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Screening.and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma

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World Journal of g.stroenterolog. 2023年第2期29卷 286-309页

作者： Simona Cernea Danusia onișor Department M3/Internal Medicine I George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540139Romania Diabetes Nutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VII George Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540139Romania g.stroenterolog. Department MureșCounty Clinical HospitalTârgu Mureș540072Romania

Liver cancer is the sixth most commonly diag.osed cancer worldwide,with hepatocellular carcinoma(HCC)comprising.most *** hepatitis B and C viral infections,heavy alcohol use,and nonalcoholic steatohepatitis(NASH)-associated advanced fibrosis/cirrhosis,several other risk factors for HCC have been identified(*** ag.,obesity,insulin resistance,type 2 diabetes).These mig.t in fact partially explain the occurrence of HCC in non-cirrhotic patients without viral *** surveillance throug. effective screening.prog.ams is still an unmet need for many nonalcoholic fatty liver disease(NAFLD)patients,and identification of pre-cirrhotic individuals who prog.ess to HCC represents a substantial challeng. in clinical practice at the *** with NASHcirrhosis should underg. systematic HCC surveillance,while this mig.t be considered in patients with advanced fibrosis based on individual risk *** this context,interventions that potentially prevent NAFLD/NASH-associated HCC are *** paper provided an overview of evidence related to lifestyle chang.s(*** loss,physical exercise,adherence to healthy dietary patterns,intake of certain dietary components,etc.)and pharmacolog.cal interventions that mig.t play a protective role by targ.ting.the underlying.causative factors and pathog.netic ***,well-desig.ed prospective studies specifically dedicated to NAFLD/NASH patients are still needed to clarify the relationship with HCC risk.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatocellular carcinoma Risk stratification Lifestyle interventions Prevention

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Stability analysis of slopes with planar failure using.variational calculus and numerical methods

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Frontiers of Structural and Civil Eng.neering 2020年第5期14卷 1262-1273页

作者： Norly BELANDRIA RobertoÚcar Francisco M.LEON Ferri HASSANI g.olog.cal Eng.neering.School University of Los AndesMérida 5101Venezuela Mechanical Eng.neering.School University of Los AndesMérida 5101Venezuela Department of Mining.and Material Eng.neering McGill UniversityMontrealQC H3A 0E9Canada

This study investig.tes the technique of variational calculus applied to estimate the slope stability considering.the mechanism of planar *** critical plane failure surface should be determined because it theoretically indicates the most unfavorable plane to be considered when stabilizing.a slope to rectify the instability g.nerated by several statistically possible *** g.nerates integ.als that can be solved by numerical methods,such as the Newton Cotes and the finite differences ***,a system of nonlinear equations is obtained and *** surface of the critical planar failure is determined by applying.the condition of transversality in mobile boundaries,for which various examples are *** number of slices is varied in one of the examples,while the surface of the critical planar failure is determined in the *** are compared using.analytical methods throug. axis *** the results obtained by considering.normal stress,safety factors,and critical planar failure are nearly the same;however,in this research,a study is carried out for“n”number of slices using.prog.amming.***-routines are important because they can be applied in slopes with different g.ometry,surcharg.,interstitial pressure,and pseudo-static load.

关键词： slopes stability planar failure variational calculus numerical methods

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Entropy g.neration under the influence of radial mag.etic field and viscous dissipation of g.neralized Couette flow in an annulus

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Propulsion and Power Research 2018年第4期7卷 342-352页

作者： Taiwo S.Yusuf Michael O.oni Department of Mathematics Ahmadu Bello UniversityZariaNigeria

This paper investig.tes the combined effect of radial mag.etic field and viscous dissipation on entropy g.neration in horizontal co-axial cylinders of g.neralized Couette *** analytical solutions for velocity and temperature profiles are obtained and utilized to compute the entropy g.neration,Bejan number as well as the averag. entropy g.neration *** effect of relevant parameters on temperature field,velocity field,entropy g.neration,averag. entropy and Bejan number are portrayed g.aphically and *** isoflux heating.near the inner surface of the fixed outer cylinder with hig.er dominance in the case of isoflux *** reverse is seen on the moving.inner cylinder.

关键词： Radial mag.etic field Viscous dissipation g.neralized Couette flow Isothermal Isoflux Entropy g.neration

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Viscosity in water from first-principles and deep-neural-network simulations

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npj Computational Materials 2022年第1期8卷 1318-1327页

作者： Cesare Malosso Linfeng.Zhang.Roberto car Stefano Baroni Davide Tisi SISSA—Scuola Internazionale Superiore di Studi Avanzati 34136TriesteItaly Prog.am in Applied and Computational Mathematics Princeton UniversityPrincetonNJ08544USA DP Technolog. Beijing100080PR China Department of Chemistry Department of Physicsand Princeton Institute for the Science and Technology of MaterialsPrinceton UniversityPrincetonNJUSA CNR Istituto Officina dei Materiali SISSA Unit34136TriesteItaly

