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Evaluation of 3D crustal seismic velocity models in southwest China:Model performance,limitation,and prospects

Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin WANG Ling CHEN qi-fu CHEN Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian plates.Constraining the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic hazards.Numerous studies have provided various 3D seismic velocity models in southwest China.However,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity models.In this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed seismograms.We particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi MS_(6.4) earthquake sequence and the 2022 Sichuan Luding MS_(6.8) earthquake sequence.The tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography Models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental China.Our results show that the tested 3D velocity models generally capture well long-period(full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages of full-waveform method in achieving sub-wavele

关键词： Southwest China Seismic tomography models Shallow Structures Waveform simulation Model evaluation

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Differences and identification on multi-time hydrocarbon generation of carboniferous-permian coaly source rocks in the Huanghua Depression,Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 765-776页

作者： Jin-Jun Xu Xian-Gang Cheng Shu-Nan Peng Jun-Cai Jiang qi-Long Wu Da Lou fu-qi Cheng La-Mei Lin National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina PetroChina Dagang Oilfield Company Tianjin300280China

Coal is a solid combustible mineral,and coal-bearing strata have important hydrocarbon generation potential and contribute to more than 12%of the global hydrocarbon resources.However,the deposition and hydrocarbon evolution process of ancient coal-bearing strata is characterized by multiple geological times,leading to obvious distinctions in their hydrocarbon generation potential,geological processes,and production,which affect the evaluation and exploration of hydrocarbon resources derived from coaly source rocks worldwide.This study aimed to identify the differences on oil-generated parent macerals and the production of oil generated from different coaly source rocks and through different oil generation processes.Integrating with the analysis of previous tectonic burial history and hydrocarbon generation history,high-temperature and high-pressure thermal simulation experiments,organic geochemistry,and organic petrology were performed on the Carboniferous-Permian(C-P)coaly source rocks in the Huanghua Depression,Bohai Bay Basin.The oil-generated parent macerals of coal's secondary oil generation process(SOGP)were mainly hydrogen-rich collotelinite,collodetrinite,sporinite,and cutinite,while the oil-generated parent macerals of tertiary oil generation process(TOGP)were the remaining small amount of hydrogen-rich collotelinite,sporinite,and cutinite,as well as dispersed soluble organic matter and unexhausted residual hydrocarbons.Compared with coal,the oil-generated parent macerals of coaly shale SOGP were mostly sporinite and cutinite.And part of hydrogen-poor vitrinite,lacking hydrocarbon-rich macerals,and macerals of the TOGP,in addition to some remaining cutinite and a small amount of crude oil and bitumen from SOGP contributed to the oil yield.The results indicated that the changes in oil yield had a good junction between SOGP and TOGP,both coal and coaly shale had higher SOGP aborted oil yield than TOGP starting yield,and coaly shale TOGP peak oil yield was lower than SOGP peak oil yield.There were significa

关键词： Thermal simulation Multi-time oil generation processes Coaly source rock Carboniferous-permian Huanghua Depression

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Ultrathin surface coating of Cu enabling long-life Zn metal anodes

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Rare Metals 2024年第5期43卷 2125-2135页

作者： Sang-Sang Liu Ya-Ru Liang Wen-Long Chen Ze-Hua Wang Yi-Long Dai fu-Gang qi Zeng-Sheng Ma Xiao-Ping Ouyang School of Materials Science and Engineering Xiangtan University Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education Xiangtan University

Aqueous zinc-ion batteries （AZIBs） are regarded as promising energy storage devices due to their low cost,high capacity,and ecological safety.Nevertheless,the severe dendritic growth and side reactions hinder their practical applicability significantly.Herein,an ultrathin Cu coating layer （～200 nm） is decorated on zinc foils via filtered cathodic vacuum arc deposition technology,aiming to achieve high-performance AZIBs.The Cu layer effectively suppresses chemical corrosion and hydrogen evolution reactions and enables preferential （002） Zn deposition during the stripping/plating cycles.Consequently,the Cu@Zn anode represents an elongated cycle life over 4,000 h at 2 mA·cm-2/2 mAh·cm-2.Even in conditions of high current density of 5 and 10 mA·cm-2,the Cu@Zn anode shows prolonged cycling stability exceeding 4000 and 2000 h,respectively.Such advantages also bring high Coulombic efficiency of 99.87% under 5 mAh·cm-2in Cu@Ti||Zn half-cell over 1500 cycles.Moreover,the Cu@Zn||MnO2full cell demonstrates a superior cyclability with a specific capacity of 203 mAh·g-1after 500 cycles a1 A·g-1.

