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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-fu Wang Jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN fu-xin SU Jin-ye ZHUO Ling-yunn ZHU Qing SUN Xiao-chuan JIANG Rong-cai YAO Zhi-gang WANG Lei DANG Yan-wei LIU De-zhong LIU Yang FANG Wen-hua WANG Fang-yu LIN Yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective To investigate whether Naoxueshu Oral Liquid(NXS)could promote hematoma absorption in post-craniotomy hematoma(PCH)*** This is an open-label,multicenter,and randomized controlled trial conducted at 9 hospitals in *** aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL,or intraventricular hemorrhage following cranial surgery were *** were randomly assigned at a 1:1 ratio to the NXS(10 mL thrice daily for 15 days)or control groups using a randomization code *** medical care was administered in both *** primary outcome was the percentage reduction in hematoma volume from day 1 to day *** secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7,the absolute reduction in hematoma volume from day 1 to day 7 and 15,and the change in neurological function from day 1 to day 7 and *** safety was closely monitored throughout the ***,subgroup analysis was performed based on age,gender,history of diabetes,and etiology of intracerebral hemorrhage(ICH).Results A total of 120 patients were enrolled and randomly assigned between March 30,2018 and April 15,*** patient was lost to follow-up in the control ***,there were 119 patients(60 in the NXS group and 59 in the control group)included in the *** the full analysis set(FAS)analysis,the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group[median(Q1,Q3):85%(71%,97%)vs.76%(53%,93%),P0.05).furthermore,no adverse events were reported during the *** the FAS analysis,the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:male patients,patients younger than 65 yea

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

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TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-fu Zhu Rong-hua Yu Shuai Zhou Pei-Pei Tang Rui Zhang Yu-Xin Wu Ran Xu Jia-Ming Wei Ying-Ying Wang Jia-Li Zhang Meng-Ke Li Xiao-Jing Shi Yu-Wei Zhang Guang-Zhi Liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of Henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China Henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

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Chinese pangolins (Manis pentadactyla) are not functionally extinct in China

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 79-81页

作者： Zhi-Cheng Liu Peng Cen Jian-Kun Sun fu-hua Zhang Amna Mahmood Chen Lei Shi-Bao Wu School of Life Sciences South China Normal UniversityGuangzhouGuangdong 510631China

DEAR EDITOR,The key features of functional extinction include continuous reproductive failure,lack of new recruitment,and persistent population decline(Jarićet al.,2016;Roberts et al.,2017).However,the conclusion of functional extinction for the Chinese pangolin(Manis pentadactyla)by the China Biodiversity Conservation and Green Development Foundation(CBC-GDF)based on preliminary field information is unconvincing as they did not assess reproductive function or new individual recruitment of Chinese pangolin populations(Supplementary Materials).

关键词： extinction Roberts Manis

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自然环境老化聚氯乙烯和橡胶微粒对邻苯二甲酸酯类塑化剂的吸附解吸行为

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环境科学 2024年第8期45卷 4946-4955页

作者：朱思甫刘建超陆光华河海大学环境学院浅水湖泊综合治理与资源开发教育部重点实验室南京210098

水环境中微塑料(MPs)与塑化剂共存形成复合污染,但在自然条件下MPs与塑化剂吸附解吸行为机制尚不清楚.以聚氯乙烯(PVC)和橡胶为目标MPs,表征其在大气暴露和湖泊沉积掩埋环境下老化1a后的形貌特征变化,探究MPs老化前后对共存邻苯二甲酸酯...

水环境中微塑料(MPs)与塑化剂共存形成复合污染,但在自然条件下MPs与塑化剂吸附解吸行为机制尚不清楚.以聚氯乙烯(PVC)和橡胶为目标MPs,表征其在大气暴露和湖泊沉积掩埋环境下老化1a后的形貌特征变化,探究MPs老化前后对共存邻苯二甲酸酯(PAEs)类塑化剂的吸附和解吸行为.结果表明,MPs在大气环境暴露和沉积环境掩埋后表面更加粗糙,表现出多孔聚合物的特征,在大气环境下PVC和橡胶羰基指数(CI)分别增加了62.2%和321.2%,而沉积环境分别增加了51.1%和223.1%,大气环境暴露能够加速MPs的老化过程.PAEs通过疏水作用吸附在MPs表面,且吸附量与其疏水特性显著正相关.老化后PVC对PAEs的吸附容量及吸附速率受到抑制.老化促进橡胶对强疏水性PAEs类塑化剂的吸附,抑制了其对弱疏水性PAEs的吸附.环境老化过程降低橡胶对强疏水性PAEs的解吸量,增强橡胶对弱疏水性PAEs的吸附可逆性,提高了PVC对PAEs的解吸率.

