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Endocrine and Metabolic Effects of Hydroethanolic Extract of Solenostemon monostachyus on Haloperidol Induced Hyperprolactinemia

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Journal of Pharmacy and Pharmacology 2015年第8期3卷 391-399页

作者： Omoloye adesina Adebiyi Quasim Kifayat Olabisi Johnson Samuel Onnolome Murtala Abdullahi Akanji Department of Clinical Pharmacy Faculty of Pharmacy Olabisi Onabanjo University Teaching Hospital Sagamu-Ogun State234 Nigeria Department of Chemical Pathology and Immunology Olabisi Onabanjo University Teaching Hospital Sagamu-Ogun State 234Nigeria Department of Phamacology Faculty of Basic Medical Sciences Olabisi Onabanjo University Sagamu-Ogun State 234 Nigeria

The rapid increase in consumption of herbal remedies worldwide has been stimulated by several factors, including the notion that all herbal products are safe and effective. Hyperprolactinemia is a major cause of infertility, and herbal remedies have been employed locally for treatment. This study was designed to investigate the effects of hydroethanolic extract of Solenostemon monostachyus on the reproductive hormones and metabolic parameters of haloperidol-induced hyperprolactinemic rats. Thirty six female albino rats were divided into 6 groups of 6 in each group. Groups A, B, C, D and E were given increasing doses （2, 3 and 4 mg/kg body weight in five-daily increments） of haloperidol by intramuscular injection for 15 days after which they were treated for another 15 days with either 2.5mg/kg body weight ofbromocriptine （group D only） or 75, 112.5 or 225mg/kg body weight of the extract （groups A, B and C, respectively）. Group F was given distilled water only. After treatment, the animals were sacrificed and blood was taken from each group for plasma analysis of the reproductive hormones and metabolic parameters. The total protein and the lipid profile （total cholesterol and HDL （high-density lipoprotein） and triglycerides were also determined. Phytochemical investigation revealed the presence of saponins, phenols, alkaloids, fiavonoids, and tannins. The result of endocrine investigation showed a dose-dependent, statistically significant reduction in prolactin and testosterone （P 〈 0.05） level by the extract with statistical significant increase （P 〈 0.05） in the levels of the follicle stimulating hormone, LH （luteinizing hormone） and estrogen. There was also a decrease in the levels of the triglycerides and total cholesterol while HDL was increased （P 〉 0.05）. It can be concluded from this study, that hydroethanolic extract has a prolactin reducing activity compared with Bromocriptine and exhibited a corresponding statistical significant difference in other reprodu

关键词： Hyperprolactinemia bromocriptine haloperidol reproductive hormones Solenostemon monostachyus.

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Effects of Use and Re-Use of Selected Vegetable Oils on the Proximate, Minerals, Mineral Ratios and Mineral Safety Index of Raw and Fried Plantain Chips: Note I

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Journal of Agricultural Chemistry and Environment 2019年第2期8卷 92-106页

作者： Emmanuel Ilesanmi Adeyeye Adeolu Jonathan adesina Sulaiman Adeoye Olagboye Mercy Ayomadewa Olatunya Department of Chemistry Faculty of Science Ekiti State University Ado Ekiti Nigeria

