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Polyhedrosis Virus in Bacillus thuringiensis

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Agricultural Sciences in China 2011年第1期10卷 92-100页

作者： YE Xiang-li XIA Li-qiu Key Laboratory of Microbial Biology of Hunan Province/College of Life Science Hunan Normal University Changsha 410081 P.R China College of Medicine Hunan Normal University Changsha 410013 P.R.China

This study was conducted to build a recombinant strain with highly insecticidal activity and a wide host range by using the crylAc and p74 gene. Firstly, the p74 gene was amplified from the genosome ofAutographa californica multicapsid nucleopolyhedrovirus. The crylAc gene and the terminator gene of crylAc, named crylAct, were amplified from the plasmid of Bt 4.0718 strain. Three T vectors, named pTp74, pT1Ac, and pT1Act which held the aimed gene p74, cry1Ac, and crylAct, respectively, and two middle vectors, named pTp74Act and pTIAcp74 which held the aimed fusion gene p74-crylAct and cry lAc-p74, respectively, were built by using pMDI 8-T. Then pTiAcp74 and the shuttle plasmid were digested and linked and an expressing-vector pH1Acp74 was built. Finally, pH1Acp74 was transformed into the acrystalliferous strain XBU001 and the aimed recombinant strain XBU-H1Acp74 was obtained. The expression of Bt transformant XBU-H1Acp74 was analyzed by SDS-PAgE which showed XBU-H1Acp74 could produce 130 kDa CrylAc protein and 50 kDa P74 protein. The insecticidal activity of transformant against Spodoptera exigua was evaluated compared with the contrast strains HTX-42 （only crylAc gene was transformed into XBU001） after autolysis. The LCs0 of HTX-42 was higher than that of the XBU-H IAcp74＇s, which implied that P74 could increase the efficacy and range of Bt Cry toxins in insect control. The fusion gene of crylAc and p74 were constructed successfully which will be served as the foundation lbr constructing the fusion genes of Bt cry gene and other foreign genes.

关键词： Bacillus thuringiensis Autographa californica multicapsid nucleopolyhedrovirus crylAc gene p74 gene fusion gene

Sarcomas in association with human herpesviral infection

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Sarcomas in association with human herpesviral infection

Quasisymmetric geometry of the Julia sets of McMullen maps Dedicated to the Memory of Professor Lei Tan

新发传染病防治热点研讨会

作者： zhang X qiu Q Huang.z.He z Department of Pathophysiology and Sino-American Collaborative Cancer Research InstituteGuangdong Provincial Key Laboratory of Molecular Diagnostics Guangdong Medical College Department of Otolaryngology Guangdong Provincial Hospital

In the recent years,two lymphotropic human gamma-herpesviruses,HHV8/Kaposi’s sarcoma associated herpesvirus has been identified as the causative agents of lymphoproliferative disorders and lymphomas,in complication with immunocompromised status due to the infection human immunodeficient virus(HIV)or immune suppressing therapy after organ *** of the transforming and proliferation promoting genomic products coded by the two herpeviruses causes malignant transformation of the lymphocytes similar with the immortalization process to convert B cells into lymphoblastoid cell lines in *** two herpesviruses are associated with other malignancies than hematopoietic *** and HHV 8play an pathogenic role in the genesis of Kaposi’s sarcoma and leiomyesarcoma,*** suggests that in immune deficient persons,opportunistic tumors other than lymphomas can be caused by the lymphotropic herpesviruses.

关键词： herpesvirus human herpesvirus type 8(HHV 8) Epstein-Barr virus(EBV) acquired immune deficiency syndrome(AIDS) lymphoproliferative disorder lymphoma post-transplant lymphoproliferative disorder(PTLD) Kaposi’s Sarcoma leiomyosarcoma

来源： cnki会议评论

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Science China Mathematics 2018年第12期61卷 2283-2298页

作者： Weiyuan qiu Fei Yang Yongcheng Yin School of Mathematical Sciences Fudan University Department of Mathematics Nanjing University School of Mathematical Sciences Zhejiang University

We study the quasisymmetric geometry of the Julia sets of McMullen maps f_λ(z) = z^m+ λ/z~?,where λ∈ C \ g and ? and m are positive integers satisfying 1/? + 1/m < 1. If the free critical points of f_λ are esca... 详细信息

We study the quasisymmetric geometry of the Julia sets of McMullen maps f_λ(z) = z^m+ λ/z~?,where λ∈ C \ g and ? and m are positive integers satisfying 1/? + 1/m give a sufficient condition on λ such that J_λ is a Sierpiński carpet and prove that most of them are quasisymmetrically equivalent to some round carpets. In particular, there exist infinitely renormalizable rational maps whose Julia sets are quasisymmetrically equivalent to the round carpets.

