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Steroid Sulfatase Inhibitor Reduces Proliferation of Ishikawa Endometrial Cancer Cells in Co-Culture Systems

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Open Journal of Endocrine and Metabolic Diseases 2016年第9期6卷 193-204页

作者： Mitsuo Nishimoto Masafumi Toyoshima Naomi Shiga Hiroki Utsunomiya fumihiko suzuki Satoru Nagase Hidekazu Nishigori Takashi suzuki Hironobu Sasano Kiyoshi Ito Nobuo Yaegashi Department of Obstetrics and Gynecology Tohoku University School of Medicine Sendai Japan Department of Obstetrics and Gynecology Iwate Prefectural Iwai Hospital Iwate Japan Department of Obstetrics and Gynecology Yamagata University School of Medicine Yamagata Japan Department of Pathology Tohoku University School of Medicine Sendai Japan Department of Disaster Obstetrics and Gynecology International Research Institute of Disaster Science Tohoku University Sendai Japan

Objectives: Estrogens significantly contribute toward the growth and development of endometrial cancers. Two principal pathways have been implicated in the final steps of estrogen synthesis: the steroid sulfatase (STS) and aromatase pathways. In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. We also assessed the biological effects of inhibitors of steroid sulfatase and aromatase in the co-culture system compared with usual monocultures. Methods/Materials: We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. Results: Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. Estradiol and androstenediol concentrations were also significantly higher in the co-cultured cells. Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. However, its proliferation was significantly decreased by the treatment of steroid sulfatase or aromatase inhibitors. The significant growth inhibition by the steroid sulfatase and aromatase inhibitors were also observed in the co-culture system. Conclusions: We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. Considering that intratumoral estrogen metabolism plays an important role, our co-culture systems provide an environment similar to that of the tumor in living patients in terms of metabolism and synthesis of intratumoral estrogens.

关键词： Aromatase Inhibitors Co-Culture System Endometrial Cancer Estrogen Estrogen Sulfatase Inhibitor

Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents

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Health 2016年第1期8卷 116-124页

作者： Junko Mitoma Masami Kitaoka Hiroki Asakura Enoch Olando Anyenda Daisuke Hori Nguyen Thi Thu Tao Toshio Hamagishi Koichiro Hayashi fumihiko suzuki Yukari Shimizu Hiromasa Tsujiguchi Yasuhiro Kambayashi Yuri Hibino Tadashi Konoshita Takiko Sagara Aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.

关键词： Quality of Life Chronic Pain Headache SF-36 Pain

The Association of Autism Spectrum Disorders and Symptoms of Asthma, Allergic Rhinoconjunctivitis and Eczema among Japanese Children Aged 3 - 6 Years

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Health 2017年第8期9卷 1235-1250页

作者： Daisuke Hori Hiromasa Tsujiguchi Yasuhiro Kambayashi Toshio Hamagishi Masami Kitaoka Junko Mitoma Hiroki Asakura fumihiko suzuki Enoch Olando Anyenda Nguyen Thi Thu Thao Yohei Yamada Satoko Tamai Koichiro Hayashi Yuri Hibino Aki Shibata Takiko Sagara Shinichiro Sasahara Ichiyo Matsuzaki Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Kanazawa Japan Faculty of Medicine University of Tsukuba Tsukuba Japan International Institute for Integrative Sleep Medicine University of Tsukuba Tsukuba Japan

There is insufficient epidemiological evidence on the relationship between autism spectrum disorder (ASD) and allergic diseases. We performed a cross-sectional survey to elucidate the associations between them using validated screening tools. The participants were children aged 3 - 6 years attending kindergarten or nursery school in Shika Town, Japan (n = 417;valid response rate = 80.4%). Autism spectrum features were scored on the Social Communication Questionnaire (SCQ). Allergic symptoms (asthma, allergic rhinoconjunctivitis, and eczema) were determined according to the criteria of the International Study of Asthma and Allergies in Childhood. A total of 15 children (4.5%) had an SCQ score of 11 points or higher. The prevalence of symptoms was 14.7% for asthma, and 5.3% for allergic rhinoconjunctivitis, and 11.4% for eczema. Logistic regression indicated that symptoms of eczema were significantly associated with SCQ scores of 11 points or higher [odds ratio (OR), 4.38;95% confidence interval (CI), 1.41 - 13.59]. The association persisted after adjustment for age, sex, and BMI (OR, 3.84;95% CI, 1.20 - 12.24). Moreover, asthmatic symptoms were significantly associated with male sex (OR, 2.09;95% CI, 1.12 - 3.92) and overweight status (OR, 2.45;95% CI, 1.03 - 5.83). This suggests that higher SCQ scores, which imply more autism spectrum features, are associated with higher prevalence of eczema symptoms. While no causal relationships can be made, ASD might be associated with eczema.

关键词： Asthma Autism Spectrum Disorder Eczema Early Screening Social Communication Questionnaire

The Association between Activity of Daily Living and the Combination of Alzheimer’s Disease and Cataract in Elderly Requiring Nursing Care

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Health 2016年第10期8卷 994-1003页

作者： Toshio Hamagishi Toshimitsu Inagawa Yasuhiro Kambayashi Hiromasa Tsujiguchi Masami Kitaoka Junko Mitoma Hiroki Asakura fumihiko suzuki Daisuke Hori Enoch Olando Anyenda Nguyen Thi Thu Thao Yuri Hibino Koichi Hayashi Aki Shibata Takiko Sagara Jiro Okochi Kiyoshi Takamoku Kotaro Hatta Tadashi Konoshita Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Department of Food Sciences and Nutrition School of Human Environmental Sciences Mukogawa Women’s University Hyogo Japan Department of Lifestyle Studies Kobe Shoin Women’s University Hyogo Japan Department of Nutritional Sciences for Well-Being Kansai University of Welfare Sciences Osaka Japan Japan Association of Geriatric Health Service Facilities Tokyo Japan Department of Psychiatry Juntendo University Nerima Hospital Tokyo Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

