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Analysis of new bone,cartilag.,and fibrosis tissue in h.aling.murine allog.afts using.wh.le slide imag.ng.and a new automated h.stomorph.metric alg.rith.

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Bone Research 2015年第4期3卷 226-234页

作者： Long.e Zh.ng.Martin Ch.ng.Ch.istoph.r A Beck edward M Sch.arz Brendan F Boyce Center for Musculoskeletal Research School of Medicine and DentistryUniversity of Rochester Medical Center

h.stomorph.metric analysis of h.stolog.c sections of normal and diseased bone samples,such.as h.aling.allog.afts and fractures,is widely used in bone ***,th. utility of traditional semi-automated meth.ds is limited because th.y are labor-intensive and can h.ve h.g. interobserver variability depending.upon th. parameters being.assessed,and primary data cannot be re-analyzed *** h.stomorph.metry h.s long.been recog.ized as a solution for th.se issues,and recently h.s become more feasible with.th. development of dig.tal wh.le slide imag.ng.and computerized imag. analysis systems th.t can interact with.dig.tal ***,we describe th. development and validation of an automated application（alg.rith.）using.Visioph.rm＇s imag. analysis system to quantify newly formed bone,cartilag.,and fibrous tissue in h.aling.murine femoral allog.afts in h.g.-quality dig.tal imag.s of h.E/alcian blue-stained decalcified h.stolog.c *** validate th.s alg.rith.,we compared th. results obtained independently using.OsteoMeasureTM and Visioph.rm imag. analysis *** intraclass correlation coefficient between Visioph.rm and OsteoMeasure was very close to one for all tissue elements tested,indicating.nearly perfect reproducibility across *** new alg.rith. represents an accurate and labor-efficient meth.d to quantify bone,cartilag.,and fibrous tissue in h.aling.mouse allog.afts.

关键词： cartilag. slide automated h.aling.fibrous Fig.re automatically sections seg.entation quantify

Isotope g.och.mistry of Volcanic Rocks from th. Barton Peninsula,King.g.org. Island,Antarctica

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Journal of Earth.Science 2011年第1期22卷 40-51页

作者： Jeong.h.ang.郑祥身 edward M Ripley Jong.Ik Lee Dong.ok Sh.n Department of g.olog.cal Eng.neering Daejeon University Institute of g.olog. and g.oph.sics Chinese Academy of Sciences Department of g.olog.cal Sciences Indiana University Korea Polar Research.Institute Department of g.olog.cal Sciences Kongju University

C, O, h. S and Sr isotopes were investig.ted to ch.racterize th. isotopic composition of th. Paleocene-Eocene volcanic rocks in Barton Peninsula, King.g.org. Island, Antarctica. Th. analyzed samples of volcanic rocks cover a rang. from basalt to andesite. Th. δ 13C and 61SO values of calcite in volcanic rocks rang. from -7.5‰ to -3.2‰ and 0.4‰ to 5.1‰, respectively. Th. h.mog.nous δ 13C cal and depleted δ18 Ccal values relative to primary mag.atic values reflect th. effect of h.g. temperature alteration of volcanic rocks. Th. δ18 O of volcanic rocks rang.s from -1.1‰ to 7.2‰, and th. majority of values are sig.ificantly lower th.n th.se of primary mag.atic values. Th. low δ18 O WR values are compatible with.h.g. temperature alteration. Th. initial values of 87Sr/86Sr of volcanic rocks span a narrow rang. from 0.703 312 to 0.703 504 wh.ch.belong.to th. present mid-oceanic ridg. basalt. Th. values of 87Sr/86Sr of volcanics in th. Barton Peninsula are similar to th.se determined in th. Fildes Peninsula, King.g.org. Island. Th. δD WR and h.O contents of volcanic rocks rang. from -74‰ to -66‰ and 0.67 wt.% to 2.74 wt.%, respectively. Th. h.g.er δD WR and h.O wt.% of volcanic rocks relative to fresh.basalts also result from h.g. temperature alteration. Sulfur isotope compositions of th. volcanic rocks rang. from -12.5‰ to -7.0‰; th.se values may represent fractionation accompanying.partial oxidation of mag.atic S or incorporation of some bacteriog.nic sulfide. Th. low S contents and neg.tive correlation with.C and h.O reflect th. formation of calcite and breakdown of sulfide as a result of h.g. temperature water-rock interaction.

关键词： isotope volcanic rock h.g. temperature alteration Antarctica.

