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血糖浓度对荷瘤小鼠^(18)F-FDG体内分布的影响

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同位素 2003年第2期16卷 88-91页

作者：付占立林景辉王荣福朱绍莉张春丽潘中允北京大学第一医院核医学科北京100034

为探讨血糖浓度对荷瘤小鼠18F-FDG体内分布的影响,取35只皮下接种艾氏腹水癌(EAC)一周后的小鼠禁食20h,随机分为对照组(n=11)与糖负荷组(n=12),分别给予蒸馏水和50%葡萄糖0.5mL灌胃,另有两组分别给予10%葡萄糖(5只)和30%葡萄糖(7只)0.5m... 详细信息

为探讨血糖浓度对荷瘤小鼠18F-FDG体内分布的影响,取35只皮下接种艾氏腹水癌(EAC)一周后的小鼠禁食20h,随机分为对照组(n=11)与糖负荷组(n=12),分别给予蒸馏水和50%葡萄糖0.5mL灌胃,另有两组分别给予10%葡萄糖(5只)和30%葡萄糖(7只)0.5mL灌胃,1h后测血糖并尾静脉注射18F-FDG,再1h后放血处死,计算各组织SUV及肿瘤SUVc。糖负荷组荷瘤小鼠血糖浓度(11.98±3.01mmol/L)较对照组(3.95±1.11mmol/L)显著升高(P0.05)。肿瘤、脑、脾、血SUV及肿瘤与肌肉摄取比与血糖浓度呈显著性负相关,r分别为:-0.76,-0.92,-0.78,-0.48,-0.63(P<0.01);心、肌肉SUV及肿瘤与脑、心与血摄取比、肿瘤SUVc与血糖浓度呈显著性正相关,r分别为:0.85,0.43,0.51,0.85,0.45(P<0.01)。结果表明,血糖浓度变化显著影响荷瘤小鼠肿瘤及正常组织对18F-FDG的摄取。

关键词：血糖浓度荷瘤小鼠 ^18F—FDG 分布影响艾氏腹水癌 EAC 葡萄糖诊断显像剂

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肺结节少见CT征象对病变的诊断价值

实用放射学杂志 2007年第3期23卷 315-317页

作者：林吉征唐立民张传玉殷泽富李绍科路晓东青岛大学医学院附属医院放射科青岛大学医学院附属医院放射科山东青岛266003

目的探讨肺结节的少见CT征象,提高周围型肺癌的诊断正确率。方法回顾分析经手术病理或临床治疗证实的186例肺内结节(139例周围型肺癌和47例其它肺内结节)的少见CT征象(多囊状透亮影、肿瘤胸膜侧的模糊小片状影、磨玻璃影)在肺癌和其它... 详细信息

目的探讨肺结节的少见CT征象,提高周围型肺癌的诊断正确率。方法回顾分析经手术病理或临床治疗证实的186例肺内结节(139例周围型肺癌和47例其它肺内结节)的少见CT征象(多囊状透亮影、肿瘤胸膜侧的模糊小片状影、磨玻璃影)在肺癌和其它结节中的出现率。结果多囊状透亮影和肿瘤胸膜侧模糊小片状影在肺癌中出现率明显高于肺内其它结节(P<0.05)。磨玻璃影在肺癌和其它结节的出现率无显著差异。在肺癌中,磨玻璃影在细支气管肺泡癌中的出现率明显高于其它类型肺癌(P<0.001)。结论多囊状透亮影和肿瘤胸膜侧模糊小片状影对肺癌的诊断有较高价值,肺癌中磨玻璃影的出现常提示细支气管肺泡癌的可能。

关键词：胸部肺结节体层摄影术,X线计算机

持续质量改进在军队中小型医院专科护士培训中的应用

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实用临床护理学电子杂志 2019年第18期4卷 1-1页

作者：何明霞张朝柱何平邵福丽解放军第273医院

目的探索持续质量改进理论在提高军队中小型医院专科护士培训中的应用。方法应用持续质量改进理论,加强对专科护士的能力培训,比较开展持续质量改进计划前后的差异。结果参加专科培训的护士在应用持续质量改进后其专科理论、专科操作、... 详细信息

目的探索持续质量改进理论在提高军队中小型医院专科护士培训中的应用。方法应用持续质量改进理论,加强对专科护士的能力培训,比较开展持续质量改进计划前后的差异。结果参加专科培训的护士在应用持续质量改进后其专科理论、专科操作、健康教育、综合技能考核得分较之开展持续质量改进前都有明显的提高。结论军队中小型医院专科护士培训中应用持续质量改进不断改进培训方法,有效地提高护士临床专业技术水平,确保了较好的培训效果。

关键词：持续质量改进专科护士培训

^(153)Sm-EDTMP和博宁治疗恶性肿瘤骨转移骨痛的疗效比较

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同位素 2002年第2期15卷 111-114页

作者：王荣福朱绍莉朱玫北京大学第一医院核医学科北京100034

为比较放射性药物^(153)Sm-EDTMP和化疗药物博宁对恶性肿瘤骨转移骨痛的疗效,将恶性肿瘤骨转移骨痛患者18例随机分为^(153)Sm组和博宁组各9例进行分组治疗;采用骨病状况评分标准,对患者治疗前后的骨痛状况进行评分。受试者治疗前骨痛评... 详细信息

