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复杂参数条件下基于空间应力解的重塑黄土沉降计算方法

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人民黄河 2024年第3期46卷 136-142页

作者：赵程斌骆亚生王博齐国庆孙哲范全西北农林科技大学水利与建筑工程学院陕西杨凌712100 陕西省引汉济渭工程建设有限公司陕西西安710038

基于***推出的弹性半空间在荷载作用下内部任意一点的应力分量解析式,得到任意一点土体的空间应力状态,并将其引入沉降计算模型,从而提出将围压参数引入重塑黄土沉降计算的方法。通过应力式加载三轴试验分析了重塑黄土基于偏应力、含水... 详细信息

基于***推出的弹性半空间在荷载作用下内部任意一点的应力分量解析式,得到任意一点土体的空间应力状态,并将其引入沉降计算模型,从而提出将围压参数引入重塑黄土沉降计算的方法。通过应力式加载三轴试验分析了重塑黄土基于偏应力、含水率、围压在内的3个参数对应变发展的影响,得到了重塑黄土在不同参数下的应变规律,提出了重塑黄土应变受多个参数影响的沉降计算公式,并通过工程实例验证了公式的可靠性。结果表明:偏应力、含水率、围压均对重塑黄土的应变有显著影响,其中偏应力、含水率均与重塑黄土的压缩变形正相关,而围压与重塑黄土的压缩变形负相关,且3个参数拟合的重塑黄土应变经验公式效果良好。通过实际工程案例验证,沉降计算结果和实际沉降监测结果基本一致,表明提出的计算方法可以更为合理且便利地应用于重塑黄土工程场地的沉降计算及分析。

关键词：重塑黄土地基沉降计算应变规律模型参数分析

马醉木二萜成分及其乙酰胆碱酯酶抑制活性研究

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广西植物 2024年第2期44卷 327-332页

作者：李慧娟全伟罗娥娥秦徐杰华燕西南林业大学西南山地森林资源保育与利用教育部重点实验室昆明650224 中国科学院昆明植物研究所植物化学与西部植物资源可持续利用国家重点实验室昆明650201 云南省农村科技服务中心昆明650021

为研究马醉木叶中的二萜成分及其乙酰胆碱酯酶抑制活性,该研究根据薄层色谱显色特征,使用硅胶、MCI和半制备高效液相等色谱技术对其进行分离与纯化,并通过波谱数据(NMR和MS)分析且结合文献报道数据进行对比,鉴定了所得化合物的结构,同... 详细信息

为研究马醉木叶中的二萜成分及其乙酰胆碱酯酶抑制活性,该研究根据薄层色谱显色特征,使用硅胶、MCI和半制备高效液相等色谱技术对其进行分离与纯化,并通过波谱数据(NMR和MS)分析且结合文献报道数据进行对比,鉴定了所得化合物的结构,同时采用Ellman法首次对其乙酰胆碱酯酶抑制活性进行评价。结果表明:从马醉木叶中分离并鉴定了8个二萜化合物,分别是pierisformoside f(1)、3-epi-grayanotoxinⅩⅧ(2)、3-epi-grayanotoxin B(3)、asebotoxin-X(4)、pierisformosin B(5)、asebotoxinⅢ(6)、rhodojaponinⅢ(7)和pierisformosin C(8)。其中,化合物1为首次从该植物中分离得到,化合物8表现出乙酰胆碱酯酶抑制活性。综上表明,马醉木中含有丰富的二萜成分和活性成分。该研究结果丰富了马醉木的化学成分多样性,为其后续综合开发和利用提供了一定的理论依据,也为寻求更多的活性成分提供了借鉴。

关键词：杜鹃花科马醉木二萜 pierisformoside f 乙酰胆碱酯酶抑制活性

Differential interference contrast phase edging net:an all-optical learning system for edge detection of phase objects

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Chinese Optics Letters 2024年第1期22卷 21-27页

作者：李一鸣李然陈泉栾海涛卢海军杨晖顾敏张启明 Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Nokia Shanghai Bell Co. Ltd.Shanghai 201206China College of Medical Instruments Shanghai University of Medicine and Health SciencesShanghai 201318China

Edge detection for low-contrast phase objects cannot be performed directly by the spatial difference of intensity *** this work,an all-optical diffractive neural network(DPENet)based on the differential interference contrast principle to detect the edges of phase objects in an all-optical manner is *** information is encoded into an interference light field by dual Wollaston prisms without lenses and light-speed processed by the diffractive neural network to obtain the scale-adjustable *** results show that DPENet achieves f-scores of 0.9308(MNIST)and 0.9352(NIST)and enables real-time edge detection of biological cells,achieving an f-score of 0.7462.