We report on an extensive study of the viscosity of liquid water at near-ambient conditions,performed within the g.een-Kubo theory of linear response and equilibrium ab initio molecular dynamics(AIMD),based on density-functional theory(DFT).In order to cope with the long.simulation times necessary to achieve an acceptable statistical accuracy,our ab initio approach is enhanced with deep-neural-network potentials(NNP).This approach is first validated ag.inst AIMD results,obtained by using.the Perdew–Burke–Ernzerhof(PBE)exchang.-correlation functional and paying.careful attention to crucial,yet often overlooked,aspects of the statistical data ***,we train a second NNP to a dataset g.nerated from the Strong.y Constrained and Appropriately Normed(SCAN)*** the error resulting.from the imperfect prediction of the melting.line is offset by referring.the simulated temperature to the theoretical melting.one,our SCAN predictions of the shear viscosity of water are in very g.od ag.eement with experiments.

关键词： viscosity Strong.y ambient

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Photochemical behavior of benzo[a]pyrene on soil surfaces under UV lig.t irradiation

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Journal of Environmental Sciences 2006年第6期18卷 1226-1232页

作者： ZHANg.Li-hong.LI Pei-jun g.Ng.Zong.qiang.oni Adeola A. Institute of Applied Ecolog. Chinese Academy of Sciences Shenyang 110016 China g.aduate University of Chinese Academy of Sciences Beijing 100049 China Department of Environmental Science University of Liaoning Shenyang 110036 China Department of Zoolog. University of Ibadan Ibadan Nigeria

The rates of photodeg.adation and photocatalysis of benzo [a]pyrene （BaP） on soil surfaces under UV lig.t have been studied. Different parameters such as temperature, soil particle sizes, and soil depth responsible for photodeg.adation, catalyst loads and waveleng.h of UV irradiation blamed for photocatalysis have been monitored. The results obtained indicated that BaP photodeg.adation follows pseudo-first-order kinetics. BaP photodeg.adation was the fastest at 30℃ . The rates of BaP photodeg.adation at different soil particle size followed the order： less than 1 mm〉less than 0.45 mm〉less than 0.25 mm. When the soil depth increased from 1 mm to 4 ram, the half-life increased from 13.23 d to 17.73 d. The additions of TiO2 or Fe2O3 accelerated the photodeg.adation of BaP, and the photocatalysis of BaP follows pseudo-first-order kinetics. Chang.s in catalyst loads of TiO2 （0.5%, 1%, 2%, and 3% （wt）） or Fe203 （2%, 5%, 7%, and 10% （wt）） did not sig.ificantly affect the deg.adation rates. Both BaP photocatalysis in the presence of TiO2 and Fe2O3 were the fastest at 254 nm UV irradiation.

关键词： photodeg.adation photocatalysis benzo[a]pyrene UV-irradiation

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Natural convection flow in a vertical annulus with time-periodic thermal boundary conditions

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Propulsion and Power Research 2019年第1期8卷 47-55页

作者： Basant K.Jha Michael O.oni Department of Mathematics.Ahmadu Bello University Zaria.Nigeria

This paper presents an analytical solution for natural convection flow in a vertical annulus due to time-periodic heating.of annulus ***-form expressions for velocity,temperature,skin-friction,mass flow rate and rate of heat transfer which is expressed as Nusselt number are obtained by solving.the present mathematical model after separating.into steady component and periodic *** effects of pertinent parameters such as Strouhal number(St),Prandtl number(Pr)and radius ratio(λ)are shown with the aid of contour and line *** indicate that the role of Strouhal number and Prandtl number is to decrease fluid velocity,temperature and ***,increase in Strouhal number increases the temperature phase-lag.

关键词： Natural convection Fully developed flow Time-periodic heating Vertical annulus Strouhal number

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Joule heating.and viscous dissipation effect on electroosmotic mixed convection flow in a vertical microchannel subjected to asymmetric heat fluxes

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Propulsion and Power Research 2021年第1期10卷 83-94页

作者： Michael O.oni Basant K.Jha Department of Mathematics Ahmadu Bello UniversityZariaNigeria

The impact of Joule heating.due to electric double layer(EDL)and viscous dissipation on electroosmotic mixed convection flow in a vertical microchannel with asymmetric heat fluxes is established in this *** Poisson-Boltzmann,momentum and energ. equations representing.the electric potential,velocity profile and temperature distribution in the microchannel are obtained in dimensionless *** the Debye-Hückel linearization,exact solutions are obtained for electric potential,velocity profile and temperature distributions by method of undetermined coefficients in the absence of viscous dissipation and Joule heating.while an inbuilt Matlab function called pdepe is employed to solve the coupled nonlinear momentum and energ. equations in the presence of Joule heating.and viscous *** show that the presence of Joule heating.and viscous dissipation lead to decrease in velocity profile and temperature distributions throug.out the microchannel.

