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Determination of the ED95 of intranasal sufentanil combined with intranasal dexmedetomidine for moderate sedation during endoscopic ultrasonography

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World Journal of Clinical Cases 2022年第9期10卷 2773-2782页

作者： Yi Zou Na Li liu-Jia-Zi Shao fu-Kun liu fu-Shan Xue Xing Tao Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Sedation during endoscopic ultrasonography(EUS)poses many challenges and moderate-to-deep sedation are often *** conventional method to preform moderate-to-deep sedation is generally intravenous benzodiazepine alone or in combination with ***,this combination has some *** medication delivery may be an alternative to this sedation *** To determine,by continual reassessment method(CRM),the minimal effective dose of intranasal sufentanil(SUF)when combined with intranasal dexmedetomidine(DEX)for moderate sedation of EUS in at least 95%of patients(ED95).METHODS Thirty patients aged 18-65 and scheduled for EUS were recruited in this *** received intranasal DEX and SUF for *** dose of DEX(1μg/kg)was fixed,while the dose of SUF was assigned sequentially to the subjects using CRM to determine *** sedation status was assessed by modified observer’s assessment of alertness/sedation(MOAA/S)*** adverse events and the satisfaction scores of patients and endoscopists were *** The ED95 was intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,with an estimated probability of successful moderate sedation for EUS of 94.9%(95%confidence interval:88.1%-98.9%).When combined with intranasal 1μg/kg DEX,probabilities of successful moderate sedation at each dose level of intranasal SUF were as follows:0μg/kg SUF,52.8%;0.1μg/kg SUF,75.4%;0.2μg/kg SUF,89.9%;0.3μg/kg SUF,94.9%;0.4μg/kg SUF,98.0%;0.5μg/kg SUF,99.0%.CONCLUSION The ED95 needed for moderate sedation for EUS is intranasal 0.3μg/kg SUF when combined with intranasal 1μg/kg DEX,based on CRM.

关键词： Moderate sedation Intranasal administration Dexmedetomidine Sufentanil Continual reassessment method Endoscopic ultrasonography

Comparison of FGFR1 expression on lens epithelial cells between adults and fetuses

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 37-39页

作者： Yu-fu liu, Shu-Ling Peng Beijing Ophthalmology & Visual Sciences Key Lab Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing 10005 China Beijing Institute of Ophthalmology Beijing 100730 China

AIM: To study the differences of fibroblast growth factor receptor 1 (FGFR1) gene on human lens epithelial cells (HLECs) of adults and fetuses. METHODS: Indirect in situ RT-PCR was adopted for detection of FGFR1 gene. The cDNA of the nnRNA in the paraffin sections of fetus and adult HLEC was synthesized by reverse transcription reaction. After PCR amplification, in situ hybridization test was performed with synthesized oligonucleotide probe and relative quantification was carried out using image analysis. RESULTS: HLECs of adults and fetuses expressed FGFR1 gene, the expression level was higher in fetuses than in adults. The difference between them had significance (P<0.05). CONCLUSION: FGFR1 Exist in HLEC and the expression is age-related, which could be one of causes of the high occurrence of post operational after-cataract in children.

关键词： human lens epithelial cells fibroblast growth factor receptor 1 indirect in situ RT-PCR after-cataract

Investigation of the biological roles of autophagy in appressorium morphogenesis in Magnaporthe oryzae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 793-796页

作者： Xiao-hong liu fu-cheng LIN State Key Laboratory for Rice Biology Biotechnology Institute Zhejiang University Hangzhou 310029 China

Magnaporthe oryzae has been used as a primary model organism for investigating fungus-plant interaction. Many researches focused on molecular mechanisms of appressorium formation to restrain this fungal pathogen. Autophagy is a very high conserved process in eukaryotic cells. Recently, autophagy has been considered as a key process in development and differentia-tion in M. oryzae. In this report, we present and discuss the current state of our knowledge on gene expression in appressorium formation and the progress in autophagy of rice blast fungi.

关键词： Magnaporthe oryzae Appressorium Gene expression Autophagy

The Homoclinic Orbit Solution for functional Equation

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Communications in Theoretical Physics 2002年第5期38卷 553-554页

作者： liu Shi-Da fu Zun-Tao liu Shi-Kuo REN Kui School of Physics Peking University Beijing 100871 China STCS Peking University Beijing 100871 China School of Physics Peking University Beijing 100871 China STCS Peking University Beijing 100871 China School of Physics Peking University Beijing 100871 China School of Physics Peking University Beijing 100871 China

In this paper, some examples, such as iterated functional systems, scaling equation of wavelet transform,and invariant measure system, are used to show that the homoclinic orbit solutions exist in the functional equat... 详细信息

关键词： functional equation, scaling equation, solitary wave, homoclinic orbit

Adsorption and diffusion of F_2 molecules on pristine graphene

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Chinese Physics B 2018年第10期27卷 525-530页

作者： Yong Yang fu-Chi liu Yoshiyuki Kawazoe College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei 230031China New Industry Creation Hatchery Center（NICHe） Tohoku University6-6-4 AobaAramakiAoba-kuSendaiMiyagi 980-8579Japan Department of Physics and Nanotechnology SRM Institute of Science and TechnologyKattankulathurm603203TNIndia

The adsorption and diffusion of F2 molecules on pristine graphene are studied by using first-principles *** the diffusion of F2 from molecular state in gas phase to the dissociative adsorption state on graphene surface, a kinetic barrier is identified, which explains the inertness of graphene in molecular F2 at room temperature, and its reactivity with F2 at higher temperatures. Study of the diffusion of F2 molecules on graphene surface determines the energy barrier along the optimal diffusion pathway, which conduces to the understanding of the high stability of fluorographene.