Raw and fried plantain chips obtained from the use and re-use of olive, refined palm olein and coconut oils were investigated for the proximate, mineral compositions, computed mineral ratios and the mineral safety index using standard analytical methods. For the selected oils (both use and re-use): first and second re-use and the fresh plantain chips (unprocessed plantain chips;UPC) had the following range results: proximate composition (%) (moisture: 8.20 - 12.3, crude protein: 9.70 - 8.60, fat: 7.40 - 12.9, fibre: 3.50 - 4.90, ash: 2.80 - 3.80 and carbohydrates: 63.5 - 64.8), % energy contributions (PEC: 63.4 - 70.8, PEF: 20.2 - 28.6, PEP: 8.03 - 9.66, UEDP: 4.49 - 5.08). The mineral composition (mg/100g) of the samples had the following greater than 80.0: Ca, Mg, K and P;Fe, Cu, Mn and Zn recorded values ranging between 1.00 and 4.00;Co, Se and Ni had their concentrations between 0.00 and 0.0363 whereas Pb and Cd recorded levels lower than 0.0006. In the mineral ratios, only K/(Ca + Mg) values fell within the acceptable ideal range. No MSI aberration was observed for the minerals from all the samples obtained from the various oils. The chi-square analysis showed that on parameter wise comparisons, there were no significant differences among the levels as treated based on the various oils except gross energy, Mg, K, P, Ca/P, Fe/Pb and K/Co. Also on pairwise comparison from linear correlation and regression, all these parameters were significantly different at r = 0.01 between the unprocessed and fried plantain samples: proximate, percentage energy distribution, mineral and mineral ratios. Generally, the first (day) frying showed fairly high nutrient concentration than the first and second re-use oils products. Therefore, for optimum nutrient preservation from fried plantain chips re-use of oil for frying should be sparingly allowed. However, olive showed highest level of nutrients in terms of proximate and mineral compositions.

关键词： Vegetable Oils Plantain Chips Proximate Minerals Ratios Safety Index

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Occurrence and Levels of Chlorinated Pesticides Residues in Cow Milk: A Human Health Risk Assessment

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Journal of Agricultural Chemistry and Environment 2019年第1期8卷 58-67页

作者： Olayinka Abidemi Ibigbami Ademola Festus Aiyesanmi Adeolu Jonathan adesina Olugbenga Kayode Popoola Department of Chemistry Ekiti State University Ado-Ekiti Nigeria Department of Chemistry The Federal University of Technology Akure Nigeria

Background: The study determined the presence and concentration of persistent organochlorine pesticides (OCPs) residues in cow milk from Ekiti State University Agricultural farm in Ado-Ekiti, Nigeria. The study was investigated in order to monitor consumer’s exposure to these chemicals pesticides. Methods: Qualitative identification and quantification evaluation of the extracted pesticides after clean-up on silica gel were done with a Gas Chromatography coupled with an Electron Capture Detector (GC-ECD). Results: The results revealed the presence of 11 OCPs residues in the milk samples, with concentration range of 0.001 - 0.189 mg/l, while α-BHC, endrin, endrin aldehyde, endosulfan II, endosulfan sulphate and methoxychlor were not detected. The analysis of variance revealed no significant variation in the levels of all the analysed pesticides except dieldrin. Conclusion: The hazard indices (HIs) were significantly lower than 1 with the range of 0.00063 - 0.107, indicating no potential health risk.

关键词： Cow Milk Organochlorine Pesticides Gas Chromatography Risk Assessment

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Chemical Composition and Bioactivity of Lippia adoensis Hochst ***(Verneneaceae) Leaf Essential Oil Against Callosobruchus maculatus Fabricius(Coleoptera: Chrysomelidae)

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Journal of Northeast Agricultural University(English Edition) 2016年第4期23卷 8-14页

作者： Babarinde Samuel Adelani Oladoye Sunday Olusegun adesina Gabriel Olulakin Adebayo Moses Adeolu Department of Crop and Environmental Protection Ladoke Akintola University of Technology Department of Pure and Applied Chemistry Ladoke Akintola University of Technology Department of Crop Production and Soil Science Ladoke Akintola University of Technology

