Screening and interventions to prevent nonalcoholic fatty liver disease/nonalcoholic steatohepatitis-associated hepatocellular carcinoma

作     者：Simona Cernea Danusia Onișor 

作者机构：Department M3/Internal Medicine IGeorge Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTârgu Mureş540139Romania DiabetesNutrition and Metabolic Diseases Outpatient UnitEmergency County Clinical HospitalTârgu Mureş540136Romania Department ME2/Internal Medicine VIIGeorge Emil Palade University of MedicinePharmacyScienceand Technology of Târgu MureşTârgu Mureş540139Romania Gastroenterology DepartmentMureșCounty Clinical HospitalTârgu Mureș540072Romania 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2023年第29卷第2期

页      面：286-309页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatocellular carcinoma Risk stratification Lifestyle interventions Prevention 

摘      要：Liver cancer is the sixth most commonly diagnosed cancer worldwide,with hepatocellular carcinoma(HCC)comprising most *** hepatitis B and C viral infections,heavy alcohol use,and nonalcoholic steatohepatitis(NASH)-associated advanced fibrosis/cirrhosis,several other risk factors for HCC have been identified(*** age,obesity,insulin resistance,type 2 diabetes).These might in fact partially explain the occurrence of HCC in non-cirrhotic patients without viral *** surveillance through effective screening programs is still an unmet need for many nonalcoholic fatty liver disease(NAFLD)patients,and identification of pre-cirrhotic individuals who progress to HCC represents a substantial challenge in clinical practice at the *** with NASHcirrhosis should undergo systematic HCC surveillance,while this might be considered in patients with advanced fibrosis based on individual risk *** this context,interventions that potentially prevent NAFLD/NASH-associated HCC are *** paper provided an overview of evidence related to lifestyle changes(*** loss,physical exercise,adherence to healthy dietary patterns,intake of certain dietary components,etc.)and pharmacological interventions that might play a protective role by targeting the underlying causative factors and pathogenetic ***,well-designed prospective studies specifically dedicated to NAFLD/NASH patients are still needed to clarify the relationship with HCC risk.