Biochanin-A attenuates high-fat diet and streptozotocin-induced hyperlipidemia and oxidative stress in rats by improving antioxidant status and lipid metabolic markers

作     者：P.P.Sethumathi V.V.Sathibabu Uddandrao P.Chandrasekaran S.Sengottuvelu P.Tamilmani P.Ponmurugan S.Vadivukkarasi M.Santhanakumar M.Shabana Begum G.Saravanan P.P.Sethumathi;V.V.Sathibabu Uddandrao;P.Chandrasekaran;S.Sengottuvelu;P.Tamilmani;P.Ponmurugan;S.Vadivukkarasi;M.Santhanakumar;M.Shabana Begum;G.Saravanan

作者机构：Centre for Biological SciencesDepartment of BiochemistryK.S.Rangasamy College of Arts and Science(Autonomous)TiruchengodeNamakkal DistrictTamilnaduIndia-637215 Department of PharmacologyNandha College of PharmacyErodeTamilnaduIndia-638052 Department of BiochemistryPGP College of Arts and ScienceNamakkalTamilnaduIndia-637207 Department of BotanyBharathiar UniversityCoimbatoreTamilnaduIndia-641046 Department of PharmacologyArulmigu Kalasalingam College of PharmacyKrishnankoilTamilnaduIndia-626126 Department of BiochemistryMuthayammal College of Arts and ScienceRasipuramTamilnaduIndia-637408 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第11期

页      面：460-468页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Antioxidant Biochanin-A Nutraceutical Obesity Hyperlipidemia Type 2 diabetes mellitus Oxidative stress 

摘      要：Objective:To determine how biochanin-A(BCA)affects high-fat diet and streptozotocin-induced pathological changes in lipid metabolism and antioxidant status in diabetic ***:Diabetic rats were orally administered BCA(10 mg/kg body weight)for 30 days to investigate its effects on lipid profiles and oxidative stress markers in the liver and *** addition,the mRNA expression of antioxidant and lipid metabolism enzymes in the liver was ***:BCA attenuated hyperlipidemia by regulating mRNA expressions of HMG-CoA reductase,fatty acid synthase,carnitine palmitoyl transferase,and acetyl-CoA ***,BCA reduced high-fat diet and streptozotocin-induced oxidative stress by suppressing lipid peroxidation,improving superoxide dismutase,catalase,and glutathione peroxidase levels,and upregulating mRNA expressions of these ***:BCA may be a promising nutraceutical for the treatment of dyslipidemia and oxidative stress associated with diabetes.