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Biochanin-A attenuates high-fat diet and streptozotocin-induced hyperlipidemia and oxidative stress in rats by improving antioxidant status and lipid metabolic markers

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 460-468页

作者： P.P.Sethumathi V.V.Sathibabu Uddandrao P.Chandrasekaran S.Sengottuvelu P.Tamilmani P.Ponmurugan S.Vadivukkarasi M.Santhanakumar M.Shabana Begum g.saravanan Centre for Biological Sciences Department of BiochemistryK.S.Rangasamy College of Arts and Science(Autonomous)TiruchengodeNamakkal DistrictTamilnaduIndia-637215 Department of Pharmacology Nandha College of PharmacyErodeTamilnaduIndia-638052 Department of Biochemistry PGP College of Arts and ScienceNamakkalTamilnaduIndia-637207 Department of Botany Bharathiar UniversityCoimbatoreTamilnaduIndia-641046 Department of Pharmacology Arulmigu Kalasalingam College of PharmacyKrishnankoilTamilnaduIndia-626126 Department of Biochemistry Muthayammal College of Arts and ScienceRasipuramTamilnaduIndia-637408

Objective:To determine how biochanin-A(BCA)affects high-fat diet and streptozotocin-induced pathological changes in lipid metabolism and antioxidant status in diabetic ***:Diabetic rats were orally administered BCA(10 mg/kg body weight)for 30 days to investigate its effects on lipid profiles and oxidative stress markers in the liver and *** addition,the mRNA expression of antioxidant and lipid metabolism enzymes in the liver was ***:BCA attenuated hyperlipidemia by regulating mRNA expressions of HMg-CoA reductase,fatty acid synthase,carnitine palmitoyl transferase,and acetyl-CoA ***,BCA reduced high-fat diet and streptozotocin-induced oxidative stress by suppressing lipid peroxidation,improving superoxide dismutase,catalase,and glutathione peroxidase levels,and upregulating mRNA expressions of these ***:BCA may be a promising nutraceutical for the treatment of dyslipidemia and oxidative stress associated with diabetes.

关键词： Antioxidant Biochanin-A Nutraceutical Obesity Hyperlipidemia Type 2 diabetes mellitus Oxidative stress

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Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of Methodology 2025年第1期15卷 88-94页

作者： Chinmay Mahatme Madhurima Kaushik Veerappan Rathinasabapathy saravanan Karthik Kumar Virna M Shah Department of general Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKgROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOgAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NMOSD and 17 MOgAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(MVD)and ganglion cell+inner plexiform layer thickness(gCIPL)were studied using *** There was a significant reduction in MVD in NMOSD and MOgAD affected as well as unaffected eyes when compared with healthy *** and MOgAD affected eyes had significant gCIPL thinning compared with healthy *** unaffected eyes did not show significant gCIPL thinning compared to healthy controls in contrast to MOgAD unaffected *** comparing NMOSD with MOgAD,there was no significant difference in terms of MVD or gCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOgAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis Macular microvascular changes Neuromyelitis optica spectrum disorders Myelin oligodendrocyte glycoprotein antibody disorder

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DSM in an area consisting of residential, commercial and industrial load in smart grid

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Frontiers in Energy 2015年第2期9卷 211-216页

作者： Balasubramaniyan saravanan School of Electrical Engineering VIT University Vellore 632014 India

With the latest introduction of the demand side management （DSM） in smart grids, the power distribution units are able to modify the load schedules of the consumers. This involves a co-operative interaction of the utility and the consumers so as to achieve customer load modifications in which the customer, utility and society all are benefited. The interaction is performed with the help of the devices known as the smart meter. This paper shows the use of game theory and logical mathematical expressions in order to achieve the objec- tives. The objectives are to minimize the peak to average ratio （PAR） and the energy cost. The outcome of the game between supplier and customers helps to shape the load profile. The design proposed in this paper is very user- friendly and is based on simple logarithmic programming computations. In this paper, residential, commercial and industrial types of loads are taken into account. A basic 24 h load schedule along with the fluctuating prices at each hour of the day is forecasted by the supplier of the various shiftable and non-shiftable loads and then that schedule is conveyed to the user. The users are encouraged to shift their high load devices to off-peak hours which will not only reduce their electricity costs but also substantially reduce the PAR in the load demand.

