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跨通道迁移及其认知神经机制

生物化学与生物物理进展 2024年第1期51卷 94-110页

作者：孙莹孙洵伟王一帆付秋芳中国科学院心理研究所脑与认知科学国家重点实验室北京100101 中国科学院大学心理学系北京100049 北京大学心理与认知科学学院北京100871

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介... 详细信息

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介绍了在物体识别、类别学习和时间知觉等不同领域对跨通道迁移效应的实验研究,之后介绍了支持跨通道迁移的表征类型和相关理论,梳理了跨通道迁移产生的理论及采用事件相关电位(ERP)和功能磁共振成像(fMRI)等技术探讨跨通道迁移神经机制的研究进展,并指出了影响跨通道迁移的因素。最后,对目前跨通道迁移研究成果及其潜在应用进行了总结,并对这一领域未来的研究问题进行了展望。

关键词：跨通道迁移多通道表征跨通道识别通道优势元通道理论

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匝数不对称的环形共模电感特性分析

电子元件与材料 2024年第8期43卷 1009-1016页

作者：邱智勇傅恺宁厦门理工学院电气工程与自动化学院福建厦门361024 厦门市高端电力装备及智能控制重点实验室福建厦门361024

共模电感会产生磁场泄漏,其漏感可以被用作差模感量。分别对匝数对称共模电感与匝数不对称共模电感进行磁路建模,发现匝数不对称共模电感在磁芯磁材的截止频率前可以进一步增加其差模感量。提出一种差共模电感集成方案,将两个匝数不对... 详细信息

共模电感会产生磁场泄漏,其漏感可以被用作差模感量。分别对匝数对称共模电感与匝数不对称共模电感进行磁路建模,发现匝数不对称共模电感在磁芯磁材的截止频率前可以进一步增加其差模感量。提出一种差共模电感集成方案,将两个匝数不对称的共模电感串联堆叠,同时保持L、N线路之间的阻抗平衡。有限元仿真表明,所提方案能够显著增加共模电感的差模阻抗,并降低磁场泄漏。实物测试中,所提方案的阻抗为传统方案的1.5~8倍。插入损耗测试结果显示,在100 kHz~10 MHz范围内,所提方案相比传统方案能够增加8~2. dB的插入损耗,验证了所提方案能够明显改善EMI滤波器的滤波效果。

关键词：不对称共模电感 EMI滤波器磁场泄漏近场耦合插入损耗

Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE qiu LIN fu-xin SU Jin-ye ZHUO Ling-yun ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei LIU De-zhong LIU Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective: To investigate whether Naoxueshu Oral Liquid(NXS) could promote hematoma absorption in post-craniotomy hematoma(PCH) patients. Methods: This is an open-label, multicenter, and randomized controlled trial conducted at 9 hospitals in China. Patients aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL, or intraventricular hemorrhage following cranial surgery were enrolled. They were randomly assigned at a 1:1 ratio to the NXS(10 m L thrice daily for 15 days) or control groups using a randomization code table. Standard medical care was administered in both groups. The primary outcome was the percentage reduction in hematoma volume from day 1 to day 15. The secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7, the absolute reduction in hematoma volume from day 1 to day 7 and 15, and the change in neurological function from day 1 to day 7 and 15. The safety was closely monitored throughout the study. Moreover, subgroup analysis was performed based on age, gender, history of diabetes, and etiology of intracerebral hemorrhage(ICH). Results: A total of 12. patients were enrolled and randomly assigned between March 30, 2.18 and April 15, 2.2.. One patient was lost to follow-up in the control group. Finally, there were 119 patients(60 in the NXS group and 59 in the control group) included in the analysis. In the full analysis set(FAS) analysis, the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group [median(Q1, Q3): 85%(71%, 97%) vs. 76%(53%, 93%), P0.05). furthermore, no adverse events were reported during the study. In the FAS analysis, the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

Investigation on vehicle occupant dummy applicability for under-foot impactloading conditions

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Chinese Journal of Traumatology 2024年第4期27卷 235-241页

作者： Teng-Fei Tian fu-Hao Mo Hao-Yang Su Can Huang Hui Zhao Jun Liu Bo Shang Kui Li Jin-Long qiu State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityChangsha410082China Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Zhongzheng Judicial Expert Center Chongqing400020China NIO Limited Liability Company Shanghai200050China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China

