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OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA

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Journal of Traditional Chinese Medicine 1997年第4期17卷 299-303页

作者：王静怡 Yasuhiro Magata Naoya Hattori Yoshiharu Yonekura Nagara Tamaki fumiko tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki Department of Nuclear Medicine Faculty of Medicine Kyoto University Japan Chemistry Department of Radio Medicine Faculty of Pharmacy Kyoto University Japan Department of Neurological Internal Medicine Faculty of Medicine Kyoto University Japan Mailing Address of Jingyi Wang: Department of Neurological Internal Medicine Hospital of Traditional Chinese Medicine Xi'an 710001 China

Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level.

关键词：镇眩饮

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考虑应变率相关性对材料性能影响的动载荷下集装箱船船体梁极限强度

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中国舰船研究 2019年第S2期14卷 32-38页

作者： tanaka fumiko Kotajima Sho Kawamura Yasumi Okada Tetsuo 横滨国立大学工程科学学院日本横滨2408501 横滨国立大学工程研究所日本横滨2408501 横滨国立大学工程系日本横滨2408501

[目的]近年来,诸如冲荡之类的动载荷对集装箱船结构强度的影响已成为重要课题之一,因此,有必要研究动载荷对船体梁极限强度的影响,并了解动载荷作用下的破坏特性。[方法]以集装箱船为研究对象,建立3 100 TEU集装箱船舯剖面半宽度模型,运... 详细信息

[目的]近年来,诸如冲荡之类的动载荷对集装箱船结构强度的影响已成为重要课题之一,因此,有必要研究动载荷对船体梁极限强度的影响,并了解动载荷作用下的破坏特性。[方法]以集装箱船为研究对象,建立3 100 TEU集装箱船舯剖面半宽度模型,运用LS-DYNA商用有限元软件,分析船体梁在冲荡等动载荷作用下的极限强度。考虑应变率相关性对材料性能的影响,采用常规Cowper-Symonds公式及其不同的改进材料模型,对结构的极限载荷进行动态分析。[结果]结果表明:对于船体梁纵向弯曲破坏,在施加冲荡的动载荷时,动态极限载荷比准静态极限强度高出约7%~9%;即使施加的动载荷时长处于正常的波浪感应载荷水平,动态极限载荷也比准静态极限强度超出约4%~5%。[结论]在评估动态船体梁的极限强度时,可以使用常规CS公式。然而,在估算残余变形和残余强度时可能需要使用适当的材料模型。

关键词：极限强度集装箱船冲荡应变率相关性

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OBSERVATION OF THE EFFECTS OF ZHENXUANYIN ON CBF OF RATS WITH VERTEBROARTERIAL ISCHEMIA AND CBF OF HEALTHY RATS

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Journal of Pharmaceutical Analysis 1999年第2期13卷 133-136,141页

作者： Wang Jingyi,Yasuhiro MagataRadio Pharmacy Department, Faculty of Medicine in Kyoto University., Naoya Hattori  ,Seok Rye ChoiNeurology Department, Faculty of Medicine in Kyoto University., Yoshiharu Yonekura , Nagara Tamaki , fumiko tanaka Department of Neurology Xi'an Chinese Traditional Med. Hosp. Xi'an 710001 China

In order to observe the improvement effects of Zhenxuanyin (ZXY) to the rats vertebral artery infarction, it's prevention ability to the Pulsinelli's 4 vessel occlusion (4VO) rats model and it's influences to the normal rats brain. The infarction of the rats vertebral artery (vertebral 2 VO) and the 4VO rats model were achieved through electrocoagulation. 123 I IMP was used to trace cerebral blood flow (CBF). Except of cerebral cortex, the blood flow of each region decreased. Dosage of ZXY at 0 3 g/kg was able to normalize the decreased blood flows in cerebral regions. Healthy rats were medicated at a daily 0 3 g/kg and 1 g/kg dosage of ZXY. At the end of 1 week, they were made into 4VO model rats. No effective prevention effect was found. ZXY had no obvious effect on the CBF of normal rats. Vertebral 2 vessel occlusion is similar to clinical mild cerebral inefficient blood supply, therefore closer to the model of clinical VID. ZXY is able to normalize this incomplete compensation state, which is consistent with the curative effect on Pulsinelli's 4VO model rats. The best curative dosage of ZXY does not improve normal rats' CBF implied that ZXY used to cure regional cerebral ischemia at the acute stage does not dilate the cerebral blood vessel in the normal region, thus does not cause blood stealing in the brain 〔5〕 , Therefore, ZXY is an ideal CBF improving agent.

关键词： cerebral ischemia/TCM therapy vertebral 2VO Zhenxuanyin (ZXY) ^(123)I-IMP

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Usefulness of a Simple Protein-Energy Wasting Score for Predicting Hospitalization in Maintenance Hemodialysis Patients: A Prospective Cohort Study

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International Journal of Clinical Medicine 2021年第9期12卷 377-385页

作者： Yoko Watanabe Keiko Suzuki fumiko Kojima Yoshiko tanaka Kosaku Nitta Shinjuku Ishikawa Clinic Tokyo Japan Department of Nephrology Tokyo Women’s Medical University Tokyo Japan

Background: Malnutrition is a strong predictor of prognosis in maintenance hemodialysis patients (MHD). We previously proposed a new and simple protein-energy wasting (PEW) score that appears to be useful for assessing the risk of mortality in patients on MHD. Objectives: In the present study, we evaluated the reliability of this PEW score as a predictor of hospitalization in Japanese patients on MHD. Methods: In this single-center, prospective cohort study conducted in Japan, PEW score was calculated for 180 MHD patients. PEW score ranged from 0 (best: S1) to 4 (worst: S4) and was calculated based on nutritional indicators including serum albumin, body mass index, serum creatinine level, and protein intake. The outcome was the number of hospitalizations during the 2-year study period. Results: Thirty-six patients were hospitalized during the study period. Kaplan-Meier curves showed there were fewer hospitalizations in the group with a PEW score of 0/1 than in the group with a score of 3/4. Multivariate analysis revealed a hazard ratio for hospitalization of 3.109 for S3/4 versus S0, 2.777 for S3/4 versus S1, and 2.048 for S3/4 versus S2. Conclusion: The new and simple PEW score is a useful predictor of hospitalization in MHD patients and is also useful for identifying subgroups of MHD patients with a high risk of mortality.

关键词： Protein-Energy Wasting Hemodialysis Hospitalization Simple Score

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Geriatric Nutritional Risk Index as a Simple Predictor of Mortality in Maintenance Hemodialysis Patients: A Single Center Study

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International Journal of Clinical Medicine 2015年第5期6卷 354-362页

作者： Sayaka Takahashi Keiko Suzuki fumiko Kojima Yoshiko tanaka Kosaku Nitta Department of Nephrology Shinjuku Ishikawa Clinic Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Background: Malnutrition is associated with higher risk of mortality in maintenance hemodialysis (MHD) patients. The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. Objectives: The purpose of the present study was to examine the significance of the GNRI as a mortality predictor in MHD patients. Methods: We retrospectively examined the GNRI of 259 MHD patients aged 59.2 ± 12.8 years, and followed up for 36 months. The patients were divided into two groups according to GNRI values of 91.0. Predictors for all-cause mortality were examined using Kaplan-Meier and Cox proportional-hazards analyses. Results: During the follow-up period of 36 months, a total of 76 patients died. Kaplan-Meier survival analysis showed that the subjects with a GNRI 91 (n = 230) (Log-rank test,

关键词： Hemodialysis Malnutrition Geriatric Nutritional Risk Index Mortality

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