关键词： Julia sets Sierpiński carpet quasisymmetrically equivalent

Histone variant H2A.z facilitates DNA replication

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Science China(Life Sciences) 2020年第5期63卷 788-790页

作者： Lei qiu Xinyi zeng Junhong Han Department of Abdominal Oncology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

In eukaryotes,DNA wraps around the histone octamer to form nucleosomes,which are further compacted into the chromosome *** chromosome contains multiple replication origins that are regulated by both DNA sequence and e... 详细信息

关键词： structure. H2A.z DNA

心脏MR在冠状动脉非阻塞性肌钙蛋白升高中的诊断价值

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中华放射学杂志 2024年第9期58卷 895-901页

作者：何祥发邱银汝叶丽丽潘伟郑晓林东莞康华医院放射科东莞523000 东莞康华医院心脏超声科东莞523000

目的探讨心脏MR(CMR)多参数成像技术对冠状动脉非阻塞性肌钙蛋白升高(TINOCA)潜在病因诊断及鉴别诊断价值。方法回顾性分析东莞康华医院2018年1月至2023年6月,所有经冠状动脉造影证实的TINOCA患者33例,于发病7 d内进行CMR检查,检查序列... 详细信息

目的探讨心脏MR(CMR)多参数成像技术对冠状动脉非阻塞性肌钙蛋白升高(TINOCA)潜在病因诊断及鉴别诊断价值。方法回顾性分析东莞康华医院2018年1月至2023年6月,所有经冠状动脉造影证实的TINOCA患者33例,于发病7 d内进行CMR检查,检查序列包括黑血成像、亮血电影、黑血T_(2)加权脂肪抑制序列、横向弛豫时间定量序列、心肌首过灌注及延迟钆增强(LgE)。根据影像学表现将入选病例分为冠状动脉非阻塞性心肌梗死(MINOCA)组、急性心肌炎组、Takotsubo综合征组及CMR阴性组。观察指标为左心室功能、心肌水肿情况、首过灌注及LgE改变。对不同病变的差异进行统计学分析,计数资料采用卡方检验或Fisher确切概率法进行组间分析;符合正态分布的计量资料,采用x±s进行统计描述,两样本均数的比较采取独立样本t检验;偏态分布的计量资料采用M(Q_(1),Q_(3))进行统计描述,采用Mann-Whitney秩和检验进行组间分析。结果33例患者中CMR诊断为MINOCA组14例(42.4%)、急性心肌炎12例(36.4%)、Takotsubo综合征组0例、CMR阴性组7例(21.2%),CMR诊断阳性率78.8%。MINOCA与急性心肌炎组相比,发病年龄差异具有统计学意义(z=3.32,P=0.001),左心功能、心肌水肿节段数及病变心肌T 2值差异无统计学意义(P>0.05),二者首过灌注异常例数差异具有统计学意义(PgE质量、体积差异均具有统计学意义(P均<0.05)。结论CMR多参数成像技术在TINOCA病因诊断中具有独特作用,能对MINOCA、急性心肌炎等心源性病因引起的TINOCA作出准确鉴别。

关键词：磁共振成像冠状动脉非阻塞性心肌梗死冠状动脉非阻塞性肌钙蛋白升高急性心肌炎

Representation Theorem for generators of Quadratic BSDEs

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Acta Mathematicae Applicatae Sinica 2018年第3期34卷 622-635页

作者： Shi-qiu zHENg Shou-mei LI College of Applied Sciences Beijing University of Technology Beijing 100124 China College of Sciences North China University of Science and TechnologyTangshan 063210 China

In this paper, we establish a general representation theorem for generator of backward stochastic differential equation（BSDE）, whose generator has a quadratic growth in z. As some applications, we obtain a general converse comparison theorem of such quadratic BSDEs and uniqueness theorem, translation invariance for quadratic g-expectation.

关键词： backward stochastic differential equation representation theorem of generator converse comparison theorem g-expectation

Maternally inherited H4K16 acetylation primes zygotic gene activation in Drosophila

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Science China(Life Sciences) 2020年第12期63卷 1950-1952页

作者： Lei qiu Xueqin Liu Junhong Han Research Laboratory of Tumor Epigenetics and genomics Department of General SurgeryFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer Centerand National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Department of Clinical Research Management West China HospitalSichuan UniversityChengdu 610041China

In a recent study published in Cell, Samata et al. demonstrated a novel mechanism that guided the genomic reprogramming. They showed that the acetylation of histone H4 at Lysine 16(H4K16ac) was intergenerationally maintained from the mother’s oocyte to the young embryo and primed zygotic gene activation in Drosophila(Samata et al., 2020).Embryonic development is initially directed by maternal gene products. Then gradually, developmental control is handed to the zygotic genome during the maternal-to-zygotic transition(MzT).