Purpose:Under-foot impact loadings can cause serious lower limb injuries in many activities,such asautomobile collisions and underbody explosions to military *** present study aims to comparethe biomechanical responses of the mainstream vehicle occupant dummies with the human body lowerlimb model and analyze their robustness and applicability for assessing lower limb injury risk in underfoot impact loading ***:The Hybrid III model,the test device for human occupant restraint(THOR)model,and a hybridhuman body model with the human active lower limb model were adopted for under-foot impactanalysis regarding different impact velocities and initial lower limb ***:The results show that the 2.dummy models have larger peak tibial axial force and highersensitivity to the impact velocities and initial postures than the human lower limb *** particular,the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lowerlimb *** the case of minimal difference in tibial axial force,Hybrid III's tibial axial force(7.5 KN)isstill 312.5%that of human active lower limb's(2.4 KN).Even with closer peak tibial axial force values,thebiomechanical response curve shapes of the THOR model show significant differences from the humanlower limb ***:Based on the present results,the Hybrid III dummy cannot be used to evaluate the lowerlimb injury risk in under-foot loading *** contrast,potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for betterapplicability.

关键词： Lower limb Under-foot impact Human body model Dummy Finite element model

网络使用非适应性认知对大学生抑郁的影响:网络风险行为和网络受欺负的链式中介作用

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中国临床心理学杂志 2024年第4期32卷 831-836页

作者：丘文福叶一舵福建师范大学心理学院福州350117 福建师范大学心理健康指导中心福州350117

目的:探究网络使用非适应性认知对大学生抑郁的影响,以及网络风险行为和网络受欺负在二者之间的中介作用。方法:采用网络使用非适应性认知问卷、网络风险行为量表、网络受欺负问卷和抑郁量表对1076名大学生进行调查。结果:(1)网络使用... 详细信息

目的:探究网络使用非适应性认知对大学生抑郁的影响,以及网络风险行为和网络受欺负在二者之间的中介作用。方法:采用网络使用非适应性认知问卷、网络风险行为量表、网络受欺负问卷和抑郁量表对1076名大学生进行调查。结果:(1)网络使用非适应性认知显著正向预测大学生的抑郁;(2.网络风险行为和网络受欺负在大学生的网络使用非适应性认知与抑郁之间均起部分中介作用;(3)网络风险行为和网络受欺负在大学生的网络使用非适应性认知与抑郁之间起链式中介作用。结论:网络使用非适应性认知可通过网络风险行为和网络受欺负显著正向预测大学生的抑郁。

关键词：网络使用非适应性认知网络风险行为网络受欺负抑郁

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Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models:A Cross-sectional Study in Rural Guangxi

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Biomedical and Environmental Sciences 2024年第1期37卷 3-18页

作者： LIANG Yu Jian RONG Jia Hui WANG Xue Xiu CAI Jian Sheng QIN Li Dong LIU qiu Mei TANG Xu MO Xiao Ting WEI Yan Fei LIN Yin Xia HUANG Shen Xiang LUO Ting Yu GOU Ruo Yu CAO Jie Jing HUANG Chu Wu LU Yu fu QIN Jian ZHANG Zhi Yong Department of Environmental and Occupational Health School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Tumor Immunology and Microenvironmental Regulation Guilin Medical UniversityGuilin 541199GuangxiChina Department of Environmental Health and Occupational Medicine School of Public HealthGuilin Medical UniversityGuilin 541199GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Key Laboratory of Environment and Health Research Guangxi Medical UniversityNanning 530021GuangxiChina Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education Guangxi Medical UniversityNanning 530021GuangxiChina Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care Guilin Medical UniversityGuilin 541199GuangxiChina

Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip *** We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip *** In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P2.−0.652.Pfunction regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength *** the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip ***,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.