Essential oil （EO） of Nigeria-grown Lippia adoensis leaf was analyzed using gas chromatography mass spectrometry （GCMS） and its fumigant and repellent properties against Callosobruchus maculatus were evaluated. Sixteen compounds predominated by monoterpenes were identified. The major compounds were Eucalyptol （28.36%）, α-Terpineol （25.99%）, γ-Terpinene （15.24%）, α-Pinene （5.08%）, 1H-Cyclopropa[a]naphthalene （4.25%） and 1, 3, 6, 10-Dodeeatetraene （3.74%）. Percentage mortality due to fumigant toxicity was dose- and exposure period-dependent. One hour after treatment （HAT）, application of L. adoensis leaf EO at 107 μL· L^-1 air caused significantly （p〈0.05） higher mortality （50.00%） than 0.00% mortality observed at 0-53 μL· L^-1 air, but not significantly （p〉0.05） different from 22.50% observed in 80 μL· L^-1 air. At 3 HAT, application ofL. adoensis EO at 80 μL· L^-1 air caused significantly higher mortality （90.00 %） than mortality observed at 0 μL· L^-1 air. At 6 HAT, application of L. adoensis EO at 53-107 μL· L^-1 air caused significantly higher mortality （100.00 %） than that was observed in the control. The same trend was observed at 12 HAT where 100 % mortality observed in 27-107 μL· L^-1 air was significantly greater than 13.33 % observed in the control. At 3 HAT, percentage repellence was significantly （p〈0.05） affected by doses. Application of EO at 10-30 μL· cm^2 caused class V repellence （86.67%-100%） compared with the control which caused class I repellence （0-20%）.

关键词： Lippia adoensis Callosobruchus maculatus GCMS bioactivity repellence fumigant

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Characterization of Clay Materials and Performance Evaluation of Fired Clay Composites Made for Low-Cost Housing

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Journal of Minerals and Materials Characterization and Engineering 2022年第4期10卷 338-359页

作者： Paulette Cathy Mengue Michel Mbessa Rodrigue Cyriaque Kaze Adeyemi adesina Chrispin Pettang Department of Civil Engineering National Advanced School of Engineering University of Yaoundé I Yaoundé Cameroon Laboratory of Applied Inorganic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon Department of Civil and Environmental Engineering University of Windsor Windsor Canada

This study deals with the physico-chemical, mineralogical and geotechnical characterization of alluvial clays from Batchenga in Cameroon with a view to their use as building materials for housing. The alluvial clay (***) was collected in the locality of Batchenga at the village Natchigal (4˚20'40''N and 11˚37'40''E at 378 m altitude) and was fired between 900˚C and 1100˚C. Characterization was performed by XRD, XRF, DTA/DTG, and firing tests. XRD, XRF, DTA/DTG infrared analysis methods were performed on these clays. The linear shrinkage, mechanical strengths, water absorption, porosity and density were measured on the fired products. The results obtained show that the major oxides are for the *** SiO2 (72.13%), Al2O3 (14.1%), Fe2O3 (4.45%) and for the ***: SiO2 (48.91%), Al2O3 (23.79%), Fe2O3 (9.54%). The fired products based on alluvial clay, present the flexural strength of 4.45 MPa at 900˚C and 6.80 MPa at 1100˚C. As for those based on lateritic clay, the flexural strength is 0.53 and 0.76 MPa respectively at 900 and 1100˚C. The porosity is 33.69% at 900˚C and 22.93% at 1100˚C for the alluvial clay and 39.55% at 900˚C and 36.01% for the lateritic clay at 1100˚C. Water absorption is 18% to 11.16% for alluvial clay and 22.43% to 21.16% for lateritic clay at 900˚C and 1100˚C respectively. These results suggest that alluvial clay and its firing products have better physico-chemical, geotechnical and mechanical characteristics regardless of the firing temperature of the manufactured products. The addition of degreaser is recommended to improve the mechanical performance of lateritic clay.

关键词： Clays Fired Products Firing Temperature Physical and Mechanical Properties Microstructure

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Information Use and Knowledge of HIV/Hepatitis B Co-Infection in Lagos, Nigeria

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Health 2019年第6期11卷 671-682页

作者： Evaristus adesina Olusola Oyero Nelson Okorie Lanre Amodu Oladokun Omojola Babatunde Adeyeye Department of Mass Communication Covenant University Ota Nigeria

Achieving the Sustainable Development Goal 3.3 is hinged on effective use of information sources for health communication interventions. This study investigated the knowledge of residents of Lagos Nigeria on HIV/HBV co-infection and the use of information sources. The study adopted the quantitative research method of survey to find out the knowledge level of residents of Lagos, Nigeria on the HIV/HBV co-infection. While the bivariate analysis presented cross tabular data on knowledge level, the multivariate was used to test highlight the hypothesis. The study indicated that more than 75% of the respondents had heard of HIV and HBV co-infection. The result established a significant relationship between the use of information sources and the knowledge on HBV/HIV co-infection. Despite the knowledge on HBV/HIV co-infection, the study concluded on the need for preventive information campaigns to create awareness to mitigate the increasing cases of HBV/HIV co-infection cum motivates individuals toward healthy lifestyle practices.