关键词： diffractive neural network edge detection phase objects

Macrophages in immunoregulation and therapeutics

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Signal Transduction and Targeted Therapy 2023年第6期8卷 I0002-I0002,2821-2854页

作者： Shanze Chen Abdullah f.U.H.Saeed quan Liu Qiong Jiang Haizhao Xu gary guishan Xiao Lang Rao Yanhong Duo Department of Respiratory Diseases and Critic Care Unit Shenzhen Institute of Respiratory DiseaseShenzhen Key Laboratory of Respiratory DiseaseShenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen518020China Department of Cancer Biology Beckman Research Institute of City of Hope National Medical CenterLos AngelesCA91010USA Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen UniversityShenzhen518052China Department of Respiratory The First Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518055China State Key Laboratory of fine Chemicals Department of Pharmaceutical SciencesSchool of Chemical EngineeringDalian University of TechnologyDalianChina Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen518132China Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstitutetStockholmSweden

Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and *** possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely *** crucial questions about macrophage signaling and immune modulation are yet to be *** addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their ***,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade ***,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic ***,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage ***,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and ***,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

关键词： becoming polarization Macrophages

结合Roberta和Bi-fLASH-SRU的中文事件因果关系抽取

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计算机系统应用 2024年第6期33卷 259-267页

作者：陈泉林贾珺樊硕军事科学院战争研究院北京100091

针对现有基于填表的事件关系抽取方法填表数目过多、表格特征获取不充分的问题,本文提出了结合Roberta和Bi-fLASH-SRU的中文事件因果关系抽取方法 Tf-ChineseERE.该方法通过制定填表策略,利用文本中已标记关系,将其转化为带有标签的表格... 详细信息

针对现有基于填表的事件关系抽取方法填表数目过多、表格特征获取不充分的问题,本文提出了结合Roberta和Bi-fLASH-SRU的中文事件因果关系抽取方法 Tf-ChineseERE.该方法通过制定填表策略,利用文本中已标记关系,将其转化为带有标签的表格;借助Roberta预训练模型和本文提出的双向内置闪电注意力简单循环单元(bidirectional built-in flash attention simple recurrent unit,Bi-fLASH-SRU)获取主客体事件特征,再利用表格特征循环学习模块挖掘全局特征,最后进行表格解码获得事件因果关系三元组.实验采用金融领域两个公开数据集进行验证,结果表明,本文提出的方法 f_(1)值分别达到59.2%和62.5%,且Bi-fLASH-SRU模型训练速度更快,填表数目更少,证明了该方法的有效性.

关键词：事件因果关系抽取 Roberta Bi-fLASH-SRU 闪电注意力填表式抽取

Typical frobenius Coverings

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2209-2214页

作者： Yan WANg Rong quan fENg Jaeun LEE Department of Mathematics Yah Tai University Yah Tai 264005 P. R. China LMAM School of Mathematical Sciences Peking University Beijing 100871 P. R. China Department of Mathematics Yeungnam University Kyongsan 712-749 Korea

A covering p from a Cayley graph Cay（g, X） onto another Cay（H, Y） is called typical frobenius if g is a frobenius group with H as a frobenius complement and the map p ： g →H is a group epimorphism. In this paper, we emphasize on the typical frobenius coverings of Cay（H, Y）. We show that any typical frobenius covering Cay（g, X） of Cay（H, Y） can be derived from an epimorphism /from g to H which is determined by an automorphism f of H. If Cay（g, X1） and Cay（g, X2） are two isomorphic typical frobenius coverings under a graph isomorphism Ф, some properties satisfied by Фare given.

