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骨盆的CT检查

放射学实践 1992年第4期7卷 161-165页

作者： E.Grabbe R.Vosshenrich m.funke 梁惠民 Zentrum Radiologie Abt. Rontgendiagnostik I. Universiatskliniken Gottingen. Robert-Koch-Straβe 40 3400 Gottingen FRG 同济医科大学附属协和医院

骨盆的CT检查可准确诊断T_3期肿瘤。良好的检查技术是保证诊断能力的前提,包括口服造影剂,必要时快速静脉注射造影剂以及用造影剂逆行性充盈结肠。

关键词：骨盆 CT

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采用闭环控制改善压铸机的性能

现代制造 2003年第27期 28-30页

作者： C.Thibault m.funke

使液压控制循环时间更快、产品质量更好、响应更高,是每一个流体动力控制系统追寻的目标。由mOOG公司设计的包括控制注射缸精确运动的伺服阀的注射液压回路子系统在实际应用中做到了这一点。

关键词：压铸机闭环控制液态金属铸件

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多层CT对肺栓塞和下半身静脉血栓的诊断

放射学实践 2002年第1期17卷 46-46页

作者： C.mller L.Kopka m.funke 王凯华中科技大学同济医学院

目的:确定多层CT对急性肺栓塞和下半身静脉血栓的诊断价值.方法:70名临床疑为急性肺栓塞的患者接受了检查.采用多层CT综合检查肺动脉以及下肢、盆腔、腹腔的静脉.以4ml/s的速度,从肘静脉一次性团注150ml Iopromid 300.先以层厚2.5mm、螺... 详细信息

目的:确定多层CT对急性肺栓塞和下半身静脉血栓的诊断价值.方法:70名临床疑为急性肺栓塞的患者接受了检查.采用多层CT综合检查肺动脉以及下肢、盆腔、腹腔的静脉.以4ml/s的速度,从肘静脉一次性团注150ml Iopromid 300.先以层厚2.5mm、螺距1.5扫描肺动脉.当对比剂示踪显示其达到静脉时,以层厚3.75mm、螺距1.5从下肢静脉扫描向上扫描至下腔静脉末端.将结果与48例行充气法扫描的患者,46例行多普勒超声检查的患者和10例采用静脉造影的患者进行比较.并且评价动静脉区域的图像质量.结果:所有接受多层CT扫描的患者,其肺动脉与下半身静脉均被完整记录下来.肺动脉的图象极好地显示了中央和肺段动脉.能清晰地分辨亚肺段血管直至第三级分支.对更外周的血管则无法作出诊断性评价.除不能可靠诊断腓肠肌外,所有层面上的静脉影像质量均极佳.在对中央、肺段动脉和从静脉到下腔静脉的诊断方面,确证了多层CT优于其他技术.相反,换气-灌流法扫描能更确切地发现外周肺栓塞.采用静脉造影评估腓肠肌静脉较为可靠.结论:多层CT是一种诊断急性肺栓塞的重要手段.能快速、可靠地发现临床怀疑引起静脉血栓的疾病.目前,多层CT不适于识别外周栓塞.但今后技术的发展必将带来这方面的进步.

关键词：肺栓塞静脉血栓 CT 诊断

肺动脉高压患者脂肪酸代谢异常与右心室脂毒性的关系

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Brittain EL Talati m Fessel JP Zhu H Penner N Calcutt mW West J funke m Lewis GD Gerszten RE Hamid R Pugh mE Austin ED Newman JH Hemnes AR 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,应用无创成像检测PAH患者及对照人群脂肪酸代谢途径不同阶段的特点。与对照组比较,PAH患者循环游离脂肪酸和长链酰基肉碱水平升高;右心室长链脂肪酸增加,长链酰基肉碱显著减少。

关键词：脂肪酸代谢长链酰基肉碱肺动脉高压右心室脂毒性长链脂肪酸动物实验模型右心衰竭三酰甘油水平脂肪变性

Proteome alterations in aqueous humour of primary open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 176-179页

作者： Hanhan Liu Fabian Anders Sebastian funke Karl mercieca Franz Grus Verena Prokosch Department of Ophthalmology University Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Experimental and Translational Ophthalmology Department of OphthalmologyUniversity Medical Center of the Johannes Gutenberg University MainzMainz 55131Germany Royal Eye Hospital School of MedicineUniversity of ManchesterManchester M202ULUnited Kingdom

AIm: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).mETHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably ***: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as ***: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins.

