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International Journal of Ophthalmology(English edition) 2024年第1期17卷 119-125页

作者： Jia-Yu Chen Li-Rong zhang Jia-Wen Liu Jie Hao Hui-Xin Li Qiong-Yue zhang Zhao-Hui Liu Jing fu beijing Tongren Eye center Beijing Tongren HospitalBeijing Key Laboratory of Ophthalmology&Visual SciencesCapital Medical UniversityBeijing 100176China Department of Radiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of Industrial Engineering and Operation research University of CaliforniaBerkeley 94720USA

AIM:To investigate the difference of medial rectus(MR)and lateral rectus(LR)between acute acquired concomitant esotropia(AACE)and the healthy controls(HCs)detected by magnetic resonance imaging(MRI).METHODS:A case-control *** subjects with AACE and eighteen HCs were *** scanning data were conducted in target-controlled central gaze with a 3-Tesla magnetic resonance *** muscles(EOMs)were scanned in contiguous image planes 2-mm thick spanning the EOM origins to the globe *** form posterior partial volumes(PPVs),the LR and MR cross-sections in the image planes 8,10,12,and 14 mm posterior to the globe were summed and multiplied by the 2-mm slice *** data were classified according to the right eye,left eye,dominant eye,and non-dominant eye,and the differences in mean cross-sectional area,maximum cross-sectional area,and PPVs of the MR and LR muscle in the AACE group and HCs group were compared under the above classifications ***:There were no significant differences between the two groups of demographic *** mean cross-sectional area of the LR muscle was significantly greater in the AACE group than that in the HCs group in the non-dominant eyes(P=0.028).The maximum cross-sectional area of the LR muscle both in the dominant and non-dominant eye of the AACE group was significantly greater than the HCs group(P=0.009,P=0.016).For the dominant eye,the PPVs of the LR muscle were significantly greater in the AACE than that in the HCs group(P=0.013),but not in the MR muscle(P=0.698).CONCLUSION:The size and volume of muscles dominant eyes of AACE subjects change significantly to overcome binocular *** LR muscle become larger to compensate for the enhanced convergence in the AACE.

关键词： acute acquired concomitant esotropia magnetic resonance imaging extraocular muscles

Neuropathological features of the spinal cords in Chinese Alzheimer s diseases

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Neuropathological features of the spinal cords in Chinese Al...

Single-atom Pd anchored in the porphyrin-center of ultrathin 2D-MOFs as the active center to enhance photocatalytic hydrogen-evolution and NO-removal

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： GUO Yan-jun~(*,#),WANG Lu-ning~*,ZHU Ming-wei~*,zhang Hong-hong~*, (*Department of Geriatric Neurology,PLA General hospital,beijing 100853,china #Department of Neurology,beijing friendship hospital,capital medical university,beijing 100050,china.)

Objective To study neuropathological features of the spinal Cords in Alzheimer s disease. Methods brain and spinal cord tissue of 3 Alzheimer s disease and 8 controls were *** sections of formalin fixed,paraffin-embedded tissue were obtained from each thoracic,lumbar and sacral spinal cord *** sections(7um) of the same segments were stained with heamaotoxylin and eosin(H-E) and Gallays-Braak(G-B) silver *** were immunostained with a panel of antibodies including anti-tau(AT8),anti-amyloidβ(Aβ),anti-amyloid precursor protein(APP),anti-α-synuclein, anti-ubiquitin,and anti-TDP-43.

关键词： Alzheimer s disease spinal cord hyper phosphorylation tau α-synuclein axonopathy

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Chinese Chemical Letters 2024年第9期35卷 364-368页

作者： Xingyan Liu Chaogang Jia Guangmei Jiang Chenghua zhang Mingzuo Chen Xiaofei Zhao Xiaocheng zhang Min fu Siqi Li Jie Wu Yiming Jia Youzhou He Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China School of Pharmacy North Sichuan Medical CollegeNanchong 637100China Carbon Neutrality Technology Application research center College of River and Ocean EngineeringChongqing Jiaotong UniversityChongqing 400074China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National Local Joint Engineering research center for Road Engineering and Disaster Prevention and Reduction Technology in Mountainous Areas China Merchants Chongqing Communications Technology Research and Design Institute Co.Ltd.Chongqing 400067China Chongqing Culture Relics and Archaeology research Institute Chongqing 400013China

