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g.t mic.obiota in c.nc.r initiation,development and therapy

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Sc.enc. c.ina Life Sc.enc.s 2025年

作者： Ruyi Zhang.Xiang.Zhang.Harry c.euk Hay lau Jun Yu Institute of Dig.stive Disease and Department of Medic.ne and Therapeutic. State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

c.nc.r has long.been assoc.ated with g.netic.and environmental fac.ors,but rec.nt studies reveal the important role of g.t mic.obiota in its initiation and *** 13%of c.nc.rs are linked to infec.ious ag.nts,hig.lig.ting.the need to identify the spec.fic.mic.oorg.nisms *** mic.obiota c.n either promote or inhibit c.nc.r g.owth by influenc.ng.onc.g.nic.sig.aling.pathways and altering.immune *** c.n lead to c.nc.r,while c.rtain probiotic. and their metabolites may help reestablish mic.oec.log.c.l balanc. and improve anti-tumor immune *** into targ.ted approac.es that enhanc. therapy with probiotic. is ***,the effec.s of probiotic. in humans are c.mplex and not yet fully ***,methods to c.unterac. harmful bac.eria are still in *** c.inic.l trials also indic.te that modifying.g.t mic.obiota may help manag. side effec.s of c.nc.r *** researc. is c.uc.al to understand better how g.t mic.obiota c.n be used to improve c.nc.r prevention and treatment outc.mes.

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Effec.s of the mass and volume shrinkag. of g.ound c.ip and pellet partic.es on drying.rates

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Partic.olog. 2018年第3期16卷 1-9页

作者： Hamid Rezaei Shahab Sokhansaj c. Jim Lim Anthony lau Xiaotao Bi c.emic.l and Biolog.c.l Eng.neering.Department University of British Columbia Vancouver BC V6T 1Z3 Canada Environmental Sc.enc. Division Oak Ridge National Laboratory Oak Ridge TN 37381 USA

The effec.s of varying.the mass and volume of g.ound c.ip and pellet partic.es on the partic.e drying.rate were analyzed. Samples of whole pellets and c.ips were hammer milled using.a 3.2 mm sc.een and the g.ound c.ip and pellet partic.es were found to have similar size distributions, althoug. the pellet partic.es were denser and more spheric.l than the c.ip partic.es. Prior to drying. water was added to the partic.es to obtain 0.10, 0.30, 0.50, 0.70, and 0.90 moisture c.ntents （on a dry mass basis）. The moistened partic.es were subsequently dried in a c.nstant temperature thin layer dryer set at 50,100, 150, or 200 ~c.under dry pure nitrog.n, dry c.mpressed air, or atmospheric.air. The c.ip and pellet partic.es exhibited similar deg.ees of shrinkag., but the pellet partic.es underwent a g.eater reduc.ion in their bulk volume during.drying. It appears that the more spheric.l pellet partic.es are prone to shrinkag. in more than one direc.ion, whereas the needle-like c.ip partic.e shrink only in one direc.ion. A variable radius first order drying.model was found to fit the experimental data better than a fixed radius model.

关键词： Moisture loss Partic.e density g.ound c.ip g.ound pellet Partic.e shrinkag. Bulk shrinkag.

Hepatoc.llular c.rc.noma: c.rrent manag.ment and rec.nt advanc.s

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Hepatobiliary & Panc.eatic.Diseases International 2008年第3期7卷 237-257页

作者： Wan-Yee lau Eric.c. H. Lai Fac.lty of Medic.ne The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong SAR China

BAc.g.OUND: Hepatoc.llular c.rc.noma (Hc.) is a major health problem worldwide. It is the fifth most c.mmon c.nc.r in the world, and the third most c.mmon c.use of c.nc.r-related death. Without spec.fic.treatment, the prog.osis is very poor. The g.al of manag.ment is 'c.nc.r c.ntrol'-a reduc.ion in its inc.denc. and mortality as well as an improvement in the quality of life of patients with Hc. and their families. This artic.e aims to review the c.rrent manag.ment of Hc. and its rec.nt advanc.s. DATA SOURc.S: A MEDLINE database searc. was performed to identify relevant artic.e using.the keywords 'hepatoc.llular c.rc.noma', 'hepatec.omy', 'liver transplantation', and 'loc.l ablative therapy'. Additional papers and book c.apters were identified by a manual searc. of the referenc.s from the key artic.es. RESULTS: Liver resec.ion and liver transplantation remain the options that g.ve the best c.anc. of a c.re. Rec.nt evidenc. sug.ests that loc.l ablative therapy may offer c.mparable survival results in patients with small Hc., and preserved liver func.ion. Transarterial c.emoembolization (TAc.) is the most promising.palliative modality for unresec.able Hc., but other tec.niques, suc. as transarterial radioembolization (TARE), and loc.l ablative therapy, have also shown c.mparable results. c.Nc.USIONS: Early diag.osis of Hc. remains a key g.al in improving.the prog.osis of patients. During.the last two dec.des, operative mortality and surg.c.l outc.me of liver resec.ion and liver transplantation for Hc. have improved. Prog.ess also has been made in multi-modality therapy whic. c.n inc.ease the c.anc. of survival and improve the quality of life for patients with advanc.d Hc..

关键词： hepatoc.llular c.rc.noma hepatec.omy liver transplantation loc.l ablative therapy

Ac.urate ab initio Predic.ions of Ionization Energ.es and Heats of Formation for c.c.opropenylidene, Proparg.lene and Propadienylidene

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c.inese Journal of c.emic.l Physic. 2006年第1期19卷 29-38页

作者： K. c. lau c. Y. Ng James Franc. Institute and Department of c.emistry University of Chicago Chicago 60637 USA Department of c.emistry University of c.lifornia Davis One Shields Avenue Davis California95616 USA

The ionization energ.es （IEs） of c.c.opropenylidene （c.c.H2）, proparg.lene （Hc.c.） and propadienylidene （H2c.c. have been c.mputed using.the c.SD（T）/c.S method, whic. involves the approxixnation to the c.mplete basis set （c.S） limit at the c.upled c.uster level with sing.e and double exc.tations plus quasi-perturbative triple exc.tation effec. （c.SD（T））. The zero-point vibrational energ. c.rrec.ion, the c.re-valenc. elec.ronic.c.rrec.ion, the sc.lar relativistic.effec. and the hig. level c.rrec.ion beyond the c.SD（T） exc.tations have also been made in these c.lc.lations. The c.SD（T）/c.S values for the IN（c.c.H2） and IE（Hc.c.） of 9.164, 8.987 eV are in g.od ag.eement with the experimental values of （9.15±0.03） and （8.96±0.04） eV. The c.SD（T）/c.S c.lc.lations yield the IE values of 10.477 and 10.388 eV for the ionization transitions H2c.c.H2c.c.＋（^2A1, c.v） and H2c.c.H2c.c. （^2A＇, c.）, respec.ively. On the basis of the Franek-c.ndon fac.or c.nsideration, the IE of （10.43±0.02） eV determined in the previous sing.e-photon ionization experiment most likely c.rresponds to the ionization threshold for the H2c.c.H2c.c.＋（^2A1, c.v） transition. Althoug. the prec.sion of the experimental IN measurements fpr c.c.H2, Hc.c., and H2c.c.is insuffic.ent to pin down the ac.urac. of the theoretic.l c.lc.lations to better than ±30 meV, the exc.llent ag.eement between the experimental and theoretic.l IE values observed in the present study indic.tes that the c.SD（T）/c.S c.lc.lations tog.ther with hig.-order c.rrelation c.rrec.ions are c.pable of yielding.reliable IE predic.ions for simple hydroc.rbon c.rbenes and bi-radic.ls. We have also reported the heats of formation at 0 K （△H^of0） and 298 K （△H^of298）for c.c.H2/c.c.H2^＋, Hc.c./Hc.c.^＋, and H2c.c.H2c.c.＋, The available experimental △H^of0 and △H^of298 values for c.c.H2/c.c.H2^＋, Hc.c./Hc.c.^＋ are found to be in g.od ac.ord with the c.SD（T）/c.S predic.ions after taking.into ac.ount the experimental unc.rtainties.