关键词： primary open angle glaucoma aqueous humor proteomics Wnt signaling pathway

An Alkali Activated Binder for High Chemical Resistant Self-Leveling mortar

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Open Journal of Composite materials 2016年第4期6卷 132-142页

作者： Henrik L. funke Sandra Gelbrich Lothar Kroll Institute of Lightweight Structures Technische Universitat Chemnitz Chemnitz Germany

This paper reports the development of an Alkali Activated Binder (AAB) with an emphasis on the performance and the durability of the AAB-matrix. For the development of the matrix, the reactive components granulated slag and coal fly ash were used, which were alkali activated with a mixture of sodium hydroxide (2 - 10 mol/l) and aqueous sodium silicate solution (SiO2/Na2O molar ratio: 2.1) at ambient temperature. A sodium hydroxide concentration of 5.5 mol/l revealed the best compromise between setting time and mechanical strengths of the AAB. With this sodium hydroxide concentration, the compressive and the 3-point bending tensile strength of the hardened AAB were 53.4 and 5.5 mPa respectively after 14 days. As a result of the investigation of the acid resistance, the AAB-matrix showed a very high acid resistance in comparison to ordinary Portland cement concrete. In addition, the AAB had a high frost resistance, which had been validated by the capillary suction, internal damage and freeze thaw test with a relative dynamic E-modulus of 93% and a total amount of scaled material of 30 g/m2 after 28 freeze-thaw cycles (exposure class: XF3).

关键词： Alkali Activated Binder Geopolymer Durability Chemical Resistance

In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida ***

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Journal of Pharmaceutical Analysis 2022年第2期12卷 350-354页

作者： mukaila B.Adekola Jacob O.Areola Oladapo F.Fagbohun funke T.Asaolu Gbenga E.Ogundepo Adeniyi O.Fajobi Olubunmi O.Babalola Department of Environmental management and Toxicology Federal University of AgricultureAbeokuta110001Nigeria Department of medical Biochemistry Obafemi Awolowo UniversityIle-Ife230001Nigeria Department of Biomedical Engineering First Technical University IbadanOyo StateIbadan200001Nigeria Department of Biochemistry and molecular Biology Obafemi Awolowo UniversityIle-Ife230001Nigeria

Blighia sapida(***)***(Family Sapindaceae)is a branchless straight bole approximately 15 m in *** study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of *** stem-bark using in vitro *** extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging activity,ferric reducing antioxidant power(FRAP),total antioxidant capacity(TAC),and quantitative phenolic and flavonoid ***-inflammatory activity was evaluated using albumin denaturation and membrane stabilization *** extract and its fractions exhibited radical scavenging and anti-inflammatory *** ethyl acetate fraction possessed maximum phenolic and flavonoid contents(136.67±1.55 gallic acid equivalent mg/g and 75.76±4.03 quercetin equivalent mg/g,respectively).Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC_(50)=0.09±0.03 mg/mL DPPH,and values of 146.96±3.81 ascorbic acid equivalent(AAE)mg/g and 359.20±4.98 AAE mg/g for FRAP and TAC,***,the anti-inflammatory activity was revealed by inhibition of heatinduced albumin denaturation and red blood cell membrane stabilization at concentrations of 200 -1000 mg/mL and 50-250 mg/mL,*** ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities,with ethyl acetate fraction showing superior activity,which could be attributed to secondary metabolites,mainly phenolic ***,the antioxidant and antiinflammatory activities of *** can be exploited by ethnomedicinal users.

关键词： Blighia sapida Extract Anti-inflammatory Antioxidant Radical scavenging

microbiology : 6th ed.

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Microbiology :

microbiology An Introduction Gerard J. Tortora, Berdell R. funke, Christine L. Case 7th ed.

1998年

作者： Gerard J. Tortora Berdell R. funke Christine L.

来源：畅想之星图书光盘版（南... 评论

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Microbiology An Introduction Gerard J. Tortora, Berdell R. F...