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Phase Ⅱ trial of carboplatin/docetaxel in patients with resected NSCLC

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World Journal of Respirology 2014年第1期4卷 1-7页

作者： Hidetaka Uramoto Ryoichi Nakanishi Akihiko Uchiyama Masaaki Inoue Masakazu Sugaya Teruo Iwata Noriyuki Ebi Takeshi Hanagiri fumihiro tanaka Second Department of Surgery School of Medicine University of Occupational and Environmental Health Kitakyushu 807-8555 Japan Department of Thoracic Surgery Shin-Kokura Hospital Federation of National Public Service Personnel Mutual Aid Associations Kokurakita-ku Kitakyushu 803-0816 Japan Department of Surgery Kyushu Kouseinenkin Hospital Kitakyushu 806-8501 Japan Department of Chest Surgery Shimonoseki City Hospital Shimonoseki 750-8520 Japan Department of Chest Surgery Chubu Rosai Hospital Nagoya 455-0018 Japan Department of Thoracic Surgery Niigata Rousai Hospital Niigata 942-0071 Japan Department of Respiratory Medicine Iizuka Hospital Iizuka 820-8505 Japan

AIM: To investigate the development of a safer chemotherapeutic regimen with better compliance, a total of 67 patients were enrolled as a single arm in a twostage multi-center phase Ⅱ ***: The patients received chemotherapy with carboplatin(CBDCA) with an area under the curve(AUC) of 5, and docetaxel(DTX) at 60 mg/m2 tri-weekly for three cycles after surgery. The primary endpoint of this study was compliance, while the secondary endpoints were the adverse events(AE) and recurrencefree survival(RFS).RESULTS: Sixty-one patients were treated in this study arm. The patients were 43 males and 18 females, with a median age of 64.6 years. Fifty-one patients(83.6%)completed all three cycles of therapy. The presence of Grade 3 and 4 neutropenia was noted in 25% and 66%of the patients, respectively. The non-hematological AE were less frequently reported, and no treatmentrelated death was registered. The two-year RFS and OS rates of the 61 patients were 69.8% and 88.3%,***: A tri-weekly schedule of CBDCA and DTX as adjuvant chemotherapy showed a favorable feasibility.

关键词： Non-small cell lung cancer Adjuvant chemotherapy Carboplatin Docetaxel Treatment compliance Surgical resection

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago fumihiro tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Periostin in cerebrovascular disease

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Neural Regeneration Research 2020年第1期15卷 63-64页

作者： fumihiro Kawakita Hidenori Suzuki Department of Neurosurgery Mie University Graduate School of Medicine

Cerebrovascular diseases,which include ischemic and hemorrhagic strokes,remain serious conditions with high mortality and disability worldwide(He et al.,2018).Ischemic stroke accounts for around 80%of all strokes(He et al.,2018).Hemorrhagic stroke consisting of intracerebral hemorrhage and subarachnoid hemorrhage(SAH)occurs less frequently but may cause poorer outcomes than ischemic stroke(Ji et al.,2017;Luo et al.,2018).It is also well known that aneurysmal SAH may have delayed cerebral ischemia(DCI):thus aneurysmal SAH has both characteristics of hemorrhagic and ischemic strokes(Kanamaru et al.,2019).In spite of enormous efforts to improve outcomes,no conclusive treatment exists thus far,once stroke is completed.

关键词： al. hemorrhagic mortality

A Hopf Type Classification Theorem for Isovariant Maps from Free G-manifolds to Representation Spheres

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Acta Mathematica Sinica,English Series 2011年第4期27卷 685-700页

作者： Ikumitsu NAGASAKI fumihiro USHITAKI Department of Mathematics Kyoto Prefectural University of Medicine Nishitakatsukasa-cho Taishogun Kita-ku Kyoto 603-8334 Japan Department of Mathematics Faculty of Science Kyoto Sangyo University Kamigamo Motoyama Kita-ku Kyoto 603-8555 Japan

An isovariant map is an equivariant map preserving the isotropy subgroups. In this paper, we develop an isovariant version of the Hopf classification theorem; namely, an isovariant homotopy classification result of G-isovariant maps from free G-manifolds to representation spheres under a certain dimensional condition, the so-called Borsuk-Ulam inequality. In order to prove it, we use equivariant obstruction theory and the multidegree of an isovariant map.

