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基于自然的青藏高原一体化生态保护修复优化管理

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中国科学院院刊 2024年第7期39卷 1123-1130页

作者：王军傅伯杰张骁刘焱序赵文武自然资源部国土整治中心(自然资源部土地科技创新中心)自然资源部土地整治重点实验室北京100035 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085 北京师范大学地理科学学部地表过程与资源生态国家重点实验室北京100875

青藏高原对中国乃至全球起着重要的生态安全屏障作用,近年来生态环境状况总体改善。但青藏高原在重点攻坚和协同治理、自然恢复和人工修复、高质量发展和高水平保护等关系处理上仍存在诸多管理挑战。文章提出利用“基于自然的解决方案... 详细信息

青藏高原对中国乃至全球起着重要的生态安全屏障作用,近年来生态环境状况总体改善。但青藏高原在重点攻坚和协同治理、自然恢复和人工修复、高质量发展和高水平保护等关系处理上仍存在诸多管理挑战。文章提出利用“基于自然的解决方案”开展适应性管理,建议基于“三级尺度框架”落实生态保护修复规划,基于定量化的生态监测、评估和预警数据开展气候变化和人类扰动下的生态保护修复工程适应性管理,基于利益相关方协同治理提升生态保护修复的公众参与度,从而实现基于自然的青藏高原一体化生态保护修复优化管理。

关键词：基于自然的解决方案适应性管理景观尺度社区参与

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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han Wenhui Li Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang Guobin liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and *** of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological *** patients with major depressive disorder,NLRP3 inflammasome levels are significantly *** the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic *** this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 ***,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating ***,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to ***,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression *** modulation of NLRP3 inflammasomes in microglia holds promise for the management of *** investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

Microstructures, Fabrics, and Seismic Properties of Mylonitic Amphibolites: Implications for Strain Localization in a Thickening Anisotropic Middle Crust of the North China Craton

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Journal of Earth Science 2024年第3期35卷 769-785页

作者： Siqi liu Bo Zhang Jinjiang Zhang Jian Zhang Lei Guo Tao Wang Baoyou Hang Xiaorong Li Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China Department of Earth Sciences The University of Hong KongHong KongChina Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

Strain localization processes in the continental crust generate faults and ductile shear zones over a broad range of scales affecting the long-term lithosphere deformation and the mechanical response of faults during the seismic *** anisotropy originated within the continental crust can be applied to deduce the kinematics and structures within orogens and is widely attributed to regionally aligned minerals,e.g.,***,naturally deformed rocks commonly show various structural layers(e.g.,strain localization layers).It is necessary to reveal how both varying amphibole contents and fabrics in the structural layers of strain localization impact seismic property and its interpretations in terms of *** present microstructures,petrofabrics,and calculate seismic properties of deformed amphibolite with the microstructures ranging from mylonite to *** transition from mylonite to ultramylonite is accompanied by a slight decrease of amphibole grain size,a disintegration of amphibole and plagioclase aggregates,and amphibole aspect ratio increase(from 1.68 to 2.23),concomitant with the precipitation of feldspar and/or quartz between amphibole *** intensities of amphibole crystallographic preferred orientations(CPOs)show a progressively increasing trend from mylonitic layers to homogeneous ultramylonitic layers,as indicated by the JAm index increasing from 1.9–4.0 for the mylonitic layers and 4.0–4.8 for the transition layer,to 5.1–6.9 for the ultramylonitic *** CPO patterns are nearly random for plagioclase and *** amphibole aggregates in the amphibolitic mylonite deform by diffusion,mechanical rotation,and weak dislocation creep,and develop CPOs *** polymineralic matrix(such as quartz and plagioclase)of the mylonite and the ultramylonite deform dominantly by dissolution-precipitation,combined with weak dislocation *** mean P and S wave velocities are estimated to be 6.3 and 3.5 km/

关键词： amphibolitic mylonite microstructures petrofabrics seismic property middle crust rheology tectonics.

Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen liu Hui Jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang Zhao Weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous *** the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified *** this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing *** work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Detection of SARS-CoV-2 based on artificial intelligence-assisted smartphone:A review

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Chinese Chemical Letters 2024年第7期35卷 25-34页

作者： Yunxin Li Jinghui Zhang Jisen Chen Feng Zhu Zhiqiang liu Peng Bao Wei Shen Sheng Tang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore

In recent years,the application of smartphone in various fields has received great attention,and it has become a promising tool in virus detection,data processing and data *** the rapid spread of COVID-19 around the world,many traditional detection methods have been combined with smartphone to assist in the analysis and detection of the novel coronavirus(SARS-CoV-2),including electrochemistry,fluorescence and *** the gradual development of artificial intelligence(AI),the combination of AI and smartphone to analyze SARS-CoV-2 was also the focus of *** on the summary of the traditional methods combined with smartphone to detect SARS-CoV-2 virus,in addition to AI-based data processing,AI algorithms are also employed for SARS-CoV-2 detection *** review discussed both strategies and focused on the application of the *** combination of AI algorithm and smartphone to detect SARS-CoV-2 has high accuracy,which is more conducive to meeting the needs of portable *** addition,the classification of SARS-CoV-2 virus samples in biological fluids such as blood and saliva was also ***,this paper briefly discussed the limitations of using smartphone analysis to detect SARS-CoV-2,as well as the prospect and future development of virus *** conclusion,the detection methods based on smartphone and AI algorithms show great potential in the detection of SARS-CoV-2 and can be a valuable complement to traditional analysis methods.

关键词： COVID-19 SARS-CoV-2 virus Detection method Smartphone analysis Artificial intelligence

Evaluation of antibody responses in healthy individuals receiving SARS-CoV-2 inactivated vaccines

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Biosafety and Health 2024年第3期6卷 153-164页

作者： Ziyu liu Liyan Cai Man Xing Nan Qiao Jiaojiao liu Xuejun Li Chiyu Zhang Naijun Tang Zhelong Xu Yingying Guo Renfei Lu Dongming Zhou Department of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Physical examination center Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226000China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China Department of Occupational and Environmental Health School of Public HealthTianjin Medical UniversityTianjin 300070China Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226000China

Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in ***,more investigation is still needed to understand antibodies'duration and effectiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants in the real *** this study,575 participants who had been vaccinated with two or three doses of the inactivated vaccine were *** samples were collected and tested for anti-spike IgG and neutralizing antibodies against SARS-CoV-2(original strain,Dela,and Omicron).Unsurprisingly,a third dose of the vaccine significantly enhanced antibody responses against SARS-CoV-2 and its ***,despite a booster dose,the neutralizing antibody levels against Omicron,particularly the BA.5.2 subvariant,remained *** was no sex bias,but an age bias was ***,the predominant IgG subclass antibodies were IgG1 and IgG2,with a much lower level of *** the booster shot,the ratio of IgG4 to IgG1 significantly *** observation of IgG1 to the IgG4 class switch after repeated inactivated vaccinations underscores the importance of continuous monitoring of subclass antibody *** clinical investigations are required to understand the implications of this class switch for optimizing immunization strategies.

关键词： Variant of concern(VOC) Inactivated vaccines Serological study IgG subclasses Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)

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Tropical Cyclone Monitoring and Analysis Techniques: A Review

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Journal of Meteorological Research 2024年第2期38卷 351-367页

作者： chuanhai QIAN Ying LI Yinglong XU Xin WANG Zenghai ZHANG Gaozhen NIE Da liu Shiwen ZHANG Institute for Development and Programme Design China Meteorological AdministrationBeijing 100081 Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081 National Meteorological Centre China Meteorological AdministrationBeijing 100081 National Satellite Meteorological Centre China Meteorological AdministrationBeijing 100081

Tropical cyclones(TCs),including tropical depressions and different categories of typhoons,hurricanes,and cyclonic storms,mostly originate over the oceans in the absence of direct ***,detailed monitoring and analysis of TCs has always been an unsolved *** the recent 20 years,great changes have taken place in domestic and foreign TC monitoring techniques,imposing a significant impact on TC operations and *** new technologies and products gradually emerge to support operations,with improved monitoring *** this paper,the progress on TC monitoring and analysis via meteorological satellites,radars,and airplanes in China and the world is reviewed,compared,and summarized,with special focuses on multisatellite fusion observations,in situ aircraft measurements,and some unconventional observation equipment such as rockets,saildrones,and underwater *** this basis,the paper points out future directions for improving TC monitoring and analysis in aid of better TC forecast and early warning.

关键词： tropical cyclone(TC) monitoring and analysis meteorological satellite aircraft reconnaissance

Bioactive compounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming liu fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang College of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech Co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions