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Association of emergency room visits for respiratory diseases with sources of ambient PM2.5

Journal of Environmental Sciences 2019年第12期31卷 154-163页

作者： Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma furong Deng Xinbiao guo Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Emergency Department Peking University Third HospitalBeijing 100191China Chinese Academy fo r Environmental Planning Beijing 100012China Beijing Center for Disease Control and Prevention Beijing 100013China

Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory *** studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory *** apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease *** association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)*** found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),*** estimated effects of PM2.5 changed little after adjusting for different air *** primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare.

关键词： Emergency room visits Respiratory diseases PM2.5 Source apportionment

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Co-Exposure to Multiple Pollutants and Its Cardiovascular Effects in a Subway System-Beijing Municipality,China,2017

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China CDC weekly 2021年第45期3卷 959-963页

作者： Wenlou Zhang Xuan Yang Xu Jia Wei Dong Hongyu Li Lu Pan Jiao Shan Shaowei Wu Xinbiao guo furong Deng Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijingChina Qingdao Municipal Center for Disease Control and Prevention Qingdao Institute of Preventive MedicineQingdaoShandongChina Department of Occupational and Environmental Health Sciences School of Public HealthXi'an Jiaotong University Health Science CenterXi'anShaanxiChina

Summary What is already known on this topic?With rapid urbanization,traffic-related air pollution has become a global ***,its association with cardiovascular health has not been fully *** is added by this report?This study provided novel evidence of the joint cardiovascular effect of multiple pollutants in subway cabins,further identified two pollutants that played dominant roles,and validated the effectiveness of targeted interventions.

关键词： pollution urbanization traffic

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Association of Road Traffic Noise with Obesity and the Role of Meat Intake:A Prospective Study from UK Biobank

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Environment & Health 2024年第5期2卷 311-321页

作者： Jiawei Wang Teng Yang Xin Hu Tianfeng He Yutong Cai guoxing Li Xinbiao guo furong Deng Jing Huang Department of Occupational and Environmental Health Sciences Peking University School of Public HealthBeijing 100191China Ningbo Municipal Center for Disease Control and Prevention Ningbo 315000China Centre for Environmental Health and Sustainability University of LeicesterLeicester LE17RHU.K. National Institute for Health Research Health Protection Research Unit in Environmental Exposures and Health at the University of Leicester Leicester LE17RHU.K. Environmental Research Group Faculty of MedicineSchool of Public HealthImperial CollegeLondon SW72AZU.K Institute for Global Health and Development Peking UniversityBeijing 100871China

Emerging evidence has indicated the linkage of traffic noise with cardiovascular diseases,However,there’s a lack of extensive studies exploring the linkage of traffic noise with cardiometabolic risk factors such as ***,the role of diet in the associations remains *** aim is to prospectively examine the linkage of road traffic noise with obesity,especially by focusing on evaluating the impact of *** recruited in the UK Biobank with at least one repeated measurement of obesity indicators including body mass index(BMI),waist circumference(WC),waist-to-hip ratio(WhR),and waist-to-height ratio(WhtR)were *** Common Noise Assessment Methods of the simplified version were used to estimate road traffic noise *** were categorized into“less meat intake”and“more meat intake”based on the median of meat intake,assessed by the frequency of unprocessed red meat and processed meat *** Poisson regression models were employed to evaluate the linkage of road traffic noise with ***,the modification effects of meat intake on this relationship were *** incidence risk ratios(IRRs)and 95%confidence interval(CI)of overall obesity,WC-based central obesity,WhR-based central obesity,and WhtR-based central obesity were 1.11(1.02,1.21),1.09(1.03,1.14),1.06(1.02,1.10),and 1.08(1.02,1.13),respectively,for every 10 dB(A)increase for *** with individuals with lower meat intake,those with higher meat intake exhibited a stronger linkage of road traffic noise with central *** prospective study demonstrates a linkage of road traffic noise with obesity,emphasizing the significance of diet on traffic noise-related obesity risk.

关键词： traffic noise obesity meat intake prospective study

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Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study

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The Innovation 2021年第1期2卷 46-55页

作者： Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao guo furong Deng Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102China

Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality ***,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain *** further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study *** health measurements and urine sample collection were conducted in each ***-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics *** including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health *** metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid *** may have a greater decrease in bile acid and RNA related *** of the nine ozone-related metabolites were also associated with cardiorespiratory function ***,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,*** to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related *** results provide metabolic evidence of the cardiorespiratory effects of indoor ozone *** ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children.