关键词： Hepatitis B Human Immunodeficiency Virus Information Use Knowledge Nigeria

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尼日利亚海侵泥质海岸粘性沉积物的可蚀性:初步实验研究

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华东师范大学学报（自然科学版） 2020年第S1期 120-124页

作者： adesina Rasheed DADA Olusegun ASIWAJU-BELLO Yinusa 贺治国浙江大学海洋学院浙江舟山316021 联邦理工大学海洋科学与技术系尼日利亚阿库雷340252 联邦理工大学应用地质系尼日利亚阿库雷340252

河口和沿海地区由于陆地和海洋的相互联系而具有重要的生态和经济意义.各种自然和人为事件影响着这些地区的地貌不平衡,因此研究泥沙输移动态有助于海岸带的可持续管理.本文研究了尼日利亚西南部大西洋沿岸海侵泥质海岸海相粘土的一些... 详细信息

河口和沿海地区由于陆地和海洋的相互联系而具有重要的生态和经济意义.各种自然和人为事件影响着这些地区的地貌不平衡,因此研究泥沙输移动态有助于海岸带的可持续管理.本文研究了尼日利亚西南部大西洋沿岸海侵泥质海岸海相粘土的一些基本物理和矿物性质.结果表明,该区粘土矿物以高岭石和伊利石为主.沉积物的水分和有机质含量较高,说明了微生物的作用和生物活性.它们具有相对较低的液限( 0.5).尽管沉积物通常是低塑性的有机粉土/粘土,但伊洛托罗泥浆倾向于中塑性到高塑性的有机粘土.此外,沉积物中有机质与粘土含量之间存在正相关关系,它们支持沉积物化学对其物理性质的影响,从而影响沉积物的可蚀性.需要进行进一步的研究,以确定沉积物的力学性质,并生成一个沉积物输运模型,用于准确预测淤泥质海岸沉积物的侵蚀阈值.这项研究的结果将适用于世界各地具有类似沉积物特性的海岸带,以满足环境、工程和公共卫生的需要.

关键词：河口泥泞的海岸可蚀性有结合力的沉积物

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Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

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World Journal of Biological Chemistry 2022年第5期13卷 83-94页

作者： Abdullah Abdulslam Abdullah Musa Ahmed adesina Oladokun Nasir Adam Ibrahim Shahd Nourain Adam Department of Reproductive Health Sciences Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119OyoNigeria Department of Obstetrics and Gynecology College of MedicineUniversity of IbadanIbadan 119OyoNigeria Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Veterinary Surgery Faculty of Veterinary MedicineAL-Salam UniversityAl-fula 120West KordofanSudan Department of Biology Faculty of ScienceImam Mohammed Ibn Saud Islamic UniversityRiyadh 13318Saudi Arabia Department of Biochemistry and Physiology Faculty of Veterinary MedicineUniversity of Al-butanaRuffaa 210Sudan College of Nursing University of BahriKhartoum 12217Sudan

BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female *** this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more *** To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February *** study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state *** serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent *** The results showed that there was a highly statistically significant difference between the two groups(P0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and *** This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.