关键词： frobenius group typical frobenius covering isomorphic

选区激光熔融Inconel 718的微铣削加工参数优化

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农业装备与车辆工程 2024年第4期62卷 112-115页

作者：权涛苏风啸李俊武汉科技大学冶金装备及其控制教育部重点实验室湖北武汉430081

选区激光熔融(SLM)Inconel 718成形件广泛应用于航空航天、汽车轨交和石油化工等领域,但成形件表面精度较差,需通过切削提升表面精度。以表面粗糙度为优化目标,开展了以主轴转速、切削深度、每齿进给量为变量的三因素四水平微铣削正交实... 详细信息

选区激光熔融(SLM)Inconel 718成形件广泛应用于航空航天、汽车轨交和石油化工等领域,但成形件表面精度较差,需通过切削提升表面精度。以表面粗糙度为优化目标,开展了以主轴转速、切削深度、每齿进给量为变量的三因素四水平微铣削正交实验,通过极差分析研究了主轴转速、切削深度及每齿进给量对表面粗糙度影响的显著性。结果表明,在n=15000 r/min、ap=60μm、f=1μm/z的加工参数下,SLM成形件的表面粗糙度值最低。优化后的参数组合为SLM Inconel 718的微铣削加工提供了参考。

关键词：微铣削表面粗糙度选区激光熔融 Inconel 718 参数优化

Establishment of human embryonic stem cell line from gamete donors

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Chinese Medical Journal 2005年第2期118卷 116-122页

作者： LITao ZHOUCan-quan MAIQing-yun ZHUANgguang-lun ReproductiveMedicalCenter FirstAffiliatedHospitalofSunYatsenUniversityGuangzhou510080China

Background Human embryonic stem (HES) cell derived from human blastocyst can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent It has exciting potential in human developmental biology, drug discovery, and transplantation medicine But there are insufficieot HES cell lines for further study Methods Three oocyte donors were studied, and 3 in vitro fertilization (IVf) cycles were carried out to get blastocysts for the establishment of HES cell line Isolated from blastocysts immunosurgically, inner cell mass (ICM) was cultured and propagated on mouse embryonic fibroblasts (MEfs) Once established, morphology, cell surface markers, karyotype and differentiating ability of the cell line were thoroughly analyzedResults four ICMs from 7 blastocysts were cultured on MEfs After culture, one cell line (cHES1) was established and met the criteria for defining human pluripotent stem cells including a series of markers used to identify pluripotent stem cells, morphological similarity to primate embryonic stem cells and HES reported else where. Normal and stable karyotype maintained over 60 passages, and demonstrated ability to differentiate into a wide variety of cell types Conclusions HES cell lines can be established from gamete donors at a relatively highly efficient rate The establishment will exert a widespread impact on biomedical research

关键词： stem cell transplantation · embryo · germ cells

Sf_(6)放电分解产物荧光抑制光纤增强拉曼光谱动态高灵敏检测研究

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光学精密工程 2024年第14期32卷 2189-2199页

作者：冉童沁万福周湶孔维平刘强龙英凯陈伟根重庆大学输变电装备技术全国重点实验室(重庆大学电气工程学院) 重庆400044 重庆大学国家储能技术产教融合创新平台重庆400044 国网重庆市电力公司电力科学研究院重庆401123

分析Sf_(6)放电分解产物组分和含量的动态变化是Sf_(6)封闭式组合电器(gas-Insulated Switchgear,gIS)状态诊断的关键。本文提出荧光抑制光纤增强拉曼光谱(fiber-Enhanced Raman Spectroscopy,fERS)动态高灵敏检测方法。首先搭建了Sf_(6... 详细信息

分析Sf_(6)放电分解产物组分和含量的动态变化是Sf_(6)封闭式组合电器(gas-Insulated Switchgear,gIS)状态诊断的关键。本文提出荧光抑制光纤增强拉曼光谱(fiber-Enhanced Raman Spectroscopy,fERS)动态高灵敏检测方法。首先搭建了Sf_(6)放电分解产物荧光抑制fERS检测系统,通过结合CCD数字滤波和小孔空间滤波的协同荧光滤波方法,系统信噪比提升228.4%;基于Allan方差分析确定了系统最佳积分时间为220 s。然后在2 bar压强、220 s积分时间下,基于标准混合气体样品分析确定了用于同时定性与定量分析Sf_(6)放电分解产物SOf_(2),SO_(2)f_(2),COS,Cf_(4),SO_(2),CO_(2),CO的特征拉曼谱峰,并计算得检测下限分别为1.95 ppm,1.78 ppm,0.83 ppm,2.41 ppm,0.93 ppm,2.51 ppm,6.69 ppm。最后通过连续168 h的gIS等比缩小模型局部放电实验证明了上述系统可实现Sf_(6)放电分解产物的动态高灵敏检测,且与气相色谱法结果偏差小于±5%。实验结果表明,本文提出的检测方法可为gIS的安全运行提供技术支撑。

关键词： Sf_(6)封闭式组合电器 Sf_(6)放电分解产物光纤增强拉曼光谱协同荧光滤波气体分析