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Atypical presentation of shoulder brucellosis misdiagnosed as subacromial bursitis:A case report

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World Journal of Clinical Cases 2021年第4期9卷 927-934页

作者： fu-sheng wang Khurram Shahzad Wei-Guo Zhang Jie Li Kang Tian Department of Bone and Joint First Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina

BACKGROUND Brucella infections in the shoulder joint are uncommon,and few have been reported in the literature.CASE SUMMARY A 26-year-old male was admitted to our hospital with complaint of recurrent pain and limited movement of the right shoulder.The patient reported the pain to have first occurred as an isolated event 6 mo previously and to have reoccurred 5 mo later,when it was accompanied by limited movement of the shoulder.Findings from physical examination and magnetic resonance imaging(referred to as MRI)suggested the diagnosis of subacromial bursitis,and diagnostic paracentesis and arthroscopic debridement were performed.Surprisingly,synovial fluid culture detected brucella,and the finding was confirmed by mass spectrometry of a colony sample.The diagnosis was corrected to brucellosis of the shoulder joint,and antibiotic drug treatment(oral rifampicin and doxycycline)was administrated for 6 wk.The 4-mo postoperative follow-up examination(MRI)yielded normal findings.The 2-year follow-up showed no signs of recurrence.CONCLUSION This rare case of brucellosis infection in shoulder highlights the importance of increasing awareness to help avoid misdiagnosis.

关键词： Shoulder Misdiagnosis Brucellosis Subacromial bursitis Brucella Case report

Mechanism of C5a-induced immunologic derangement in sepsis

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Cellular & Molecular Immunology 2017年第9期14卷 792-793页

作者： Ruonan Xu Fang Lin Chunmei Bao fu-sheng wang Treatment and Research Centre for Infectious Disease Beijing 100039China The Institute of Intensive Care Unit Beijing 100039China The Institute of Clinical Examination Centre Beijing 100039China

Sepsis is a life-threatening medical condition that triggers an uncontrolled inflammatory reaction and is caused by the entry of various microorganisms into the human bloodstream.Sepsis is mainly encountered in intensive care units(ICUs)due to the reduced immunological defenses of ICU patients.Approximately 1.5 million patients develop sepsis annually in industrialized countries.

关键词： annually C5a ang

Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases

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Cellular & Molecular Immunology 2011年第1期8卷 19-22页

作者： Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi fu-sheng wang Liver Disease Research Center for Biological Therapy Beijing 302 HospitalBeijingChina

Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic disorders.Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte apoptosis.In addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate conditions.Although remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in detail.furthermore,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials.This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases.

关键词： immunomodulation liver diseases mesenchymal stem cells transplantation

Effect of Different Factors on the Quality of Life and Sequelae of COVID-19 Patients After Discharge

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Infectious Diseases & Immunity 2023年第2期3卷 60-66页

作者： Nan Guo Ya-Ping Yao Le Song Guan-Zhen wang Jun-Li He Ning Zheng Qiong Mo Wen-Xu Ni Bo Zhang fu-sheng wang Lei Huang Chinese PLA Medical School Beijing 100853China Department of Infectious Diseases the Fifth Medical CenterChinese PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China Southern Medical University Guangzhou 510515Guangdong ProvinceChina Department of Infectious Diseases Chinese PLA General Hospital of Central Theater CommandWuhan 430070Hubei ProvinceChina Capital Medical University Beijing 100053China Xuanwu Hospital Capital Medical UniversityBeijing 100053China Department of Transfusion Chinese PLA General Hospital of Central Theater CommandWuhan 430070Hubei ProvinceChina.