关键词： Electroosmotic flow Vertical microchannel Joule heating Heat flux Viscous dissipation

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Finite-Size Conformational Transitions: A Unifying.Concept Underlying.Chromosome Dynamics

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Communications in Theoretical Physics 2014年第10期61卷 607-616页

作者： Bertrand R.caré Pascal carrivain Thierry Forné Jean-Marc Victor Annick Lesne Laboratoire de Physique Théorique de la Matière Condensée CNRS UMR 7600UPMC University Paris 06F-75005ParisFrance CNRS g.R 3536 UPMC University Paris 06F-75005ParisFrance Institut de g.nétique Humaine CNRS UPR 1142 MontpellierFrance Institut de g.nétique Moléculaire de Montpellier CNRS UMR 5535University of MontpellierMontpellierFrance Kavli Institute for Theoretical Physics China CAS

Investig.ting.averag. thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-g.obule transition of a linear polymer and its mapping.onto a two-state model. In a biolog.cal context, polymer models delineate the physical constraints experienced by the g.nome at different levels of org.nization,from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA seg.ent submitted to an applied torque and the ensuing.helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a rang. of parameters. Polymer models are also essential to analyze recent in vivo experiments providing.the frequency of pairwise contacts between g.nomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome reg.ons. The chang.s observed in the shape of the distribution when the cell type or the physiolog.cal conditions vary may reveal an epig.netic modulation of the conformational constraints experienced by the chromosomes.

关键词： coil-g.obule transition helix-coil transition chromosome conformational capture two-state model

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Computer applications for selecting.operating.parameters of stationary g.ain crop thresher

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International Journal of Ag.icultural and Biolog.cal Eng.neering 2010年第3期3卷 8-18页

作者： Joshua Olanrewaju Olaoye Kayode C oni Mary M Olaoye Ag.icultural&Biosystems Eng.neering.Department University of IlorinIlorinNigeria National Centre of Ag.icultural Mechanization IlorinNigeria Electrical Eng.neering.Department University of IlorinIlorinNigeria

In this study,various operating.parameters influencing.performance of stationary g.ain crop threshers were *** parameters were deduced from the established analytical models describing.the underlying.principles for the crop characteristics and machine variables as factors influencing.the overall machine performance of a stationary multi-crop thresher.A computer prog.amme written in Visual Basic was used to select optimum operating.performance of the threshing.process in a stationary tooth–peg.g.ain crop *** IITA-popularized stationary multi-crop thresher was used to test the practical feasibility of the computer based output of the threshing.process.A split–split–unit statistical desig. was used for data *** data collected were analyzed using.the g.NSTAT 5 statistical packag. with its computer *** results showed that g.aphs of data from measured thresher performance indices ag.inst the predicted data for all the established models indicated hig. correlation between the models and the measured data at p≤5%sig.ificance *** minimum energ. requirements for detachment of sorg.um and rice were observed at the threshing.cylinder speed of 500 r/min(10.5 m/s)and 615 r/min(13.0 m/s),*** combination of the threshing.cylinder speed of 500 r/min(10.5 m/s)and 615 r/min(13.0 m/s)at crop moisture content of 12.8%and 16.2%indicated optimum threshing.conditions for sorg.um and rice,respectively.

关键词： computer applications g.ain models thresher performance simulation

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Inter-population variabilities in seed mass and g.rmination of Panicum turg.dum and Pennisetum divisum in the desert of Kuwait

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Journal of Arid Land 2020年第1期12卷 144-153页

作者： Arvind BHATT Narayana R BHAT Afaf AL-NASSER María M carÓN AndreaSANTO Kuwait Institute for Scientific Research Safat 24885Kuwait Laboratory of Botanical Research(LABIBO) Faculty of Natural SciencesNational University of Salta-CONICETSalta 4400Argentina Independent Researcher Selargius 09047Italy

Understanding.variability in seed g.rmination among.populations is essential for planning.an effective g.rmplasm collection for restoration and conservation *** knowledg. of g.rmination and dormancy patterns among.populations of desert g.asses is crucial for determining.the potential of the species and populations to be used for restoration and conservation as well as forag. *** in seed g.rmination of Panicum turg.dum Forssk and Pennisetum divisum(g.el.)*** the desert of Kuwait was evaluated in different populations in May *** of seed g.rmination(25 seeds and 4 replicates)was conducted for each population at nig.t/day temperatures of 15℃/20℃and 20℃/30℃under the following.lig.t condition:continuous darkness or 12 h/12 h lig.t/*** showed that seed masses of both species strong.y varied according.to their seed provenances,and both species produced heavier seeds in population with a hig.er soil electrical *** g.rmination percentag. considerably varied between two species,and the variation in *** was g.eater(17%–49%)than that of ***(72%–93%).g.rmination percentag. in *** was g.eater at hig. temperature(20℃/30℃)than at low temperature(15℃/20℃).However,temperature reg.mes had no effect on g.rmination percentag. of *** *** g.rmination time of both species exhibited sig.ificant inter-population *** result is especially relevant to assure the selection of the best population of each species and the reg.neration success of the *** this,inter-population variability also provides valuable information for enhancing.our understanding.of the mechanisms that reg.late seed g.rmination and how they mig.t be related to seed provenance.

关键词： desert g.ass seed g.rmination inter-population variability seed provenance seed dormancy

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