关键词： demand side management (DSM) smartgrids peak to average ratio (PAR) smart meters andlogarithmic price function

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Charge distribution around Ba-O and Ti-O bonds in BaTi_(1-x)Zr_(x)O_(3)through powder X-ray diffraction

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Rare Metals 2021年第12期40卷 3660-3667页

作者： Jegannathan Mangaiyarkkarasi Ramachandran saravanan Post graduate and Research Department of Physics Nadar Mahajana Sangam S.Vellaichamy Nadar CollegeNagamalaiMaduraiTamil Nadu 625019India Research Centre and Post graduate Department of Physics The Madura CollegeMaduraiTamil Nadu 625011India

Ferroelectric lead-free BaTi_(1-x)Zr_(x)O_(3)ceramic powder samples with various compositions(x=0,0.04,0.06)have been synthesized by conventional high-temperature solid-state reaction method at 1450℃for 10 *** of Zr doping on the inter-atomic bonding and charge density distributions inside the lattice structure of BaTiO_(3)were analyzed through powder X-ray diffraction(XRD)and maximum entropy *** parameter and cell volume values are found to be increasing with the incorporation of Zr *** average grain sizes are found to be in the range of 23-28 *** entropy mapping of electron density analysis reveals the reduction in ionic nature along Ba-O bond and the enhancement of covalent nature along Ti-O *** band gap values were determined from ultraviolet-visible(UV-Vis)*** morphology and microstructures of the samples were analyzed from scanning electron microscopy(SEM)*** with irregular sizes were observed in all the prepared *** of the samples was further confirmed by energydispersive X-ray spectroscopy(EDAX).

关键词： Barium zirconium titanate Structure factors Electron density Rietveld analysis Maximum entropy method

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High-temperature synthesis and electronic bonding analysis of Ca-doped LaMnO_(3) rare-earth manganites

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Rare Metals 2022年第11期41卷 3932-3942页

作者： Natarajan Thenmozhi Ramachandran saravanan Post graduate and Research Department of Physics Nadar Mahajana Sangam S.Vellaichamy Nadar CollegeNagamalaiMaduraiTamil Nadu625019India Research Centre and Post graduate Department of Physics The Madura CollegeMaduraiTamil Nadu625011India

Doped lanthanum manganites La_(1-x)Ca_(x)MnO_(3) with five different concentrations of Ca(x=0.1,0.2,0.3,0.4 and 0.5) were synthesized by high-temperature solidstate reaction method and *** prepared samples were experimentally analyzed by X-ray diffraction(XRD),ultraviolet-visible spectroscopy(UV-Vis),scanning electron microscopy/energy dispersive spectroscopy(SEM/EDS) and vibrating sample magnetometer(VSM)*** structure is confirmed for this compound from powder X-ray diffraction *** XRD data confirm the shrinkage in the unit cell of synthesized samples for increasing calcium *** UV-Visible analysis for the estimation of optical band gap(E_(g)) reveals that the band gap decreases with the incorporation of *** synthesized samples were investigated for charge density distribution using maximum entropy method,utilizing the XRD data *** the charge density analysis,it is found that the bond lengths for La-O and Mn-O bonds decrease with the addition of *** ionic nature between La and O atoms and covalent nature between Mn and O atoms are enhanced for 40% of *** 50% of Ca-doped sample,ionic nature between La and O atoms and covalent nature between Mn and O atoms *** the prepared samples exhibit ferromagnetism at 20 K and paramagnetism at 300 K.

关键词： Manganites Mixed valency Magnetocaloric Magnetoresistive SOFC

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Cross Layer QoS Aware Scheduling based on Loss-Based Proportional Fairness with Multihop CRN

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Computer Systems Science & Engineering 2022年第9期42卷 1063-1077页

作者： K.saravanan g.M.Tamilselvan A.Rajendran Department of ECE KPR Institute of Engineering and TechnologyCoimbatoreIndia Department of IT Sri Krishna College of TechnologyCoimbatoreIndia Department of ECE Karpagam College of EngineeringCoimbatoreIndia

As huge users are involved,there is a difficulty in spectrum allocation and scheduling in Cognitive Radio Networks(CRNs).Collision increases when there is no allocation of spectrum and these results in huge drop rate and network performance *** solve these problems and allocate appropriate spectrum,a novel method is introduced termed as Quality of Service(QoS)Improvement Proper Scheduling(QIPS).The major contribution of the work is to design a new cross layer QoS Aware Scheduling based on Loss-based Proportional Fairness with Multihop(QoSAS-LBPFM).In Medium Access Control(MAC)multi-channel network environment mobile nodes practice concurrent broadcast between several *** the advantage of introduced cross layer design,the real-time channel conditions offered by Cognitive Radio(CR)function allows adaptive sub channel choice for every *** optimize the resources of network,the LBPFM adaptively plans the radio resources for allocating to diverse services without lessening the quality of *** obtained from simulation proved that QoSAS-LBPFM provides enhanced QoS guaranteed performance against other existing QIPS algorithm.

关键词： Network efficiency distributed architecture mobile ad hoc networks Cognitive Radio Networks(CRNs) QoS improvement scheduling

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Microstructure and Mechanical Strength Predictive Modeling in Al 5052-Trapezoidal grooved SS 304 Explosive Cladding

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Journal of Wuhan University of Technology(Materials Science) 2020年第5期35卷 958-966页

作者： saravanan S Raghukandan K Department of Mechanical Engineering Annamalai UniversityAnnamalainagar-608002India Department of Manufacturing Engineering Annamalai UniversityAnnamalainagar-608002India

Aluminum alloy plates were explosively cladded to stainless steel plates with trapezoidal grooves on the mating *** process parameters viz,loading ratio,standoff distance and flyer plate thickness were varied based on the Taguchi *** variation in the process parameters alters the kinetic energy dissipation and the deformation work performed at the interface,and dictates the interfacial wave amplitude and the mechanical strength of the dissimilar explosive *** optimum level of process parameters for attaining higher tensile and shear strength is computed by signal-to-noise ***,a mathematical model is developed for calculating tensile and shear strength of the clad,based on the regression analysis using statistical software Minitab-16,and the level of fit is determined by analysis of variance.