关键词： activation maintained initially

山西省2010—2018年20岁及以上成年居民超重和肥胖的流行趋势研究

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中国全科医学 2024年第10期27卷 1245-1251页

作者：宋伟梅王旭春任浩赵英陈利民仇丽霞山西医科大学公共卫生学院卫生统计学教研室山西省太原市030001 山西省太原市疾病预防控制中心慢病科 030001 山西省疾病预防控制中心慢病科山西省太原市030012 山西省人民医院党委办公室山西省太原市030012

背景超重、肥胖和中心性肥胖现已成为全球范围内影响居民生命健康的严重公共卫生问题。分析山西省居民超重、肥胖和中心性肥胖的流行趋势,可为相关疾病防治提供一定的科学价值。目的分析2010—2018年山西省20岁及以上成年人超重、肥胖... 详细信息

背景超重、肥胖和中心性肥胖现已成为全球范围内影响居民生命健康的严重公共卫生问题。分析山西省居民超重、肥胖和中心性肥胖的流行趋势,可为相关疾病防治提供一定的科学价值。目的分析2010—2018年山西省20岁及以上成年人超重、肥胖及中心性肥胖情况,分析其流行趋势。方法选取2010年8月—2018年11月(2010、2013、2015和2018年)中国慢病监测项目中山西省部分20岁及以上成年人的调查数据,计算不同年份、性别、年龄和地区20岁及以上成年人的超重率、肥胖率和中心性肥胖率,分析不同特征成年人的超重、肥胖和中心性肥胖的流行趋势。结果本研究2010、2013、2015、2018年分别获得有效人数3527、4066、4545、4788人,年龄20~108岁。调查对象以40~59岁年龄段人群较多,女性居民较男性居民多,农村居民较城市居民多。山西省2010—2018年20岁及以上成年人整体超重粗率和经年龄、性别标化后的标化超重率分别为37.7%~40.1%、36.1%~39.6%,无明显上升趋势(z=0.005、2.413,P=0.942、0.120);整体标化肥胖率和整体中心性肥胖粗率、标化中心性肥胖率分别由2010年的17.2%、53.8%、52.4%增长至2018年的20.0%、61.6%、60.2%(z=8.100、10.994、12.218,P0.05)。2013年男性标化超重率高于女性(χ^(2)=4.259,P=0.039)、男性标化肥胖率低于女性(χ^(2)=13.724,P0.05)。20~39岁年龄组的整体肥胖率、男性肥胖率以及男、女性中心性肥胖率均呈现上升趋势(P0.05),不同性别和地区之间的变化趋势也无明显差异(P>0.05)。结论2010—2018年山西省20岁及以上成年居民超重率趋于稳定,肥胖率和中心性肥胖率整体呈现上升趋势。肥胖、中心性肥胖防治方面应以20~39岁青壮年为重点干预人群,减缓增长速度,以40岁以上人群为重点防治人群,采取相应预防干预措施,以控制超重、肥胖和中心性肥胖的流行。

关键词：超重肥胖中心性肥胖 Joinpoint回归流行趋势山西省

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基于水质荧光指纹技术的复合污染河道溯源研究

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光谱学与光谱分析 2024年第6期44卷 1773-1780页

作者：熊秋燃沈鉴胡远柴一荻顾意琴冷晓婷程澄吴静清华大学环境学院环境污染溯源与精细监管技术研究中心北京100084 清华苏州环境创新研究院先进监管技术仪器研发团队江苏苏州215163 苏州国溯科技有限公司江苏苏州215011

复合污染水体的污染源组成解析是当前水污染溯源领域难题,基于三维荧光光谱的水质荧光指纹技术是解决该难题的关键方法。采用水质荧光指纹技术对苏南地区Y河开展溯源分析。通过平行因子分解与水质荧光指纹比对有效识别Y河中印染废水荧... 详细信息

复合污染水体的污染源组成解析是当前水污染溯源领域难题,基于三维荧光光谱的水质荧光指纹技术是解决该难题的关键方法。采用水质荧光指纹技术对苏南地区Y河开展溯源分析。通过平行因子分解与水质荧光指纹比对有效识别Y河中印染废水荧光信号来自上游河道异地输入。利用氨氮浓度划分重污染区域,依托水质荧光指纹对Y河流域内109个排口开展筛查,通过污染路径溯源法精准定位35家主要责任单位。落实整改要求后,Y河水质由劣Ⅴ类迅速提升至Ⅲ类,并持续稳定达标。Y河河道治理工程取消,降本增效效果显著。针对复合污染河道提出了以水质荧光指纹技术为抓手的精准溯源与微创治理新模式,对实现精准治污、科学治污、依法治污具有重要指导意义。

关键词：三维荧光光谱水质荧光指纹复合污染溯源污染路径溯源法精准治污