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Multilocus analysis of the Exophiala jeanselmei clade containing black yeasts involved in opportunistic disease in humans

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Fungal Diversity 2014年第2期65卷 3-16页

作者： Jingsi Zeng Peiying Feng A.H.g.gerrits van den Ende Liyan Xi M.J.Harrak g.s.de Hoog Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD Utrechtthe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamthe Netherlands department of dermatology and Venereology Union HospitalTongji Medical CollegeHuazhong Science and Technology UniversityWuhanChina Third Affiliated Hospital Sun Yat-sen UniversityGuangzhouChina sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Peking University Health science Center Research Center for Medical MycologyBeijingChina shanghai Institute of Medical Mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina

To confirm species delimitations in the‘jeanselmeiclade’in the Chaetothyriales,four independent markers were analysed,and phylogenetic trees were reconstructed using different *** isolation within the complex and reproductive modes in the species involved were determined,in order to explore specific borderlines using genealogical Concordance Phylogenetic species Recognition(gCPsR).sequences of the Internal Transcribed spacer(ITs),partial Translation Elongation Factor 1-α(TEF1),β-Tubulin(BT2),and Actin(ACT1)genes were analysed for a set of 81 *** reconstruction was performed using neighbour-joining(NJ),maximum parsimony(MP),maximum likelihood(ML)and Bayesian analysis(BA)to evaluate the concordance of topologies obtained under different optimization *** among lineages was detected by Partition Homogeneity Test(PHT).Most Exophiala species analysed in this study seemed to be preponderantly clonal.A group of species around Exophiala spinifera showed a tendency toward human pathogenicity,whereas species around *** were often associated with environments rich in *** the tree topologies were not completely identical when different algorithms were used,the four gene lineages were nearly congruent and the trees of the combined multilocus data set did not provide more phylogenetic information than those of separate data *** data are sufficient for identification of species in the‘jeanselmei-clade’.

关键词： Black yeasts Clonality Exophiala ITs diagnostics Phylogeny

Mountain tips as reservoirs for new rock-fungal entities: saxomyces gen. nov. and four new species from the Alps

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Fungal Diversity 2014年第2期65卷 167-182页

作者： L.selbmann D.Isola E.Egidi L.Zucconi C.gueidan g.s.de Hoog s.Onofri deB Universitàdegli Studi della TusciaLargo dell’UniversitàViterboItaly Division of genomic&Microbial Diversity Department of Life SciencesNatural History MuseumCromwell roadSW75BD LondonUK CBs-KNAW Fungal Biodiversity Centre Uppsalalaan 83584 CT UtrechtThe Netherlands

As part of a worldwide sampling nine black fungi were isolated from rocks collected in four distinct sites of the Alps at high *** on a nucssU,nucLsU and mtssU multi-locus phylogeny,seven of them were found to cluster into a distinct and wellsupported clade in a basal position within the Class *** in other rock fungi these new groups of isolates were characterized by a meristematic growth and a scarcely differentiated morphology with highly melanized and thick-walled toruloid ***,few peculiar characters were also observed as convoluted hyphal tips and the production of spherical *** new genus and species saxomyces alpinus and ***,are here described based on morphological and molecular data,in a yet to be defined order of the *** remaining two black fungi clustered in Cryomyces,a genus previously exclusively found in rocks from the McMurdo Dry Valleys in *** two isolates were genetically distant from other Antarctic Cryomyces species based on ITs sequences,and they showed a peculiar morphology;they are here described as the new species *** and *** of our results on the evolution,adaptation and dispersal of rock-inhabiting fungi under extreme conditions are discussed.

关键词： Microcolonial fungi Dothideomycetes Extremotolerance Multilocus phylogeny

Novel Phialophora species from leaf-cutting ants (tribe Attini)

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Fungal Diversity 2014年第2期65卷 65-75页

作者： D.Attili-Angelis A.P.M.Duarte F.C.Pagnocca N.s.Nagamoto M.de Vries J.B.stielow g.s.de Hoog Center for the study of social Insects UNESP-São Paulo State UniversitySão PauloSPBrazil Division of Microbial Resources CPQBAUniversity of CampinasCampinasSPBrazil department of Plant Protection UNESP-São Paulo State UniversityBotucatuSPBrazil Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Research Center for Medical Mycology Peking University Health Science CenterBeijingChina shanghai Institute of Medical Mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina Basic Pathology department Federal University of ParanáStateCuritibaParanáBrazil King Abdulaziz University JeddahSaudi Arabia

