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针状球墨铸铁的拉伸性能

现代铸铁 1982年第3期 41-45页

作者： g.j.cox 刘元烈

一些高强度球铁件的生产,可采用若干30毫米厚的针状球铁基尔试块来进行下列几方面的研究:(1)硅和镍对铸态球铁机械性能的影响。(2)不同回火处理对一般球铁的影响。(3)回火对高硅和低镍球铁拉伸性能的影响。

关键词：球铁高硅冲击值冲击韧性球墨铸铁针状

Rodent management in Aotearoa New Zealand: approaches and challenges to landscape-scale control

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Integrative Zoology 2024年第1期19卷 8-26页

作者： john g.INNES grant NORBURY Araceli SAMANIEgO Susan WALKER Deborah j.WILSON Manaaki Whenua-Landcare Research HamiltonNew Zealand Manaaki Whenua-Landcare Research AlexandraNew Zealand Manaaki Whenua-Landcare Research AucklandNew Zealand Manaaki Whenua-Landcare Research DunedinNew Zealand

Aotearoa—New Zealand has only four rodent species,all *** order of arrival,they are Pacific rat Rattus exulans,brown rat ***,house mouse Mus musculus,and black rat *** management in New Zealand aims mainly to conserve indigenous biodiversity rather than to protect crops or manage diseases,as is usual *** describe four major“regimes”and one major vision for rodent control in New Zealand to meet ecological restoration *** challenges for island eradications are for large islands that are remote or populated by *** 1080 is the only large-scale(tens of thousands of hectares)option for black rat control,but its application requires adjustment to counter subsequent rapid black rat ***“ecosanctuaries”(mean 720 ha)use ground-based traps and poisons to target mainly black rats and face constant *** with mammal-resistant fences(up to 3500 ha)limit reinvasion and target more pest species and have enabled the return of previously extirpated taxa to the main *** Free 2050 aims to eradicate the rat species(but not mice)plus some other introduced mammals from New Zealand by *** vision is not attainable with current tools,but research and experimental management is exploring techniques and *** large scale(to 100000 ha)at which black rats are now targeted for control to extremely low abundance seems to be unique to New Zealand.

关键词： black rat brown rat eradication house mouse rodent control

Drug Repurposing for the Treatment of Mycobacterium abscessus Infections

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感染微生物与疾病(英文) 2023年第3期5卷 101-110页

作者： Emily j.Baker Antonia Molloy jonathan A.g.cox School of Life and Health Sciences Aston UniversityAston TriangleBirminghamUK.

With the ever-increasing burden of antimicrobial resistance,the demand to introduce countermeasures becomes increasingly *** urgency of this need is intensified by the void in antibiotic discovery,with the identification of novel compounds declining with *** increasing concern is Mycobacterium abscessus,which displays high levels of intrinsic resistance that lead to poor success rates,even after lengthy drug *** tackling these issues is now focused on the repurposing of preexisting drugs for antimycobacterial use,facilitating the discovery of antimicrobial compounds amidst a crisis where novel antibiotics are *** of this includes the use of combination treatments,whereby coadministration of synergistic compounds can reduce dose requirements and slow the progression of antimicrobial resistance in the long *** this review,we will introduce the current therapeutic options for *** and provide insight into why treatment is so *** will also compile the current updates within drug repurposing for this pathogen,including the use of unconventional agents such as antimalarial drugs,the repositioning of antitubercu-losis candidates and the repurposing of preexisting antibiotics,including the application of combination *** addition,the in vitro drug screening platforms used in their discovery will be appraised,with the view of highlighting potential future perspectives that may help increase physiological *** review provides a timely appraisal of the future of *** treatment.

关键词： drug repurposing Mycobacterium abscessus antimycobacterial drug discovery antimicrobials

Integrated Risk Identification, Analysis, and Assessment:A Dynamic Household Economy Analysis Methodology and Example

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International journal of Disaster Risk Science 2013年第2期4卷 77-88页

作者： Bob Alexander Linda j.cox junko Mochizuki Rural Livelihood Risk Management Consulting P.O.Box 1251HonoluluHI 96807USA Department of Natural Resource and Environmental Management University of Hawai`i at ManoaHonoluluHI 96822USA

Many methodologies identify, analyze, and assess static risks to quantify potential disaster losses based on past and current events. Static methodologies will not, however, capture how climate change and adaptation are rapidly affecting the natural and social systems in many areas. Local and global changes such as those associated with development investments, livelihood pressures, political stability, and demographic trends are also affecting many areas, especially in emerging economies. Risk identification, analysis, and assessment methodologies must integrate all changes dynamically so that risk reduction and development decisions can be based on future needs. After a theoretical explanation of how to integrate dynamic changes, a static Household Economy Analysis(HEA) completed for a rapidly changing area of East Timor was altered using current trends to make the analysis more dynamic. Some inherent difficulties exist with a more dynamic approach and recommendations for overcoming them are presented. Research, government, and nongovernment personnel interested in integrated approaches to risk reduction and development decision-making in areas subject to rapid change will find the study useful.

