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Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury

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Neural Regeneration Research 2014年第2期9卷 179-189页

作者： Fuyong Li Shuai Han yi Ma fuxin yi Xinmin Xu Yunhui Liu Department of Neurosurgery Shengjing HospitalChina Medical University Department of Neurosurgery the First Hospital of China Medical University Second Department of Neurosurgery the People’s Hospital of Liaoning Province First Department of Neurosurgery the First Affiliated HospitalLiaoning Medical College

Percutaneous microballoon compression of the trigeminal ganglion is a brand new operative technique for the treatment of trigeminal neuralgia. However, it is unclear how the procedure mediates pain relief, and there are no standardized criteria, such as compression pressure, com- pression time or balloon shape, for the procedure. In this study, percutaneous microballoon compression was performed on the rabbit trigeminal ganglion at a mean inflation pressure of 1,005 ＋ 150 mmHg for 2 or 5 minutes. At 1, 7 and 14 days after percutaneous microballoon compression, the large-diameter myelinated nerves displayed axonal swelling, rupture and demy- elination under the electron microscope. Fragmentation of myelin and formation of digestion chambers were more evident after 5 minutes of compression. Image analyzer results showed that the diameter of trigeminal ganglion cells remained unaltered after compression. These experi- mental findings indicate that a 2-minute period of compression can suppress pain transduction. Immunohistochemical staining revealed that vascular endothelial growth factor expression in the ganglion cells and axons was significantly increased 7 days after trigeminal ganglion compression, however, the changes were similar after 2-minute compression and 5-minute compression. The upregulated expression of vascular endothelial growth factor in the ganglion cells after percu- taneous microballoon compression can promote the repair of the injured nerve. These findings suggest that long-term compression is ideal for patients with recurrent trigeminal neuralgia.

关键词： nerve regeneration peripheral nerve injury trigeminal neuralgia percutaneous micro-balloon compression trigeminal ganglion cell demyelination axons vascular endothelial growthfactor neural regeneration

Influence of all-trans retinoic acid(ATRA) on the expression of NANOG in Glioma cell lines

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重庆医学 2012年第7期41卷 625-629,F0002页

作者： Liu Weixian yi fuxin Department of Neurosurgery the First Affiliated HospitalLiaoning Medical UniversityJ inzhouLiaoning 121001China

Objective To investigate the effects of all-trans retinoic acid(ATRA) on the expression of NANOG in glioma cell *** Each cell line was divided into the experimental group which was treated with ATRA for 5 days,and the control group which was cultured normally without ATRA *** and RT-PCR were adopted to detect the expression of NANOG at protein and mRNA level among the three kinds of cell *** Positive rates of NANOG protein in glioma cell lines SHG-44,U87 MG and U251 in control groups were(65.5±3.0)%,(64.8±8.0)% and(64.5±1.2)%,respectively,and the difference was not statistically significant(F=0.190,P=0.829).NANOG mRNA of the three cell lines in the relative content were 0.636 8±0.039 9,0.642 1±0.063 7,0.651 6±0.044 4,and the difference was not statistically significant(F=0.427,P=0.662).However,5 days after application of ATRA-induced NANOG protein in the three cell lines,the positive rates of NANOG protein of experimental groups were(36.5±7.3)%,(35.5±7.9)%,(35.2±6.1)%,respectively,compared with the control groups,the differences were statistically significant(FSHG-44=259.1,FU87=129.5,FU251= 431.8,PSHG-44=0.0,PU87=0.0,PU251=0.0),and the relative level of NANOG mRNA in these groups were 0.458 3±0.079 1,0.255 1±0.079 3 and 0.333 1±0.054 0,respectively,compared with the control groups,the difference was significant(FSHG-44=77.8,FU87=277.9,FU251=398.1,PSHG-44=0.0,PU87=0.0,PU251=0.0).Conclusion NANOG which highly expressed in glioma cell line SHG-44,U87 MG and U251 can be reduced by ATRA.

