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On the continued acceleration of bomb casing fragments following casing fracture

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Defence Technology（防务技术） 2014年第2期10卷 211-218页

作者： Michael D.HUTCHINSON david W.price AWE.Aldermaston Reading RG7 4PR Institute of Shock Physics Imperial College

It has been said that,once a bomb casing has fractured, "detonation gases will then stream around the fragments or bypass them,and the acceleration process stops there." However,while apparently copious gas flow through casing fractures indicates some pressure release,it is also an indication of significant gas drive pressure,post casing *** paper shows two approaches to the problem of calculating the actual loss of *** presents first-order analytical calculations,in cylindrical geometry,of pressure loss to the inside surface of a fractured *** second shows the modelling of a selected example in the CTH *** approaches reveal that gas escape,while occurring at its own soundspeed relative to the adjacent casing fragments,has to compete with rapid radial expansion of the *** with some historic experiments now publicly available,our calculations indicate that post-fracture casing fragment acceleration is,for most systems,unlikely to be reduced significantly.

关键词：壳体破裂外壳炸弹气体逸出压力损失计算表加速过程压力释放

A benchtop brain injury model using resected donor tissue from patients with Chiari malformation

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Neural Regeneration Research 2023年第5期18卷 1057-1061页

作者： Jacqueline A.Tickle Jon Sen Christopher Adams david N.Furness Rupert price Viswapathi Kandula Nikolaos Tzerakis Divya M.Chari Aston Pharmacy School College of Health and Life SciencesAston UniversityBirminghamUK School of Medicine Faculty of Medicine and Health SciencesKeele UniversityStaffordshireUK School of Life Sciences Keele UniversityStaffordshireUK Department of Neurosurgery Royal Stoke University HospitalStoke-on-TrentUK

The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative models that replicate the 3 D architecture of the central nervous system have prompted the development of organotypic neural injury models. However, the lack of reliable means to access normal human neural tissue has driven reliance on pathological or post-mortem tissue which limits their biological utility. We have established a protocol to use donor cerebellar tonsillar tissue surgically resected from patients with Chiari malformation(cerebellar herniation towards the foramen magnum, with ectopic rather than diseased tissue) to develop an in vitro organotypic model of traumatic brain injury. Viable tissue was maintained for approximately 2 weeks with all the major neural cell types detected. Traumatic injuries could be introduced into the slices with some cardinal features of post-injury pathology evident. Biomaterial placement was also feasible within the in vitro lesions. Accordingly, this ‘proof-of-concept’ study demonstrates that the model offers potential as an alternative to the use of animal tissue for preclinical testing in neural tissue engineering. To our knowledge, this is the first demonstration that donor tissue from patients with Chiari malformation can be used to develop a benchtop model of traumatic brain injury. However, significant challenges in relation to the clinical availability of tissue were encountered, and we discuss logistical issues that must be considered for model scale-up.

关键词： biomaterial Chiari malformation cerebellar slice human tissue injury model neuroregeneration organotypic traumatic brain injury

Life:Different Colours(1)

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英语学习 1996年第1期 32-34页

作者：沈学文 david price

生活是丰富多彩的。现代人应当体验各种生活,使生活更富有意义。这一点,读者朋友可从这篇小文章中先体验一下。

关键词： Life:Different Colours

趋于线性标度的增长法:基于局域定域分子轨道的双电子积分（英文）

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中山大学学报（自然科学版） 2019年第1期58卷 91-102页

作者： price david R 彭亮李少鹏顾凤龙 AOKI Yuriko 环境理论化学教育部重点实验室∥华南师范大学化学与环境学院广东广州510006 日本九州大学工学院材料科学系日本科学技术厅

基于哈特里-福克的增长法与量子快速多极展开方法相结合对大体系的计算可以达到线性标度。然而,只要把双电子积分从原子轨道转换到定域轨道,然后直接从定域分子轨道构建福克矩阵是更加简单的方法。增长法采用截断的手段剔除那些不需要... 详细信息

基于哈特里-福克的增长法与量子快速多极展开方法相结合对大体系的计算可以达到线性标度。然而,只要把双电子积分从原子轨道转换到定域轨道,然后直接从定域分子轨道构建福克矩阵是更加简单的方法。增长法采用截断的手段剔除那些不需要转换的积分从而每一步增长法的计算量几乎不变,这些手段包括采用舒瓦茨不等式、分子轨道系数的筛选、以及利用杂化轨道等可进一步减少双电子转换的数目。对水分子链体系的测试证明线性标度是可以达到的。这个新方法表明如果一个相互作用区域不超过120个定域分子轨道,它就比从原子轨道构建福克矩阵的方法更有效率。

关键词：线性表度增长法定域轨道

Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： gonzalo Tapia Rico Timothy J. price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy guy Maddern James Moore Scott Carruthers david Roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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构建大脑

China's Pathways to Achieving 40%～45% Reduction in CO2 Emissions per Unit of gDP in 2020:Sectoral Outlook and Assessment of Savings Potential

作者： (英)david J.price[等]

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China's Pathways to Achieving 40%～45% Reduction in CO2 Emis...

