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China CDC weekly 2023年第1期5卷 1-4,I0001-I0003页

作者： Keyang Lyu Qin Wang Xia Li Zhuona Zhang Xiaoning Zhao Yunpu Li Zhigang Tang Longjian Li fuchang deng Xiaoyu Zhang Kaiqiang Xu Rong Zhao Dongqun Xu Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Division of Chemical Analysis Biology and MedicineBeijing Institute of MetrologyBeijingChina Mentougou District Center for Disease Control and Prevention BeijingChina Beijing Center for Disease Control and Prevention BeijingChina

Summary What is already known about this topic?There is a toilet flush-soil stack-floor drain pathway of aerosol transmission in multistory and high-rise buildings,but the influencing factors are not completely *** is added by this report?The poor airtightness of the connecting parts of the floor drain,as well as pressure fluctuations in the sewage pipe during toilet flushing caused by blockage of the soil stack vent,may lead to the cross-floor transmission of viral aerosols through the soil stack and floor drains.

关键词： connecting floor drain

Independent and Interactive Effects of Environmental Conditions on Aerosolized Surrogate SARS-CoV-2-Beijing,China,June to September 2020

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China CDC weekly 2022年第26期4卷 565-569,I0004,I0005页

作者： Yixin Mao Yueyun Luo Wenda Zhang Pei Ding Xia Li fuchang deng Kaiqiang Xu Min Hou Cheng Ding Youbin Wang Zhaomin Dong Raina MacIntyre Xiaoyuan Yao Song Tang Dongqun Xu China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina University of South Carolina ColumbiaSCUSA School of Space and Environment Beihang UniversityBeijingChina Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijingChina The Kirby Institute Faculty of MedicineThe University of New South WalesSydneyNSWAustralia Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu ProvinceChina

Summary What is already known about this topic?Environmental factors such as temperature and humidity play important roles in the transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)via droplets/*** is added by this report?Higher relative humidity(61%–80%),longer spreading time(120 min),and greater dispersal distance(1 m)significantly reduced SARS-CoV-2 pseudovirus *** was an interaction effect between relative humidity and spreading *** are the implications for public health practice?The findings contribute to our understanding of the impact of environmental factors on the transmission of SARS-CoV-2 via airborne droplets/aerosols.

关键词： humidity finding interaction

PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study

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The Innovation 2022年第2期3卷 110-118页

作者： Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang fuchang deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Jinan Municipal Center for Disease Control and Prevention JinanShandong 250021China Shandong Provincial Center for Disease Control and Prevention JinanShandong 250014China

Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular *** addition,an association between PM_(2.5) and gut microbiota and metabolites was *** above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence.

关键词： exposure explain PM

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基于规则的混合型燃料电池汽车能量管理策略

青岛大学学报（工程技术版） 2023年第3期38卷 75-80页

作者：邓富昌张校锋广西科技师范学院职业技术教育学院广西来宾546100

针对燃料电池存在的启停次数多和耐久性差等问题,本文主要对燃料电池与锂电池组合的混合驱动型燃料电池汽车能量管理策略进行研究。结合燃料电池汽车动力系统结构布置形式,通过使用AVL Cruise软件,搭建燃料电池汽车整车模型,并对燃料电... 详细信息

针对燃料电池存在的启停次数多和耐久性差等问题,本文主要对燃料电池与锂电池组合的混合驱动型燃料电池汽车能量管理策略进行研究。结合燃料电池汽车动力系统结构布置形式,通过使用AVL Cruise软件,搭建燃料电池汽车整车模型,并对燃料电池汽车能量管理策略进行分析,给出了能量管理控制策略工作流程。同时,通过Matlab DLL方式,将在Matlab/Simulink中制定的能量管理策略模型加载到整车仿真模型中,采用NEDC测试工况进行仿真分析。仿真结果表明,车辆在NEDC循环工况运行过程中,仿真车速与期望车速重合度较高,呈现出较好的车速跟随效果,满足驾驶员对车速的需要,使动力电池SOC保持在合理范围内。改变仿真初始条件,当电池SOC初始值为75%,55%和45%时,氢气消耗量有所不同,最高可达2.131 kg/100 km,该研究对实车能量控制具有一定的借鉴意义。

关键词：燃料电池汽车能量管理策略动力系统有限状态机动力电池

Reproductive toxicity, plasma cytokines and non-targeted metabolomics of male rats affected by borax

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Reproductive toxicity, plasma cytokines and non-targeted met...