Some clinical and epidemiological studies have suggested that Alzheimer’s Disease (AD) and cataract, may share common pathogenetic mechanisms, subsequently a positive association between the prevalence of AD and cataract, although other studies found no significant relationship between dementia and visual impairment including cataract in the elderly. Little is known about the association between Activity of Daily Living (ADL) and the combination of AD and cataract. To examine the association between ADL and the combination of AD and cataract, we performed a national survey in nursing care institutions in Japan, examining the decreased ADL in elderly with and without AD and cataract for 453 elderly aged 85.0 ± 8.13 years. The proportion, 43.5% of AD in subjects without cataract was significantly higher than that, 23.5% with cataract. Almost all ADL in AD with cataract was significantly lower than that without cataract, although all ADL in cataract patients receiving surgery in AD was significantly (all p < 0.002) higher than that in cataract patients without surgery in AD, as was confirmed by the multiple regression analysis incorporating into the relevant factors as independent variables. These results showed that ADL scores including cognitive functions decreased by cataract were increased by the surgery in the patients with AD. A significantly negative association between AD and cataract seen in our data, which was inconsistent with the previous result, might lead to the necessities of the clinical diagnosis for slight severity of cataract for patients with AD.

关键词： Alzheimer’s Disease Cataract Elderly Activity of Daily Living Cognitive Function

Vibration Analysis of Vehicle Floor Panel Using Hybrid Method of FEM and SEA

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Journal of Mechanics Engineering and Automation 2014年第4期4卷 305-310页

作者： Kazuhito Misaji Yusuke suzuki Ayumi Takahashi fumihiko Ide Theophane Courtois Department of lndustrial Technology Nihon University Chiba 275-8575 Japan Honda R&D Americas Inc. Raymond 43067 America autoneum Winterthur 43 8406 Switzerland

In order to improve the mass efficiency of an automotive soundproof package, it is important to predict the middle to high frequency range of noise and vibration during vehicle operation. A hybrid method of experimental and analytical SEA （statistical energy analysis） has been applied for the prediction of air-borne noise. However, for predicting structure-borne noise, there are no definitive simulation methods that can address the soundproof specifications in an actual vehicle. Thus, in this paper, a FEM （finite element method）＇SEA hybrid method is used. The FEM＇SEA hybrid method predicts structure-borne noise in the middle to high frequency range. First, we explain the basic concept of the FEM＇SEA hybrid method; Second, we describe our experiment to verify the analytical results of the FEM＇SEA hybrid method; Third, we provide the details of the FEM model versus the FEM＇SEA hybrid model; Finally, we verify the validity and availability of the FEM＇SEA hybrid method through comparisons of the FEM analysis results, FEM-SEA analysis results and measured results.

关键词： Vibration noise statistical energy analysis finite element method.

Structural Analysis of Thermally-Annealed Bulk Heterojunction Films Based on Sexithiophene and Fullerene

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Advances in Materials Physics and Chemistry 2014年第7期4卷 127-133页

作者： Yosei Shibata Takahiro Kono Takahiko suzuki Yuzuru Narita fumihiko Hirose Yuji Yoshida Graduate School of Science and Engineering Yamagata University Yonezawa Japan Research Center for Photovoltaic Technologies National Institute of Advanced Industrial Science and Technology Tsukuba Japan

Recently, power conversion efficiencies of organic photovoltaics based on small molecules have been dramatically improved by means of the bulk heterojunction (BHJ) structure. Moreover, to optimize photovoltaic performance, thermal annealing treatments have often been used because of the simplicity of the process. However, the elucidation of effects of thermal annealing treatment on BHJ film structure based on small molecules is still not enough. Here, we report the results of structural analysis with synchrotron radiation of α-sexithiophene:fullerene BHJ films before and after thermal annealing treatment. In particular, the open-circuit voltage was increased to as high as 0.72 V;moreover, the BHJ films based on α-sexithiophene and fullerene were also clearly crystallized by the thermal annealing treatment. In this study, we found that the optimal crystal size existed in BHJ films for high-performance organic photovoltaics.

关键词： Organic Photovoltaics Oligothiophene Bulk Heterojunction Structure Thermal Anneal Morphological Control

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强电子束引发的高功率HF化学激光器的研制

中国激光 1983年第Z1期 592-592页

作者： fumihiko Kannari Shigeru Yamaguchi Kenji Kumamoto Tadashi suzuki Minoru Obara Tomoo Fujioka 日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系日本庆应大学科学技术分部电工系

强电子束是高功率激光器的一种重要的引发和激励源,由于高的引发和激励强度能均匀地激励高气压、大体积气体混合物。此外,电子束脉冲具有很快的电流上升时间,这样可以研究寿命很短的激光物质。电子束引发的HF化学激光器对应用于激光聚... 详细信息

强电子束是高功率激光器的一种重要的引发和激励源,由于高的引发和激励强度能均匀地激励高气压、大体积气体混合物。此外,电子束脉冲具有很快的电流上升时间,这样可以研究寿命很短的激光物质。电子束引发的HF化学激光器对应用于激光聚变来说是有兴趣的,引起这种兴趣的特性是由于HF化学激光器可以获得高的电效率和高的能量密度。我们已对电子束引发的HF（H2/F2）激光器作了研究,并获得了电效率为200％时180J/脉冲的HF激光能量。最近,我们已研制成几千焦耳的电子束引发的高功率HF激光系统。强电子束引

关键词：电效率激光能量化学激光器高功率

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung