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COCP:Coupling Parameters Content Placement Strategy for In-Network Caching-Based Content-Centric Networking

Computers, Materials & Continua 2022年第6期71卷 5523-5543页

作者： Salman Rashid Shukor Abd Razak fuad A.Ghaleb Faisal Saeed Eman H.Alkhammash School of Computing Faculty of EngineeringUniversiti Teknologi MalaysiaJohor Bahru81310Malaysia College of Computer Science and Engineering Taibah UniversityMedina 42353Saudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

On-path caching is the prominent module in Content-Centric Networking(CCN),equipped with the capability to handle the demands of future networks such as the Internet of Things(IoT)and vehicular *** main focus of the CCN caching module is data dissemination within the *** of the existing strategies of in-network caching in CCN store the content at the maximumnumber of routers along the downloading ***,content redundancy in the network increases significantly,whereas the cache hit ratio and network performance decrease due to the unnecessary utilization of limited cache ***,content redundancy adversely affects the cache resources,hit ratio,latency,bandwidth utilization,and server *** proposed an in-network caching placement strategy named Coupling Parameters to Optimize Content Placement(COCP)to address the content redundancy and associated *** novelty of the technique lies in its capability tominimize content redundancy by creating a balanced cache space along the routing path by considering request rate,distance,and available cache *** proposed approach minimizes the content redundancy and content dissemination within the network by using appropriate locations while increasing the cache hit ratio and network *** COCP is implemented in the simulator(Icarus)to evaluate its performance in terms of the cache hit ratio,path stretch,latency,and link *** experiments have been conducted to evaluate the proposed COCP *** proposed COCP technique has been compared with the existing state-of-theart techniques,namely,Leave Copy Everywhere(LCE),Leave Copy Down(LCD),ProbCache,Cache Less forMore(CL4M),and *** results obtained with different cache sizes and popularities show that our proposed caching strategy can achieve up to 91.46%more cache hits,19.71%reduced latency,35.43%improved path stretch and 38.14%decreased link *** results confirm that the proposed COCP strateg

关键词： Content-centric networking on-path caching content redundancy security privacy data dissemination internet of things

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Efficient protocols and methods for high-throughput utilization of the Collaborative Cross mouse model for dissecting the genetic basis of complex traits

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Animal Models and Experimental Medicine 2019年第3期2卷 137-149页

作者： Hanifa J.Abu-Toamih Atamni fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of Medicine Tel Aviv University

The Collaborative Cross(CC)mouse model is a next‐generation mouse genetic reference population(GRP)designated for a high‐resolution quantitative trait loci(QTL)mapping of complex traits during health and *** CC lines were generated from reciprocal crosses of eight divergent mouse founder strains composed of five classical and three wild‐derived *** traits are defined to be controlled by variations within multiple genes and the gene/environment *** this article,we introduce and present variety of protocols and results of studying the host response to infectious and chronic diseases,including type 2 diabetes and metabolic diseases,body composition,immune response,colorectal cancer,susceptibility to Aspergillus fumigatus,Klebsiella pneumoniae,Pseudomonas aeruginosa,sepsis,and mixed infections of Porphyromonas gingivalis and Fusobacterium nucleatum,which were conducted at our laboratory using the CC mouse *** traits are observed at multiple levels of the body systems,including metabolism,body weight,immune profile,susceptibility or resistance to the development and progress of infectious or chronic ***,we present full protocols and step‐by‐step methods,implemented in our laboratory for the phenotypic and genotypic characterization of the different CC lines,mapping the gene underlying the host response to these infections and chronic *** CC mouse model is a unique and powerful GRP for dissecting the host genetic architectures underlying complex traits,including chronic and infectious diseases.