为比较放射性药物^(153)Sm-EDTMP和化疗药物博宁对恶性肿瘤骨转移骨痛的疗效,将恶性肿瘤骨转移骨痛患者18例随机分为^(153)Sm组和博宁组各9例进行分组治疗;采用骨病状况评分标准,对患者治疗前后的骨痛状况进行评分。受试者治疗前骨痛评分均≥6分;止痛效果采用4级评定法。结果:^(153)Sm-EDTMP。组9例中2例好转,7例显效,无完全缓解,有效率为77.8％;博宁组9例中无效和加重4例,1例好转,显效3例,完全缓解1例,有效率44.4％;^(153)Sm-EDTMP对骨髓抑制作用为一过性,博宁无明显骨髓抑制作用;^(153)Sm-EDTMP与博宁治疗恶性肿瘤骨转移骨痛有效率相近(P=0.334 8),且疼痛减轻持续3周以上,但一过性血液毒性比博宁略为显著。

关键词：博宁治疗 ^153Sm-EDTMP 帕米磷酸二钠恶性肿瘤骨转移骨痛疗效放射性药物并发症骨转移癌

Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan li Carl Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing Sun Jie lin Xiaoyu Fan Binbin Jia Mengdi Cai linlin li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Guest Editorial: Understanding low temperature plasmas for device reliability, modulation and application to green energy strategy

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High Voltage 2023年第6期8卷 1093-1094页

作者： Yangyang fu Tao shao Department of Electrical Engineering Tsinghua UniversityBeijingChina Institute of Electrical Engineering Chinese Academy of SciencesBeijingChina

Low temperature plasma stands at the forefront of green and clean energy technologies,showcasing remarkable versatility across a wide array of applications including material processing,water splitting,methane conversion,and plasma *** fully harness the potential of this technology,it is imperative to deepen our understanding of the physics underlying various discharge structures.

关键词： energy methane splitting

ANALYSIS OF ELASTO-PLASTIC POSTBUCKliNG AND ENERGY RELEASE RATE FOR DELAMINATED FIBER METAL LAMINATED BEAMS IN THERMAL ENVIRONMENT

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Acta Mechanica Solida Sinica 2015年第6期28卷 693-705页

作者： Yiming fu Yang Chen Xuefei shao State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University College of Mechanical and Vehicle Engineering Hunan University

The elasto-plastic postbuckling of fiber metal laminated beams with delamination and the energy release rate along the delamination front are discussed in this paper. Considering geometrical nonlinearity, thermal environment and geometrical initial imperfection, the incremental nonlinear equilibrium equations of delaminated fiber metal laminated beams are established, which are solved using the differential quadrature method and iterative method. Based on these, according to the J-integral theory, the elasto-plastic energy release rate is studied. The effects of some important parameters on the elasto-plastic postbuckling behavior and energy release rate of the aramid reinforced aluminum laminated beams are discussed in details.

关键词： fiber metal laminated beams delamination temperature effect elasto-plastic post- buckling elasto-plastic energy release rate

Position, Singularity and Workspace Analysis of 3-PSR-O Spatial Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2015年第3期28卷 437-450页

作者： shao Jiejie CHEN Wenyu fu Xin State Key Laboratory of Fluid Power Transmission and Control Zhejiang University

Although the parallel mechanisms have the advantages of high accuracy, velocity, stiffness, and payload capacity, the shortcomings of the space utilization and workspace limit the applications in the confined space. A novel 3 degrees of freedom spatial parallel manipulator 3-PSR-O（prismatic-spherical-revolute） is proposed, which possesses a compact architecture and extended workspace while maintaining the inherent advantages of the parallel mechanisms. The direct-inverse position, singularity and workspace are investigated. The mapping method is adopted in the position analysis, and the closed form solution is derived in the form of a six order equation. The singularity analysis of the mechanism is also carried out based on the geometrical constraints, including six singularity boundaries. A feature boundary, which is independent of the prismatic joints＇ stroke limit, is obtained by integrating the six singularity boundaries. According to the formation of the reachable workspace, a concept of basic workspace is also introduced and presented in the analytical way. By demarcating the basic workspace along the central height with the feature boundary, the reachable workspace can be derived and analyzed more efficiently. Finally, a comparative study on the space utilization between the 3-PSP parallel mechanism and the new mechanism is also presented. The area of feature boundary of the new mechanism is about 140% of the 3-PSP parallel mechanism, while its installation radius is only 1/2 of the 3-PSP parallel mechanism. The proposed parallel mechanism shows great space utilization, and is ideally suited for applications in confined space occasions such as immersion lithography, nano-imprint etc.

关键词： spatial-planar parallel mechanism direct-inverse position analysis reachable workspace basic workspace feature boundary