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Chinese Journal of Chemistry 2021年第5期39卷 1113-1120页

作者： Dongdong Wang Tianxin Bai Xue Wang Yuting Xiong Yahui zhang Zhenqiang Shi fusheng zhang Wenqi Lu Guangyan Qing Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China Institute of Molecular Sciences and Engineering Shandong UniversityQingdaoShandong 266237China College of Chemistry and Chemical Engineering Wuhan Textile University1 Sunshine RoodWuhanHubei 430200China

Excited-state hydrogen bond strongly affects the intramolecular charge conversion process,which is very suitable for the design and development of high-performance fluorescent ***,as one of the most common solvents or additives used in sensing,the role of dimethyl sulfoxide(DMSO)in the system of the excited-state hydrogen bond is seldom *** the goal of this research,we investigated the sensing mechanism of a C0RM3-green fluorescent probe system for carbon monoxide releasing molecule(CORM-3)detection and tracking in vivo,through quantum chemistry calculations based on density-functional-theory(DFT)/time-dependent density-functional-theory(TDDFT)*** on the analysis of the solvent effect of DMSO by the reduced density gradient function and IR spectroscopy,we provided a new strategy to explain the fluorescence ***,we verified the result through the potential energy curve of Phthalimide(PTI,the reduced product of C0RM3-green).The excited-state hydrogen bond between PTI and DMSO promotes radiation transition and leads to obvious difference in the photophysical properties of PTI and PTI-DMSO.

关键词： Density-functional-theory/Time-dependent density-functional-theory Hydrogen bonds Fluorescent probes Electron transfer Dimethyl ulfoxide

Microstructure and mechanical properties of transient liquid phase bonding DD5 single-crystal superalloy to CrCoNi-based medium-entropy alloy

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Journal of Materials Science & Technology 2022年第1期96卷 140-150页

作者： Shiwei Li Jinglong Li Junmiao Shi Yu Peng Xuan Peng Xianjun Sun Feng Jin Jiangtao Xiong fusheng zhang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical UniversityXi’an 710072China

This study focuses on the transient liquid phase(TLP)bonding of DD5 single-crystal superalloy to Cr Co Nibased medium-entropy alloy(MEA)using a BNi-2 filler *** microstructure and mechanical properties of the TLP-bonded DD5/MEA joint were evaluated,and the microstructural evolution mechanism was *** formation of the isothermal solidification zone(ISZ)depended on the diffusion of the melting-point depressants(Si and B elements)from the liquid filler into the DD5 and MEA substrates,as well as the dissolution of the *** diffused along theγchannel of DD5 and reacted to form M_(5)B_(3)boride,herein referred to as the diffusion-affected zone(DAZ I).Similarly,the Cr_(5)B_(3)boride precipitated in the Ni-rich MEA matrix adjacent to the MEA substrate(i.e.,DAZ II).Additionally,a coherent orientation of[0]_(BCY)//[011]_(FCC)and(002)_(BCY)//(200)_(FCC)was detected between M_(5)B_(3)boride with a body-centered tetragonal(BCT)structure and the face-centered cubic(FCC)*** performance of the joint was dominated by the properties of the bonding *** the bonding time increased from 20to 80 min,the athermal solidification zone(including eutectic microstructure)was gradually replaced by the ISZ exhibiting excellent plastic deformation capability,and the shear strength of the joint was *** maximum shear strength(752 MPa)was achieved when the eutectic-free joint was bonded at 1050℃ for 80 *** fracture morphology revealed a mixture mode,indicating the initiation of cracks in the DAZ II,mainly propagating in the ISZ,and passing through the DAZ I.

