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Neural Regeneration Research 2024年第8期19卷 1802-1811页

作者： fudong li Xiaofei Sun Kaiqiang Sun Fanqi Kong Xin Jiang Qingjie Kong Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthopedic Surgery Spine CenterShanghai Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Orthopedic Surgery Naval Medical CenterNaval Medical UniversityShanghaiChina Department of Anesthesiology Shanghai Changzheng HospitalNaval Medical UniversityShanghaiChina

Spinal cord injury-induced motor dysfunction is associated with *** have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect in the context of chronic ***,the effects of lupenone on acute inflammation induced by spinal cord injury remain *** this study,we established an impact-induced mouse model of spinal cord injury,and then treated the injured mice with lupenone(8 mg/kg,twice a day)by intrape ritoneal *** also treated BV2 cells with lipopolysaccharide and adenosine5’-triphosphate to simulate the inflammatory response after spinal cord *** res ults showed that lupenone reduced IKBa activation and p65 nuclear translocation,inhibited NLRP3 inflammasome function by modulating nuclear factor kappa B,and enhanced the conve rsion of proinflammatory M1 mic roglial cells into anti-inflammatory M2 microglial ***,lupenone decreased NLRP3 inflammasome activation,NLRP3-induced mic roglial cell polarization,and microglia pyroptosis by inhibiting the nuclear factor kappa B *** findings suggest that lupenone protects against spinal cord injury by inhibiting inflammasomes.

关键词： inflammasome inflammation lupenone microglia polarization pyroptosis spinal cord injury

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基于多元成本结构的分时电价定价机制

湖南科技大学学报（自然科学版） 2024年第1期39卷 60-69页

作者：王岱刘颖潘昌忠李春来李福东国网宁夏电力有限公司银川供电公司宁夏银川750011 湖南科技大学信息与电气工程学院湖南湘潭411201 湖南理工学院物理与电子学院湖南岳阳414006 北京信息科技大学机电工程学院北京100192

建设新型电力系统对完善分时电价机制提出了新的要求.针对目前分时电价研究多侧重于市场机制,对电价设置菜单与实际供电成本结构关系有待深化机理建模的问题,提出一种基于多元化供电成本和需求响应的分时电价模型.该模型兼顾经济性与可... 详细信息

建设新型电力系统对完善分时电价机制提出了新的要求.针对目前分时电价研究多侧重于市场机制,对电价设置菜单与实际供电成本结构关系有待深化机理建模的问题,提出一种基于多元化供电成本和需求响应的分时电价模型.该模型兼顾经济性与可靠性,建立考虑需求削减的负荷切片与成本定价机制,明确供电配置的多元化成本结构,建立各类电源的可变成本、固定成本与可靠性损失成本的成本结构.对电力销售收入分析、电源的实际可变成本、电源可靠性损失和固定成本回收进行了基础性研究.通过相关算例验证,研究各类电源事故率对模型中附加费率的影响,以及各类电源事故率、不同负荷水平波动与分时电价定价的关联性,验证了文章建立的分时电价模型在提高分时电价适应性,正确引导用户用电行为,提高削峰填谷方面的有效性.同时,该模型有助于优化各类电源的容量管理,确保峰值电源的成本回收,从而有效地平衡电源侧和用户侧利益,兼顾供电充分性、可靠性和经济性目标.

关键词：需求响应分时电价机制固定成本可变成本可靠性成本削峰填谷

Structural insights reveal the specific recognition of meiRNA by the Mei2 protein

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Journal of Molecular Cell Biology 2022年第5期14卷 27-42页

作者： Siyuan Shen Yanze jian Zhaokui Cai fudong li Mengqi Lv Yongrui liu Jihui Wu Chuanhai Fu Yunyu Shi School of life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China MOE key Laboratory for Cellular Dynamics University of Science&Technology of ChinaHefei 230026China Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis ***2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes *** research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in ***,the underlying mechanisms still remain *** first employed an in vitro crosslinking and immunoprecipitation sequencing(CliP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 *** then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro *** results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)***,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis.

关键词： Mei2 meiRNA meiosis RNA-binding protein crystallography

Al-(Cu,Mg,Mn)-(Sc,Zr)合金选区激光熔化成形工艺及机械性能研究

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应用激光 2024年第5期44卷 11-20页

作者：张圣华张森铭吴锦华王碧霞王春蔚单铃李富东郑建明刘斌浙江万丰科技开发股份有限公司浙江绍兴312400 中北大学材料科学与工程学院山西太原030051

为提高铝合金的机械性能,针对高冷速的选区激光熔化(selective laser melting,SLM)成形技术,设计Al-1Cu-1Mg-3Mn-0.8Sc-0.8Zr合金,研究SLM成形参数对设计合金的影响,以确定最优的成形工艺,并测试直接成形铝合金的机械性能。通过正交试... 详细信息

