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Chronic heat stress induces renal fibrosis and mitochondrial dysfunction in laying hens

Journal of Animal Science and Biotechnology 2023年第5期14卷 2002-2011页

作者： fumika nanto‑hara Makoto Yamazaki Hitoshi Murakami Haruhiko Ohtsu Division of Meat Animal and Poultry Research Institute of Livestock and Grassland ScienceNational Agriculture and Food Research Organization(NILGS)2 IkenodaiTsukubaIbaraki 305‑0901Japan

Background Heat stress in laying hens negatively affects egg production and shell quality by disrupting the homeo-stasis of plasma calcium and phosphorus *** the kidney plays an important role in calcium and phos-phorus homeostasis,evidence regarding the effect of heat stress on renal injury in laying hens is yet to be ***,the aim of this study was to evaluate the effects of chronic heat stress on renal damage in hens during laying *** A total of 16 white-leghorn laying hens(32 weeks old)were randomly assigned to two groups(n=8).One group was exposed to chronic heat stress(33°C for 4 weeks),whereas the other group was maintained at 24°*** Chronic heat exposure significantly increased plasma creatinine and decreased plasma albumin levels(P<0.05).Heat exposure also increased renal fibrosis and the transcription levels of fibrosis-related genes(COLA1A1,αSMA,and TGF-β)in the *** results suggest that renal failure and fibrosis were induced by chronic heat exposure in laying *** addition,chronic heat exposure decreased ATP levels and mitochondrial DNA copy number(mtDNA-CN)in renal tissue,suggesting that renal mitochondrial dysfunction occurs under conditions of heat *** mitochondria leak mtDNAs into the cytosol and mtDNA leakage may activate the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling *** results showed that chronic heat exposure activated the cGAS-STING pathway as indicated by increased expression of MDA5,STING,IRF7,MAVS,and NF-κB ***,the expression of pro-inflammatory cytokines(IL-12)and chemokines(CCL4 and CCL20)was upregulated in heat-stressed *** These results suggest that chronic heat exposure induces renal fibrosis and mitochondrial damage in laying *** damage by heat stress may activate the mtDNA-cGAS-STING signaling and cause subse-quent inflammation,which contributes to the progression of renal fibrosis and

关键词： cGAS-STING Heat stress Laying hens Mitochondrial DNA Renal fibrosis

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Relation of CagA seropositivity to cagPAI phenotype and histological grade of gastritis in patients with Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第24期11卷 3751-3755页

作者： Tadashi Shimoyama Shinsaku Fukuda fumika Nakasato Tetsuro Yoshimura Tatsuya Mikami Akihiro Munakata First Department of Internal Medicine

AIM: Infection with Helicobacter pylori(H pylori) possessing the cag pathogenicity island (PAI) has been associated with severe clinical outcome and CagA-antibody has been used to indicate cagPAI-positive infection. The aim of this study was to examine the accuracy of CagA seropositivity to indicate the virulence of the cagPAI in Japan. METHODS: Sixty isolates of H pylori cultured from gastric biopsies were examined by polymerase chain reaction assays for the presence of cagA, cagE and VirD4. Anti CagA IgG antibody in matching sera was tested by both ELISA and immunoblot assay. Histological grade of gastritis was graded according to the updated Sydney System. RESULTS: Amongst 53 patients infected with cagA+/cagE+/ VirD4+ strain, 38 were CagA seropositive. There were four patients infected with strains possessing incomplete cagPAI. Two out of three patients with cagA+/cagE-/VirD4- infection were CagA seropositive, while a patient with cagA-/cagE+/ VirD4+ infection was CagA seronegative. Accuracy of ELJSA to predict bacterial possession of cagA was 61.7% whereas 58.3% for cagE and VirD4. The immunoblot assay showed relatively higher sensitivity and showed better accuracy. The lower grade of gastric mucosal inflammatory infiltration was seen in false CagA-seronegative patients. CONCLUSION: Some serodiagnosis does not seem to have enough accuracy to indicate virulence of cagPAI, particularly in infection of strains with incomplete cagPAI. The degree of gastric mucosal inflammation may affect the results of CagA serodiagnosis.