关键词： Hopf classification theorem Borsuk Ulam theorem isovariant map multidegree finitegroup action

Matricellular proteins as possible biomarkers for early brain injury after aneurysmal subarachnoid hemorrhage

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Neural Regeneration Research 2018年第7期13卷 1175-1178页

作者： Hidenori Suzuki Hirofumi Nishikawa fumihiro Kawakita Department of Neurosurgery Mie University Graduate School of Medicine

Aneurysmal subarachnoid hemorrhage remains devastating,and the most important determinant of poor outcome is early brain injury（EBI）.In clinical settings,as a surrogate marker of EBI,loss of consciousness at ictus,poor initial clinical grades,and some radiographic findings are used,but these markers are somewhat ***,it is imperative to find biomarkers of EBI that have beneficial prognostic and therapeutic *** our opinion,an ideal biomarker is a molecule that is implicated in the pathogenesis of both EBI and subsequently developing delayed cerebral ischemia（DCI）,being a therapeutic target,and can be measured easily in the peripheral blood in an acute stage.A good candidate of such a biomarker is a matricellular protein,which is a secreted,inducible and multifunctional extracellular matrix *** are many kinds of matricellular proteins reported,but only tenascin-C,osteopontin,galectin-3 and periostin are reported relevant to EBI and *** biomarkers of EBI may stratify aneurysmal subarachnoid hemorrhage patients into categories of risk to develop DCI,and allow objective monitoring of the response to treatment for EBI and earlier diagnosis of *** review emphasizes that further investigation of matricellular proteins as an avenue for biomarker discovery is warranted.

关键词： biomarker early brain injury galectin-3 matricellular protein osteopontin periostin subarachnoid hemorrhage tenascin-C

Effect of multifunction cavitation using phosphoric acid on fatigue and surface properties of AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2023年第6期11卷 1996-2005页

作者： Shunta Matsuoka fumihiro Kato Toshihiko Yoshimura Masataka Ijiri Shoichi Kikuchi Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Department of Mechanical Engineering Sanyo-Onoda City University1-1-1 Daigaku-DoriSanyo-OnodaYamaguchi 756-0884Japan Tokyo Metropolitan University 1-1 Minami-OsawaHachiojiTokyo 192-0397Japan Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1 JohokuNaka-kuHamamatsu-shiShizuoka 432-8561Japan

Magnesium alloy is attractive for lightweight construction but often suffers from poor corrosion resistance and low *** processing with chemicals,i.e.,multifunction cavitation(MFC),was introduced to form a high-corrosion film and improve the fatigue properties of an AZ31 magnesium *** analysis and plane bending fatigue tests were conducted for the MFC-treated magnesium alloy at a stress ratio,R,*** mechanical action of cavitation bubbles improved the fatigue life of magnesium alloys due to increasing the surface hardness and generating compressive residual ***,the combined mechanical and electrochemical action during MFC formed pits on the *** pits were large enough to easily nucleate an initial fatigue *** addition,the magnesium alloys without pit formation,for which a coating process using phosphoric acid was conducted after MFC using water,showed superior fatigue properties.