关键词： Microstructure Mechanical properties Transient liquid phase bonding Single-crystal superalloy Medium-entropy alloy

Spinal cord injury in patients with systemic lupus Erythematosus Clinical manifestations, imaging characteristics and treatment

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Neural Regeneration Research 2007年第3期2卷 179-182页

作者： Yamei Tang fusheng zhang Qingyu Shen Xiangpen Li Yigang Xing Department of Neurology Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120 Guangdong Province China

BACKGROUND： There are fewer reports on systemic lupus erythematosus （SLE） related myelitis, and definite and uniform therapeutic program is not available. OBJECTIVE： To observe the clinical manifestations, imaging characteristics, results of laboratory examination and treatment of SLE. DESIGN： A retrospective case analysis. SETTING： Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS： Totally 1 052 SLE inpatients were selected from the Second Affiliated Hospital of Sun Yat-sen University from January 1995 to May 2005, and they all accorded with the diagnostic standards for SLE set by American Rheumatism Association in 1982. 124 of them were diagnosed to have damage of central nervous system. Inclusive criteria： Patients with one of the focal physical signs, including mental and behavior disorders, headache, seizure and involvement of nervous system. Exclusive criteria： Patients with hypertensive encephalopathy, damage of nervous system due to uremia and infection of central nervous system. Spinal cord lesion occurred in 15 female cases of 23 - 51 years old. Informed consents were obtained from all the participants. METHODS： The physical signs, laboratory examinations, therapeutic program and prognosis were recorded in the 15 patients with symptoms of spinal cord lesions. All the patients underwent MRI scan of brain or lesioned segment of spinal cord, and 8 cases of them underwent lumbar puncture to determine intracranial pressure, routine and biochemical examinations were cerebrospinal fluid were performed. The disease activity of SLE in systems beyond central nervous system was evaluated with modified lupus activity criteria count （LACC）. MAIN OUTCOME MEASURES：① Incidence of SLE related myelitis, attack age distribution and its association with the activity of SLE; ② Comparisons of the clinical characteristics, cranial and spinal cord MRI manifestations, different therapeutic program and prognosis. RESULTS： All the 15 SLE

关键词： systemic lupus erythematosus (SLE) myelitis magnetic resonance imaging (MRI)

IGF2BPs as novel m^(6)A readers:Diverse roles in regulating cancer cell biological functions,hypoxia adaptation,metabolism,and immunosuppressive tumor microenvironment

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Genes & Diseases 2024年第2期11卷 890-920页

作者： Meiqi Duan Haiyang Liu Shasha Xu Zhi Yang fusheng zhang Guang Wang Yutian Wang Shan Zhao Xiaofeng Jiang Department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Gastroendoscopy The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China Department of Rheumatology and Immunology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China

m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.

关键词： Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy

Cellular senescence and metabolic reprogramming:Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment

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Cancer Communications 2024年第9期44卷 929-966页

作者： fusheng zhang Junchen Guo Shengmiao Yu Youwei Zheng Meiqi Duan Liang Zhao YihanWang Zhi Yang Xiaofeng Jiang Department of General Surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Hepatobiliary and Pancreatic Surgery Peking University First HospitalBeijingP.R.China Department of Radiology The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoningP.R.China Outpatient Department The Fourth Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China

The intrinsic oncogenic mechanisms and properties of the tumor microenvironment(TME)have been extensively *** features of the TME include metabolic reprogramming,hypoxia,chronic inflammation,and tumor *** studies suggest that senescence-associated secretory phenotypes that mediate intercellular information exchange play a role in the dynamic evolution of the ***,hypoxic adaptation,metabolic dysregulation,and phenotypic shifts in immune cells regulated by cellular senescence synergistically contribute to the development of an immunosuppressive microenvironment and chronic inflammation,thereby promoting the progression of tumor *** review provides a comprehensive summary of the processes by which cellular senescence regulates the dynamic evolution of the tumor-adapted TME,with focus on the complex mechanisms underlying the relationship between senescence and changes in the biological functions of tumor *** available findings suggest that components of the TME collectively contribute to the progression of tumor *** potential applications and challenges of targeted cellular senescence-based and combination therapies in clinical settings are further discussed within the context of advancing cellular senescence-related research.