关于药学教育课程设置的现阶段和理想设置着重点的调研

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药学教育 2001年第3期17卷 45-48页

作者： Jean Nappi,edward h. O'Neil 美国南卡罗来纳州医科大学卫生管理和政策系美国南卡罗来纳州医科大学药学院美国加州大学旧金山分校

一、前言过去的几十年里,美国医疗服务体系发生了重大变化,从专业人员的有偿服务型过渡至市场化服务型。人口结构和疾病谱的变化及科技的迅猛发展,导致药物用量和成本大大增加。这些变化对承担着培养美国未来药学专业人才的人士提出了... 详细信息

一、前言过去的几十年里,美国医疗服务体系发生了重大变化,从专业人员的有偿服务型过渡至市场化服务型。人口结构和疾病谱的变化及科技的迅猛发展,导致药物用量和成本大大增加。这些变化对承担着培养美国未来药学专业人才的人士提出了新课题。近十年来,普伊医疗专业委员会(Th. Pew

关键词：药学教育医学教育课程改革医疗护理着重点门诊病人课程设置

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C-V测量技术的进展

微电子学 1990年第4期20卷 48-51,70页

作者： edward h. Nicollian 黄子伦北卡罗来纳大学

本文论述了可以同时进行高/低频电容测量的改进方法,采用这类测量技术可以避免先期方法带来的麻烦。

关键词： C-V电容测量技术电容测量仪器

美国城市、汽车及区域交通规划:寻求21世纪可持续发展

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国际城市规划 2012年第4期27卷 89-94页

作者：爱德华·h.齐格勒李心彤(译) 李宗兵(译) 丹佛大学斯特姆法学院

文章主要探讨21世纪美国大都市区所面临的挑战,各级政府与城市本身该如何协助各大都市发展与改革。大都市无法独自解决它们所面临的挑战。一个国家,其所辖各级城市,与邻近郊区都是在一个国家整体政策框架下运作的;且城市同时也面临着许... 详细信息

文章主要探讨21世纪美国大都市区所面临的挑战,各级政府与城市本身该如何协助各大都市发展与改革。大都市无法独自解决它们所面临的挑战。一个国家,其所辖各级城市,与邻近郊区都是在一个国家整体政策框架下运作的;且城市同时也面临着许多超过它们能力所及的挑战。此时所需要的便是跨联邦、州、地方,以及私人领域的全体参与者的协调合作,以协助城市建立其经济实力,扶植强壮且多元的中产阶级,并以环境可持续发展的理念成长。

关键词：环境可持续发展美国城市区域交通规划汽车大都市区都市发展协调合作经济实力

Mech.0}sig.aling.activation of Tg.βmaintains intervertebral disc h.meostasis

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Bone Research 2017年第1期5卷 27-40页

作者： Qin Bian Lei Ma Amit Jain Janet L Crane Kh.led Kebaish.Mei Wan Zh.ng.ong.Zh.ng.X edward g.o Paul D Sponseller Ch.ryle A Seg.in Lee h.Riley Yong.un Wang.Xu Cao Department of Orth.paedic Surg.ry Institute for Cell EngineeringJohns Hopkins UniversityBaltimoreMDUSA Institute of Spine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiPR China Department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA Department of Biomedical Eng.neering Columbia UniversityNYUSA Departments of Ph.siolog. and Ph.rmacolog. University of Western OntarioLondonCanada

Intervertebral disc （IVD） deg.neration is th. leading.cause of disability with.no disease-modifying.treatment. IVD deg.neration is associated with.instable mech.nical loading.in th. spine, but little is known about h.w mech.nical stress reg.lates nucleus notoch.rdal （NC） cells to maintain IVD h.meostasis. h.re we report th.t mech.nical stress can result in excessive integ.in αvβ6-mediated activation of transforming.g.owth.factor beta （Tg.β）, decreased NC cell vacuoles, and increased matrix proteog.ycan production, and results in deg.nerative disc disease （DDD）. Knockout of Tg.β type II receptor （TβRII） or integ.in αv in th. NC cells inh.bited functional activity of postnatal NC cells and also resulted in DDD under mech.nical loading. Administration of Rg. peptide, Tg.β, and αvβ6-neutralizing.antibodies attenuated IVD deg.neration. Th.s, integ.in-mediated activation of Tg.β plays a critical role in mech.nical sig.aling.transduction to reg.late IVD cell function and h.meostasis. Manipulation of th.s sig.aling.path.ay may be a potential th.rapeutic targ.t to modify DDD.

关键词： Mech.0}sig.aling.activation of Tg. maintains intervertebral disc h.meostasis IVD

Emerg.ng.roles of Aurora-A kinase in cancer th.rapy resistance

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药学学报:英文版 2023年第7期13卷 2826-2843页

作者： Dayong.Zh.ng.Jun Li h.n Yan g.ng.Zh.ng.Wei Li edward Ch. Ning.Wei Sch.ol of Ph.rmacy North China University of Science and TechnologyTangshan 063210China Basic Medical Science Colleg. Liaoning University of Traditional Chinese MedicineShenyang 110032China Division of Biolog. and Biolog.cal Eng.neering California Institute of TechnologyPasadenaCA 91125USA Department of Oncolog. and Cancer Th.rapeutics Prog.am Montefiore Einstein Cancer CenterAlbert Einstein College of MedicineBronxNY 10461USA

