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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-Hee Park su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

A Model for Precipitation Kinetics in Vanadium Microalloyed Steel

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Journal of Iron and Steel Research International 2010年第2期17卷 36-42页

作者： FANG Fang yong Qi-long YANG Cai-fu su Hang Structure Material Institute Central Iron and Steel Research Institute Beijing 100081 China

Small dispersoid particles inhibit recrystallization which is critical in controlling the grain structure of many high strength low alloy steels. A general kinetic model has been developed to predict precipitation of V（C, N） in vanadium microalloyed steels with a series of carbon and nitrogen contents. The solubility product and driving force of carbonitrides precipitated in austenite as well as the interracial energy and other parameters can be evaluated to predict Nucleation rates-Temperature （NrT） and Precipitation-Time-Temperature （PTT） diagram. By using stress relaxation tests and fitting with Avrami equation, it is possible to draw PTT diagrams. The predictions of the model coincide with results of experimental investigation on V（C, N） precipitation in austenite. The nose temperature is around 850 ℃ obtained by experiment which is different from the prediction of the model and the difference is 30 ℃, and nitrogen has more effect on the shape of ＂C＂ curve of PTT diagram than carbon that makes ＂C＂ curve move leftward significantly.

关键词： kinetic calculation model PTT curve stress relaxation nitrogen

Application of underdetermined blind source separation in ultra-wideband communication signals

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The Journal of China Universities of Posts and Telecommunications 2013年第3期20卷 13-19页

作者： fu yong-qing GUO Hui su Dong-lin LIU Yan College of Information and Communication Engineering Harbin Engineering University EMC Laboratory Beijing University of Aeronautics and Astronautics

Aiming to the estimation of source numbers, mixing matrix and separation of mixing signals under underdetermined case, the article puts forward a method of underdetermined blind source separation （UBSS） with an application in ultra-wideband （UWB） communication signals. The method is based on the sparse characteristic of UWB communication signals in the time domain. Firstly, finding the single source area by calculating the ratio of observed sampling points. Then an algorithm called hough-windowed method was introduced to estimate the number of sources and mixing matrix. Finally the separation of mixing signals using a method based on amended subspace projection. The simulation results indicate that the proposed method can separate UWB communication signals successfully, estimate the mixing matrix with higher accuracy and separate the mixing signals with higher gain compared with other conventional algorithms. At the same time, the method reflects the higher stability and the better noise immunity.

关键词： UBSS UWB single source area detection hough-windowed amended subspace projection

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Microstructure and Precipitation Behavior in HAZ of V and Ti Microalloyed Steel

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Journal of Iron and Steel Research International 2009年第3期16卷 68-72,77页

作者： FANG Fang yong Qi-long YANG Cai-fu su Hang China Iron and Steel Research Institute Group Beijing 100081 China

Three steels containing 0.05%C-0.1%V-0.01%N （steel V-LN）,0.05%C-0.1%V-0.02%N （steel V-HN）,and 0.05%C-0.1%V-0.02%N-0.01%Ti （steel V-HN-Ti）,which were all essentially vanadium microalloyed steels,were subjected to simulating the microstructure of a coarse grained heat affected zone （CGHAZ）. The process involved reheating to 1 350 ℃,rapid cooling to room temperature,and varying the welding heat input from 15 kJ/cm to 54 kJ/cm,including four cooling rates of t8/5 equal to 7.5 s,20 s,40 s,100 s,and the relationship of heat input to t8/5 was calculated by Quiksim software. The microstructure and precipitation of vanadium and titanium carbon nitrides are studied. The results indicate that the microstructure consists of granular bainite and some side plate ferrite in the grain boundary when the steels are produced with the highest heat input. As the heat input decreased,numerous polygonal ferrites and grain boundary ferrites appeared,and the size apparently increased. When the steel contained high nitrogen,it was considerably easier to form martensite-austenite island,which was even worse for the toughness and other properties of the steel. For the limitation of cooling time,vanadium carbon nitrides could not precipitate sufficiently,but as titanium was added,the unmelted or precipitated TiN on cooling absorbed some fraction of nitrogen in the matrix and made more precipitate positions for the round V（C,N）,and thus several useful round particles could be seen in titanium-contained steel,and most of them were around TiN. By this experiment,we can conclude that with the help of titanium,nitrogen-enhanced steel had a better prior austenite grain size,was considerably easier to precipitate,reduced free nitrogen in the matrix effectively,and provided a very effective mechanism for restriction grain growth in the HAZ.