Ants in the tribe Attini(Hymenoptera,Formicidae)maintain a 50 million-year-old lifestyle of co-evolution with symbiotic basidiomycetous fungi which they cultivate as essential source of ***,other microorganisms have been reported from ant habitats indicating a higher diversity of consistently associated species than established to ***,black yeast-like fungi have been reported as a possible symbiont,like a competitor of the actinomycete bacteria that grow in the integument of the *** the mating season,gynes of Atta capiguara and *** were collected from nests located in Botucatu,sP,Brazil and sampled using flotation *** analysis based on ITs,partial 28s(LsU)andβ-tubulin sequences revealed the occurrence of two novel species of Phialophora among the melanized fungi isolated.

关键词： Black yeasts Chaetothyriales gynes Phialophora Cyphellophora Atta Ant cuticle Neotropical fungal ecology

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan serneels Julie D.de schutter Lies de groef Lieve Moons steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Environmental siblings of black agents of human chromoblastomycosis

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Fungal Diversity 2014年第2期65卷 47-63页

作者： V.A.Vicente M.J.Najafzadeh Jiufeng sun R.R.gomes D.Robl s.g.Marques C.M.P.s.Azevedo g.s.de Hoog CBs-KNAW Fungal Biodiversity Centre P.O.Box 851673508AD UtrechtThe Netherlands Microbiology Parasitology and Pathology Post-graduation ProgramDepartment of Basic PathologyFederal University of ParanáCuritibaPRBrazil Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Peking University Health science Center Research Center for Medical MycologyBeijingChina sun-Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina second Medical Military University ShanghaiChina King Abdulassiz University Jeddah JeddahSaudi Arabia department of Parasitology and Mycology and Cancer Molecular Pathology Research CenterGhaem HospitalSchool of MedicineMashhad University of Medical SciencesMashhadIran guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina Federal University of Maranhão University Hospital of the Federal University of MaranhãoSão LuísBrazil Cedro Laboratory and University Hospital of the Federal University of Maranhão São LuísBrazil Institute of Biomedical sciences University of São Paulo(USP)CEP 05508-900 São PauloBrazil

Agents of human chromoblastomycosis,a skin disease almost exclusively caused by members of the order Chaetothyriales,are assumed to be traumatically inoculated into the skin with sharp environmental materials such as plant thorns or wooden splinters carrying the respective *** the supposition that such fungi should have their main habitat in the environment,we investigated the occurrence of black fungi in living areas of patients with *** south America Fonsecaea agents are prevalent as agents of the disease,while also related Cladophialophora species,known from other types of skin infections,are known from the *** environmental isolates were preliminarily selected as possible agents of chromoblastomycosis,based on *** from ITs sequence data isolates were attributed to the genera Cladophialophora,Cyphellophora,Exophiala,Fonsecaea,Phialophora,and Veronaea.A total of 45 fungi morphologically identified as Fonsecaea or Cladophialophora isolated from debris and thorns of living prickly plants in Brazil were processed for taxonomic *** analysis revealed that the isolates indeed belonged to the Chaetothyriales,but only rarely an agent of chromoblastomycosis was concerned;only two strains of *** and one *** were isolated from debris *** remaining isolates belonged to hitherto unknown molecular siblings of *** novel taxa are introduced.

关键词： Black yeasts Environmental isolation Chromoblastomycosis Opportunistic fungi Virulence Infection route

Phylogeny and taxonomy of meristematic rock-inhabiting black fungi in the Dothideomycetes based on multi-locus phylogenies

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Fungal Diversity 2014年第2期65卷 127-165页

作者： E.Egidi g.s.de Hoog D.Isola s.Onofri W.Quaedvlieg M.de Vries g.J.M.Verkley J.B.stielow L.Zucconi L.selbmann Dipartimento di scienze Ecologiche e Biologiche(deB) Universitàdegli Studi della TusciaLargo dell’Universitàsnc01100 ViterboItaly Centraalbureau voor schimmelcultures KNAW Fungal Biodiversity Centre UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina Research Center for Medical Mycology Peking University Health Science CenterBeijingChina shanghai Institute of Medical Mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina Basic Pathology department Federal University of ParanáStateCuritibaParanáBrazil King Abdulaziz University JeddahSaudi Arabia

The last decade has revealed an unexpected fungal diversity associated with natural rocks,often collected in environments influenced by harsh climatic *** the phylogenetic affiliations and the taxonomy of many of these extreme fungi,mainly within Dothideomycetes,the largest class of Ascomycota,have only partially been *** the present study we confirm that most rock inhabiting-fungi(RIF)are highly polyphyletic among Dothideomycetidae,mainly within the order Capnodiales,an order otherwise incorporating several families of major plant pathological *** taxa were identified within the two major and distinct clades of Teratosphaeriaceae,both comprising meristematic black *** one novel species and 13 new genera are proposed,based on ITs and partial nucLsU,RPB2 and BT2 sequences.