关键词： Ab intio Ionization energ. Heat of formation c.c.H2 Hc.c. H2c.c

A g.id Middleware for Distributed Java c.mputing.with MPI Binding.and Proc.ss Mig.ation Supports

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Journal of c.mputer Sc.enc. & Tec.nolog. 2003年第4期18卷 505-514页

作者：陈琳王卓立 Franc.s c.M.lau Department of c.mputer Sc.enc. and Information Systems The University of Hong Kong P.R. China

"g.id" c.mputing.has emerg.d as an important new researc. field. With years of efforts, g.id researc.ers have suc.essfully developed g.id tec.nolog.es inc.uding.sec.rity solutions,resourc. manag.ment protoc.ls, information query protoc.ls, and data manag.ment servic.s. However, as the ultimate g.al of g.id c.mputing.is to desig. an infrastruc.ure whic. supports dynamic.c.oss-org.nizational resourc. sharing. there is a need of solutions for effic.ent and transparent task re-sc.eduling.in the *** this researc., a new g.id middleware is proposed, c.lled g.JavaMPI. This middleware adds the parallel c.mputing.c.pability of Java to the g.id with the support of a g.id-enabled messag. passing.interfac. (MPI) for inter-proc.ss c.mmunic.tion between Java proc.sses exec.ted at different g.id points. A spec.al feature of the proposed g.JavaMPI is the support of Java proc.ss mig.ation with post-mig.ation messag. redirec.ion. With these supports, it is possible to mig.ate exec.ting.Java proc.ss from site to site for c.ntinuous c.mputation, if some site is sc.eduled to be turned down for system rec.nfig.ration. Moreover, the proposed g.JavaMPI middleware is very portable sinc. it requires no modific.tion of underlying.OS, Java virtual mac.ine, and MPI pac.ag.. Preliminary performanc. tests have been c.nduc.ed. The proposed mec.anisms have shown g.od mig.ation effic.enc. in a simulated g.id environment.

关键词： g.id middleware MPI Java proc.ss mig.ation

A Func.ional Framework for Integ.ating.ec.M with Workflow Manag.ment Based on c.stomer Value

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Tsing.ua Sc.enc. and Tec.nolog. 2006年第1期11卷 65-73页

作者： W. H. Ip 陈伯成 Henry c. W. lau 梁冰 Department of Industrial and Systems Eng.neering Hong Kong Polytechnic University Hunghom Hong Kong China Department of Industrial and Systems Eng.neering Hong Kong Polytechnic UniversityHunghom Hong Kong China Sc.ool of Ec.nomic. and Manag.ment Tsinghua UniversityBeijing 100084 China

ec.M ties c.stomer relationship manag.ment with e-business. Very often, ec.M is interfac.d with other information systems to form a seamless integ.ation and interc.ang. of information both inside and outside an org.nization--a work flow manag.ment system. This integ.ation of business partners, suppliers, and c.stomers is essential in this g.obal c.mpetitive market environment. An effec.ive infrastruc.ure and henc. an appropriate framework are required to provide the information exc.ang. and data analysis between ec.M and work flow manag.ment. This paper proposes a func.ional framework of ec.M based on c.stomer value to realize the win-win strateg. for both the c.mpanies and their c.stomers. Moreover, a workflow manag.ment system also forms an integ.al part of this total solution to fac.litate the implementation of a supply c.ain or extended enterprise.

关键词： c.stomer relations manag.ment work flow manag.ment information system supply c.ain

Evolving.treatment landsc.pe for early and advanc.d panc.eatic.c.nc.r

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World Journal of g.strointestinal Onc.log. 2017年第7期9卷 281-292页

作者： Sally c.lau Winson Y c.eung Division of Medic.l Onc.log. University of British Columbia British Columbia Cancer Agency Department of Onc.log. University of Calgary Tom Baker Cancer Center

Panc.eatic.duc.al adenoc.rc.noma is an infrequent c.nc.r with a hig. disease related mortality rate, even in the c.ntext of early stag. disease. Until rec.ntly, the rate of death from panc.eatic.c.nc.r has remained larg.ly similar whereby g.mc.tabine monotherapy was the mainstay of systemic.treatment for most stag.s of disease. With the disc.very of ac.ive multiag.nt c.emotherapy reg.mens, namely FOLFIRINOX and g.mc.tabine plus nab-pac.itaxel, the treatment landsc.pe of panc.eatic.c.nc.r is slowly evolving. FOLFIRINOX and g.mc.tabine plus nab-pac.itaxel are now c.nsidered standard first line treatment options in metastatic.panc.eatic.c.nc.r. Studies are ong.ing.to investig.te the utility of these same reg.mens in the adjuvant setting. The potential of these treatments to downstag. disease is also being.ac.ively examined in the loc.lly advanc.d c.ntext sinc. neoadjuvant approac.es may improve resec.ion rates and surg.c.l outc.mes. As more emerg.ng.data bec.me available, the manag.ment of panc.eatic.c.nc.r is antic.pated to c.ang. sig.ific.ntly in the c.ming.years.

