterogeneity abundance

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Decision support model for effects estimation and proportionality assessment for targeting in cyber operations

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Defence Technology（防务技术） 2021年第2期17卷 352-374页

作者： C.Maathuis W.Pieters j.van den Berg Delft University of Technology Jaffalaan 52628 BXDelftNetherlands TNO Military Operations Oude Waaldorperweg 632597 AKDen HaagNetherlands Netherlands Defense Academy De la Reyweg 1204818 BBBredaNetherlands Open University of the Netherlands Valkenburgerweg 1776419 ATHeerlenNetherlands

Cyber operations are relatively a new phenomenon of the last two *** that period,they have increased in number,complexity,and agility,while their design and development have been processes well kept under *** a consequence,limited data(sets)regarding these incidents are *** various academic and practitioner public communities addressed some of the key points and dilemmas that surround cyber operations(such as attack,target identification and selection,and collateral damage),still methodologies and models are needed in order to plan,execute,and assess them in a responsibly and legally compliant *** on these facts,it is the aim of this article to propose a model that i))estimates and classifies the effects of cyber operations,and ii)assesses proportionality in order to support targeting decisions in cyber *** order to do that,a multi-layered fuzzy model was designed and implemented by analysing real and virtual realistic cyber operations combined with interviews and focus groups with technical e military *** proposed model was evaluated on two cyber operations use cases in a focus group with four technical e military *** the design and the results of the evaluation are revealed in this article.

关键词： Cyber operations Cyber warfare Cyber weapons Artificial intelligence Fuzzy logic Targeting

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