关键词： Leptin Serum level Unexplained infertility Sudanese women Reproductive hormones

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Optimal Location Determination of Some Public Facilities within Minna Metropolis: A Geospatial Technique Approach

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Journal of Geographic Information System 2015年第6期7卷 658-666页

作者： Abdulkareem A. Umar Matthew O. Adepoju Ekundayo A. adesina Michael O. Bamgbose National Space Research and Development Agency Abuja Nigeria Department of Surveying & Geoinformatics Federal University of Technology Minna Nigeria Destrack Nigeria Limited Ikeja Nigeria

Theoretical frameworks used to explain the location of services include central place theory, aspects of industrial location theory and spatial diffusion theory. They are all described as normative theories which optimize with respect to defined criteria operating in prescribed environmental conditions (Rushton, 1979). However, recent advancement in geospatial technologies has led to several applications in geographically orientated challenges, hence, the adoption of an effective decision tool like Geographic Information System (GIS), high resolution products of satellite remote sensing as well as the Global Positioning System (GPS) in solving the rather challenging task of optimal location for facilities with respect to necessary criteria. Minna metropolis is being affected adversely by the problem of appropriate location of public facilities. These facilities are either too far from their market zone or they are too congested in a particular location and in some cases, political consideration to the siting of these facilities dominate without given considerations to the necessary criteria for demands and public interest. The study is an investigation into the “optimal determination of the locations of some public facilities in Minna metropolis of Niger State, using geospatial techniques”. The fusion of remote sensing, geographic information system (GIS) and GPS techniques was explored. Geodata base of existing facilities was created and Euclidean-distance geometry used to spatially analyze the appropriate locations with regards to the set of standard criteria. The results showed the haphazard and uncontrolled pattern of development of schools location. However, petrol stations met the evaluated criteria and optimal location indexes.

关键词： Optimal Locations Conformity Assessment Geo-Spatial Technologies Spatial Analysis and Planning

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Parental Disclosure of Own HIV Status to Children in Two Ghanaian Regions;Examining the Determinants within a Child Vulnerability Context

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Health 2019年第10期11卷 1347-1366页

作者： Seth Christopher Yaw Appiah Adeyemi Olu Adekunle adesina Oladokun Jonathan Mensah Dapaah Karikari Mensah Nicholas Pan African University Institute of Life and Earth Sciences Including Health and Agriculture University of Ibadan (PAULESI) Ibadan Nigeria Department of Sociology and Social Work Faculty of Social Sciences Kumasi College of Humanities and Social Science Kwame Nkrumah University of Science and Technology Kumasi Ghana Department of Obstetrics and Gynaecology University College Hospital University of Ibadan Ibadan Nigeria Public Health Unit Komfo Anokye Teaching Hospital Kumasi Ghana.

Purpose: Parent informing children and adolescents about their own HIV infection status is crucial for harmonious and interfamilial relationship despite the associated dilemma. This study assessed the factors associated with parental disclosure of own HIV status to their biological children. Methods: The facility based cross-sectional design approach informed the recruitment of 192 HIV positive parents. This was done through a two-stage stratified (rural/urban) and random sampling technique across 7 ART clinics and hospitals in the Ashanti and Brong Ahafo regions in Ghana between June 2018 and June 2019. Data was collected through interviewer-administered structured questionnaires. Parental disclosure to children was defined as parent own verbal statement of having mentioned HIV or AIDS as the name of his/her illness to at least one of his or her biological children. The study compared weighted proportions for variables measured categorically by the use of chi-square (χ2) significant at P Results: Of the 192 HIV positive parents aged 20 to 64 years (M, SD = 38.56, 8.34), 89.1% were females, averagely having 3 children with 89.5% having only one child being HIV positive, out of which one in every four parent was without formal education. Parental disclosure to biological children was 11% while parental own status disclosure to any child under the parent’s care was 14.6%. Parental disclosure was associated with being married or living with a sexual partner (OR = 3.4;95% CI: 1.08 - 10.66, P Conclusions: Only a tenth of all HIV positive parents had told their children about their own (parents) HIV status. Parental disclosure should be encouraged and interventions designed to improve it particularly as they contribute to shaping the vulnerability context of HIV and AIDS positive children.

关键词： HIV and AIDS Parental Children and Adolescents Disclosure Vulnerability Ghana

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