Background The continued spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)remains an international public health emergency,resulting in a significant global disease burden.The long-term effects of SARS-CoV-2 infection in humans and the long-term prognosis of patients with coronavirus disease 2019(COVID-19)after discharge remain unclear.We aimed to assess the quality of life(QoL)and sequelae in patients with COVID-19 after discharge from the hospital by conducting multiple follow-up visits to understand the long-term effects of SARS-CoV-2 on patients'health and its possible influencing factors.Methods COVID-19 patients discharged from Huoshenshan Hospital(Wuhan,China)between February 15 and April 5,2020,were followed up at 6,9,and 12 months after discharge.They completed questionnaires on postdischarge QoL and sequelae under the guidance of medical staff with professional training.The demographic and clinical characteristics of the COVID-19 patients were analyzed using descriptive statistics.A generalized estimating equation model was used to analyze the QoL-related factors.Theχ2 test(or Fisher exact test)and multivariate logistic regression analysis were used to analyze the sequelae and influencing factors.Results A total of 175 patients participated in at least 1 follow-up visit,and 120 completed all 3 follow-up visits.Patients diagnosed with severe and critically ill COVID-19 had worse mental conditions(χ2=7.653,P=0.022)than those with the nonsevere type(not severe or critical)and were more likely to feel fatigued(χ2=4.836,P=0.028).Female patients had a higher risk of sleep disturbance(χ2=10.026,P=0.002)and dyspnea(χ2=5.672,P=0.017)and had more difficulty returning to their original work and life(χ2=8.922,P=0.003)than male patients.Patients with diabetes had a worse appetite(χ2=4.669,P=0.031)and were more prone to sleep disturbance(χ2=4.417,P=0.036)after discharge.The proportion of patients with at least 1 sequela increased from 29.76%(50/168)at 6 months to 51.11%(69/135)at 9 months(χ2=14.30

关键词： COVID-19 Quality of life Sequelae Follow-up

Hepatitis C: Milestones from discovery to clinical cure

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Military Medical Research 2021年第3期8卷 444-446页

作者： Wei Hu Chao Zhang Ji-Jing Shi Ji-Yuan Zhang fu-sheng wang Medical School of Chinese PLA Beijing 100842China Department of Infectious Diseases the Fifth Medical Centre of Chinese PLA General HospitalNational Clinical Research Centre for Infectious DiseasesBeijing 100039China The Central Laboratory the First People’s Hospital of ZhengzhouZhengzhou 450004China

On October 5th, 2020, Drs. Harvey J. Alter, Michael Houghton and Charles M. Rice were rewarded with Nobel Prize in Physiology or Medicine for "the discovery of hepatitis C virus(HCV)". During the past 50 years, remarkable achievements have been made in treatment of HCV infection: it has changed from being a life-threatening chronic disease to being curable. In this commentary, we briefly summarized the milestone events in the "scientific journey" from the first report of non-A, non-B hepatitis and discovery of the pathogen(HCV) to final identification of efficacious direct-acting antivirals. further, we address the challenges and unmet issues in this field.

关键词： Hepatitis C Nobel prize 2020 Treatment Milestone event

Granulocyte-macrophage colony-stimulating factor:an immunotarget for sepsis and COVID-19

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Cellular & Molecular Immunology 2021年第8期18卷 2057-2058页

作者： Xiuying Mu Kai Liu Huajie Li fu-sheng wang Ruonan Xu Peking University 302 Clinical Medical School BeijingChina Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina

Granulocyte-macrophage colony-stimulating factor(GM-CSF),which belongs to the colony-stimulating factor(CSF)superfamily and was originally identified as a hemopoietic growth factor,is mainly produced by lymphocytes and innate lymphoid cells.Nonhematopoietic cell populations such as fibroblasts,endothelial cells,and epithelial cells may also secrete GM-CSF in response to an activating stimulus.

关键词： stimulating macrophage lymphocytes

Diagnosis and Treatment Protocol for COVID-19 Patients (Tentative 8th Edition): Interpretation of Updated Key Points

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Infectious Diseases & Immunity 2021年第1期1卷 17-19页

作者： Gui-Qiang wang Lei Zhao Xia wang Yan-Mei Jiao fu-sheng wang Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100034China Medical Department of Infectious Diseases Fifth Medical Center of PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China