关键词： Collaborative Cross(CC)mouse model complex traits genetic reference population(GRP),infectious and chronic diseases quantitative trait loci(QTL)

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Lowering fasting blood glucose with non-dialyzable material of cranberry extract is dependent on host genetic background,sex and diet

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Animal Models and Experimental Medicine 2023年第3期6卷 196-210页

作者： Fatima Amer-Sarsour Rana Tarabeih Itzhak Ofek fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

Background:Type 2 diabetes(T2D)is a polygenic metabolic disease,character-ized by high fasting blood glucose(FBG).The ability of cranberry(CRN)fruit to regulate glycemia in T2D patients is well ***,a cohort of 13 lines of the genetically diverse Collaborative Cross(CC)mouse model was assessed for the effect of non-dialyzable material(NDM)of cranberry extract in lowering fasting blood ***:Eight-week-old mice were maintained on either a standard chow diet(con-trol group)or a high-fat diet(HFD)for 12 weeks,followed by injections of intraperi-toneal(IP)NDM(50 mg/kg)per mouse,three times a week for the next 6 *** FBG(mg/dl)was measured bi-weekly and percentage changes in FBG(%FBG)between weeks 0 and 12 were ***:Statistical analysis showed a significant decrease in FBG between weeks 0 and 12 in male and female mice maintained on ***,a non-significant in-crease in FBG values was observed in male and female mice maintained on HFD dur-ing the same *** administration of NDM during the following 6 weeks,the results show a variation in significant levels of FBG lowering between lines,male and female mice and under the different ***:The results suggest that the efficacy of NDM treatment in lowering FGB depends on host genetic background(pharmacogenetics),sex of the mouse(phar-macosex),and diet(pharmacodiet).All these results support the need for follow-up research to better understand and implement a personalized medicine approach/uti-lization of NDM for reducing FBG.

关键词： chow diet(CHD) collaborative cross(CC)mouse model fasting blood glucose(FBG) high-fat diet(HFD) non-dialyzable material(NDM)of cranberry extract type 2 diabetes(T2D)

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Dissipative flow features of Carreau nanofluid with thermal radiation inside plane wall channel:Jeffery-Hamel analysis

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Propulsion and Power Research 2023年第2期12卷 253-272页

作者： Sohail Rehman Hashim fuad A.MAl-Yarimi Sultan Alqahtani Mohammed Awade Department Mechanical Engineering School of Material Sciences and EngineeringGeorgia Institute of TechnologyAtlantaGAUSA Department of Mathematics and Statistics University of HaripurHaripur 22620Pakistan Department of Computer Science King Khalid UniversityMuhayel AseerSaudi Arabia College of Engineering Mechanical Engineering DepartmentKing Khalid UniversityAbhaSaudi Arabia Department of Information Systems King Khalid UniversityMuhayel AseerSaudi Arabia

The current article communicates a numerical investigation on laminar flow of dissipative generalized Newtonian Carreau nanofluid flowing through vertical conduit with converging and diverging plane *** and concentration characteristics due to enthalpy change,activation energy,and non-linear thermal radiation have been examined in the presence of buoyancy *** channel walls for both temperature and volumetric fraction are assumed to be *** instability mechanism of nanofluids is reported using a two-phase nanofluid model,which works reasonably well for nanoparticle concentrations below a certain threshold.A Jeffery-Hamel(J-H)flow model is developed by assuming an incompressible purely radial flow of Carreau nanofluids with heat and mass *** the suitable non-dimensional variables,the resulting nonlinear partial differential equations are turned into a system of ordinary differential *** modified governing equations are then numerically solved using the built-in boundary value problem solver bvp4c,on the template form of commercial software *** impacts of material,geometrical and thermophysical parameters governing the J-H problem are discussed and *** indicate that higher buoyance forces incline the velocity profiles in converging enclosure,while a slight reduction is perceived in opposing forces.A significant decrease of wall heat transmission is reflected for larger values of activation energy and radiation *** endorsing this communication,a comparison analysis is established with existing research and noticed a remarkable ***,the flow inside converging and diverging channels are deployed in nuclear reactors that use plate-type nuclear energies,high heat-flux condensed heat exchangers,high-performance micro-electronic cooling systems,jets,rockets nozzles,and jet propulsion inlet.