Aurora kinase A(Aurora-A),a serine/th.eonine kinase,plays a pivotal role in various cellular processes,including.mitotic entry,centrosome maturation and spindle *** or g.ne-amplification/mutation of Aurora-A kinase occurs in different types of cancer,including.lung.cancer,colorectal cancer,and breast *** of Aurora-A impacts multiple cancer h.llmarks,especially,immortalization,energ. metabolism,immune escape and cell death.resistance wh.ch.are involved in cancer prog.ession and *** review h.g.lig.ts th. most recent advances in th. oncog.nic roles and related multiple cancer h.llmarks of Aurora-A kinase-driving.cancer th.rapy resistance,including.ch.moresistance(taxanes,cisplatin,cycloph.sph.mide),targ.ted th.rapy resistance(osimertinib,imatinib,sorafenib,etc.),endocrine th.rapy resistance(tamoxifen,fulvestrant) and ***,th. mech.nisms of Aurora-A kinase promote acquired resistance th.oug. modulating.DNA damag. repair,feedback activation bypass path.ays,resistance to apoptosis,necroptosis and autoph.g.,metastasis,and ***,our review also summarizes th. promising.synth.tic leth.lity strateg. for Aurora-A inh.bitors in RB1,ARID1A and MYC g.ne mutation tumors,and potential synerg.stic strateg. for m TOR,PAK1,MDM2,MEK inh.bitors or PD-L1 antibodies combined with.targ.ting.Aurora-A *** addition,we discuss th. desig. and development of th. novel class of Aurora-A inh.bitors in precision medicine for cancer treatment.

关键词： Aurora-A Th.rapy resistance Ch.moresistance Targ.ted th.rapy Radioresistance Synth.tic leth.lity Alisertib PROTAC

麻醉住院医师行随机药物检测可降低药物成瘾的发生率：来自一项研究的初步结果

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麻醉与镇痛 2013年第6期9卷 1-6页

作者： Mich.el g. Fitzsimons, MD Keith.h. Baker, MD, Ph. edward Lowenstein, MD Warren M. Zapol, MD 邱必军(译) 俞卫锋(校) Department of Anesth.sia and Critical Care Harvard Medical School Massachusetts General Hospital Boston Massachusetts 不详

麻醉住院医师中药物滥用的发生率为1％～2％，并且近80％的培训计划中会有一个或更多的住院医师存在这个问题。教育与管制上的努力对降低药物滥用的发生率是失败的。为了患者的身体健康，麻醉医师负有远离成瘾性药物的职业责任。我们制... 详细信息

麻醉住院医师中药物滥用的发生率为1％～2％，并且近80％的培训计划中会有一个或更多的住院医师存在这个问题。教育与管制上的努力对降低药物滥用的发生率是失败的。为了患者的身体健康，麻醉医师负有远离成瘾性药物的职业责任。我们制定了一个项目拟通过对录用前的麻醉科住院医师进行随机尿液检测以降低药物滥用的发生率。虽然存在逻辑和文化上的障碍，但我们证明该计划的可行性。仍需要大型的多中心研究来决定是否需要制定一项随机尿液检测项目以降低麻醉科住院医师药物滥用的发生率。

关键词：住院医师麻醉医师发生率药物成瘾药物检测随机药物滥用尿液检测

Towards a Th.oretical Framework of Autonomous Systems Underpinned by Intellig.nce and Systems Sciences

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 52-63页

作者： Ying.u Wang.Ming.h.u Konstantinos NPlataniotis Sam Kwong.h.nry Leung.edward Tunstel Imre JRudas Ljiljana Trajkovic International Institute of Cog.itive Informatics and Cog.itive Computing Department of Electrical and Computer EngineeringSchulich School of Engineering and Hotchkiss Brain InstituteUniversity of CalgaryCalgary T2N 1N4Canada Toronto Research.Centre Defence Research&Development CanadaToronto M3K 2C9Canada Department of Electrical&Computer Eng.neering University of TorontoToronto M5S3G4Canada Department of Computer Science City University of Hong KongHong KongChina Department of Electrical and Computer Eng.neering Schulich School of EngineeringUniversity of CalgaryCalgary T2N 1N4Canada Autonomous&Intellig.nt Systems Department United Technologies Research CenterCT 06108 USA University Research.Innovation Center(EKIK) Óbuda UniversityBudapest H-1034Hungary Sch.ol of Eng.neering.Science Simon Fraser UniversityBurnaby V5A 1S6Canada

Autonomous systems are an emerg.ng.AI tech.olog. functioning.with.ut h.man intervention underpinned by th. latest advances in intellig.nce,cog.ition,computer,and systems *** paper explores th. intellig.nt and math.matical foundations of autonomous *** focuses on structural and beh.vioral properties th.t constitute th. intellig.nt power of autonomous *** explains h.w system intellig.nce ag.reg.tes from reflexive,imperative,adaptive intellig.nce to autonomous and cog.itive intellig.nce.A h.erarch.cal intellig.nce model(h.M)is introduced to elaborate th. evolution of h.man and system intellig.nce as an inductive *** properties of system autonomy are formally analyzed towards a wide rang. of applications in computational intellig.nce and systems *** paradig.s of autonomous systems including.brain-inspired systems,cog.itive robots,and autonomous knowledg. learning.systems are *** in autonomous systems will pave a way towards h.g.ly intellig.nt mach.nes for aug.enting.h.man capabilities.

关键词： Autonomous systems(AS) cog.itive systems computational intellig.nce eng.neering.paradig.s intellig.nce science intellig.nt math.matics