Single-atom catalysts were widely used to treat atmospheric pollution and alleviate energy crises through ***,how to prevent the aggregation of single atoms during the preparation and catalytic processes remained a great ***,a novel ultrathin two-dimensional porphyrin-based single-atom photocatalyst Ti-MOF(abbreviated as TMPd)obtained through a simple hydrothermal synthesis strategy was used for photocatalytic hydrogen evolution and NO removal,in which the singleatom Pd tightly anchored in the center of porphyrin to ensure single-atom Pd stable *** with most reported MOFs-based photocatalysts,the TMPd showed an excellent hydrogen evolution rate(1.32 mmol g^(-1)h^(-1))and the NO removal efficiency(62%)under visible light *** high-angle annular dark-field scanning transmission electron microscope(HAADF-STEM)and synchrotron-radiation-based X-ray absorption fine-structure spectroscopy(XAFS)proved that pd in TMPd existed in an isolated state,and the atomic force microscope(AFM)proved the ultrathin morphology of *** calculations had demonstrated that single-atom Pd could serve as the active center and more effectively achieve electron transfer,indicating that single-atom Pd played a vital role in photocatalytic hydrogen *** addition,a possible photocatalytic pathway of NO removal was proposed based on ESR and in-situ infrared spectra,in which the catalysts anchored with single-atom Pd could produce more active substances and more effectively oxidize NO to NO_(2)^(-)or NO_(3)^(-).The results suggested that coordinating single-atom metal species as the active site in the center of porphyrin could be a feasible strategy to obtain various ultrathin porphyrin-based single-atom photocatalysts to acquire excellent photocatalytic performance further.

关键词： Porphyrin-based MOFs Single-atom Pd Ultrathin 2D nanosheets Hydrogen evolution NO removal

A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

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Science china(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor Serrano Lopes Fangxiao Cheng Junhao Yan Yu fu Wanyi fu Zhaoheng Xie Jianfei Sun Jicong zhang Zhiqian Tong Yajuan Gao Hongbin Han Department of Radiology Peking University Third HospitalBeijing 100191China beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Institute of medical Technology Peking University Health Science CenterBeijing 100191China Department of Informatics Technical University of MunichGarching 80539Germany Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Biological Science and medical Engineering Beihang UniversityBeijing 100191China Key Laboratory of Alzheimer’s Disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA Key Laboratory for Evaluation of medical Imaging Equipment and Technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

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A normalized thoracic coordinate system for atlas mapping in 3D CT images

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Progress in Natural Science:Materials International 2008年第1期18卷 111-117页

作者： Hongkai Wang,Jing Bai*,Yonghong zhang Department of Biomedical Engineering,Tsinghua university,beijing 100084,china Department of Biomedical Engineering Tsinghua University Beijing 100084 China

In this paper,a normalized thoracic coordinate system(NTCS)is defined for rapidly mapping the 4D thoracic organ atlas into indi- vidual CT volume *** coordinate system is defined based on the thoracic *** coordinate values are normalized by the size of the individual thorax so that this coordinate system is universal to different *** compensating the respiratory motion of the organs,a 4D dynamic torso atlas is introduced.A method for mapping this dynamic atlas into the individual image using the NTCS is also *** this method,the dynamic atlas was mapped into the clinical thoracic CT images and rough positions of the organs were found *** NTCS-based 4D atlas mapping method may provide a novel way for estimating the thoracic organ positions in low-resolution molecular imaging modalities,as well as in modern 4D medical images.

关键词： Atlas mapping Registration Segmentation Molecular imaging

Hyperthermia by a nitinol stent in an alternating magnetic field:Safety and feasibility in rabbit esophageal cancer

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Progress in Natural Science:Materials International 2009年第12期19卷 1713-1719页

作者： Jumei Zhou~(a,b),Ning Li~c,Qisheng Xia~d,Lehui Du~a,Xiaowen Wang~b,Linyun Zhao~b, Xufei Wang~b,Jintian Tang~(b,*) a Department of Oncology,Xiangya hospital of Central South university,Changsha 410008,china b Institute of medical Physics and Engineering,Department of Engineering Physics,TsingHua university,beijing 100084,china c The People hospital of zhangqiu City,Jinan 250200,china d Clinical Institute of Science,china-Japan friendship hospital,beijing 100029,china Department of Oncology Xiangya Hospital of Central South University Changsha 410008 China Institute of medical Physics and Engineering Department of Engineering Physics TsingHua University Beijing 100084 China The People hospital of zhangqiu City Jinan 250200 China Clinical Institute of Science China-Japan Friendship Hospital Beijing 100029 China

Hyperthermia by heating in-stent is a potentially new method to treat esophageal *** study assessed the safety of heating the rabbit esophagus with a nitinol stent in an alternating magnetic field(AMF) and investigated whether this method offers a therapeutic option for esophageal *** stents were placed in the cervical esophagi of healthy rabbits,which were heated in an AMF for different times at 43,46 and 50℃.The esophagi were histologically examined after a week to observe whether there was transmural *** esophageal cancer of rabbit placed nitinol stents were heated in an AMF at 46℃for 10 *** were heated to a target temperature within 5 *** highest tolerated temperature and time for the healthy rabbit esophagus was at 46℃for 10 *** growth was delayed by heating and it was statistically *** the rabbit esophageal wall at 46℃for 10 min proves to be safe and effective in delaying tumor growth.