关键词： cellular senescence metabolic reprogramming hypoxia chronic inflammation immunosuppressive tumor microenvironment tumor-targeted therapy

Remarkable difference of phospholipid molecular chirality in regulating PrP aggregation and cell responses

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Chinese Chemical Letters 2023年第2期34卷 236-243页

作者： Cunli Wang Xue Wang Dongdong Wang Shengxu Qian fusheng zhang Mingyang Li Minmin Li Wenqi Lu Bo Liu Guangyan Qing School of Biomedical Engineering Dalian University of TechnologyDalian 116024China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry and Chemical Engineering Wuhan Textile UniversityWuhan 430200China

Prion diseases are fatal neurodegenerative diseases that can cause severe *** misfolding and accumulation of the prion peptide (PrP)_(106–126) is crucial,and this process is closely relevant to biological ***,how PrP_(106–126)aggregation is affected by the molecular chirality of phospholipid membrane is ***,in this study,a pair of L-and D-aspartic acid (Asp)-modified 1,2-dipalmitoyl-sn–glycero-3-phosphoethanolamine (DPPE) were synthesized to construct chiral *** discover that L-Asp-DPPE liposomes strongly inhibit the oligomerization and amyloidogenesis of PrP_(106–126),whether acting on monomers or oligomers,which rescues cytotoxicity induced by PrP_(106–126).By comparison,D-Asp-DPPE liposomes inhibit peptide oligomerization only at a high concentration and cannot prevent amyloidogenesis when acting on oligomers,which lead to pronounced *** experiment,dynamic change of intracellular Ca^(2+)(_(i)Ca^(2+)) and Ca^(2+)release from endoplasmic reticulum(ER),reactive oxygen species (ROS) production,adsorption dynamics and affinity tests,and fluorescent imaging clearly disclose that molecular chirality of the liposomes dominates conformational transition of PrP_(106–126)from random coil to β-sheet,binding and adsorption of the monomers and oligomers,and subsequent fibrillation process,resulting in distinct inhibition effect in Ca^(2+)overload and release,ROS production and cell *** work is the first to report that interfacial molecular chirality is a potentially crucial influence on the fibrillation process of PrP_(106–126) and its cell responses,whereas the convergence of chiral amino acids and liposomes can be considered potential inhibitors in prion diseases.

关键词： Prion disease Liposome Chirality Interface Cytosolic Ca^(2+)

Clinical characteristics and changes in living quality of patients with radiation encephalopathy induced by radiation therapy for treating nasopharyngeal carcinoma

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Neural Regeneration Research 2007年第2期2卷 99-102页

作者： Yamei Tang Yi Li fusheng zhang Yunlin Liu Haihong Zhou Jianhong Ye Yigang Xing Department of Neurology the Second Affiliated Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

BACKGROUND： Radiation encephalopathy （RE） caused by radiation therapy of nasopharyngeal carcinoma severely influences patients＇ quality of life （QOL）. The factors, which influence such patients＇ QOL, have not been confirmed. OBJECTIVE： To observe the clinical and imageological characteristics of patients with radiation therapy of nasopharyngeal carcinoma-induced RE and the changes in QOL, and analyze QOL influencing factors. DESIGN： Retrospective case analysis. SETTING： Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University. PARTICIPANTS： Eighty-nine inpatients or outpatients with RE induced by radiation therapy of nasopharyngeal carcinoma admitted to Sun Yat-sen University Cancer Center and Department of Neurology, the Second Affiliated Hospital of Sun Yat-sen University from March 1994 to August 2004 were involved in this experiment. They all met the diagnosis criteria of RE from MERRITT＇S neurology （10th edition）. Thirty-three involved patients were randomly chosen as RE group. Another 34 concurrent inpatients or outpatients with nasopharyngeal carcinoma who received radiation therapy but without RE were chosen as control group. Informed consents of detected items were obtained from all the involved subjects. METHODS：（1） Patients were evaluated when they were followed up. The World Health Organization Quality of Life Questionnaire abbreviated version （WHOQOL-BREF） was used for on-the-spot evaluation. High points of WHOQOL-BREF indicated better QOL. The Late Effects on Normal Tissues - Subjective, Objective, Management and Analytic （LENT-SOMA） scale for evaluating radiation injury was used to evaluate headache and neurologic disorder of patients with RE induced by radiation therapy of nasopharyngeal carcinoma. The evaluation was graded into 5 degrees. High degrees indicted severer clinical symptoms. （2） Disease latency （i.e. time interval from symptoms and body signs appearing or radiation therapy ending to onset）, initial symptoms, com