关键词： precipitate weld input toughness nitrogen

Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer

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Journal of Integrative Medicine 2021年第5期19卷 408-417页

作者： Hao Gou Ruo-chen Huang fu-lei Zhang yong-hua su Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Internal Medicine Tianjin Binhai New Area Hospital of TCMFourth Teaching Hospital of Tianjin University of TCMTianjin 300451China International Joint Cancer Institute Naval Medical UniversityShanghai 200433China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China

Objective: Bufalin is an effective drug for the treatment of liver cancer. But its high toxicity, poor watersolubility, fast metabolism and short elimination half-life limit its use in tumor treatment. How to make the drug accumulate in the tumor and reduce side effects while maintaining its efficacy are urgent problems to be solved. The goal of this study is to solve these ***: A copolymer with tunable poly-N-isopropylacrylamide and polylactic acid was designed and synthesized. The corresponding dual targeting immunomicelles(DTIs) loaded with bufalin(DTIs–BF)were synthesized by copolymer self-assembly in an aqueous solution. The size and structure of DTIs–BF were determined by ZetaSizer Nano-ZS and transmission electron microscopy. Then, its temperature sensitivity, serum stability, critical micelle concentration(CMC), entrapment efficiency(EE), drug release and non-cytotoxicity of blank block copolymer micelles(BCMs) were evaluated. Next, the effects of DTIs–BF on cellular uptake, cytotoxicity, and tumor cell inhibition were evaluated. Finally, the accumulation of DTIs–fluorescein isothiocyanate(FITC) and the in vivo anti-tumor effect were observed using an interactive video information ***: DTIs–BF had a small size, spherical shape, good temperature sensitivity, high serum stability, low CMC, high EE, and slow drug release. The blank BCMs had very low cytotoxicity. Compared with free bufalin, the in vitro cellular internalization and cytotoxicity of DTIs–BF against SMMC-7721 cells were significantly enhanced, and the effects were obviously better at 40 ℃ than 37 ℃. In addition, the therapeutic effect on SMMC-7721 cells was further enhanced by the programmed cell death specifically caused by bufalin. When DTIs–FITC were injected intravenously in BALB/c nude mice bearing liver cancer,the accumulation of FITC was significantly increased in ***: DTIs–BF is a potentially effective nano-formulation and has broad prospects in the cl

关键词： Bufalin Liver cancer Epidermal growth factor receptor Immunomicelles

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Effect of geometric parameters and grazing incidence on magnetic polaritons excited in 1D multi-groove gratings

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Science China(Technological Sciences) 2021年第8期64卷 1589-1598页

作者： su ChengShuai fu CeJi LTCS and Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China

In this paper,effect of geometric parameters and grazing incidence on excitation of magnetic polaritons(MPs)in a 1D multigroove grating with different groove depths made of silver was *** results reveal that when the distance between grooves is sufficiently small,the resonance wavelengths of MPs excited in the grooves of unequal depths exhibit red shift with decrease of the distance,contrary to the case with equal groove *** shift of the MP resonance wavelengths was explained with the LC circuit ***,it was found that the resonance wavelengths of MPs depend linearly on the groove depths except when the difference between the groove depths is *** the grooves have equal depths,a large drop of the absorptance can occur due to the interaction and cancellation of the electric field vectors in the region between the ***,the results show that when a TM wave is at grazing incidence,MPs can be excited simultaneously in the grooves at a blue-shifted wavelength due to reduction of the effective capacitance,resulting in a dramatic enhancement of the ***,the results in this work may provide useful guidance in the design of wavelength-selective absorbers based on MPs.

关键词： multi-groove grating magnetic polaritons absorptance LC circuit model