为提高铝合金的机械性能,针对高冷速的选区激光熔化(selective laser melting,SLM)成形技术,设计Al-1Cu-1Mg-3Mn-0.8Sc-0.8Zr合金,研究SLM成形参数对设计合金的影响,以确定最优的成形工艺,并测试直接成形铝合金的机械性能。通过正交试验发现,激光功率和扫描速度是影响合金致密度和硬度的主要因素;不同成形参数对缺陷的影响研究表明,合金中不规则的冶金孔和裂纹等缺陷随激光功率的降低和线扫描速度的升高而增多,而激光功率过高或扫描速度过低会导致合金中出现大的圆形孔洞,最终确定的SLM成形Al-(Cu,Mg,Mn)-(Sc,Zr)合金最优工艺为:激光功率330 W,扫描速度900 mm/s,扫描间距0.12 mm;合金的抗拉强度为349 MPa,屈服强度为267 MPa,伸长率为7%。

关键词：选区激光熔化铝合金工艺优化力学性能

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Effectiveness and safety of Shenmai injection in treatment of shock:a Meta-analysis

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Journal of Traditional Chinese Medicine 2018年第2期38卷 155-166页

作者： li Xiaoli Shen Yi He Fan Zhu Yinchao li fudong Department of Gynecology the Second Affiliated Hospital of Zhejiang University School of Medicine Department of Epidemiology and Health Statistics School of Public HealthZhejiang University Department of Public Health Surveillance and Advisory Zhejiang Provincial Center for Disease Control and Prevention Institute of Non-Communicable Disease Control and Prevention Ningbo Municipal Center for Disease Control and Prevention

OBJECTIVE:To evaluate the effectiveness and safety of Shenmai injection for ***: Randomized controlled trials(RCTs)that evaluated the therapeutic effect of Shenmai injection on shock(including septic shock, cardiogenic shock, hypovolemic shock, neurogenic shock and anaphylactic shock) were included in this analysis. The major electronic databases were searched until May 2015. The methodological quality of the trials was assessed according to the Cochrane Handbook. Review Manager 5.3 and Stata 12.0 software were applied for data ***: Thirty RCTs involving 2038 participants were included. The methodological quality of the trials was generally passable. The combined use of Shenmai injection and conventional medicine was significantly more effective at managing shock compared to conventional medicine alone in the outcomes of total effective rate [risk ratio(RR 1.25,95% confidence interval(CI) 1.18 to 1.31] and mortality rate [risk difference(RD)-0.10, 95% CI-0.17 to-0.02]. likewise, improvements were observed in other metrics. Three trials reported adverse events, but no trial reported serious adverse ***: Our results indicated the potential effectiveness of Shenmai injection combined with conventional medicine treatment for shock. However, further rigorously designed trials are needed to collect and weigh up all the evidence for the use of Shenmai injection.

关键词：注射安全过敏反应联合使用度量标准方法学试用随机化

不同加强节点对‘宝石解百纳’利口酒品质的影响

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中外葡萄与葡萄酒 2024年第1期 74-80页

作者：师旭李长征谷翔昕王海绮乔岩李福东于庆泉中粮长城桑干酒庄(怀来)有限公司河北张家口075400 中粮名庄荟国际酒业有限公司北京100020 河北农业大学食品科技学院河北保定071000

以‘宝石解百纳’葡萄为原料进行发酵,设置残糖量为156、126、96 g·L^(-1)的3组发酵液;以‘白玉霓’白兰地为基酒,用不同糖度的发酵液配成酒度分别为22%、20%、18%(Vol)的酒样,并通过顶空固相微萃取-气相色谱-质谱联用技术,检测挥发性... 详细信息

以‘宝石解百纳’葡萄为原料进行发酵,设置残糖量为156、126、96 g·L^(-1)的3组发酵液;以‘白玉霓’白兰地为基酒,用不同糖度的发酵液配成酒度分别为22%、20%、18%(Vol)的酒样,并通过顶空固相微萃取-气相色谱-质谱联用技术,检测挥发性香气组成,调查不同加强节点对‘宝石解百纳’利口酒理化性质和感官品质的影响。结果表明,‘宝石解百纳’发酵液总糖为96 g·L^(-1)时终止发酵,与设定的理想目标节点差异较小;感官总得分以发酵液低残糖低酒度(残糖96 g·L^(-1)、酒度18%)和中残糖低酒度(残糖126 g·L^(-1)、酒度18%)组合相对较高,其中低残糖低酒度组合在香气优雅细腻度和口感结构协调性得分最高。以该组合为对象共检测出41种挥发性香气,包括C6醇2种、高级醇5种、脂肪酸乙酯13种、酸类和乙酸酯各3种、其他酯类6种、4种萜烯类;呋喃醛类2种;酚类、醛类和内酯类各1种。本研究初步探明了高品质利口酒的加强节点工艺,同时明确了‘宝石解百纳’利口酒的挥发性香气组成,为国产利口酒工艺研发提供了参考。

关键词： ‘宝石解百纳’利口酒残糖-酒精度加强节点感官品质挥发性香气

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An Open Access 4×4 MIMO Testbed and its Validation with an IEEE 802,11n WLAN System

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China Communications 2014年第A1期11卷 64-71页

作者： SUN Jian li fudong ZHANG Haixia JIANG Mingyan YUAN Dongfeng SchoolofInformationScienceandEngineering ShandongUniversityJinan250100ShandongChina

Multiple-Input Multiple-Output (MIMO) and Orthogonal Frequency Division Multiplexing (OFDM) have been widely accepted as key techniques of the current and future wireless communication systems. In this paper, an open access MIMO testbed is presented, on which the researchers can demonstrate and evaluate their baseband algorithms over the real wireless channel, without knowing much details about the hardware of the testbed. Moreover, an IEEE 802.11n transmission scheme is implemented as a design example to validate this testbed as well as demonstrate the transmission characteristics of MIMO-OFDM.