应用型本科职教师范专业“岗课赛证”融合育人路径探析

中国毒理学会第七次全国会员代表大会暨中国毒理学会第六次...

作者： Chong Wang Lian Duan Chao Wang Ying Shi Wen Gu Yongjun Xu fuchang deng Yufeng Gong Song Tang Hongwei Zhang National Institute of Environmental Health Chinese Center for Disease Control and Prevention

OBJECTIVE To investigate effects of boron on reproductive system, plasma cytokines and non-targeted metabolommics of male rats and indicate the possible mechanisms of it. METHOD Male rats were treated with different doses of borax for 28 days via oral gavage,then blood samples and tissues were used for determination of plasma cytokines, non-targeted metabolomics and testicular enzymes respectively. At the end of boron exposure period, male rats performed series mating assay to assess fertility. RESULT The results of this study indicated FSH increased significantly at the highest dose of boron （100mg B/kg bw/day） while LH levels in plasma had little be influenced. Testicular biomarker enzymes in testis especially MDH and G3PDH levels showed that had a tendency of decrease and declined significantly relative to control group in the highest group. In addition, female pregnancy rate and fetal malformation rate reduced apparently at the first two weeks in recovery fertility test. Metabolomics demonstrated only in the highest dose group had obvious differences from control group and at least six main possible pathways involved in the metabolic mechanisms of boron exposure. Moreover, immunerelated factors and metabolic hormones determined by high-throughput method with Milliplex MAP Liquid phase chip analysis platform failed to show any changes. except for IL-5 and VEGF significantly changed. CONCULUSION The results indicated boron could partly affect immunerelated factors which regulated hormone secretion and release to further influence reproductive system and immune system and several lipid classes and amino acid metabolism have been strongly affected at the highest level of borax by global metabolic analysis. Fertility recovery test showed the effects of boron on the teratogenicity was earlier than that on fertility. It would be beneficial to further reveal boron toxic mechanism correlating these findings from the study and better assess any potential benefit of boron

关键词：

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宁波职业技术学院学报 2023年第6期27卷 77-84页

作者：莫家业刘霞云邓富昌广西科技师范学院广西来宾456199

“岗课赛证”融合育人是职教师资培养改革发展的新举措。职教师范专业在“岗课赛证”融合育人过程中,其核心任务是对接职业岗位、职业技能大赛、职业技能等级证书的新要求重构课程体系。推进职教师范专业“岗课赛证”融合育人的路径包括... 详细信息

“岗课赛证”融合育人是职教师资培养改革发展的新举措。职教师范专业在“岗课赛证”融合育人过程中,其核心任务是对接职业岗位、职业技能大赛、职业技能等级证书的新要求重构课程体系。推进职教师范专业“岗课赛证”融合育人的路径包括:明晰职教师范专业人才培养目标,促进“岗课赛证”融合育人发展;构建多元协同的职教师范专业“岗课赛证”融通模式;深化校企命运共同体,搭建多元参与共同培养的职教师资平台,推动职教师范专业技术性、职业性、师范性“三性”融合。

关键词：应用型本科职教师范专业 “岗课赛证”融合

北京市不同季节室外细菌气溶胶分布特征及其环境影响因素分析

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环境科学研究 2022年第2期35卷 556-565页

作者：雒月云毛怡心庄思琪邓富昌侯敏唐宋姚孝元中国疾病预防控制中心环境与人群健康重点实验室中国疾病预防控制中心环境与健康相关产品安全所北京100021 徐州医科大学公共卫生学院江苏徐州221004 南京医科大学公共卫生学院全球健康中心江苏南京211166

