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TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： Yu Qian Ying Xiao Qiu-Rong Lin Zhao-Yu Xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-Ran Qin Hai-dong Zou Chen-Hao Yang Pei-Yao Jin Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China Shanghai Eye Diseases Prevention&Treatment Center Shanghai Eye HospitalShanghai 200040China National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A total of 40 T1DM children was included in the first *** no participant has DR,retina thinning was used as a surrogate indicator for *** lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were *** DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control *** DMS with a potential role in diabetes were *** second survey included 27 T1DM children,among which four had *** methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.●RESULTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.P0.05)between participants with and without DR.●CONCLUSION:The hypermethylation of the TCERG1L gene is a risk factor for DR development in Chinese children with T1DM.

关键词： DNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-Min Wang Min-Yue Xie Yi-Qing Sun Xiao-Huan Zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han Min-Wen Zhou Xiao-dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research Center for Eye Disease Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai Engineering Center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren Hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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PHASE SEPARATION BEHAVIOR OF SURLYN IN POLY (ETHYLENE TEREPHTHALTE)

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Chinese Chemical Letters 1991年第11期2卷 905-906页

作者： dong TIAN, Hai Shan (Department of Materials Science, fudan University, Shanghai, 200433)

The phase separation behavior of blend of Surlyn and poly(ethylene terephthalate) (PET) has been studied by scanning electron microscopy and IR. It is shown that particles of Surlyn are dispersed in PET matrix, and th... 详细信息

关键词： PET ETHYLENE TEREPHTHALTE PHASE SEPARATION BEHAVIOR OF SURLYN IN POLY

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Demonstration of radar-aided flexible communication in a photonics-based W-band distributed integrated sensing and communication system for 6G

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Chinese Optics Letters 2024年第4期22卷 119-124页

作者：贾俊连董博宇陶理施剑阳迟楠张俊文 Key Laboratory of EMW Information(MoE) Fudan UniversityShanghai 200433China Shanghai ERC of LEO Satellite Communication and Applications Shanghai CIC of LEO Satellite Communication TechnologyShanghai 200433China Science and Technology on Electromagnetic Compatibility Laboratory China Ship Development and Design CentreWuhan 430000China Peng Cheng Laboratory Shenzhen 518055China

This paper experimentally demonstrates a distributed photonics-based W-band integrated sensing and communication(ISAC) system, in which radar sensing can aid the communication links in alignment and data rate estimation. As a proof-of-concept, the ISAC system locates the users, guides the alignment, and sets a communication link with the estimated highest data rate. A peak net data rate of 68.6 Gbit/s and a target sensing with a less-than-1-cm error and a sub-2-cm resolution have been tested over a 10-km fiber and a 1.15-m free space transmission in the photonics-based W-band ISAC system. The achievable net data rates of the users at different locations estimated by sensing are experimentally verified.

关键词： integrated sensing and communication photonics-aided technique W-band radar-aided flexible communication

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Synthesis of Nanometer-sized Mesoporous Oxide Spheres

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Chemical Research in Chinese Universities 2001年第2期17卷 143-147页

作者： LUO Qian, LI Li, XUE Zhi-yuan and ZHAO dong-yuan (Department of Chemistry Analysis and Measurement Center, fudan University, Shanghai 200433, P. R. China) 复旦大学上海 200433

A few hundreds nanometer-sized mesoporous silica and alumina spheres were synthesized in organic solvents. The impacts of ammonia, N, N-dimethylformamide (DMF) and stirring speed were also investigated.

关键词： Nanometer-sized Mesoporous Sphere Silica Alumina

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Inferring Mycobacterium Tuberculosis Drug Resistance and Transmission using Whole-genome Sequencing in a High TB-burden Setting in China

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Biomedical and Environmental Sciences 2024年第2期37卷 157-169页

作者： FAN Yu Feng LIU dong Xin CHEN Yi Wang OU Xi Chao MAO Qi Zhi YANG Ting Ting WANG Xi Jiang HE Wen Cong ZHAO Bing LIU Zhen Jiang ABULIMITI Maiweilanjiang AIHEMUTI Maimaitiaili GAO Qian ZHAO Yan Lin Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Medical CollegeFudan UniversityShanghai 200032China National Tuberculosis Reference Laboratory Chinese Center for Disease Control and PreventionBeijing 102206China Hangzhou Red Cross Hospital Hangzhou 310005ZhejiangChina Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention Urumqi 830026XinjiangChina Tuberculosis Dispensary of Kashgar Prefecture Kashgar 844099XinjiangChina

Objective China is among the 30 countries with a high burden of tuberculosis(TB)worldwide,and TB remains a public health *** Prefecture in the southern Xinjiang Autonomous Region is considered as one of the highest TB burden regions in ***,molecular epidemiological studies of Kashgar are *** A population-based retrospective study was conducted using whole-genome sequencing(WGS)to determine the characteristics of drug resistance and the transmission *** A total of 1,668 isolates collected in 2020 were classified into lineages 2(46.0%),3(27.5%),and 4(26.5%).The drug resistance rates revealed by WGS showed that the top three drugs in terms of the resistance rate were isoniazid(7.4%,124/1,668),streptomycin(6.0%,100/1,668),and rifampicin(3.3%,55/1,668).The rate of rifampicin resistance was 1.8%(23/1,290)in the new cases and 9.4%(32/340)in the previously treated *** resistance mutations were detected more frequently in lineage 2 strains than in lineage 3 or 4 strains,respectively:18.6%vs.8.7 or 9%,P<*** estimated proportion of recent transmissions was 25.9%(432/1,668).Multivariate logistic analyses indicated that sex,age,occupation,lineage,and drug resistance were the risk factors for recent *** the low rate of drug resistance,drug-resistant strains had a higher risk of recent transmission than the susceptible strains(adjusted odds ratio,1.414;95%CI,1.023–1.954;P=0.036).Among all patients with drug-resistant tuberculosis(DR-TB),78.4%(171/218)were attributed to the transmission of DR-TB *** Our results suggest that drug-resistant strains are more transmissible than susceptible strains and that transmission is the major driving force of the current DR-TB epidemic in Kashgar.