Coronavirus Disease 2019 (COVID-19) has become a major global public health pandemic. China was the first country to report the epidemic situation, which quickly identified the pathogen, and released the novel coronavirus gene sequence globally. Thus, China has played an essential role in the global fight against COVID-19. Since the outbreak of the epidemic, the Chinese government and citizens have pursued robust prevention and control measures, including wearing masks, hand hygiene, social distancing, etc. Large-scale nucleic acid testing has been fully implemented and has resulted in early detection, reporting, quarantine, and treatment. China’s epidemic situation has been generally brought under control, and the fatality rate has been effectively controlled.[1,2,3,4] Recently there are sporadic cases of COVID-19 in China. Of the locally transmitted cases reported at January 20, 2021, 68 were reported in Heilongjiang, 33 in Jilin, 20 in Hebei, two each in Beijing and Shanxi, and one in Shandong, the National Health Commission reported.[5]

关键词： prevention globally Heilongjiang

Mesenchymal stem cell therapy for severe COVID-19

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Signal Transduction and Targeted Therapy 2021年第10期6卷 2945-2949页

作者： Lei Shi Lifeng wang Ruonan Xu Chao Zhang Yunbo Xie Kai Liu Tiantian Li Wei Hu Cheng Zhen fu-sheng wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious Diseases100039BeijingChina

The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has placed a global public burden on health authorities.Although the virological characteristics and pathogenesis of COVID-19 has been largely clarified,there is currently no specific therapeutic measure.In severe cases,acute SARS-CoV-2 infection leads to immune disorders and damage to both the adaptive and innate immune responses.Having roles in immune regulation and regeneration,mesenchymal stem cells(MSCs)serving as a therapeutic option may regulate the over-activated inflammatory response and promote recovery of lung damage.Since the outbreak of the COVID-19 pandemic,a series of MSC-therapy clinical trials has been conducted.The findings indicate that MSC treatment not only significantly reduces lung damage,but also improves patient recovery with safety and good immune tolerance.Herein,we summarize the recent progress in MSC therapy for COVID-19 and highlight the challenges in the field.

关键词： acute lung clarified

Surveillance for respiratory infectious diseases caused by 6 common viruses in a recruit training site in the Northern region of China

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Military Medical Research 2017年第4期4卷 193-199页

作者： Wei-Wei Chen Wen Xu Yang-Xin Xie Yun-Hui Zhang Dan Wu fu-sheng wang Min Zhao Treatment and Research Center for Infectious Diseases 302 Hospital of PLABeijing 100039China Center for Medical information 302 Hospital of PLABeijing 100039China

Background: Recruit training sites are places with a high incidence of respiratory infectious diseases. Effective surveillance for acute respiratory infectious diseases in a recruit training site is an important way to prevent disease outbreaks.Methods: Eight hundred recruits(722 males and 78 females) enlisted in autumn 2015 received a background survey within 24 h of settlement at the recruit training site, including their general personal information, vaccination history, mental status and clinical symptoms. Then, nasopharyngeal swabs of these recruits were collected to detect common respiratory pathogens [influenza virus type A, influenza virus type B, adenovirus(Adv), human respiratory syncytial virus, human bocavirus and human metapneumovirus] by PCR. In addition, fasting venous blood was collected in the morning for Adv Ig G antibody detection. During the three months of training, the recruits were monitored for symptoms of respiratory infection, and nasopharyngeal swabs were collected from those with an axillary temperature ≥38℃ and other respiratory symptoms within 4 h of symptom onset. Samples were further examined by PCR.Results: Among the 795 effective nasopharyngeal swab samples collected during survey, two cases of group C type 1 Adv were identified by PCR. During the 3 months of training, fever and respiratory symptoms occurred in 39 recruits(incidence rate of 4.9%) and 5 cases of Adv were detected(positive rate of 12.8%). Genotyping showed 3 cases of type 4 Adv and 2 of type 3 Adv. No type 7, 14 or 55 Adv was detected. The Adv-Ig G positive rate of recruits was 48.2%. Among the 5 Adv positive cases with fever and respiratory symptoms, 4 were Adv-Ig G positive.Conclusion: The pathogen carrier rate in recruits was low, and only group C Adv, which causes mild infection in humans, was detected. No respiratory outbreak was observed at the recruit training site, and sporadic cases were mainly caused by type 3 and type 4 Adv.

关键词： Recruit Surveillance Respiratory infectious diseases