Sarcomas in association with human herpesviral infection
作者单位：Department of Pathophysiology and Sino-American Collaborative Cancer Research InstituteGuangdong Provincial Key Laboratory of Molecular Diagnostics Guangdong Medical College Department of Otolaryngology Guangdong Provincial Hospital
会议名称：《新发传染病防治热点研讨会》
会议日期：2014年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from National Natural Scientific Foundation of China (NSFC) Guangdong Provincial Medical Research Fund (A2014467)
关 键 词：herpesvirus human herpesvirus type 8(HHV 8) Epstein-Barr virus(EBV) acquired immune deficiency syndrome(AIDS) lymphoproliferative disorder lymphoma post-transplant lymphoproliferative disorder(PTLD) Kaposi’s Sarcoma leiomyosarcoma
摘 要：In the recent years,two lymphotropic human gamma-herpesviruses,HHV8/Kaposi’s sarcoma associated herpesvirus has been identified as the causative agents of lymphoproliferative disorders and lymphomas,in complication with immunocompromised status due to the infection human immunodeficient virus(HIV)or immune suppressing therapy after organ *** of the transforming and proliferation promoting genomic products coded by the two herpeviruses causes malignant transformation of the lymphocytes similar with the immortalization process to convert B cells into lymphoblastoid cell lines in *** two herpesviruses are associated with other malignancies than hematopoietic *** and HHV 8play an pathogenic role in the genesis of Kaposi’s sarcoma and leiomyesarcoma,*** suggests that in immune deficient persons,opportunistic tumors other than lymphomas can be caused by the lymphotropic herpesviruses.