关键词： Mycobacterium tuberculosis Whole-genome sequencing(WGS) Transmission Drug resistance Xinjiang

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Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li Juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia Liu Shikun Xu Lihua Guan dong Huang Qibing Wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge Xiao Huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

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Non-proteolytic ubiquitination of HBx controls HBV replication

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Virologica Sinica 2024年第2期39卷 338-342页

作者： Xiangpeng Sheng Yi Yang Min Zhu Linlin Zhou Fang Zhu Yuanfei Zhu Siying dong Hui Kong Honghua Wang Ji Jiang Mingyue Wan Mingyang Feng Qiang Deng Yumin Xu Qing You Ronggui Hu State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Thoracic Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China Department of Pathogenic Biology West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China School of Medicine Guizhou UniversityGuiyang 550025China Key Laboratory of Medical Molecular Virology(MOE&MOH) School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Hospital Infection Management Department of Infectious DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Dear Editor,Although effective vaccines and antiviral therapies are available,hepatitis B virus(HBV)infection is still a serious global health *** HBV infection remains the principal cause of liver cirrhosis and hepatocellular carcinoma(HCC).HBV is a small DNA virus,owning a~3.2 kb genome that encodes several proteins:viral DNA polymerase,core antigen(HBcAg),E antigen(HBeAg),three surface antigens(PreS1/PreS2/HBsAg),and a regulatory X protein(HBx)(Lamontagne et al.,2016).X protein,named for its lack of homology with any known proteins,is a 154 aa protein that plays an essential role in HBV biology and regulates the development of HCC(Yang et al.,2022).Although previous studies have strongly expanded our understanding of HBx,the regulation of HBx is not completely elucidated.

关键词： infection cirrhosis

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Photonics-assisted THz wireless communication enabled by wide-bandwidth packaged backilluminated modified uni-traveling-carrier photodiode

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Opto-Electronic Science 2024年第7期3卷 20-29页

作者： Yuxin Tian Boyu dong Yaxuan Li Bing Xiong Junwen Zhang Changzheng Sun Zhibiao Hao Jian Wang Lai Wang Yanjun Han Hongtao Li Lin Gan Nan Chi Yi Luo Beijing National Research Center for Information Science and Technology(BNRist) Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Key Laboratory of Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China Flexible Intelligent Optoelectronic Device and Technology Center Institute of Flexible Electronics Technology of THUJiaxing 314000China

This paper presents a wide-bandwidth back-illuminated modified uni-traveling-carrier photodiode(MUTC-PD)packaged with standard WR-5 rectangular waveguide for high-speed wireless *** optimized epitaxy structure and coplanar waveguide electrodes,the fabricated 4-μm-diameter PD exhibits ultra-flat frequency response and high saturation *** passive circuits including low-loss bias-tee and E-plane probe are designed to package the PD into a compact module with waveguide *** packaged PD module has demonstrated a flat frequency response with fluctuations within±2.75 d B over a broadband of 140–220 GHz and a high saturated output power of-7.8 d Bm(166μW)at 140 *** wireless communication applications,the packaged PD is used to implement 1-m free space transmission at carrier frequencies of 150.5 and 210.5 GHz,with transmission rates of 75 and 90 Gbps,respectively.

关键词： modified uni-traveling-carrier photodiode integrated bias-tee E-plane probe flat frequency response high saturation power WR-5 output THz wireless communications

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Application of subharmonic-aided pressure estimation in a patient with giant hepatic cyst:A case report

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Portal Hypertension & Cirrhosis 2024年第2期3卷 124-127页

作者： Xiuyun Lu Jiaying Cao Yaozu Liu Jingqin Ma Jianjun Luo Yi dong Wenping Wang Shanghai Institute of Medical Imaging ShanghaiChina Department of Ultrasound Zhongshan HospitalFudan UniversityShanghaiChina Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Interventional Radiology Zhongshan HospitalFudan UniversityShanghaiChina National Clinical Research Center for Interventional Medicine Zhongshan HospitalFudan UniversityShanghaiChina

Giant hepatic cysts may lead to impaired liver function by compressing surrounding tissue,resulting in symptoms such as nausea or portal ***-aided pressure estimation(SHAPE)offers a noninvasive method for quantitatively estimating pressure and monitoring interstitial fluid pressure.A 55-year-old female patient with giant hepatic cysts was admitted to our hospital with elevated protein electrophoretic gamma levels,likely caused by compression of important liver vessels by the *** surgery,B-mode ultrasound(BMUS)revealed multiple anechoic cystic lesions with thin,smooth walls in the right *** SHAPE,the curve of the portal vein was lower than that of the hepatic vein,which is absolutely different from a healthy volunteer in our previous SHAPE *** suggested that the patient may have had portal *** days after laparoscopic fenestration and drainage of hepatic cysts,the size of the largest cyst had decreased on BMUS and protein electrophoretic gamma levels had *** the curve of the portal vein remained lower than that of the hepatic vein,the difference between them had decreased compared to presurgery *** shows promise as a tool for noninvasively estimating portal hypertension and improving prognosis assessment in patients.

关键词： hepatic admitted impaired

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