关键词： indoor ozone metabolomics meet-in-metabolite approach cardiorespiratory function children

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基于全局节点和多片段的格栅命名实体识别

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计算机工程 2023年第12期49卷 96-102页

作者：郭江涛彭甫镕山西大学大数据科学与产业研究院太原030006

现有命名实体识别模型对标注数据量要求较高,基于主动学习的命名实体识别模型需要人工分词造成标注代价大。针对上述问题,提出一种结合全局节点和多片段的格栅命名实体识别模型。将Transformer的全连接结构替换为全局节点和多片段结构,... 详细信息

现有命名实体识别模型对标注数据量要求较高,基于主动学习的命名实体识别模型需要人工分词造成标注代价大。针对上述问题,提出一种结合全局节点和多片段的格栅命名实体识别模型。将Transformer的全连接结构替换为全局节点和多片段结构,每个节点仅与构造的上下文向量进行注意力计算,全局和片段节点分别获取全局和局部信息,从而降低对标注数据的需求量。对Flat-Lattice结构进行改进,解决现有主动学习策略需要分词的问题,从而在保证模型性能的情况下降低数据标注代价。在MSRA、OntoNotes 5.0、Weibo、PeopleDaily这4个数据集上的实验结果表明,与FLAT模型相比,所提模型达到对应F1阈值所需的标注数据量分别降低了39.90%、2.17%、34.60%和35.67%。

关键词：全局节点多片段格栅命名实体识别主动学习 Transformer结构

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Ambient Air Particulate Matter and Hospital Admissions for Chronic Kidney Disease in China:A Nationwide Case-Crossover Study

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Environment & Health 2024年第8期2卷 553-562页

作者： Juan Chen Huimeng Liu Ge Li Lijun Bai Yunxing Jiang Jinxi Wang Chen Wei Yinxiang Li Jian Lei furong Deng Luxia Zhang Xinbiao guo Shaowei Wu Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Key Laboratory of Environment and Genes Related to Diseases Ministry of EducationXi’anShaanxi 710061China Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health Xi’anShaanxi 710061China Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province Xi’anShaanxi 710061China Shaanxi Provincial Institute for Endemic Disease Control Xi’anShaanxi 710003China Yunyi Health Technology Co.Ltd. Beijing 102629China China-Europe Association for Technical and Economic Cooperation Beijing 101318China Renal Division Department of MedicinePeking University First HospitalPeking University Institute of NephrologyBeijing 100034China Advanced Institute of Information Technology Peking UniversityHangzhou 311200China National Institutes of Health Data Science at Peking University Beijing 100191China

Incident chronic kidney disease(CKD)may be accelerated(could be indicated by repeated admissions to the hospital)by environmental triggers such as ambient particulate matter(PM).Additionally,hospital admission is a sensitive proxy reflecting the disease ***,the association of PM exposure with hospital admissions for CKD is still unknown,let alone the excess risks(ERs)in hospital admissions for CKD due to high PM level *** this study,a two-stage time-stratified case-crossover study was conducted to investigate the association of ambient air PM exposure with hospital admission for CKD in 282 Chinese cities of prefecture-level or above during 2013–***-specific associations of single and cumulative 0–3 days lagged exposure to fine particulate matter(PM_(2.5))and inhalable particles(PM_(10))with hospital admissions for total CKD and its subtypes were evaluated by the conditional logistic regression model,then were pooled using the random-effect model.A total of 3,490,416 hospital admissions for CKD were *** found that per interquartile range(IQR)increment in PM_(2.5) at lag02 and per IQR increment in PM_(10) at lag03 were associated with increases of 2.36%(95%CI:1.58%,3.14%)and 2.87%(95%CI:1.91%,3.85%)in hospital admissions for total CKD,*** to control concentrations(PM_(2.5):35μg/m^(3);PM_(10):50μg/m^(3)),the largest ERs in hospital admissions for total CKD were 2.63%(95%CI:2.15%–3.11%)and 4.45%(95%CI:3.85%–5.06%)in association with exposure to heavily excessive PM_(2.5)(≥75μg/m^(3))and PM_(10)(≥150μg/m^(3)),***,the attributable fractions(AFs)for CKD admissions were 2.83%for PM_(2.5) and 3.46%for PM_(10) during the study *** findings suggested that exposure to PM_(2.5) and PM_(10) is associated with substantially increased risk and burden of CKD admissions.

关键词： particulate matter hospital admission chronic kidney disease excess risks case-crossover

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Exposure to Ambient Particulate Air Pollution and Circulating C-reactive Protein Level:A Meta-analysis

Exposure to Ambient Particulate Air Pollution and Circulatin...