关键词： MIMO-OFDM 测试平台 IEEE WLAN系统验证无线通信系统正交频分复用多输入多输出

Tuning SMSI to stabilize metallic Pd species:A case study on Pd/TiO_(2) for HCHO oxidation

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Chinese Chemical Letters 2024年第3期35卷 162-166页

作者： Chunying Wang Xiaofeng liu Jingyi Wang Yaobin li Shaohua Xie fudong liu Changbin Zhang Yuming Zheng Wenpo Shan Hong He Center for Excellence in Regional Atmospheric Environment Key Laboratory of Urban Pollutant ConversionInstitute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationChinese Academy of SciencesNingbo 315800China Department of Civil Environmentaland Construction Engineering(CECE)Catalysis Cluster for Renewable Energy and Chemical Transformations(REACT)Nano Science Technology Center(NSTC)University of Central FloridaOrlandoFL 32816USA State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-environmental SciencesChinese Academy of SciencesBeijing 100085China

Pretreatment of the carrier for supported catalysts can effectively improve the strong metal-support interaction(SMSI)and increase the dispersion of precious metals,which are critical to many important catalytic *** this work,we tuned SMSI on Pd/TiO_(2)catalysts through inducing surface defects of TiO_(2)by pretreated with different atmospheres(H_(2)/N_(2),N_(2),O_(2)/N_(2))at the high temperature(800℃).Multiple characterization results illustrated that surface defects anchored Pd species and thus enhanced their *** reduction,Ti^(3+)species formed and transferred onto the metallic Pd species and then induced SMSI,which effectively stabilize Pd species in the metallic *** stronger MSI,the more stability of Pd *** a case,Pd/TiO_(2)–800H_(2),with strongest MSI,displayed the best HCHO oxidation performance at low temperature(10℃).

关键词： Pd/TiO_(2) Surface defects SMSI Formaldehyde Stability of Pd species

Structural insights of phosphorylated into the recognition FUNDC1 by LC3B in mitophagy

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Protein & Cell 2017年第1期8卷 25-38页

作者： Mengqi Lv Chongyuan Wang fudong li Junhui Peng Bin Wen Qingguo Gong Yunyu Shi Yajun-Tang Hefei National Laboratory for Physical Sciences at Microscale and School of life Sciences University of Science and Technology of China Hefei 230027 China

Mitophagy is an essential intracellular process that eliminates dysfunctional mitochondria and maintains cellular homeostasis. Mitophagy is regulated by the post-translational modification of mitophagy receptors. Fun14 domain-containing protein 1 （FUNDC1） was reported to be a new receptor for hypoxia-induced mitophagy in mammalian cells and interact with micro-tubule-associated protein light chain 3 beta （LC3B） through its LC3 interaction region （liR）. Moreover, the phosphorylation modification of FUNDC1 affects its binding affinity for LC3B and regulates selective mitophagy. However, the structural basis of this regulation mechanism remains unclear. Here, we present the crystal structure of LC3B in complex with a FUNDCI liR peptide phosphorylated at Ser17 （pS17）, demonstrating the key residues of LC3B for the specific recognition of the phosphorylated or dephosphorylated FUNDC1. Intriguingly, the side chain of LC3B Lys49 shifts remarkably and forms a hydrogen bond and electrostatic interaction with the phosphate group of FUNDC1 pS17. Alternatively, phosphorylated Tyr18 （PY18） and Ser13 （PS13） in FUNDC1 significantly obstruct their interaction with the hydrophobic pocket and Arg10 of LC3B, respectively. Structural observations are further validated by mutation and isothermal titration calorimetry （ITC） assays. Therefore, our structural and biochemical results reveal a working model for thespecific recognition of FUNDCI by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.

关键词： microtubule-associated protein light chain 3 beta (LC3B) fun14 domain-containing protein 1 (FUNDC1) phosphorylation selective mitophagy

Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4

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Protein & Cell 2018年第8期9卷 738-742页

作者： Aiai Sun fudong li Zhonghua liu, Yiyang Jiang Jiahai Zhang Jihui Wu Yunyu Shi Hefei National Laboratory for Physical Sciences at Microscale and School of life Sciences University of Science and Technology of China Hefei 230027 China

Dear Editor,Polycomb repressive complex 2 （PRC2） plays a critical role in organ development, adult homeostasis, and tumorigene- sis via enzymatic activities to di- or td-methylate lysine 27 of H3 （H3K27me2/me3）, w... 详细信息

关键词： REPRESSIVE COMPLEX 2 NURD COMPLEX PRC2 CLASSIFICATION