关键词：聚氯乙烯(PVC) 邻苯二甲酸酯(PAEs) 橡胶老化吸附解吸

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场景如何基于竞争战略选择借助价值主导逻辑演变赋能商业模式创新?——西贝莜面案例研究

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科学学与科学技术管理 2024年第7期45卷 129-148页

作者：王福高化刘俊华长青内蒙古工业大学经济管理学院呼和浩特010051 内蒙古现代物流与供应链管理研究中心呼和浩特010051 内蒙古互联网经济研究中心呼和浩特010051

场景基于竞争战略选择借助价值主导逻辑演变赋能商业模式创新,但其过程和机理仍不甚清晰。为此,基于竞争战略选择,借助价值主导逻辑演变,以大型餐饮连锁企业西贝莜面为例,采用扎根范式与案例研究相结合的方法发掘和提炼商业模式创新机...

场景基于竞争战略选择借助价值主导逻辑演变赋能商业模式创新,但其过程和机理仍不甚清晰。为此,基于竞争战略选择,借助价值主导逻辑演变,以大型餐饮连锁企业西贝莜面为例,采用扎根范式与案例研究相结合的方法发掘和提炼商业模式创新机理和路径。研究发现:(1)企业以用户时空化消费期望及其变化为航标,以竞争战略选择为航向,以价值主导逻辑演变为航线赋能商业模式创新形成实际航迹。(2)在产品市场化阶段,企业以成本领先战略为主导,借助产品功能价值主导逻辑,通过场景化情境的标准化配置赋能商业模式创新,形成解决痛点的感知市场能力。(3)在服务品牌化阶段,企业以差异化战略为主导,借助服务效用价值主导逻辑,通过场景化情境的个性化配置赋能商业模式创新,形成发掘痒点的感知市场能力和学习吸收能力。(4)在场景体验化阶段,企业以集中化战略为主导,借助场景体验价值主导逻辑,通过场景化情境的双路径配置赋能商业模式创新,形成打造爽点的感知市场能力、学习吸收能力和革新重构能力。

关键词：竞争战略选择价值主导逻辑演变场景化商业模式创新动态能力

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机器人辅助腹腔镜根治性前列腺切除术后Hem-o-lok夹移位嵌入膀胱颈1例报告

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中华泌尿外科杂志 2024年第2期45卷 150-151页

作者：姜力刘超颖付炼胡华重庆市第五人民医院泌尿外科重庆400062

本文报道1例患者, 接受机器人辅助腹腔镜根治性前列腺切除术后22个月出现2枚Hem-o-lok夹移位嵌入膀胱颈, 导致反复下尿路症状。行经尿道联合耻骨上膀胱穿刺, 使用钬激光、电切镜针形电极和腹腔镜设备等, 完全取除移位的Hem-o-lok夹, 效...

本文报道1例患者, 接受机器人辅助腹腔镜根治性前列腺切除术后22个月出现2枚Hem-o-lok夹移位嵌入膀胱颈, 导致反复下尿路症状。行经尿道联合耻骨上膀胱穿刺, 使用钬激光、电切镜针形电极和腹腔镜设备等, 完全取除移位的Hem-o-lok夹, 效果良好。术后6 d拔除尿管后患者排尿通畅。术后随访1个月, 无下尿路症状。对于此类患者, 可采用各种腔内器械配合将移位的Hem-o-lok夹经腔内安全完整取除。

关键词：下尿路症状前列腺肿瘤膀胱结石

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基于MIWOA优化SCN的变压器故障诊断研究

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电工电能新技术 2024年第6期43卷 79-89页

作者：丰胜成张宗瑞付华韩猛辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105 山西潞安环保能源开发股份有限公司王庄煤矿山西长治046204

针对变压器故障诊断精确度低的问题,本文提出了一种多策略改进的鲸鱼优化算法(MIWOA)优化随机配置网络(SCN)的变压器故障诊断模型。首先,对变压器冗杂繁多的原始故障数据进行核主成分分析(KPCA)降维处理,降低无效特征的影响;其次,利用T...

针对变压器故障诊断精确度低的问题,本文提出了一种多策略改进的鲸鱼优化算法(MIWOA)优化随机配置网络(SCN)的变压器故障诊断模型。首先,对变压器冗杂繁多的原始故障数据进行核主成分分析(KPCA)降维处理,降低无效特征的影响;其次,利用Tent混沌映射、动态自适应权重和初级知识获取共享算法对鲸鱼算法(WOA)进行改进,提高其优化能力;然后,在SCN中引入L2范数惩罚项进行正则化处理,并使用改进后的MIWOA算法对SCN惩罚项系数C进行寻优求解,提高SCN分类精度和泛化能力;最后,将降维的数据输入到MIWOA-SCN故障诊断模型中,提高模型收敛速度。结果表明,本文所提出的模型诊断精度为93.1%,与WOA-SCN、GWO-SCN和PSO-SCN诊断模型相比,分别提高了6.89%、9.48%、14.65%,证明MIWOA-SCN诊断模型在变压器故障诊断上具有良好的诊断效果。

关键词：变压器鲸鱼优化算法核主成分分析动态自适应权重初级知识获取共享算法随机配置网络

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黄河流域绿色科技创新竞争力时空分异演变及障碍因素

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地球科学与环境学报 2024年第1期46卷 14-24页

作者：蒋兵付华健张力元山东理工大学管理学院山东淄博255000 长江大学经济与管理学院湖北荆州434023

加快提升绿色科技创新竞争力是实现黄河流域高质量发展的必然需求。在利用纵横向拉开档次法系统评价2009~2020年黄河流域绿色科技创新竞争力的基础上,进一步采用核密度估计和空间马尔科夫链对其时空分布格局和动态演进特征进行深入分析...

加快提升绿色科技创新竞争力是实现黄河流域高质量发展的必然需求。在利用纵横向拉开档次法系统评价2009~2020年黄河流域绿色科技创新竞争力的基础上,进一步采用核密度估计和空间马尔科夫链对其时空分布格局和动态演进特征进行深入分析,并借助障碍度模型分析阻碍黄河流域绿色科技创新竞争力提升的主要因素。结果表明:①黄河流域绿色科技创新竞争力整体发展呈现出“衰退期”“上升期”“再衰期”“重振期”4个阶段的“W”型变化趋势,地区间绿色科技创新竞争力的绝对差异有所缩小,但仍具有显著的“梯度”发展特征,黄河流域上、中、下游绿色科技创新竞争力依次递增;②黄河流域不同等级间的绿色科技创新竞争力具有转移“惰性”,低竞争力地区面临严重的“等级壁垒”,而高竞争力地区则存在“俱乐部趋同”现象,空间溢出效应下,绿色科技创新竞争力转移的“等级锁定”概率有所降低,但仍无法实现跨级跃迁;③黄河流域绿色科技创新竞争力的阻碍因素主要体现在绿色发展不足和成果转化不充分等方面,其中单位GDP能耗、能源消费结构、能源消耗、开放程度和绿色科技论文发表数量是阻碍黄河流域绿色科技创新竞争力提升的主要因素。

关键词：绿色科技创新竞争力时空分异障碍因素拉开档次法核密度估计空间马尔科夫链黄河流域

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全并联AT牵引供电系统雷击故障测距多路径行波算法研究

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铁道学报 2024年第1期46卷 60-71页

作者：钟汉华陈剑云华敏傅钦翠石杰夏天华东交通大学省部共建轨道交通基础设施性能监测与保障国家重点实验室江西南昌330013 中车戚墅堰机车有限公司工艺技术部江苏常州213011

针对AT变压器和并联结构导致行波传播路径复杂,行波波头性质难以有效识别和行波色散现象,线路频变参数特性导致波速不稳定的问题,提出一种基于多路径行波测距方法。基于上下行电流行波传播的差异性,利用电流相似度识别故障区段。探讨全...

针对AT变压器和并联结构导致行波传播路径复杂,行波波头性质难以有效识别和行波色散现象,线路频变参数特性导致波速不稳定的问题,提出一种基于多路径行波测距方法。基于上下行电流行波传播的差异性,利用电流相似度识别故障区段。探讨全并联AT牵引网结构对行波传播特性的影响,并对电流、电压行波传播路径进行标定。基于多路径电流、电压行波极性分析,筛选出用于故障测距的多路径行波,以推导出消去波速的测距方程。仿真表明:所提测距方法可以有效识别波头性质,且计算故障距离基本与波速无关,不受牵引网区段长度、结构影响。

关键词：雷击故障多路径行波全并联AT牵引供电系统行波极性故障测距

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