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Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behaviour is essential for designing resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Non-native plant species richness and influence of greenhouses and human populations in the conterminous United States

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Ecological Processes 2023年第1期12卷 388-401页

作者： brice B.Hanberry USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA

Background One issue in invasive plant ecology is identification of the factors related to the invasion process that increase number of non-native *** invasion by non-native species increases,so does the probability that some non-native species will become harmful,or classified as invasive species,which disrupt natural ecosystems with attendant economic and social costs.I quantified patterns of how non-native species richness varied with vegetation types and human *** evaluate the relative importance of different predictor variables for invasion pathways in the conterminous United States,I modeled non-native plant species richness by county compared to current and historical human populations;greenhouses and nurseries;railroads,pipelines,transmission lines,and oil and gas wells;and land covers of impervious surface,development intensity categories,agriculture,and vegetation types.I also modeled these variables within vegetation types,excluding vegetation *** To summarize patterns,non-native plant species richness increased from 72 to 200 with increasing human population density *** and forest land use mosaics had the greatest mean number of non-native plant species,ranging from 121 to 166,whereas grasslands and grassland mosaics had the least number of non-native plant species,about *** modeling variable importance,all combined variables had R^(2)values of 56%(random forests regressor)and 54%(cubist regressor)for predictions of withheld observations of non-native plant species rich-ness,with greenhouse density and percent forestlands as most influential *** variables of greenhouses(R^(2)=29%),historical and current human populations(R^(2)=27%and 23%),impervious surface(25%),and medium intensity development(23%)were most associated with non-native plant species *** vegetation types,greenhouse and historical human population densities were influential variables particularly in forestlands,shrubland

关键词： Agriculture Energy Forest grassland Invasive Propagule Rural Transport Urban

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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Looking Back and Beyond Sendai:25 Years of International Policy Experience on Disaster Risk Reduction

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International Journal of Disaster Risk Science 2015年第1期6卷 1-7页

作者： Sálvano briceo Science Committee Integrated Research on Disaster Risk(IRDR) Program of International Council for Science (ICSU)/International Social Science Council (ISSC)/United NationsInternational Strategy for Disaster Reduction (UNISDR)

The evolution in knowledge and application of disaster risk reduction in the 25 years of global cooperation on this issue has been uneven. While advances in knowledge have improved our understanding of the full nature of risk—the combination of hazards meeting vulnerability—the application of such knowledge has not been conducive to the development of institutional and technical mechanisms to address the full range of risk elements. governance of risk(policies, legislation, and organizational arrangements) still focuses largely on preparing to respond to the hazards and planning for recovery. This leaves largely unattended the vulnerability component of risk, which is the only component on which change can be *** arrangements, risk assessments, early warning systems, and other institutional and technical capacities still concentrate on natural hazards and this is the main change that remains to be substantively addressed.

关键词： Climate change adaptation Disaster risk reduction Risk governance Risk management

Trajectory from beech and oak forests to eastern broadleaf forests in Indiana, USA

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Ecological Processes 2019年第1期8卷 21-28页

作者： brice B.Hanberry USDA Forest Service Rocky Mountain Research StationRapid CitySD 57702USA

Background:Historical forests(circa 1799 to 1846)of Indiana were predominantly composed of American beech(25%of all trees)and upland oaks(27%of all trees).I compared historical forest composition,using studies of smaller areas to approximate composition for uncommon species or genera(gar maple currently comprises greater than 10%of all *** increasing species were yellow-poplar,red maple,black cherry,and eastern *** redcedar increased from no presence to one of the most abundant ten species(≥3.5%of composition),similarly to the pine genus,becoming more common currently than American *** or oak or beech-oak forest types(≥24%of all trees)became eastern broadleaf forests,with no dominant species,and black cherry,red maple,and eastern redcedar forest types now *** of historical oak or beech forests ranged from 28 trees per hectare to 175 trees per hectare,which probably represent savannas and *** mean density of Indiana forests is 385 trees per hectare,ranging from 180 trees per hectare to 450 trees per *** forests likely contain dense layers of woody vegetation,filling the midstory and replacing herbaceous vegetation in the ground ***:Historically dominant beech and oak forests in the eastern United States have transitioned to an alternative state of closed eastern broadleaf forests due to uncontrolled establishment of many tree species.

关键词： Fire Historical Range of variability Transition

Recent shifts in shade tolerance and disturbance traits in forests of the eastern United States

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Ecological Processes 2019年第1期8卷 391-401页

作者： brice B.Hanberry Rocky Mountain Research Station USDA Forest ServiceRapid CitySD 57702USA

Background:Current forests of the eastern USA have the potential to succeed in composition to more shade-tolerant ***,long-term processes of transition from fire-tolerant tree species to fire-sensitive species and effects of current land use on forests may interfere with successional ***:I examined if forests in three regions have increased in shade tolerance and if life history strategy groups that represent response to disturbance(i.e.,fire-tolerance,early-successional species based on low shade tolerance,mid-successional species,late-successional species,and trees valued for traits related to short harvest rotations)have changed,using Forest Inventory and Analysis surveys,adjusted for comparison,and generalized linear mixed models to assess approximately 30 year trends,with adjustments to equalize different survey ***:Although statistically significant,a slight increase of 2 to 4%in regional mean shade tolerance may not be ecologically *** the central East,mid-successional species replaced early-successional species and early-successional species replaced fire-tolerant oaks,resulting in an overall shift from fire-tolerant oaks to mid-successional *** fire-tolerant pine species and increased planted pine species were the major changes in the northern Southeast and Coastal ***:The successional process of increased composition by shade-tolerant species over time was overshadowed by land use changes that resulted in decreased fire-tolerant species and increased planted ***,frequent land use disturbance may continue to prevent the slow progress of compositional succession to very shade-tolerant species.

关键词： Disturbance Eastern United States Fire Land use Mesophication Oak Pine Succession Traits

Mountaineering incidents in France: analysis of search and rescue interventions on a 10-year period(from 2008 to 2018)

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Journal of Mountain Science 2021年第2期18卷 446-461页

作者： VANPOULLE Maud LEFEVRE brice SOULE Bastien Laboratory on Vulnerabilities and Innovation in Sport(L-VIS EA7428)University Claude Bernard Lyon1LyonDoua Campus27/29 Boulevard du 11 Novembre 1918Villeurbanne Cedex 69622France

In Europe and especially in France,there is a growing enthusiasm for outdoor sports and *** the meantime,the risk of both severe and frequent injuries associated with active pursuits is acknowledged,especially in mountainous *** effectiveness of prevention must rely on detailed knowledge of typical circumstances and scenarios but thorough understanding of the mechanisms of accidentality remains limited by the fragmentation of sources and by mostly heterogeneous *** paper aims at giving insights on victims’profiles,season,location,and circumstances of mountaineering accidents in the French Alps,through the study of rescue interventions data from 2008 to *** to the analysis of the exhaustive database of search and rescue interventions from the French mountain national police force,and while questioning its limitations,we strive to answer two questions:what are the characteristics of the hazardous situations leading to a rescue intervention in mountaineering?Among these situations,what are the characteristics that tend to make them more harmful?

关键词： Accident studies Mountaineering Outdoor recreation Mountain rescue Victim profiles Multilevel logistic regression