平滑肌肉瘤中PRUNE2mRNA的表达及其与非编码RNAPCA3的一致性关系

第十三届中国科协年会第7分会场-实现“2020年单位gDP二氧化碳排放强度下降40-45%”的途径研讨会

作者： david FRIDLEY Mark LEVINE Lynn price China Energy group Environmental Energy Technologies DivisionLawrence Berkeley National Laboratory

Achieving China’s goal of reducing its carbon intensity(CO2 per unit of gDP) by 40% to 45% percent below 2005 levels by 2020 will require the strengthening and expansion of energy efficiency policies across the buildings,industries and transport *** study uses a bottom-up,end-use model and two scenarios——anenhancedenergy efficiency(E3) scenario and an alternative maximum technically feasible energy efficiency improvement(Max Tech) scenario-to evaluate what policies and technical improvements are needed to achieve the 2020 carbon intensity reduction *** findings from this study show that a determined approach by China can lead to the achievement of its 2020 *** particular,with full success in deepening its energy efficiency policies and programs but following the same general approach used during the 11th Five Year Plan,it is possible to achieve 49% reduction in CO2 emissions per unit of gDP(CO2 emissions intensity) in 2020 from 2005 levels(E3 case).Under the more optimistic but feasible assumptions of development and penetration of advanced energy efficiency technology(Max Tech case),China could achieve a 56% reduction in CO2 emissions intensity in 2020 relative to 2005 with cumulative reduction of energy use by 2700 Mtce and of CO2 emissions of 8107 Mt CO2 between 2010 and *** savings and CO2 mitigation potential varies by sector but most of the energy savings potential is found in energy-intensive *** the same time,electricity savings and the associated emissions reduction are magnified by increasing renewable generation and improving coal generation efficiency,underscoring the dual importance of end-use efficiency improvements and power sector decarbonization.

关键词： China energy end-use bottom-up modeling scenario analysis energy efficiency

来源： cnki会议评论

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中华肿瘤杂志 2012年第7期34卷 497-500页

作者：杨吉龙 david Cogdell James Eddy Jonathan Trent Nathan price ZHANg Wei 天津医科大学附属肿瘤医院骨与软组织肿瘤科 300060

目的探讨平滑肌肉瘤中PRUNE2mRNA的表达及其与非编码RNAPCA3的关系。方法采用安捷伦基凶表达芯片的方法检测31例平滑肌肉瘤和42例胃肠间质瘤中PRUNE2mRNA的表达水平，分析其表达与平滑肌肉瘤患者的预后关系；采用实时荧光定量聚合酶链... 详细信息

目的探讨平滑肌肉瘤中PRUNE2mRNA的表达及其与非编码RNAPCA3的关系。方法采用安捷伦基凶表达芯片的方法检测31例平滑肌肉瘤和42例胃肠间质瘤中PRUNE2mRNA的表达水平，分析其表达与平滑肌肉瘤患者的预后关系；采用实时荧光定量聚合酶链反应的方法分析13例平滑肌肉瘤中PCA3mRNA和PRUNE2mRNA的表达水平并分析二者间的关系。7例前列腺癌组织作为PCA3mRNA表达的阳性对照。结果在31例平滑肌肉瘤中，PRUNE2mRNA的平均表达水平为368．43±29．67，高于37例胃肠间质瘤（82．56±7．45）和7例前列腺癌（4．76±0．98，均P〈0．05）。PRUNE2mRNA高表达的平滑肌肉瘤患者的生存期与低表达者比较，差异无统计学意义（X2=0．96，P=0．326）。PRUNE2mRNA高表达的胃肠间质瘤患者的生存期与低表达者比较，差异无统计学意义（X2=3．10，P=0．078）。平滑肌肉瘤中PcA3mRNA平均表达水平为26．38±3．04，低于前列腺癌（3272．00±240．87，P=0．004）。在平滑肌肉瘤中，PCA3mRNA与PRUNE2mRNA的表达呈正相关（r=0．901，P〈0．001）。结论PRUNE2的表达与平滑肌肉瘤患者的生存期有关，PCA3的表达与PRUNE2mRNA的表达呈正相关。

关键词：平滑肌肉瘤 RNA,未翻译 PRUNE2 PCA3 预后

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斑斓的田园风情

现代装饰 2017年第5期 84-89页

作者： david price 法国david price Design

这座迷人的三层别墅坐落于法国旺斯，距离著名的里维埃拉小镇仅有几分钟车程。别墅自带泳池与花园，内部空间经过了全面的翻新，如今的新布局更加敞亮流通，确保了更好的采光效果及空气流通，同时也满足了新业主的生活需求及审美偏好。

关键词：风情三层别墅空气流通内部空间采光效果生活需求花园泳池