关键词： Urinary metals Handgrip strength Quantile g-computation Bayesian kernel machine regression

无人机技术在矿山地形测绘中的应用及其精度分析

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世界有色金属 2024年第16期 160-162页

作者：邱福生江西浒坑钨业有限公司

矿山测绘是矿山开发的基础，决定着后期矿山利用的科学性、合理性乃至安全性。因此，做好矿山测绘工作具有重要意义。但目前，传统测绘存在效率低、误差大等弊端，已经难以满足当前矿山测绘的需求。本文通过对无人机测绘技术及优势阐述... 详细信息

矿山测绘是矿山开发的基础，决定着后期矿山利用的科学性、合理性乃至安全性。因此，做好矿山测绘工作具有重要意义。但目前，传统测绘存在效率低、误差大等弊端，已经难以满足当前矿山测绘的需求。本文通过对无人机测绘技术及优势阐述，明确了无人机技术在矿山测绘中的应用方法，探究了三维重建方法及软件，分析了无人机技术在矿山地形测绘中的应用及其精度，为无人机技术在矿山地形测绘中的应用提供了参考。

关键词：无人机技术矿山地形测绘测绘精度

Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2655-2668页

作者： Rao fu Ruoyao Qi Hualong Xiong Xing Lei Yao Jiang Jinhang He Feng Chen Liang Zhang Dekui qiu Yiyi Chen Meifeng Nie Xueran Guo Yuhe Zhu Jinlei Zhang Mingxi Yue Jiali Cao Guosong Wang Yuqiong Que Mujing Fang Yingbin Wang Yixin Chen Tong Cheng Shengxiang Ge Jun Zhang Quan Yuan Tianying Zhang Ningshao Xia State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryDepartment of Laboratory MedicineSchool of Public Health&School of Life SciencesXiamen UniversityXiamen 361102 FujianChina National Institute of Diagnostics and Vaccine Development in Infectious Diseases Xiamen 361102 FujianChina

Antitumor therapies based on adoptively transferred T cells or oncolytic viruses have made significant progress in recent years,but the limited efficiency of their infiltration into solid tumors makes it difficult to achieve desired antitumor effects when used *** this study,an oncolytic virus(rVSV-LCMVG)that is not prone to induce virus-neutralizing antibodies was designed and combined with adoptively transferred T *** transforming the immunosuppressive tumor microenvironment into an immunosensitive one,in B16 tumor-bearing mice,combination therapy showed superior antitumor effects than *** occurred whether the OV was administered intratumorally or *** therapy significantly increased cytokine and chemokine levels within tumors and recruited CD8^(+)T cells to the TME to trigger antitumor immune *** with adoptively transferred T cells and subsequent oncolytic virotherapy sensitizes refractory tumors by boosting T-cell recruitment,downregulating the expression of PD-1,and restoring effector T-cell *** offer a combination therapy with greater translational value,mRNA vaccines were introduced to induce tumor-specific T cells instead of adoptively transferred T *** combination of OVs and mRNA vaccine also displays a significant reduction in tumor burden and prolonged *** study proposed a rational combination therapy of OVs with adoptive T-cell transfer or mRNA vaccines encoding tumor-associated antigens,in terms of synergistic efficacy and mechanism.

关键词： transferred rational boosting

LD-identify:基于无源RFID的网络学习状态识别

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控制与决策 2024年第1期39卷 219-226页

作者：王涛春邱庆王成田陈付龙安徽师范大学计算机与信息学院安徽芜湖241002 安徽师范大学安徽省医疗大数据智能系统工程研究中心安徽芜湖241002

在线教育中,学生实时动作能够准确反映学生当前的学习状态,在不影响学习注意力和保证个人隐私信息安全的情况下,准确识别学习动作是监测在线教育质量的关键要素.对此,提出一种基于无源RFID的网络学习动作识别系统LD-identify. LD-ident... 详细信息

在线教育中,学生实时动作能够准确反映学生当前的学习状态,在不影响学习注意力和保证个人隐私信息安全的情况下,准确识别学习动作是监测在线教育质量的关键要素.对此,提出一种基于无源RFID的网络学习动作识别系统LD-identify. LD-identify仅通过射频信号完成学生动作识别,所以识别系统可以很好地保护个人的隐私信息,且避免设备昂贵等一系列问题.通过提取相位和信号强度的有效特征和深度学习算法, LD-identify能够获得很好的识别准确率的性能.实验表明, LD-identify只需要在帽子的背面粘贴两个射频标签,就能很好地识别出抬头低头、左右摇头、前倾后倾3种动作.为了进一步验证系统性能,研究6名志愿者在不同的场景中的动作识别的准确率,实验结果显示LD-identify能够在不同的场景下很好地识别所有用户的3种动作,利用卷积神经网络构建分类模型来识别动作可以取得很好的识别率,识别准确率达到95.5%以上.

关键词：无线射频识别动作识别机器学习深度学习标签注意力机制