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2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： Qisijing Liu Xuelin Gu furong Deng Xinbiao guo Shaowei Wu Peking University

Objectives Ambient particulate air pollution is a major threat to the cardiovascular health of the *** is an important component of the pathophysiological process linking air pollution and cardiovascular disease(CVD).A classical marker of inflammation—C reactive protein(CRP),has been recognized as an independent predictor of CVD *** to ambient particulate matter(PM)may cause systemic inflammatory response but the association with CRP has been inconsistently *** A systematic literature search of the PubMed,Web of Science,Embase,and Scopus databases for publications up to January 2018 was conducted for studies reporting the association between ambient particulate matter 2.5(PM2.5),particulate matter 10(PM10) and circulating CRP *** performed meta-analysis for associations reported in individual studies using a random-effect model and evaluated the effect modification by major potential *** This meta-analysis comprised data from 41 observational studies with241,186 ***-term exposure to particulate air pollution was more strongly associated with CRP level than short-term exposure.A 10 ug/m3 increase in short-term exposure to PM2.5 and PM10 was associated with increases of 0.79%(95%CI:0.29%,1.29%) and 0.26%(95%CI:-0.02%,0.54%) in CRP level,respectively,and a 10 ug/m3 increase in long-term exposure to PM2.5 and PM10 was associated with much higher increases of 18.49%(95%CI:8.50%,28.49%) and11.10%(95%CI:2.73%,19.46%) in CRP level,*** Exposure to ambient particulate air pollution is associated with elevated circulating CRP level,suggesting an activated systemic inflammatory state upon exposure which may help explain the association between particulate air pollution and CVD risk.

关键词： Ambient air pollution C-reactive protein Cardiovascular disease Meta-analysis

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Structural attributes,evolution and petroleum geological significances of the Tongnan negative structure in the central Sichuan Basin,SW China

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Petroleum Exploration and Development 2023年第5期50卷 1120-1136页

作者： TIAN Fanglei WU furong HE Dengfa ZHAO Xiaohui LIU Huan ZHANG Qiaoyi LE Jinbo CHEN Jingyu LU guo School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing 100083China Southwest Geophysical Research Institute BGPCNPCChengdu 610213China

The Tongnan secondary negative structure in central Sichuan Basin has controls and influences on the structural framework and petroleum geological conditions in the Gaoshiti-Moxi *** clarify the controls and influences,the deformation characteristics,structural attributes and evolution process of the Tongnan negative structure were investigated through a series of qualitative and quantitative methods such as balanced profile restoration,area-depth-strain(ADS)analysis,and structural geometric forward numerical simulation,after comprehensive structural interpretation of high-precision 3D seismic *** results are obtained in three ***,above and below the P/AnP(Permian/pre-Permian)unconformity,the Tongnan negative structure demonstrates vertical differential structural *** experiences two stages of structural stacking and reworking:extensional depression(from the Sinian Dengying Formation to the Permian),and compressional syncline deformation(after the Jurassic).The multi-phase trishear deformation of the preexisting deep normal faults dominated the extensional *** primary depression episodes occurred in the periods from the end of Late Proterozoic to the deposition of the 1st–2nd members of the Dengying Formation,and from the deposition of Lower Cambrian Longwangmiao Formation–Middle–Upper Cambrian until the ***,the multi-stage evolution process of the Tongnan negative structure controlled the oil and gas migration and adjustment and present-day differential gas and water distribution between the Tongnan negative structure and the Gaoshiti and Moxi-Longnüsi structural ***,the Ordovician,which is limitedly distributed in the Tongnan negative structure and is truncated by the P/AnP unconformity on the top,has basic geological conditions for the formation of weathering karst carbonate *** is a new petroleum target deserving attention.

关键词： structural attribute structural evolution Sinian Dengying Formation oil and gas negative structure Gaoshiti-Moxi area Sichuan Basin

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无机砷对人皮肤成纤维细胞缝隙连接通讯的影响

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中华预防医学杂志 2001年第1期35卷 51-54页

作者：邓芙蓉郭新彪北京大学公共卫生学院劳动卫生与环境卫生学系 100083，北京大学公共卫生学院劳动卫生与环境卫生学系

目的　探讨无机砷对人皮肤成纤维细胞缝隙连接通讯的影响。方法　采用细胞划痕染料标记示踪技术 ,以荧光染料在细胞间的扩散作为评价缝隙连接通讯的指标 ,观察亚砷酸和砷酸对原代培养的人皮肤成纤维细胞缝隙连接通讯的影响。结果　亚砷... 详细信息