关键词： explosive cladding trapezoidal grooves microstructure optimization strength

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Electronic structure and bonding interactions in Ba1-xSrxZr0.1Ti0.9O3 ceramics

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Frontiers of Materials Science 2017年第2期11卷 182-189页

作者： Jegannathan MANgAIYARKKARASI Subramanian SASIKUMAR Olai Vasu saravanan Ramachandran saravanan Pg and Research Department of Physics NMSSVN College Nagamalai Madurai-625 019 Tamil Nadu India Research Centre and Pg Department of Physics The Madura College Madurai-625 011 Tamil Nadu India

An investigation on the precise electronic structure and bonding interactions has been carried out on Ba1-xSrxZr0.1Ti0.9O3 （short for BSZT, x = 0, 0.05, 0.07 and 0.14） ceramic systems prepared via high-temperature solid state reaction technique. The influence of Sr doping on the BSZT structure has been examined by characterizing the prepared samples using PXRD, UV-visible spectrophotometry, SEM and EDS. Powder profile refinement of X-ray data confirms that all the synthesized samples have been crystallized in cubic perovskite structure with single phase. Charge density distribution of the BSZT systems has been completely analyzed by the maximum entropy method （MEM）. Co-substitution of Sr at the Ba site and Zr at the Ti site into the BaTiOz structure presents the ionic nature between Ba and O ions and the covalent nature between Ti and O ions, revealed from MEM calculations. Optical band gap values have been evaluated from UV-visible absorption spectra. Particles with irregular shapes and well defined grain boundaries are clearly visualized from SEM images. The phase purity of the prepared samples is further confirmed by EDS qualitative spectral analysis.

关键词： barium titanate X-ray diffraction Rietveld refinement maximum entropy method bonding

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Effect of silicon carbide and wire-mesh reinforcements in dissimilar grade aluminium explosive clad composites

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Defence Technology（防务技术） 2020年第6期16卷 1160-1166页

作者： S.saravanan K.Raghukandan Department of Mechanical Engineering Annamalai UniversityAnnamalainagarTamilnaduIndia Department of Manufacturing Engineering Annamalai UniversityAnnamalainagarTamilnaduIndia

Aluminium composites are inevitable in the manufacture of aircraft structural elements owing to less weight,superior corrosion resistance and higher specific *** composites reduce the weight of the aircraft,improve the fuel efficiency and enhance the maintenance *** study proposes the development of dissimilar grade aluminium(aluminium 1100-aluminium 5052)composites with different reinforcement’s viz.,stainless steel wire-mesh,silicon carbide(SiC)powders and SiC powder interspersed wire-mesh,by explosive cladding ***-mesh enhances the friction and restricts the movement of flyer plate to craft a defect free clad,while SiC particles form a band on the *** strength is obtained when SiC powder interspersed wire mesh is employed as *** dissimilar aluminium explosive clad with SiC particle reinforcement results in lower strength,which is higher than that of the weaker parent alloy and that of the conventional dissimilar aluminium explosive clads without any reinforcement.

关键词： Explosive cladding Aluminium Wire mesh Silicon carbide Microstructure Strength

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Nanoindentation and Wear Characteristics of Al 5083/SiC_p Nanocomposites Synthesized by High Energy Ball Milling and Spark Plasma Sintering

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Journal of Materials Science & Technology 2012年第11期28卷 969-975页

作者： Sivaiah Bathula saravanan M Ajay Dhar Metals and Alloys group Materials Physics and Engineering Division CSIR-National Physical Laboratory

AI 5083//10 wt% SiCp nano composites have been synthesized by means of high energy ball milling followed by spark plasma sintering （SPS）. Nano composites produced via this method exhibited near-theoretical density while retaining the nano-grained features. X-ray diffraction （XRD） analysis indicated that the crystalline size of the ball milled AI 5083 matrix was observed to be～25 nm and it was coarsened up to～30 nm after SPS. Nano indentation results of nano composites demonstrated a high hardness of～280 HV with an elastic modulus of 126 gPa. Wear and friction characteristics with addition of SiCp reinforcement exhibited significant improvement in terms of coefficient of friction and specific wear rate to that of nano structured AI 5083 alloy. The reduction in specific wear rate in the nanocomposite was mainly due to the change of wear mechanism from adhesive to abrasive wear with the addition of SiCp which resulted in high hardness associated with nano-grained microstructure.

关键词： Metal matrix nano composites Friction/wear Mechanical properties Highresolution transmission electron microscopy Spark plasma sintering Nanoindentation

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