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Falling sperm counts and global oestrogenic pollution：postscript

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Asian journal of Andrology 2013年第2期15卷 208-211页

作者： Trevor g cooper David j Handelsman Tuen Mun NT Hong Kong SAR PR China ANZAC research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia

This Special Issue provides reflections after 20 years, summarized in 12 papers, on the controversial issue of alleged decline in human sperm output due to global oestrogen pollution by industrial chemicals.

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Falling sperm counts and global estrogenic pollution： what have we learned over 20 years？

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Asian journal of Andrology 2013年第2期15卷 159-161页

作者： David j Handelsman Trevor g cooper ANZAC research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia Tuen Mun NT Hong Kong SAR PR ChinaGuest Editors for this special issue: Prof. DJ Handelsman

If scandal is the engine of progress in politics, and sensation is that of the media, while anti-modern panic is that of environmentalism, what is the dynamic of medical science？ Certainly discovery and invention represent the admirable high road, whereas competition and controversy represent the quotidian low road. This Special Issue is directed to reviewing the lessons learned from the most public, fervent and durable controversy in the short history of Andrology, the claims of world-wide falling sperm counts, due to global pollution by industrial estrogenic chemicals, published two decades ago.

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In memoriam roger V Short(31.7.1930-6.8.2021)

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Asian journal of Andrology 2022年第6期24卷 681-683页

作者： Trevor g cooper David j Handelsman Tuen Mun Hong Kong SARChina ANZAC research Institute Concord HospitalSydneyNSW 2139Australia

FOrEWOrD FrOM TrEVOr g cooper roger V Short,Fellow of the royal Society(FrS),born in England in 1930,itally trained as a vet at Bristol University,then completed a Fulbright Scholarship in the states and a PhD at the University of *** research in the University's Department of Veterinary Clinical studies until 1972,he became the director of the Medical research Council Unit of reproductive Biology in Edinburgh for the next decade,teaming up with Professor David Baird to run a globally renowned research institute where he trained numerous famous *** 2007 to 2014,he was an Editorial Board Member of Asian journal of Andrology.

关键词： Bristol Edinburgh institute

Sperm maturation in the epididymis： a new look at an old problem

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Asian journal of Andrology 2007年第4期9卷 533-539页

作者： Trevor g. cooper Institute of reproductive Medicine of the University Münster D-48129 Germany

The osmotic challenges facing maturing spermatozoa and their responses to them are discussed in relation to the concept of sperm maturation, defined as the increased ability of more distally recovered epididymal spermatozoa to fertilize eggs when inseminated into the female tract. One explanation could be that the more distal cells are better able to regulate their volume, and reach the oviducts, as a consequence of uptake of epididymal osmolytes. Increased motility, zona binding and oolemma fusion capacities are also acquired within the epididymis and are necessary for those cells that finally arrive at the site of fertilization. （Asian j Androl 2007 july; 9： 533-539）

关键词： epididymal function fertilization in vivo osmotic challenge sperm maturation

Afterword to Semen Analysis in 21st Century Medicine special issue in Asian journal of Andrology

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Asian journal of Andrology 2010年第1期12卷 118-123页

作者： David j. Handelsman Trevor g. cooper reproductive Endocrinology ＆ Andrology Director ANZA C Research Institute Sydney Australia Andrology Laboratory Institute of Reproductive Medicine of the University Munster Germany

We summarise and comment on the topics discussed by the contributors to this Special Issue. As an introduction, Ann jequier＇s [ 1 ] generally positive assessment of the new-look manual was tempered with her res- ervations about reference values, on which other chapters dwelt at length. Aspects of laboratory technique were discussed by Charlene Brazil [2], whose offering gives a rare insight into the actual workings of andrology laboratories and highlights the need for greater involvement of laboratory directors （often clinicians） in assessing the quality of data provided.

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Foreword to Semen Analysis in 21st Century Medicine special issue in Asian journal of Andrology

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Asian journal of Andrology 2010年第1期12卷 7-10页

作者： David j. Handelsman Trevor g. cooper reproductive Endocrinology ＆ Andrology ANZA C Research Institute Sydney Australia Andrology Laboratory Institute of Reproductive Medicine of the University Munster Germany

Semen analysis as an integral part of infertility investigations has a surprisingly long history, emerging only slowly, from under a cloud of disrepute and occupying a solitary niche outside conventional pathology tests, until relatively recently. From origins in the 19th century when spermatozoa were only identified as present or absent in cervical mucus samples from postcoital tests, even then a practice deemed ＂... dabbling incompatible with decency and self-respect...＂（cited in [1]）.