关键词： Magnesium alloy Multifunction cavitation Surface modification Fatigue Residual stress

Fluorescence and Auger Decay Properties of the Core-Excited F-Like Ions from Ne to Kr

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Chinese Physics Letters 2012年第4期29卷 58-60页

作者： WANG Xiang-Li DONG Chen-Zhong SU Mao-Gen KOIKE fumihiro Key Laboratory of Atomic and Molecular Physics&Functional Materials of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070 Physics Laboratory School of MedicineKitasato University1-15-1Kitasato 252-0374Japan

Ve systematically study the decay properties of the K-shell excited F-like ions with 10≤Z≤36 based on the multiconfiguration Dirac-Fock *** Breit interaction,the QED corrections and the nuclear finite mass effects are also considered as *** transition rates,radiative,Auger and natural widths,as well as fluorescence and Auger yields for K-shell excited F-like ions are *** is shown by means of concrete figures that the decay properties change significantly with the increase of the atomic number Z;the Auger rate is overtaken at Z =30 by the radiative decay *** fitting formulae for the radiative and Auger widths and the fluorescence yields have been evaluated which is expected to be useful in plasma analysis and plasma modeling.

关键词： perturbation method radiative

Dielectronic Recombination of Br-Like Tungsten Ions

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Plasma Science and Technology 2014年第3期16卷 182-187页

作者：李麦娟符彦飙苏茂根董晨钟 Koike fumihiro Key Laboratory of Atomic and Molecular Physics & Functional Material of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal University Joint Laboratory of Atomic and Molecular Physics Northwest Normal University and Institute of Modern Physics of Chinese Academy of Sciences Atomic and Molecular Data Research Center National Institute for Fusion Science

Accurate data for dielectronic recombination of tungsten ions are essential in the modeling of tungsten impurity transport and radiative power loss in International Thermonuclear Experimental Reactor （ITER）. Theoretical calculations have been made for dielectronic recombi- nation （DR） rate coefficients of Br-like tungsten ions using a flexible relativistic atomic code （FAC） from i eV to 50 keV. Level-by-level calculations are carried out for evaluating the contributions to DR through all the relevant Kr-like tungsten ions autoionizing inner-shell excited configuration complexes：（3s23p63d10）-14s24p5nlntl＇（n = 4-5, n＇ = 4-100,l＇ = 0-8）, （4s24pS）-lnln＇l＇（n = 4-6, n＇ = 4-100, l＇ = 0-12）. Comparison of the rate coefficients for 3s, 3p, 3d, 4s and 4p subshell excitations shows that the 4p subshell excitation dominates over the whole temperature region, 4s subshell excitation at low temperature and 3p, 3d subshell excitations at high temperature can not be neglected. In order to facilitate simple applications, the total DR rate coefficient, △n = 0,1 and 2 core excitations DR rate coefficients are fitted to an empirical formula.

关键词： Br-like tungsten dielectronic recombination rate coefficients

Excitation and decay dynamics of 1s2s inner-shell double-vacancy states of neon atoms

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Chinese Physics B 2008年第2期17卷 592-598页

作者：丁晓彬董晨钟 fumihiro Koike Takako Kato Stephan Fritzsche College of Physics and Electronic Engineering Northwest Normal University Center of Theoretical Nuclear Physics National laboratory of Heavy-Ion Accelerator of Lanzhou Physics Department School of MedicineKitasato University1-15-1 Kitasato228-8555Japan National Institute for Fusion Science Department of Physics University of KasselHeinrich-Plett-Straβe 40D-34132KasselGermany

The photo-excitation and Auger decay processes of inner-shell double vacancy states 1s2s2p^6（1,3^S）3s3p of neutral neon atoms have been studied theoretically. Multi-configuration Dirac-Fock （MCDF） calculations have been carried out, with electron correlation effects taken into consideration. The relaxation of core and excited orbitals and configuration interaction are found to be crucial to creating the double vacancy states by single photo-absorption. The predominant decay paths for the double vacancy states turn out to be of the LLM Auger decay to 1s 2s^22p^53s（3p）, KLL Auger decay to 1s^22s2p^43s3p, and KLM Auger decay to 1s^22p^63s（3p）. They lead to further Auger decay, creating the neon ions of multiple charge states. For both double and single vacancy states the spectator type of Auger process is dominated in all the Auger decay processes. Theoretical Anger electron spectra are presented for further investigations, experimental and theoretical.

关键词： correlation effects multi-configuration Dirac-Fock (MCDF) method Auger decay