为了解北京市室外细菌气溶胶的分布特征,基于培养法分析了2020年9月—2021年5月不同季节细菌气溶胶浓度及粒径的分布特征,探讨气象因素(温度和相对湿度)和空气颗粒物(PM_(10)和PM_(2.5))对细菌气溶胶分布特征的影响.结果表明:①北京市... 详细信息

为了解北京市室外细菌气溶胶的分布特征,基于培养法分析了2020年9月—2021年5月不同季节细菌气溶胶浓度及粒径的分布特征,探讨气象因素(温度和相对湿度)和空气颗粒物(PM_(10)和PM_(2.5))对细菌气溶胶分布特征的影响.结果表明:①北京市室外细菌气溶胶平均浓度为447.10 CFU/m^(3)(每立方米空气中的菌落形成单位),呈春季〔(648.55±537.24)CFU/m^(3)〕>冬季〔(324.50±181.99)CFU/m^(3)〕>秋季〔(319.59±305.07)CFU/m^(3)〕的特征,不同季节细菌气溶胶浓度差异不显著.②北京市室外约80%的细菌气溶胶直径大于2.1μm,细菌气溶胶浓度在第2级(粒径为4.7~7.0μm)显著降低,峰值粒径出现在第1级(粒径>7.0μm).粒径大于7.0μm的细菌气溶胶在春季与秋季以及春季与冬季之间均存在统计学差异(p均小于0.05).可进入人体下呼吸道的细菌气溶胶(≤4.7μm)比例近50%(冬季、秋季、春季占比分别为61.0%、58.9%、41.6%),冬季空气中可进入人体下呼吸道的细菌气溶胶比例最高.③Spearman相关性分析表明,室外环境细菌气溶胶浓度与相对湿度呈显著负相关(p<0.05),与PM_(10)浓度呈显著正相关(p<0.05),表明细菌气溶胶浓度受气象因素和空气污染物的影响.研究显示,北京市室外环境中可进入人体下呼吸道的细菌气溶胶比例近50%,冬季细菌气溶胶暴露风险最高.

关键词：室外环境细菌气溶胶浓度粒径分布

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偶氮染料毒性效应研究进展

中华预防医学杂志 2020年第12期54卷 1478-1483页

作者：邓富昌王超顾雯陈圆圆韩家骏杜华茂彭辉唐宋中国疾病预防控制中心环境与人群健康重点实验室中国疾病预防控制中心环境与健康相关产品安全所北京100021 多伦多大学化学系 M5S3H6 西南大学生物技术学院重庆400715

中国是世界第一大染料生产和使用国。偶氮染料的大量生产和广泛使用导致环境污染,以及潜在的人体健康风险。环境介质(水、土、气、灰尘等)、食物和服装中的偶氮染料可经多种暴露途径进入人体,部分可代谢生成毒性更强的代谢产物,从而引... 详细信息

中国是世界第一大染料生产和使用国。偶氮染料的大量生产和广泛使用导致环境污染,以及潜在的人体健康风险。环境介质(水、土、气、灰尘等)、食物和服装中的偶氮染料可经多种暴露途径进入人体,部分可代谢生成毒性更强的代谢产物,从而引发过敏反应、肿瘤生成、内分泌干扰等毒性效应。本文综述了偶氮染料的生产使用、环境浓度、人群暴露、毒代动力学、毒性效应及其机制和法规标准,同时展望了偶氮染料的研究趋势。

关键词：毒性作用致癌物,环境内分泌干扰物分散染料

超高含量的α-酮戊二酸和谷胱甘肽促成HeLa细胞耐受纳米银

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生物工程学报 2023年第10期39卷 4189-4203页