关键词： nasopharyngeal cancer radiation encephalopathy quality of life

＂Events＂ Approach to Basic Accounting Theory： How Far Away Can It Go

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Journal of Modern Accounting and Auditing 2005年第7期1卷 11-15页

作者： fusheng Yu Min zhang Renmin University of China

As a totally new accounting theory, ＂events＂ approach to basic accounting theory tends to reform traditional accounting theory. Its main idea is providing detailed information about economic events that allow individual users to generate their own input values for their own individual decision model. From existing literature, we can find that this theory has not formed a perfect system, study on it is not deep and the theory itself has some drawbacks. The goal of this paper is to introduce this theory systematically. By analyzing the drawbacks of this theory, this paper proposes some solutions to improve it.

关键词： "events" approach drawbacks solutions

Unique three-component co-assembly among AIEgen,L-GSH,and Ag^(+)for the formation of helical nanowires

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Aggregate

Aggregate 2023年第2期4卷 253-266页

作者： Xiaohuan Huang Junrong Li Hong Tang Miao Guo Xue Wang Xiaorong Wang Xu Wang Mingliang Tang fusheng zhang Yahui zhang Xiaopei Li Guangyan Qing Hubei Key Laboratory of Pollutant Analysis and Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshiP.R.China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianP.R.China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushunP.R.China College of Life Sciences Wuhan UniversityWuhanP.R.China

Nature has selected,produced,and evolved numerous molecular architectural motifs over billions of years for particular *** this process,molecular self-assembly plays a critically important *** by these delicate assemblies,scientists devote themselves to developing various sophisticated complexes assembled by diverse and numerous structural *** far,most of the examples focus on single-molecule self-assembly or co-assembly between two molecules,seldom works report the co-assembly among three building blocks due to the substantially increased complexity and decreased *** we report a novel three-component co-assembly among L-glutathione(L-GSH),AgNO_(3),and an aggregation-induced emission luminogen(AIEgen),namely triphenylamine-pyridinium(abbreviated to TPA-Py).TPA-Py,L-GSH,and Ag^(+)co-assemble into numerous long and ordered nanowires with left-handed helices,which show remarkable AIE properties that can be observed by naked *** effect is only detected in this system,the replacement of TPA-Py with other AIEgens,L-GSH with other cysteine derivatives or anions,Ag^(+)with other metal ions,could not lead to the unique AIE effect,which endows this system with high specificity and *** work provides new insight into the design of biomolecule recognition systems and discloses that ternary co-assembly could become a facile route to build sophisticated nanobiomaterials.

关键词： aggregation-induced emission fluorescence multicomponent assembly nanowires supramolecular helicity

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电力系统谐波分析的全分量校正方法

中国电机工程学报 2018年第12期38卷 3481-3487页

作者：耿中行张伏生厦门工学院

快速傅里叶变换（fast Fourier transform,FFT）是电力系统谐波分析的常用工具,为提高FFT的计算精度,消除栅栏效应和泄漏现象造成的误差,必须对计算结果进行修正。目前已有的各种修正方法除了所加窗种类不同或插值方式不同外,都是仅对... 详细信息

快速傅里叶变换（fast Fourier transform,FFT）是电力系统谐波分析的常用工具,为提高FFT的计算精度,消除栅栏效应和泄漏现象造成的误差,必须对计算结果进行修正。目前已有的各种修正方法除了所加窗种类不同或插值方式不同外,都是仅对单个谐波分量进行修正,无法消除各分量之间泄漏的相互影响,因此对谐波信号的分析精度不高。该文给出全分量校正方法,对信号中所有的谐波分量同时进行校正计算,从而完全消除泄漏的影响,将计算精度提高3-4个数量级。该算法涵盖传统的单谱峰插值法,算法形式统一规范,便于计算机编程计算。

关键词：谐波分析快速傅里叶变换插值多分量校正