目的　探讨无机砷对人皮肤成纤维细胞缝隙连接通讯的影响。方法　采用细胞划痕染料标记示踪技术 ,以荧光染料在细胞间的扩散作为评价缝隙连接通讯的指标 ,观察亚砷酸和砷酸对原代培养的人皮肤成纤维细胞缝隙连接通讯的影响。结果　亚砷酸可显著抑制人皮肤成纤维细胞间荧光黄染料的扩散 ,在 0 0 0 5～ 5 0 μmol/L浓度范围内有明显的剂量依赖关系。砷酸也可明显抑制荧光黄染料在人皮肤成纤维细胞间的扩散 ,但剂量依赖关系不明显。进一步的研究发现 ,亚砷酸可显著增高人皮肤成纤维细胞胞膜和胞浆蛋白激酶C的活性 ,其中对胞膜蛋白激酶C活性的作用更为明显。结论　无机砷可显著抑制人皮肤成纤维细胞缝隙连接通讯 ,提示它们在癌症发生的促长阶段扮演重要角色。

关键词：无机砷人皮肤成纤维细胞缝隙连接通讯细胞交流蛋白激酶C 致癌物肿瘤

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Psychosocial Stress Modifies the Acute Cardiac Health Effects of Traffic-Related Air Pollution

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Environment & Health 2024年第1期2卷 11-22页

作者： Tongjun guo Wanzhou Wang Xi Chen Huaqi guo Kai Wang Yating Ma Hongyan Deng Xianggui Li Anqi Shan Qian Wu Yaoyan Li Hongyu Li Qisijing Liu Juan Chen Yang Lan Jian Lei furong Deng Zhiwei Sun Xinbiao guo Shaowei Wu Yan Wang Naijun Tang Department of Occupational and Environmental Health Sciences School of Public HealthPeking UniversityBeijing 100191China Department of Occupational and Environmental Health Tianjin Key Laboratory of EnvironmentNutrition and Public HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Department of Respiratory and Critical Care Medicine The Ninth People’s Hospital of Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Occupational and Environmental Health School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710049China Key Laboratory of Trace Elements and Endemic Diseases in Ministry of Health Xi’anShaanxi 710049China Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province Xi’anShaanxi 710049China Institute of Social Psychology School of Humanities and Social SciencesXi’an Jiaotong UniversityXi’anShaanxi 710049China Qinglongqiao Community Health Service Centre Beijing 100091China Key Laboratory of Environment and Genes Related to Diseases(Xi’an Jiaotong University) Ministry of EducationXi’an 710061China School of Public Health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of HAI Management Tianjin Huanhu HospitalTianjin 300060China Office for National Clinical Research Center for Geriatric Diseases Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100005China Research Institute of Public Health School of MedicineNankai University300071 TianjinChina Department of Toxicology and Sanitary Chemistry School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China The Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine Shanghai 200011China

Previous studies have shown that exposure to black carbon(BC,a tracer of traffic-related air pollution)and psychosocial stress are both associated with adverse cardiac effects,but whether psychosocial stress could modify the cardiac effects of BC is *** investigate the potential modifying effect of psychosocial stress on the associations between acute exposure to BC and typical cardiac health variables,real-time personal 24 h measurements were conducted in a repeated-measure study among adults with elevated blood pressure(high-risk group)and a panel study among normal adults(low-risk group)in *** cardiac health variables included ST-segment depression events,heart rate,and heart rate variability(HRV)*** Stress Scale,State Anxiety Inventory and Self-rating Depression Scale were used to assess the recent psychosocial stress status of the participants,and a composite stress index was established based on these *** linear mixed-effects model was used to analyze the associations between BC exposure and cardiac health variables and potential effect modification by psychosocial stress.A total of 9724 h measurements among 97 participants in the repeated-measure study and 20224 h measurements among 87 participants in the panel study were included in the final *** BC exposure was significantly associated with increased ST-segment depression events and heart rate and decreases in HRV in both *** marginal effects of acute BC exposure on most cardiac health variables generally tended to be amplified under higher vs low levels of psychosocial stress in both studies,with the composite stress index apparently modifying the associations of BC exposure with most ST-segment depression events and HRV *** findings suggest that psychosocial stress may increase the participants’cardiac susceptibility to BC exposure,which could be helpful for the identification of susceptible individuals in the context of traff

关键词： Air pollution Black carbon Cardiac health Effect modification Psychosocial stress

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