作者：陈鹤鸣何雨婧陈学情邓富昌鲁志松刘英帅杜华茂西南大学蚕桑纺织与生物质科学学院重庆400715 中国疾病预防控制中心环境与健康相关产品安全所北京100021 西南大学材料与能源学院重庆400715

纳米银(silver nanoparticles,AgNPs)兼有优良的抗菌和抗癌作用,但病原体或癌细胞对其的耐受作用将影响其临床应用,前者耐受纳米银已见报道。本研究以HeLa细胞为模型,探讨癌细胞耐受纳米银的可能性及耐受机制。将HeLa细胞代谢物与纳米... 详细信息

纳米银(silver nanoparticles,AgNPs)兼有优良的抗菌和抗癌作用,但病原体或癌细胞对其的耐受作用将影响其临床应用,前者耐受纳米银已见报道。本研究以HeLa细胞为模型,探讨癌细胞耐受纳米银的可能性及耐受机制。将HeLa细胞代谢物与纳米银混合后测定其抗菌活性和细胞毒性变化,并用紫外-可见(ultraviolet visible,UV-Vis)分光光度计、粒度仪和透射电镜等检测混合体系中纳米银的理化特征。用非靶向代谢组学分析纳米银结合的代谢物种类,经腹腔注射HeLa细胞建立荷瘤小鼠,并分析血清对纳米银稳定性的影响。结果表明HeLa细胞代谢物可抑制纳米银的抗癌和抗菌作用,这种抑制作用表现出剂量依赖性,对纳米银生物学活性产生抑制作用的效应代谢物耐热、不溶于氯仿、含硫元素,分子量小于1 kDa。抑制作用的实质是使纳米银发生了聚集,筛选得到有115种代谢物能结合纳米银。进一步探究发现仅当α-酮戊二酸(α-ketoglutarate,AKG)和谷胱甘肽(glutathione,GSH)的浓度共同达到一定阈值才导致纳米银聚集,而HeLa细胞代谢物中两者的浓度分别是正常宫颈上皮细胞的10倍和6倍,达到了该阈值。动物实验结果显示荷瘤小鼠血清导致纳米银聚集率显著高于健康鼠血清(P<0.05)。本研究揭示HeLa细胞中具有超常含量的α-酮戊二酸和谷胱甘肽,两者协同破坏纳米银的胶体稳定性,从而实现逃逸纳米银的抗癌作用。

关键词：纳米银癌细胞耐药性代谢组学胶体稳定性

Filtration efficiency of face masks against aerosolized surrogate SARS-CoV-2 at different social distances

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Science Bulletin 2022年第6期67卷 565-568页

作者： Song Tang Xia Li Pei Ding Yixin Mao fuchang deng Yu’e Cha Siqi Zhuang Cheng Ding Jiao Wang Youbin Wang Xiaoning Zhao Rachael M.Jones Biao Kan C.Raina MacIntyre Dongqun Xu Xiaoming Shi China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China Section of Ecological Environment&Energy Resources Beijing Institute of MetrologyBeijing 100012China Department of Family and Preventive Medicine School of MedicineUniversity of UtahSalt Lake City 84108USA State Key Laboratory for Infectious Disease Prevention and Control National Institute of Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The Kirby Institute Faculty of MedicineThe University of New South WalesSydney 2052Australia

The coronavirus disease 2019(COVID-19)pandemic is an unpreedented global *** has become clear that COVID-19 is transmitted by virus-containing droplets(>5μm)and aerosols(<5μm),and that all human exhalatory activities(e.g.,breathing,speaking,singing,shouting,coughing,and sneezing)result in the emission of suspended droplets/aerosols of various *** an example,COVID-19 patients exhale millions of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA copies into the air per hour[1].SARS-CoV-2-laden aerosols play a profound role in disease transmission,as they can linger and remain viable in the air for a long duration(~16 h)[2]and travel a long distance(~4.8 m)due to their smaller size[3].

关键词：过滤效率气溶胶替代物