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Detecting the ?ngerprints of observed climate change on surface ozone variability

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Science Bulletin 2019年第6期64卷 359-360页

作者： Owen r.cooper cooperative Institute for research in Environmental Sciences University of Colorado NOAA Earth System research Laboratory

At the surface, tropospheric ozone is an air pollutant that adversely impacts human health, natural vegetation and crop yield and quality. This important trace gas also plays key roles as a greenhouse gas, and as the primary source of the hydroxyl (OH) radical, which determines the lifetime of many other trace gases in the atmosphere. Tropospheric ozone has a variety of sources including photochemical production from anthropogenic and naturally occurring precursor gases, and transport from the stratosphere. As a result of 让s high reactivity and its wide range of sources,*sozone lifetime can vary from minutes in the polluted boundary layer to several weeks in the mid- and upper troposphere.

关键词： tropospheric ozone greenhouse gas polluted boundary layer

Object-Based Method Outperforms Per-Pixel Method for Land Cover Classification in a Protected Area of the Brazilian Atlantic rainforest region

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Pedosphere 2013年第3期23卷 290-297页

作者： T.rITTL M.cooper r.j.HECK M.V.r.BALLESTEr Department of Soil Quality University of Wageningen Department of Soil Science University of So Paulo School of Environmental Sciences University of Guelph Center for Nuclear Energy in Agriculture (CENA) University of So Paulo

Conventional image classification based on pixels hinders the possibilities to obtain information contained in images, while modern object-based classification methods increase the acquisition of information about the object and the context in which it is inserted in the image. The objective of this study was to investigate the performance of different classification methods for land cover mapping in the vicinity of the Alto ribeira Tourist State Park, a Brazilian Atlantic rainforest area. Two classification methods were tested, including i） a hybrid per-pixel classification using the image processing software ErDAS Imagine version 9.1 and ii） an object-based classification using the software eCognition version 5. In the first method, six different classes were established, while in the second method, another two classes were established in addition to the six classes in the first method. Accuracy assessment of the classification results presented showed that the object-based classification with a Kappa index value of 0.8687 outperformed the per-pixel classification with a Kappa index value of 0.2224. Application of the user＇s knowledge during the object-based classification process achieved the desired quality; therefore, the use of inter-relationships between objects, superelasses, subclasses, and neighboring classes were critical to improving the efficiency of land cover classification.

关键词： accuracy assessment image classification Kappa index user's knowledge

regionalization of epididymal duct and epithelium in rats and mice by automatic computer-aided morphometric analysis

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Asian journal of Andrology 2005年第3期7卷 267-275,页

作者： C.Soler.j.j.deMonserrat M.Núez r.gutiérrez j.Núez M.Sancho T.g.cooper Departmentof Functional Biology and Physical Anthropology University of ValènciaValència 46112Spain Departamentode Ouímica y Biología Universidad del NorteBarranquillaColombia Instituteof reproductive Medicine University of MünsterMünster D-48129Germany

Aim： To establish a rat and mouse epididymal map based on the use of the Epiquatre automatic software for histologic image analysis. Methods： Epididymides from five adult rats and five adult mice were fixed in alcoholic Bouin＇s fixative and embedded in paraffin. Serial longitudinal sections through the medial aspect of the organ were cut at 10 jam and stained with hematoxylin and eosin. As determined from major connective tissue septa, nine subdivisions of the rat epididymis and seven for the mouse were determined, consisting of five sub-regions in the caput （rat and mouse）, one （mouse） or three （rat） in the corpus and one in the cauda （rat and mouse）. Using the Epiquatre software, several tubular, luminal and epithelial morphometric parameters were evaluated. results： Statistical comparison of the quantitative parameters revealed regional differences （2-5 in the rat, 3-6 in the mouse, dependent on parameters） with caput regions 1 and 2 being largely distinguishable from the similar remaining caput and corpus, which were in turn recognizable from the cauda regions in both species. Conclusion： The use of the Epiquatre software allowed us to establish regression curves for different morphometric parameters that can permit the detection of changes in their values under different pathological or experimental conditions. （Asian j Androl 2005 Sep; 7： 267-275）

关键词： rat mouse epididymis morphometry zonation computer-aided image analysis Epiquatre Software