关键词：《重庆医学》期刊编辑部编辑工作

The top cited articles on glioma stem cells in Web of Science

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Neural Regeneration Research 2013年第15期8卷 1431-1438页

作者： fuxin yi Jun Ma Weimin Ni Rui Chang Wenda Liu Xiubin Han Dongxiao Pan Xingbo Liu Jianwu Qiu Department of Neurosurgery First Affiliated Hospital of Liaoning Medical University

BACKGROUND： Glioma is the most common intracranial tumor and has a poor patient prognosis. The presence of brain tumor stem cells was gradually being understood and recognized, which might be beneficial for the treatment of glioma. OBJECTIVE： To use bibliometric indexes to track study focuses on glioma stem cell, and to investigate the relationships among geographic origin, impact factors, and highly cited articles indexed in Web of Science. METHODS： A list of citation classics for glioma stem cells was generated by searching the database of Web of Science-Expanded using the terms ＂glioma stem cell＂ or ＂glioma, stem cell＇＂ or ＂brain tumor stem cell＂. The top 63 cited research articles which were cited more than 100 times were retrieved by reading the abstract or full text if needed. Each eligible article was reviewed for basic information on subject categories, country of origin, journals, authors, and source of journals. Inclusive criteria：（1） articles in the field of glioma stem cells which was cited more than 100 times; （2） fundamental research on humans or animals, clinical trials and case reports; （3） research article; （4） year of publication： 1899-2012; and （5） citation database： Science Citation Index-Expanded. Exclusive criteria：（1） articles needing to be manually searched or accessed only by telephone; （2） unpublished articles; and （3） reviews, conference proceedings, as well as corrected papers. RESULTS： Of 2 040 articles published, the 63 top-cited articles were published between 1992 and 2010. The number of citations ranged from 100 to 1 754, with a mean of 280 citations per article. These citation classics came from nineteen countries, of which 46 articles came from the United States. Duke University and University of California, San Francisco led the list of classics with seven papers each. The 63 top-cited articles were published in 28 journals, predominantly Cancer Research and Cancer Cell, followed by Cell Stem Cell and Nature. CONCLUSION： Our bib

关键词： Neural regeneration reviews brain glioma stem cells glioma stem cells cancer stem cells literature analysis Web of Science bibliometrics citation neuroregeneration

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错觉的唯识学解释与现象学分析

南京大学学报（哲学．人文科学．社会科学） 2019年第6期56卷 91-98页

作者：傅新毅南京大学哲学系

如何来解释错觉的发生,从根本上关乎感性认识的纯粹性与可靠性「在佛教哲学“量论的转向”即认识论的转向后,陈那的量论体系被导入到唯识学中,唯识今学的理论体系体现出鲜明的认识论特征。唯识今学基于陈那的“量分别”原则,为确保感性... 详细信息

如何来解释错觉的发生,从根本上关乎感性认识的纯粹性与可靠性「在佛教哲学“量论的转向”即认识论的转向后,陈那的量论体系被导入到唯识学中,唯识今学的理论体系体现出鲜明的认识论特征。唯识今学基于陈那的“量分别”原则,为确保感性认识的纯粹性与可靠性,将错觉的发生都落实到了第六意识上,并进而区分出了纯粹幻像与错误判断这两种不同性质的错觉,所谓无分别、有分别的“似现量”,这种解释不能令人信服。从舍勒对“假象”的现象学分析来看,错觉只是在意识中形成,但这并不是说,此时意识将前五识所呈现的感性林料转换为了观念构造物;与错误判断不同之处在于,纯粹幻像的形成并不涉及被给予的纯感知本身,而是由于在意识中它的确然领域发生了变化。

关键词：佛教哲学认识论错觉似现量五俱意识第六意识

含大规模新能源的电力系统STATCOM选址及容量优化

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电网与清洁能源 2024年第5期40卷 139-150页

作者：黎萌林章岁林毅江昌旭丁嘉鑫欧阳富鑫国网福建电力经济与技术研究院福建福州350012 福州大学电气工程与自动化学院福建福州350108

为了改善含大规模新能源电力系统电压稳定性,针对大电网系统提出了一种基于分区优化的静止同步补偿器(static synchronous compensator,STATCOM)动态无功多目标选址定容方法。提出了一种基于电气距离和暂态电压特性的分区方法,能够有效... 详细信息