关键词： Hyperthermia Nitinol stent Alternating magnetic field Rabbit Esophageal tumor

Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis

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Military medical research 2024年第2期11卷 287-307页

作者： Pan Luo fu-Qiang Gao Wei Sun Jun-You Li Cheng Wang Qing-Yu zhang Zhi-Zhuo Li Peng Xu Department of Joint Surgery Honghui HospitalXi'an Jiaotong UniversityXi'an 710054China Department of Orthopedics China-Japan Friendship HospitalBeijing 100029China Department of Orthopaedic Surgery of the Perelman School of Medicine University of PennsylvaniaPhiladelphiaPA 19104USA School of Mechanical Engineering Sungkyunkwan UniversitySuwon 16419South Korea Department of Orthopaedic Surgery Peking University Third HospitalPeking UniversityBeijing 100191China Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China State Key Laboratory of Pharmaceutical Biotechnology Division of Sports Medicine and Adult Reconstructive SurgeryDepartment of Orthopedic SurgeryNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China

Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life ***,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of *** fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo ***,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.

关键词： Rheumatoid arthritis Fluorescent probe Imaging Diagnosis Biomarker

Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs

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Acta Pharmacologica Sinica 2004年第12期25卷 93-99页

作者： Ya-li zhang, Xiao-hong TAN2, Mei-fang XIAO, Hui LI, Yi-qing Mao, Xiao YANG2, Huan-ran TAN3 Department of Pharmacology, School of Basic medical Science, Peking university Health Science center, beijing 100083 2Institute of Biotechnology Academy ofMilitary medical Science, beijing 100071, china Department of Pharmacology School of Basic Medical Science Peking University Health Science Center Beijing 100083 China

AIM: To characterize the liver-specific role of glucokinase in maintaining glucose homeostasis and to create an animal model for diabetes. METHODS: We performed hepatocyte-specific gene knockout of glucokinase in mice using Cre-loxP gene targeting strategy. First, two directly repeated loxP sequences were inserted to flank the exon 9 and exon 10 of glucokinase in genomic DNA. To achieve this, linearized targeting vector was electroporated into ES cells. Then G418- and Gancyclovir-double-resistant clones were picked and screened by PCR analysis and the positives identified by PCR were confirmed by Southern blot. A targeted clone was selected for microinjection into C57BL/6J blastocysts and implanted into pseudopregnant FVB recipient. Chimeric mice and their offspring were analyzed by Southern blot. Then by intercrossing the Alb-Cre transgenic mice with mice containing a conditional gk allele, we obtained mice with liver-specific glucokinase gene knockout. RESULTS: Among 161 double resistant clones 4 were positive to PCR and Southern blot and only one was used for further experiments. Eventually we generated the liver specific glucokinase knockout mice. These mice showed increased glucose level with age and at the age of 6 weeks fasting blood glucose level was significantly higher than control and they also displayed impaired glucose tolerance. CONCLUSION: Our studies indicate that hepatic glucokinase plays an important role in glucose homeostasis and its deficiencies contribute to the development of diabetes. The liver glucokinase knock- out mouse is an ideal animal model for MODY2, and it also can be applied for screening anti-diabetic drugs.

关键词： animal disease model non insulin dependent diabetes mellitus type 2 diabetes mellitus glucokinase knockout mice

Analysis on background magnetic field to generate eddy current by pulsed gradient of permanent-magnet MRI

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Science china(Technological Sciences) 2010年第4期53卷 886-891页

作者： ZU DongLin,HONG LiMing,CAO XueMing & TANG Xin Institute of Heavy Ion Physics,beijing City Key Laboratory of medical Physics and Engineering,School of Physics,Peking university,beijing 100871,china Institute of Heavy Ion Physics Beijing City Key Laboratory of Medical Physics and Engineering School of Physics Peking University

In this paper the analytical expressions for the magnetic field H and induction B in iron-pole plates generated by MRI gradient coil are given using line-current and the multilayer dielectric plate model with the mirror-image *** current emanates from the magnetic flux in the iron-pole *** order to fully suppress the eddy current,this magnetic flux should be fully *** research results indicate the magnetic permeability of the resist-eddy plate must be bigger than that of magnetic pole material,*** iron,and that the resist-eddy plate should be thick enough to be far away from its magnetic saturation.

关键词： MRI suppress eddy current gradient coil resist-eddy plate mirror-image method