关键词： Black yeasts Capnodiales Meristematic fungi Microcolonial fungi Phylogeny Taxonomy

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： gabriela seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy department of surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of Pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Taxonomy of Ochroconis, genus including opportunistic pathogens on humans and animals

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Fungal Diversity 2014年第2期65卷 89-126页

作者： K.samerpitak E.Van der Linde H.-J.Choi A.H.g.gerrits van den Ende M.Machouart C.gueidan g.s.de Hoog CBs-KNAW Fungal Biodiversity Centre UtrechtThe Netherlands department of Microbiology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Mycology Unit Biosystematics ProgrammePlant Protection Research InstituteAgricultural Research CouncilPretoriaSouth Africa Evangelisches und Johanniter Klinikum Niederrhein DuisburgGermany service de Parasitologie-Mycologie CHU de BraboisVandœuvre-lès-NancyFrance department Life sciences Division of Microbial&Genomic DiversityNatural History MuseumLondonUK Peking University Health science Center Research Center for Medical MycologyBeijingChina sun-Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhouChina second Medical Military University ShanghaiChina

The genus Ochroconis(sympoventuriaceae,Venturiales)is revised and currently contains 13 species for which the phylogenetic position has been determined using multilocus *** older generic name scolecobasidium is considered to be of doubtful identity because the type specimen is *** the Ochroconis lineage,phylogenetic distances of all markers analyzed are exceptionally large,both between and within species.A new genus Verruconis is proposed for the neurotropic opportunist Ochroconis *** accepted within the lineages are keyed out on the basis of phenotypic *** ecological traits within each species are *** species are thermophilic and one of them is an important agent of infection in the brain,while Ochroconis is mesophilic,several species causing infections in cold-blooded animals.

关键词： Taxonomy Ecology Thermophilic fungi Human infection Avian pathogen Fish pathogen Neurotropism

Nitric oxide-mediated s-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling

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Journal of genetics and genomics 2023年第7期50卷 473-485页

作者： Hongwei Jing Xiaolu Yang Ryan J.Emenecker Jian Feng Jian Zhang Marcelo Rodrigues Alves de figueiredo Patarasuda Chaisupa R.Clay Wright Alex s.Holehouse Lucia C.strader Jianru Zuo state Key Laboratory of Plant genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of sciences Beijing 100049China department of Biology Duke UniversityDurhamNC 27008USA department of Neurobiology Duke University Medical CenterDurhamNC 27710USA department of Biochemistry and Molecular Biophysics Washington University School of MedicineSt.LouisMO 63110USA Center for Biomolecular Condensates(CBC) Washington University in St.LouisSt.LouisMO 63130USA department of Biological systems Engineering Virginia TechBlacksburgVA 24061USA The Translational Plant sciences Center(TPsC) Virginia TechBlacksburgVA 24061USA CAs Center for Excellence in Molecular Plant sciences Chinese Academy of SciencesBeijing 100101China

The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and *** signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID(Aux/IAA)family of transcriptional ***,many auxin-modulated physiological processes are also regulated by nitric oxide(NO)that executes its biological effects predominantly through protein s-nitrosylation at specific cysteine ***,little is known about the molecular mechanisms in regulating the interactive NO and auxin ***,we show that NO represses auxin signaling by inhibiting IAA17 protein *** induces the s-nitrosylation of Cys-70 located in the intrinsically disordered region of IAA17,which inhibits the TIR1-IAA17 interaction and consequently the proteasomal degradation of *** accumulation of a higher level of IAA17 attenuates auxin ***,an IAA17^(C70W)nitrosomimetic mutation renders the accumulation of a higher level of the mutated protein,thereby causing partial resistance to auxin and defective lateral root *** together,these results suggest that s-nitrosylation of IAA17 at Cys-70 inhibits its interaction with TIR1,thereby negatively regulating auxin *** study provides unique molecular insights into the redox-based auxin signaling in regulating plant growth and development.

关键词： Arabidopsis thaliana Auxin Aux/IAA Nitric oxide s-nitrosylation Intrinsically disordered region