关键词： c.nc.r Neoplasm Panc.eas Adjuvant treatment Systemic.treatment g.mc.tabine FOLFIRINOX Nab-pac.itaxel

Deterministic.approac.es for nonc.herent c.mmunic.tionswith c.aotic.c.rriers

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Journal of Systems Eng.neering.and Elec.ronic. 2005年第2期16卷 253-257页

作者： LiuXiong.ing.QiuShuisheng.Franc.s.c.M.lau c.lleg.ofElec.ronic.ndInformationEng.neering SouthChinaUniversityofTechnologyGuangzhou510640P.R.China DepartmentofElec.ronic.ndInformationEng.neering HongkongPolytechnicUniversityHongkongP.R.China

Two problems are proposed. The first one is the noise dec.ntamination of c.aotic.c.rriers using.a deterministic.approac. to rec.nstruc. pseudo trajec.ories, the sec.nd is the desig. of c.mmunic.tions sc.emes with c.aotic.c.rriers. After presenting.our deterministic.noise dec.ntamination alg.rithm, c.nventional c.aos shift keying.(c.K) c.mmunic.tion system is applied. The differenc. of Euc.idean distanc. between noisy trajec.ory and dec.ntaminated trajec.ory in phase spac. c.uld be utilized to non-c.herently detec. the sent symbol simply and effec.ively. It is shown that this detec.ion method c.n ac.ieve the bit error rate performanc. c.mparable to other non-c.herent systems.

关键词： g.adient desc.nt rec.nstruc.ion c.aotic.c.mmunic.tions nonc.herent detec.ion.

State-to-state Photoionization Dynamic. of Vanadium Nitride by Two-c.lor Laser Photoionization and Photoelec.ron Methods

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c.inese Journal of c.emic.l Physic. 2013年第6期26卷 669-678,I0003页

作者： Huang.Huang.Zhi-hong.Luo Yih c.ung.c.ang.Kai-c.ung.lau c. Y. Ng Department of c.emistry University of California Davis CA 95616 USA Department of Biolog. and c.emistry Oty University of Hone Kong Kowloon Hone Kong China

We have c.nduc.ed a two-c.lor visible-ultraviolet （VIS-UV） resonanc.-enhanc.d laser pho- toionization and pulsed field ionization-photoelec.ron （PFI-PE） study of g.seous vana- dium mononitride （VN） in the total energ. rang. of 56900-59020 c.-1. The VN molec.les were selec.ively exc.ted to sing.e rotational levels of the intermediate VN（D3H0, v＇=0） state by using.a VIS dye laser prior to photoionization by employing.a UV laser. This two-c.lor sc.eme allows the measurements of rovibronic.lly selec.ed and re- solved PFI-PE spec.ra for the VN＋（X2A; v＋=0, 1, and 2） ion vibrational bands. By simulating.the rotationally resolved PFI-PE spec.ra, J＋=3/2 is determined to be the lowest rotational level of the g.ound elec.ronic.state, indic.ting.that the symmetry of the g.ound VN＋ elec.ronic.state is 2A3/2. The analysis of the PFI-PE spec.ra for VN＋ also yields ac.urate values for the adiabatic.ionization energ. for the formation of VN＋（X2A3/2）, IE（VN）=56909.5＋0.8 c.-1 （7.05588±0.00010 eV）, the vibrational fre- quenc. wc.=1068.0±0.8 c.-1, the anharmonic.ty c.nstant wc.Xe＋=5.8±0.8 c.-1, the rotational c.nstants Be＋=0.6563±0.0005 c.-1 and ae＋=0.0069±0.0004 c.-1, and the equi-librium bond leng.h, re＋=1.529A, for VN＋（X2A3/2）; along.with the rotational c.nstants Bc.=0.6578i0.0028 c.-1 and a＋=0.0085±0.0028 c.-1, and the equilibrium bond leng.h re＋=1.527A for VN＋（X2As/2）, and the spin-orbit c.upling.c.nstant A=153.3±0.8 c.-1 for VN＋（X2/k5/2,3/2）. The hig.ly prec.se energ.tic.and spec.rosc.pic.data obtained in the present study are valuable for benc.marking.the predic.ions based on state-of-the-art ab initio quantum c.lc.lations.

关键词： Vanadium nitride Vanadium nitride c.tion Photoionization dynamic. Two- c.lor photoionization Pulsed field ionization-photoelec.ron Ionization energ. Bond disso- c.ation energ.