Exposure to Ambient Particulate Air Pollution and Circulating C-reactive Protein Level:A Meta-analysis
作者单位：Peking University
会议名称：《2018环境与健康学术会议--精准环境健康：跨学科合作...》
会议日期：2018年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 070602[理学-大气物理学与大气环境] 0706[理学-大气科学] 100402[医学-劳动卫生与环境卫生学] 10[医学]
关 键 词：Ambient air pollution C-reactive protein Cardiovascular disease Meta-analysis
摘 要：Objectives Ambient particulate air pollution is a major threat to the cardiovascular health of the *** is an important component of the pathophysiological process linking air pollution and cardiovascular disease（CVD）.A classical marker of inflammation—C reactive protein（CRP）,has been recognized as an independent predictor of CVD *** to ambient particulate matter（PM）may cause systemic inflammatory response but the association with CRP has been inconsistently *** A systematic literature search of the PubMed,Web of Science,Embase,and Scopus databases for publications up to January 2018 was conducted for studies reporting the association between ambient particulate matter 2.5（PM2.5）,particulate matter 10（PM10） and circulating CRP *** performed meta-analysis for associations reported in individual studies using a random-effect model and evaluated the effect modification by major potential *** This meta-analysis comprised data from 41 observational studies with241,186 ***-term exposure to particulate air pollution was more strongly associated with CRP level than short-term exposure.A 10 ug/m3 increase in short-term exposure to PM2.5 and PM10 was associated with increases of 0.79%（95%CI:0.29%,1.29%） and 0.26%（95%CI:-0.02%,0.54%） in CRP level,respectively,and a 10 ug/m3 increase in long-term exposure to PM2.5 and PM10 was associated with much higher increases of 18.49%（95%CI:8.50%,28.49%） and11.10%（95%CI:2.73%,19.46%） in CRP level,*** Exposure to ambient particulate air pollution is associated with elevated circulating CRP level,suggesting an activated systemic inflammatory state upon exposure which may help explain the association between particulate air pollution and CVD risk.