为了改善含大规模新能源电力系统电压稳定性,针对大电网系统提出了一种基于分区优化的静止同步补偿器(static synchronous compensator,STATCOM)动态无功多目标选址定容方法。提出了一种基于电气距离和暂态电压特性的分区方法,能够有效地考虑电力系统拓扑结构、线路参数以及励磁系统参数和稳定器参数等对电力系统分区的影响;采用电压控制指标辨识STATCOM最优安装节点;构建了包含投资成本、静态电压稳定指标和暂态电压严重性指标的多目标动态无功规划模型;采用基于自适应协方差矩阵和混沌搜索的多目标群搜索优化算法和熵权理想度排序法对多目标无功规划模型进行求解和决策推理。对所提方法在某省级规划电网中进行了测试,仿真结果表明,优化后的STATCOM配置方案能够有效改善电力系统静态和暂态电压稳定性。

关键词： STATCOM优化选址定容新能源电气距离电压稳定

环状RNA同源域相互作用蛋白激酶3(circHIPK3)通过吸附miR-124-3p促进神经胶质瘤细胞增殖及转移

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细胞与分子免疫学杂志 2020年第7期36卷 609-615页

作者：夏立军衣服新翟旭张洺源锦州医科大学附属第一医院神经外科辽宁锦州121000

目的探究环状RNA同源域相互作用蛋白激酶3(circHIPK3)通过海绵吸附微小RNA-124-3p(miR-124-3p)对神经胶质瘤细胞增殖和转移的影响。方法按照LipofectamineTM 3000试剂说明书将circHIPK3短发夹RNA(sh-circHIPK3)、pcDNA3.1-circHIPK3、miR-124-3p模拟物(miR-124-3p mimics)和pcDNA3.1-WEE1转染T98G细胞;实时荧光定量PCR检测circHIPK3和miR-124-3p在神经胶质瘤组织和细胞系中的表达情况;CCK-8法检测T98G细胞增殖情况;TranswellTM法检测T98G细胞侵袭能力;双荧光素酶报告基因验证miR-124-3p与circHIPK3和丝氨酸/苏氨酸激酶WEE1的靶向关系;Western blot法检测WEE1和上皮间质转化(EMT)相关蛋白[上皮钙黏素(E-cadherin)、神经钙黏素(N-cadherin)和波形蛋白(vimentin)]的表达情况;此外,circHIPK3和WEE1竞争性结合miR-124-3p后,采用CCK-8法检测T98G细胞增殖,TranswellTM检测T98G细胞侵袭。结果circHIPK3在神经胶质瘤组织和细胞中高表达,敲减circHIPK3抑制T98G细胞增殖和侵袭能力,并抑制其EMT;双荧光素酶报告基因结果证实miR-124-3p是circHIPK3的靶基因,WEE1是miR-124-3p的靶基因;同时过表达miR-124-3p与circHIPK3或WEE1,或共转染sh-circHIPK3和pcDNA3.1-WEE1可恢复过表达miR-124-3p对T98G细胞增殖、侵袭和EMT的抑制作用。结论circRNA-HIPK3与WEE1海绵吸附miR-124-3p促进神经胶质瘤细胞增殖、侵袭和EMT。

关键词：环状RNA同源域相互作用蛋白激酶3(circHIPK3) miR-124-3p 神经胶质瘤细胞增殖侵袭

腹腔镜辅助下脑室腹腔分流术治疗脑积水的临床研究

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重庆医学 2012年第13期41卷 1270-1271页

作者：衣服新白敬洋马俊常锐辽宁医学院附属第一医院神经外科辽宁锦州121000

目的比较腹腔镜辅助下脑室-腹腔(V-P)分流术与传统的V-P分流术的手术操作时间和手术疗效。方法回顾性分析该院2008年10月至2011年3月收治的脑积水患者60例的临床资料。结果腹腔镜手术组平均手术时间(52min)低于常规手术组(109min),差异... 详细信息