关键词： Nanofluids Buoyancy forces Converging/diverging channels Thermal radiation Activation energy Carreau fluid

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Source rock geochemistry of central and northwestern Niger Delta: Inference from aromatic hydrocarbons content

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能源地球科学(英文) 2023年第3期4卷 9-17页

作者： Akinsehinwa Akinlua Olugbemiga Raphael Dada fuad Oluseyi Usman Solomon Adeniyi Adekola Fossil Fuels and Environmental Geochemistry Department of ChemistryObafemi Awolowo UniversityIle-IfeNigeria Department of Geology Obafemi Awolowo UniversityIle-IfeNigeria

The influence of origin, depositional environment and thermal maturity of organic matter on the occurrence of aromatic hydrocarbons in source rocks from the central and northwestern Niger Delta was investigated. Eighty two source rock samples from four oil wells in the central and northwestern Niger Delta were analyzed for the aromatic hydrocarbon content using gas chromatography-mass spectrometry (GC-MS). The results of analysis of aromatic hydrocarbon fractions of the source rock extracts show the presence of many classes of aromatic hydrocarbons, which include naphthalenes, phenanthrenes, biphenyls, dibenzothiophenes and fluorenes. Trimethylnaphthalene (TMN) is the most abundant among the naphthalenes while dimethylphenanthrene (DMP) is the most abundant among the phenanthrenes. Among the biphenyls, 3-methylbiphenyl (3 MB) is the most abundant while 4-methyldibenzothiophene (4MDBT) is the most abundant among the dibenzothiphenes. Only two fluorenes were detected, and fluorene is more in abundance than 1-methylfluorene (1 MF). Depositional environment indicators of aromatic hydrocarbon organic matter reveal that the organic materials in the source rocks in these wells were deposited in marine-to-swamp depositional environments under reducing to suboxic conditions. Thermal maturity indicators calculated from the abundance of the aromatic hydrocarbons indicate that the source rock samples are thermally mature. Most of the source rocks are at the peak of oil window while a few at the early oil window. Source rocks from wells GB, OP and OT in the central Niger Delta are thermally more mature than those from well AW in the northwestern Niger Delta.

关键词： Source rock Aromatic hydrocarbon Thermal maturity Depositi onal envir onment Niger Delta

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A New Approach to Select Doubled Haploid Rice Lines under Salinity Stress Using Indirect Selection Index

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Rice science 2021年第4期28卷 368-378,I0024-I0026页

作者： Muhammad fuad ANSHORI Bambang Sapta Purwoko Iswari Saraswati Dewi Sintho Wahyuning Ardie Willy Bayuardi SUWARNO Graduate School of IPB University(Bogor Agricultural University) Bogor 11680Indonesia Department of Agronomy Faculty of AgricultureHasanuddin UniversitySouth Sulawesi 90245Indonesia Department of Agronomy and Horticulture Faculty of AgricultureIPB University(Bogor Agricultural University)Bogor 11680Indonesia Indonesian Center for Agricultural Biotechnology and Genetic Resources Research and Development Bogor 16112Indonesia

This study determined the indirect selection index of doubled haploid(DH)rice using a multivariate analysis approach to select lines adaptive to salinity stress,comprising three *** first experiment involved the selection of good agronomic characters in a field experiment conducted at an experimental station in Bogor,*** second experiment involved salinity tolerance screening through hydroponic cultures using 0 and 120 mmol/L NaCl,conducted at a greenhouse in *** third experiment involved the validation of the indirect adaptability selection index(IASI)through a field experiment in Sukra(saline area).Field experiments followed a randomized complete block design(RCBD),whereas an RCBD nested factorial design was used for the greenhouse *** first and second experiments used 56 DH lines and four check varieties with three *** the second experiment,Pokkali and IR29 varieties were also added as tolerant and sensitive checks of salinity,*** third experiment used 28 selected DH lines,Inpari 29 and one sensitive DH *** good agronomic index(GAI)was 0.465 yield+0.433 number of productive tillers+0.31 number of filled *** generated 24 DH rice lines with good agronomic *** salinity tolerance index(SaTI)was developed through the average of standardized salinity tolerance score and salinity selection index based on discriminant *** generated 34 DH rice lines with good salinity stress *** IASI(IASI=GAI–SaTI)selected 28 DH rice lines adaptive to salinity stress and it was considered effective by Sukra validation.