关键词： integrate disaster interested

Heat Transfer to Foods: Modelling and Validation

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journal of Thermal Science 2002年第4期11卷 320-330页

作者： P.W.cox P.j.Fryer Centre for Formulation Engineering Chemical Engineering University of BirminghamCentre for Formulation Engineering Chemical Engineering University of Birmingham Edgbaston Birmingham UK Edgbaston Birmingham UK

The food industry uses a wide variety of processes which are not well understood. Current modelling and measurement approaches are reviewed, with specific reference to work at Birmingham on Particle tracking (PEPT) an... 详细信息

关键词： heat transfer food processing.

Molecular advances in pancreatic cancer:A genomic,proteomic and metabolomic approach

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World journal of gastroenterology 2021年第31期27卷 5171-5180页

作者： Srujan Rajesh Michael j cox Franscois Runau Department of general Surgery Leicester General HospitalLeicester LE54PWUnited Kingdom

Pancreatic ductal adenocarcinoma(PDAC)represents a challenging pathology with very poor outcomes and is increasing in incidence within the general *** majority of patients are diagnosed incidentally with insidious symptoms and hence present late in the disease *** significantly affects patient outcomes:the only cure is surgical resection but only up to 20%of patients present with resectable disease at the time of clinical *** use of“omic”technology is expanding rapidly in the field of personalised medicine-using genomic,proteomic and metabolomic approaches allows researchers and clinicians to delve deep into the core molecular processes of this difficult *** review gives an overview of the current findings in PDAC using these“omic”approaches and summarises useful markers in aiding clinicians treating *** strategies incorporating these findings and potential application of these methods are presented in this review article.

关键词： Pancreatic ductal adenocarcinoma,Pancreatic adenocarcinoma genomic Proteomic Metabolomic

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés gómez-De León Yesica A López-Mora Valeria garcía-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly j gonzález-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza Olga g Cantú-Rodríguez César H gutiérrez-Aguirre Luz Tarín-Arzaga Elías E gonzález-López David gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKgROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

New potential-energy functions for Cu, Ag and Au solids and their applications to computer simulations on metallic surfaces

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Science China Chemistry 1998年第6期41卷 566-574页

作者：刘新厚甄珍 H.cox j.N.Murrell Institute of Photographic Chemistry Chinese Academy of Sciences Beijing China School of Chemistry Physics and Environment Science University of Sussex Brighton U.K.

A set of potential energy functions for noble metals: copper, silver and gold crystals has been derived. New potential energy functions reproduce not only bulk properties, including elastic constants, phonon dispersion curves, cohesive energies, etc., but also surface behaviors of the metals. New potential energy functions have been used to simulate the surface properties of the three noble metals, computer simulations are in good agreement with experimental results.

关键词： potential function noble metal surface computer simulation.

A quasi-crystal model of collagen microstructure based on SHg microscopy

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Chinese Optics Letters 2010年第2期8卷 213-216页

作者： Pu Xu Eleanor Kable Colin j. R. Sheppard guy cox Australian Key Centre for Microscopy and MicroanMysis University of Sydney NSW 2006 Australia Division of Bioengineering National University of Singapore Singapore 117576 Key Laboratory of Ecophysics Department of Physics Shihezi University Shihezi 832000 China

Second harmonic generation （SHg） results from molecules which are polarized by an external electric field often provided by an intense laser beam. The polarizability depends on firstly the intrinsic structural properties of the substance and hence the second-order nonlinear susceptibility, and secondly the intensity and polarization direction of the incident light. The polarization characteristics of the beam are therefore of interest. In this letter, we discuss some considerations in SHg microscopy of collagen when the incoming beam is circularly polarized, and present some supporting results as well as a numerical analysis. We propose a quasi-crystal model of collagen microstructure in an effort to further our understanding on this protein.

关键词： Collagen Electric fields Harmonic generation Nonlinear optics Numerical analysis Polarization Quasicrystals