目的比较腹腔镜辅助下脑室-腹腔(V-P)分流术与传统的V-P分流术的手术操作时间和手术疗效。方法回顾性分析该院2008年10月至2011年3月收治的脑积水患者60例的临床资料。结果腹腔镜手术组平均手术时间(52min)低于常规手术组(109min),差异有统计学意义(P<0.05);腹腔镜手术组发生分流管阻塞、感染和腹腔脏器损伤分别为2、0、0例,低于常规手术组(6、1、1例),差异有统计学意义(P<0.05)。结论与传统剖腹V-P分流术比较腹腔镜引导下V-P分流术可精确定位导管位置,有效防止并发症的发生,是一种快速、安全的方法。

关键词：腹腔镜脑室腹膜分流术脑积水

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颅脑外伤后长期昏迷的影响因素

中国医学创新 2021年第2期18卷 134-137页

作者：吕明日衣服新锦州医科大学附属第一医院辽宁锦州121000

目的:调查颅脑外伤后长期昏迷(昏迷时间≥30 d)的影响因素,为制定干预措施提供参考。方法:选择2018年9月-2019年12月本院诊治的颅脑外伤后昏迷患者113例。收集患者社会人口学特征、临床数据及昏迷状态(昏迷时间≥30 d为昏迷组,昏迷时间<... 详细信息

目的:调查颅脑外伤后长期昏迷(昏迷时间≥30 d)的影响因素,为制定干预措施提供参考。方法:选择2018年9月-2019年12月本院诊治的颅脑外伤后昏迷患者113例。收集患者社会人口学特征、临床数据及昏迷状态(昏迷时间≥30 d为昏迷组,昏迷时间<30 d为清醒组),采用单因素、多因素逻辑回归模型分析昏迷状态的影响因素。结果:113例患者中清醒组81例、昏迷组32例。收缩压异常、二便失禁、脑内血肿、肺部感染和RCTC评分高是影响长期昏迷的独立风险因素(P<0.05)。结论:入院时收缩压异常、二便失禁、脑内血肿、并发肺部感染和RCTC评分高可能预示患者发生长期昏迷,提示对上述指标加以监测对预防长期昏迷的发生和发展有重要价值。

关键词：颅脑外伤长期昏迷

微血管减压术(MVD)与微球囊压迫术(PMC)治疗原发性三叉神经痛的疗效比较

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辽宁医学院学报 2016年第4期37卷 85-87页

作者：鲍龙李想衣服新锦州医科大学附属第一医院神经外科辽宁锦州121000

目的探讨微血管减压术(Microvascular Decompression,MVD)与微球囊压迫术(Percutaneous Microballoon Compression,PMC)治疗原发性三叉神经痛的疗效比较。方法调查并收集我院神经外科行MVD与PMC对原发性三叉神经痛患者治疗情况,从术前... 详细信息

目的探讨微血管减压术(Microvascular Decompression,MVD)与微球囊压迫术(Percutaneous Microballoon Compression,PMC)治疗原发性三叉神经痛的疗效比较。方法调查并收集我院神经外科行MVD与PMC对原发性三叉神经痛患者治疗情况,从术前评估、术后有效率、复发率及并发症等多个方面评价两种治疗方案。结果两种治疗方法均有效,疗效及术后复发率无显著差异。MVD组17例患者中,4例出现口角单纯疱疹,2例出现暂时性感觉减退,1例出现暂时性耳聋耳鸣。PMC组中全部出现暂时性感觉减退,10例出现咀嚼肌无力,1例面部麻木"蚁走感"。结论对于年轻、身体状态佳、术前辅助检查有明确血管压迫的患者,主张首选微血管减压术(MVD)治疗。对于高龄、一般状态差、不耐受或拒绝接受开颅手术者,主张选择经皮穿刺微球囊压迫(PMC)治疗。安全有效且微创,短期之内可以重复实施,从而降低了医疗费用及住院时间。

关键词：三叉神经痛微血管减压术微球囊压迫术