关键词： adsorption diffusion F2 molecule graphene first-principles calculations

Structure and magnetic property of bimetallic hexanuclear cluster based on 5-chlorosalicylaldehyde oxime

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Chinese Chemical Letters 2014年第6期25卷 937-940页

作者： Yuan Zhang Chen-Yan Wei Tian-fu liu School of Chemistry Beijing Institute of Technology

The bimetallic hexanuclear cluster [Mn4Ni2O2（Cl-Sao）6.（CH3OH）8].10CH3OH （1） was synthesized. Single-crystal X-ray analysis reveals that 1 consists of two [Mn2Ni（μ3-O）（Cl-Sao）3] subunits linked together via two pairs of long Ni-O bonds involving two oximate oxygen atoms and two phenolate oxygen atoms. Each Mn and Ni center achieves six-coordination with axial methanol molecules. The spin centers of the Mnm and Niu ions exchange magnetic coupling through O2-, O-phenolate and -N-O- bridges. The magnetic properties of the cluster have been investigated.

关键词： Cluster Crystal structure Magnetic property Manganese complex Nickel complex

First preparation of a novel polyol resin for purifying arylboronic acids

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Chinese Chemical Letters 2012年第9期23卷 993-995页

作者： fu Long liu Sheng Biao Wan Tao Jiang Key Laboratory of Marine Drugs Chinese Ministry of Education Shandong Provincial Key Laboratory of Glycoscience & Glycotechnology School of Medicine and Pharmacy Ocean University of China Qingdao 266003

A novel polystyrene-supported triol resin was first prepared by reaction of the Merrifield resin with trometamol. Using this resin, arylboronic acids were efficiently isolated and purified through a ＂capture-release＂ procedure in organic solvents. However, in basic aqueous solvents arylboronic acids were immobilized on the resin only with low yield. 2012 Tao Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

关键词： Polystyrene-supported polyol resin Arylboronic acid Immobilization

Essence of Pseudogap and Oscillation in High-Temperature Cuprate Superconductor Junction of Pseudogap State

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Communications in Theoretical Physics 2007年第2期47卷 343-348页

作者： liu fu-Sui HOU Yu-Min CHEN Wan-Fang Department of Physics Beijing University Beijing 100871 China CCAST （World Lab.） P.O. Box 8730 Beijing 100080 China Graduate Schools the Chinese Academy of Sciences Beijing 100049 China

This paper gives methods to calculate the pairing temperature T＊, at which a pseudogap is opened, and the superconducting temperature Tc, at which superconductivity appears, in the high-Te cuprates, and demonstrates directly that at Tc 〈 T 〈 T＊ the pseudogap is the gap of Cooper pair without long-range phase coherence, and at T 〈 Tc there is long-range phase coherence between Cooper pairs. Based on the above clear physical picture on the pseudogap state and our mechanism for the ac Josephson effect, this paper proposes that there should he a novel oscillatory current in P-I-P junction, induced by a constant bias on the junction. Here, P represents the high-Tc curates in the pseudogap state, where Cooper pairs do not have long-range phase coherence, and I represents the thin insulating barrier. This paper conjectures that there is a possible high-temperature superconductivity in the heavily underdoped high-Tc cuprates.

关键词： pseudogap high-Tc cuprate oscillation

Environmental and biological influences on the stability of silver nanoparticles

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Chinese Science Bulletin 2011年第19期56卷 2009-2015页

作者： liu Wei ZHOU QunFang liu JiYan fu JianJie liu SiJin JIANG GuiBin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-environmental Sciences Chinese Academy ofSciences Beijing 100085 China

Silver nanoparticles (Ag NPs) are easily dispersed and stable, and their application has become widespread. Consequently, concern has arisen regarding their potential effects on the environment and human health. However, the current understanding on the stability of Ag NPs is limited. Therefore, in this study the influence of environmental and biological factors, such as ionic strength, valence, biological molecules, pH and temperature, on the properties of Ag NPs was investigated. The absorption spectra, size, zeta potential, and release of silver ions were evaluated. Ionic strength, valence, Dulbecco’s Modified Eagle’s Medium (DMEM), without fetal bovine serum (FBS), reduced the stability of the Ag NPs. However, in DMEM with 10% FBS, the Ag NPs maintained their stability and nanoscale characteristics. These findings provide an essential insight into the environmental and biological factors that should be evaluated in a risk assessment of Ag NPs.

关键词：银纳米粒子生物因素稳定性环境 Zeta电位离子强度胎牛血清 DMEM