关键词： CagA seropositivity cagPAI Gastric inflammation

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High-power non-perturbative laser delivery diagnostics at the final focus of 100-TW-class laser pulses

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High Power Laser Science and Engineering 2021年第2期9卷 174-183页

作者： fumika Isono Jeroen van Tilborg Samuel K.Barber Joseph Natal Curtis Berger Hai-En Tsai Tobias Ostermayr Anthony Gonsalves Cameron Geddes Eric Esarey Lawrence Berkeley National Laboratory BerkeleyCAUSA University of California BerkeleyCAUSA

Controlling the delivery of multi-terawatt and petawatt laser pulses to final focus,both in position and angle,is critical to many laser applications such as optical guiding,laser–plasma acceleration,and laser-produced secondary *** present an online,non-destructive laser diagnostic,capable of measuring the transverse position and pointing angle at *** diagnostic is based on a unique double-surface-coated wedged-mirror design for the final steering optic in the laser line,producing a witness beam highly correlated with the main *** propagating low-power kilohertz pulses to focus,we observed spectra of focus position and pointing angle fluctuations dominated by frequencies below 70 *** setup was also used to characterize the excellent position and pointing angle correlation of the 1 Hz high-power laser pulses to this low-power kilohertz pulse train,opening a promising path to fast non-perturbative feedback concepts even on few-hertz-class high-power laser systems.

关键词： high-power lasers laser diagnostics laser stabilization

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甜瓜果实中乙烯生产量及一些相关性状的遗传分析

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华北农学报 2005年第3期20卷 25-29页

作者：刘莉柿原文香加藤正弘天津大学农业与生物工程学院天津300072 爱媛大学农学部

为改进甜瓜货架期,利用成熟果实乙烯释放量及变化速率存在显著差异的3个甜瓜变种为亲本,配制了皇后×9-8(非跃变类型材料间)和皇后×Charentais(非跃变类型与跃变类型材料间)两个组合,对各组合F1,F2及回交世代BC果实中乙烯的生成变化及... 详细信息

为改进甜瓜货架期,利用成熟果实乙烯释放量及变化速率存在显著差异的3个甜瓜变种为亲本,配制了皇后×9-8(非跃变类型材料间)和皇后×Charentais(非跃变类型与跃变类型材料间)两个组合,对各组合F1,F2及回交世代BC果实中乙烯的生成变化及果实脱落性、外果皮迅速黄化等相关性状的遗传变化进行了分析。结果表明,甜瓜果实中乙烯生成量为不完全显性遗传,受两对以上基因控制。在皇后×Charentais组合的F1中,内源乙烯含量在采收1d后表现出急剧升高,同时伴随着外果皮迅速黄化及果柄脱落的发生,根据这些性状在F2及分别与父母本回交世代中的不同分离比率指出,乙烯的跃变类型、外果皮迅速黄化及果柄脱落在甜瓜果实中为显性遗传。

关键词： Cucurnis melo L. 变种货架期乙烯呼吸跃变遗传分析

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高亚油酸低亚麻酸甘蓝型油菜育种材料的选育(英文)

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西南农业大学学报（自然科学版） 2001年第2期23卷 126-129页

作者：李德谋杨光伟罗小英加藤正弘柿原文香西南农业大学农学系生物技术中心重庆400716 爱媛大学农学部植物育种学研究室

运用毛细管气相色谱仪对无芥酸甘蓝型油菜品种lisadra (B .napusL .cv.)和高亚油酸、低亚麻酸芥菜型油菜JN6 3(B .juncea)杂交产生的F4 代各株系进行了脂肪酸组分分析。并选出其中 5个优良的株系 ,采用半粒法对各株系单株的脂肪酸组分... 详细信息

运用毛细管气相色谱仪对无芥酸甘蓝型油菜品种lisadra (B .napusL .cv.)和高亚油酸、低亚麻酸芥菜型油菜JN6 3(B .juncea)杂交产生的F4 代各株系进行了脂肪酸组分分析。并选出其中 5个优良的株系 ,采用半粒法对各株系单株的脂肪酸组分进行了分析 ,在这些单株中发现一个高油酸、无亚麻酸、无芥酸的特殊材料 46 4- 5 - 1- 5 ,以及一系列的高油酸、高亚油酸、低亚麻酸、无芥酸含量的材料。

关键词：甘蓝型油菜高亚油酸低亚麻酸无芥酸半粒分析法育种材料选育

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