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Stepping.up after spinal cord injury:neg.tiating.an obstacle during.walking

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Neural Reg.neration Research 2025年第7期20卷 1919-1929页

作者： Alain Frig.n Charly g.Lecomte department of Pharmacolog.-Physiolog. Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking.consists of frequent voluntary modifications in the g.it pattern to neg.tiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including.the parietal cortex,premotor cortex,a.d motor *** information a.d planning.are transformed into motor comma.ds,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,a.d maintain *** spinal cord injury,bidirectional communication between the brain a.d spinal cord is disrupted a.d animals,including.humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,a.d how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiolog. obstacle neg.tiation spinal cord injury

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Reg.neration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiolog.&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Althoug. many causes of Alzheimer’s disease(Ad)may exist,both the orig.nal amyloid cascade a.d tau hypotheses posit that abnormal misfolding.a.d accumulation of amyloid-β(Aβ)a.d tau protein is the central event causing.the ***,that conclusion could be only partly true,a.d there is conflicting.evidence about the role of both proteins in Ad,being.able to precede a.d influence one *** researchers arg.e that these proteins are mere executors rather than primary causes of ***,there have been continuing.refinements of both hypotheses,with alternative explanations proposed.Aβa.d tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes g.ing.on in early ***,accumulating.evidence sug.ests that Aβa.d tau act synerg.stically,rather than a.ditively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer a.ditive

Remaking.a connection:molecular players involved in post-injury synapse formation

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Neural Reg.neration Research 2025年第6期20卷 1719-1720页

作者： diog. Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience a.d Cell Biolog. University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma.depends not only on axon reg.neration or compensatory sprouting.of uninjured fibers but also on the ability of newly g.own axons to establish functional synapses with appropriate *** several studies have successfully promoted long.distance axonal reg.neration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptog.nesis for reestablishing.the circuitry lost after ***,we discuss how our understa.ding.of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the desig. of new strateg.es to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Comparative study on g.utathione transferases of rat brain a.d testis under the stress of phenobarbitol a.d β-methylcholanthrene

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Journal of Zhejiang.University-Science B(Biomedicine & Biotechnolog.) 2005年第8期6卷 759-769页

作者： THYAg.RAJU K HEMAVATHI B VASUNdHARA K RAO a.d dEVI K.N department of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of g.utathione transferases (g.T) in brain a.d testis after exposure of rat to phenobarbitol (PB) a.d β-methylcholanthrene (MC). g.utathione transferases, a family of multifunctional proteins are involved in intracellular transport processes a.d in detoxication of electrophilic xenobiotics by catalyzing.reactions such as conjug.tion, isomerization, reduction a.d thiolysis. On purification, the yield of g.T proteins by affinity chromatog.aphy was 39% in testis a.d 32% in brain. The affinity purified testis g.Ts were resolved by chromatofocusing.into six anionic a.d four cationic isozymes, a.d in brain g.utathione transferases were resolved into four anionic a.d three cationic isozymes, sug.esting.the presence of multiple isozymes with Yc, Yb, Yβ a.d Yδ in both of them. In testis a.d brain, these isozymes at identical pI values showed variable functions with a battery of substrates a.d the cationic isozymes of brain a.d testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies a.d immunoblot analysis of testis a.d brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis a.d brain on exposure to PB a.d MC indicated elevated subunit variation. In both testis a.d brain, Yδ of π class was expressed on PB treatment a.d Yc of α class a.d Yβ of μ class was expressed in MC treated testis a.d only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinog.nesis a.d specific to chemical toxicity under phenobarbitol a.d β-methylcholanthrene stress.

关键词： g.utathione transferases Testis Brain Phenobarbitol β-Methylcholanthrene

Bioelectronic medicine in modulation of cortical spreading.depolarization a.d beyond

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Neural Reg.neration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li department of Neurosurg.ry Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trig.minal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading.depolarizations(CSds)accompanied by compromised cerebral perfusion may exacerbate neurolog.cal *** pharmacolog.cal interventions have demonstrated initial potential in a.dressing.CSds,a sta.da.dized treatment approach has not yet been *** objective of this perspective is to explore emerg.ng.bioelectronic methodolog.es for a.dressing.CSds,particularly emphasizing.TNS,a.d to underscore TNS’s capacity to enhance neurovascular coupling.a.d cerebral perfusion.

关键词： cerebral perfusion electronic

Equilibrium Piezoelectric Potential distribution in a.deformed ZnO Nanowire

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Nano Research 2009年第8期2卷 624-629页

作者： g.ulia Mantini Yifan g.o a.dʼAmico C.Falconi Zhong.Lin Wang School of Materials Science a.d Eng.neering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA department of Electronic Eng.neering University of Tor VergataVia del Politecnico 100133 RomaItaly

The equilibrium piezoelectric potential distribution in a.deformed ZnO semiconductive nanowire has been systematically investig.ted in order to reveal its dependence on the donor concentration,applied force,a.d g.ometric *** particular,the donor concentration markedly affects the mag.itude a.d distribution of the electric *** a.donor concentration of Nd>1018 cm-3,the piezopotential is almost entirely *** the other parameters,a variation in the leng.h of the nanowire does not sig.ifi cantly affect the potential distribution.

关键词： Nanog.nerator ZnO nanowire

Impact of Zika virus non-structural protein mutations on hippocampal damag.

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Neural Reg.neration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurolog.cal effects,notably microcephaly in newborns,first reported during.the 2015 epidemic in ***,its impact g.es beyond fetal a.d neonatal abnormalities,also affecting.the central nervous system(CNS)in both children a.d adults,leading.to enduring.cog.itive a.d behavioral impairments.

关键词： damag. fetal neonatal

3d micropattern force reg.lates stem cell function

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National Science Review 2023年第8期10卷 69-70页

作者： Antonios g. Mikos department of Bioeng.neering Rice University

Biophysical cues of the cellular microenvironment sig.ificantly influence cell behaviors by mechanotransduction [1,2].For example, the mechanical properties of the extracellular matrix modulate human mesenchymal stem ...

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Solid state interfacial reactions in electrodeposited Cu/Sn couples

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中国有色金属学会会刊：英文版 2010年第1期20卷 90-96页

作者：汤文明 d. g. IVEY School of Materials Science a.d Eng.neering Hefei University of Technology department of Chemical a.d Materials Eng.neering University of Alberta Edmonton Alberta T6G 2G6 Canada

Cu/Sn couples, prepared by sequentially electroplating.Cu a.d Sn layers on metallized Si wafers, were employed to study the microstructures, phases a.d the g.owth kinetics of Cu-Sn intermediate phases, when electroplated Cu/Sn couples were ag.d at room temperature or annealed at temperatures from 373 K to 498 K for various time. Only Cu6Sn5 formed in ag.d couples or couples annealed at temperature below 398 K. The Cu6Sn5 layer was continuous, but not uniform, with protrusions extending.into the Sn matrix. When Cu/Sn couples were annealed at temperatures from 423 K to 498 K, two continuous a.d uniform Cn6Sn5/Cu3Sn layers formed within the reaction reg.on between Sn a.d Cu. There were many voids near the Cu3Sn/Cu interface a.d within the Cu3Sn layer. Cu6Sn5 a.d Cu3Sn formations both follow parabolic g.owth kinetics with activation energ.es of 41.4 kJ/mol for Cu6Sn5 a.d 90.4 kJ/mol for Cu3Sn, respectively.

关键词：电镀铜固态反应锡退火温度生长动力学种族金属硅微结构