关键词： adaptability to salinity doubled haploid multivariate analysis rice selection index

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Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model,cellular platform,and clinical human data

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Animal Models and Experimental Medicine 2023年第6期6卷 537-558页

作者： Osayd Zohud Iqbal M.Lone Aysar Nashef fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael Department of Oral and Maxillofacial Surgery Baruch Padeh Medical CenterPoriyaIsrael Azrieli Faculty of Medicine Bar-Ilan UniversityRamat GanIsrael

Head and neck squamous cell cancer(HNSCC)is a leading global *** year,More than 830000 people are diagnosed with HNSCC globally,with more than 430000 *** is a deadly diverse malignancy with many tumor locations and biological *** originates from the squamous epithelium of the oral cavity,oropharynx,nasopharynx,larynx,and *** most frequently impacted regions are the tongue and *** investigations have demonstrated the critical role of host genetic susceptibility in the progression of *** the advances in our knowledge,the improved survival rate of HNSCC patients over the last 40 years has been *** to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic *** results indicate a need to identify more genetic factors underlying this complex disease,which can be better used in early detection and prevention *** lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC *** this report,we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes(*** 4 and P53 genes)to identify genetic factors affecting the development of this complex disease using genome-wide association studies,epigenetics,micro RNA,long noncoding RNA,lnc RNA,histone modifications,methylation,phosphorylation,and proteomics.

关键词： animal models Collaborative Cross mice genomics head and neck squamous cell cancinoma host genetic susceptibility

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Histopathologic effects of a low molecular weight heparin on bone healing in rats:a promising adjuvant in dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 838-842页

作者： Mehmet Numan Alp Ozdamar fuad Oken Mustafa Fevzi Sargon Ahmet Ucaner Department of Ophthalmology Numune Training andResearch HospitalAnkara 06100Turkey Department of Orthopedics and Traumatology NumuneTraining and Research HospitalAnkara 06100Turkey Department of Anatomy Faculty of MedicineHacettepeUniversityAnkara 06100Turkey

AIM： To investigate the effect of short -term prophylactic dose of a low molecular weight heparin （LMWH） drug on the bone healing process in an animal model simulating the osteotomy obtained in dacryocystorhinostomy. METHODS： Forty male Wistar albino rats were divided into 2 groups. Subcutaneous injections of enoxaparin 1 mg/kg （enoxaparin-treated group） and saline solution （control group） were performed once daily for 4d, beginning on the first preoperative day. The osteotomy was created at the femoral diaphysis in all animals by using a Kirschner wire. Each group was further divided into 2 subgroups depending on the timing of the second operation, 14 or 21d following initial osteotomy. Patent osteotomy area on the second and the third weeks in each group were calculated by using a computer software on digital micrographs. RESULTS： The patent osteotomy areas at the second and the third weeks were significantly larger in the enoxaparin-treated group than those of the control group （P〈0.001 for each time-period）. In the control group, the patent osteotomy area at the third week of healing was significantly smaller than that of the second week （P=0.003）, whereas there was no significant difference between these two measurements in the enoxaparin-treated group （P=0.185）. CONCLUSION： Short -term administration of enoxaparin resultes in a significant alteration in bone healing at 14 and 21d after injury. LMWHs can be regarded as promising alternative adjuvants in dacryocystorhinostomy after being evaluated with further clinical and animal studies,

关键词： dacryocystorhinostomy enoxaparin woundhealing low molecular weight heparin

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A study of the influence of genetic variance and sex on the density and thickness of the calvarial bone in collaborative cross mice

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动物模型与实验医学(英文) 2023年第4期6卷 355-361页

作者： Uriel Kaspersky Roei Levy Aysar Nashef fuad A.Iraqi Yankel Gabet Department of Anatomy and Anthropology Tel Aviv UniversityTel AvivIsrael Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel Aviv69978Israel Department of Oral and Maxillofacial Surgery Baruch Padeh medical centerPoriyaIsrael

Background:Bone microarchitecture is affected by multiple genes,each having a small effect on the external *** is thus challenging to characterize the genes and their specific effect on bone thickness and *** purpose of this study was to assess the heritability and the genetic variation effect,as well as the sex effect on the calvarial bone thickness(***)and calvarial porosity(%PoV)using the Collaborative Cross(CC)mouse ***:In the study we examined the parietal bones of 56 mice from 9 lines of CC *** parameters were evaluated using microcomputed tomography(μCT)and included *** and%*** then evaluated heritability,genetic versus environmental variance and the sex effect for these ***:Our morphometric analysis showed that *** and%PoV are both significantly different among the CC lines with a broad sense heritability of 0.78 and 0.90,*** sex effect within the lines was significant in line IL111 and showed higher values of *** and%PoV in females compared to *** line IL19 there was a borderline sex effect in *** in which males showed higher values than ***:These results stress the complexity of sex and genotype interactions controlling *** and%PoV,as the skeletal sexual dimorphism was dependent on the genetic *** study also shows that the CC population is a powerful tool for establishing the genetic effect on these traits.

关键词： calvarial porosity(%PoV) calvarial thickness(Ca.Th) collaborative cross mouse population diploe heritability sex effect

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Preparation and Investigation of Mechanical and Physical Properties of Flax/Glass Fabric Reinforced Polymer Hybrid Composites

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Journal of Flow Control, Measurement & Visualization 2023年第3期11卷 165-182页

作者： Sayed hasan Mahmud Md. Washim Akram Md. fuad Ahmed Md. Atik Bin Habib Department of Textile Engineering National Institute of Textile Engineering & Research Dhaka Bangladesh Department of Fashion Design & Apparel Engineering National Institute of Textile Engineering & Research Dhaka Bangladesh Department of Textile Fashion and Design R. P. Shaha University Narayangaj Bangladesh

Synthetic reinforced composites affect the environment adversely and have become a global concern, causing increased natural composite demand for sustainability and cost effectiveness. Glass is a popular material that is highly consumed in reinforced composites for its superior mechanical strength. As opposed to that, flax obtained from flax stalks can be used as an alternative reinforcing material with synthetic fibers to minimize manmade fiber consumption. Hence, this research work addresses a few flax/glass-reinforced hybrid composites by using a thermoset polyester matrix. Here, six categories of samples are made, like neat flax, neat glass, and flax/glass fabric reinforced hybrid composite, followed by different stacking layer sequences and hand layout techniques during processing. Afterwards, the mechanical behavior, thermal stability, morphological behavior, and water absorption of hybrid samples were investigated. Among the developed samples, neat glass (NG) composite exhibits superior mechanical properties, while neat flax (NF) shows the lowest result. It is apparent that the mechanical properties and thermal stability of hybrid samples are in between NF and NG because, by adding glass with flax fabric, the strength of hybrid samples is increased. Moreover, it is noticeable that, due to multiple stacking layers of flax and glass, hybrid 3 and hybrid 4 show better strength than consecutive single stacking layers in hybrid 1 and hybrid 2. Among all hybrid composites, the H4 shows comparatively better mechanical and thermal properties due to having the glass layers on the outermost surface. In summary, this research work demonstrated the feasibility of flax fabric with glass fabric as a reinforced hybrid composite that can be used in automobile inner bodies, household furnishing, and home interior decoration.

关键词： Flax-Glass Fabric Reinforced Composites Mechanical Properties SEM TGA Polyester Resin

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