关键词： Zn ion battery Zn metal anode Zn (002) plane Cu coating

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A nanoagent for concurrent therapy of breast cancer bone metastasis and cancer-induced bone pain through SLC7A11 interruption and photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 295-299页

作者： qi fu Zhongming Lian Mengya Niu Yaru Huang Yanqiu Ai Long He Dandan Zhang Cuixia Zheng Jian-Jun Yang Lei Wang Dandan Tian Department of Anesthesiology Pain and Perioperative MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China Translational Medical Center of Huaihe Hospital Henan UniversityKaifeng 475004China Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Bone metastasis,a life-threatening complication of advanced breast cancer,is often accompanied by debilitating pain(cancer-induced bone pain,CIBP)that severely impairs life quality and survival.The concurrent treatment of bone metastases and CIBP remains a clinical challenge because the therapeutic options are limited.In this study,we construct a near-infrared light-activated nano-therapeutic system to meet this conundrum.In detail,sorafenib(SRF)and photosensitizer(chlorin e6,Ce6)are encapsulated into mesoporous hydroxyapatite nanoparticles(HANPs),which are further functionalized with hyaluronic acid(HA)to obtain HA-SRF/Ce6@HANPs system.The designed nanoplatform destroys tumor cells in vitro and in vivo via the synergism of SRF(interrupting the exchange of cystine/glutamate by inhibiting SLC7A11)and photodynamic therapy(PDT,inducing reactive oxygen species generation).The decrease in tumor burden and reduction of extracellular glutamate significantly attenuate CIBP in mice model with developing bone cancer.Moreover,the combination of HA-SRF/Ce6@HANPs and PDT inhibit osteoclasts activation,promote osteoblast differentiation and accelerate bone repair.Overall,the nanoagent with good biocompatibility may provide an effective therapy method for the concurrent treatment of breast cancer bone metastasis and CIBP.

关键词： Breast cancer bone metastasis Cancer-induced bone pain Cystine/glutamate antiporter Sorafenib Photodynamic therapy

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Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

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Science China(Life Sciences) 2024年第3期67卷 504-517页

作者： qi fu Yu qian Hemin Jiang Yunqiang He Hao Dai Yang Chen Zhiqing Xia Yucheng Liang Yuncai Zhou Rui Gao Shuai Zheng Hui Lv Min Sun Kuanfeng Xu Tao Yang Department of Endocrinology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

During the pathogenesis of type 1 diabetes(T1D) and type 2 diabetes(T2D), pancreatic islets, especially the β cells, face significant challenges. These insulin-producing cells adopt a regeneration strategy to compensate for the shortage of insulin, but the exact mechanism needs to be defined. High-fat diet(HFD) and streptozotocin(STZ) treatment are well-established models to study islet damage in T2D and T1D respectively. Therefore, we applied these two diabetic mouse models, triggered at different ages, to pursue the cell fate transition of isletβ cells. Cre-LoxP systems were used to generate islet cell type-specific(α, β, or δ) green fluorescent protein(GFP)-labeled mice for genetic lineage tracing, thereinto β-cell GFP-labeled mice were tamoxifen induced. Single-cell RNA sequencing(scRNA-seq) was used to investigate the evolutionary trajectories and molecular mechanisms of the GFP-labeled β cells in STZ-treated mice. STZ-induced diabetes caused extensive dedifferentiation of β cells and some of which transdifferentiated into α or δ cells in both youth-and adulthood-initiated mice while this phenomenon was barely observed in HFD models. β cells in HFD mice were expanded via self-replication rather than via transdifferentiation from α or δ cells, in contrast, α or δ cells were induced to transdifferentiate into β cells in STZ-treated mice(both youthand adulthood-initiated). In addition to the re-dedifferentiation of β cells, it is also highly likely that these “α or δ” cells transdifferentiated from pre-existing β cells could also re-trans-differentiate into insulin-producing β cells and be beneficial to islet recovery. The analysis of ScRNA-seq revealed that several pathways including mitochondrial function, chromatin modification, and remodeling are crucial in the dynamic transition of β cells. Our findings shed light on how islet β cells overcome the deficit of insulin and the molecular mechanism of islet recovery in T1D and T2D pathogenesis.

关键词： islet regeneration lineage tracing high fat diet(HFD) streptozotocin(STZ)

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Plant-derived nanovesicles: further exploration of biomedical function and application potential

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3300-3320页

作者： Aixue Li Dan Li Yongwei Gu Rongmei Liu Xiaomeng Tang Yunan Zhao fu qi Jifu Wei Jiyong Liu College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmacy Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pharmacy Jiangsu Cancer HospitalNanjing 210009China Jiangsu Institute of Cancer Research Nanjing 210009China The Affiliated Cancer Hospital of Nanjing Medical University Nanjing 210009China Department of Pharmacy Shanghai Proton and Heavy Ion CenterShanghai 201315China

Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular communication.Based on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers.Among them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in vivo.This review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic agents.We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19.Finally,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were analyzed.We expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases.

关键词： Plant-derived nanovesicles Extracellular vesicles Therapeutic agents Drugdelivery systems Clinical application

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技能习得模型与运动意向性——兼论德雷福斯与塞尔、麦克道尔的争论

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科学技术哲学研究 2024年第3期41卷 13-20页

作者：程瑞伏其秦山西大学科学技术哲学研究中心太原030006

德雷福斯通过批判笛卡尔主义式的人类智能解释传统模型,提出了基于熟练应对的技能习得模型。这一模型包括技能水平的五个发展阶段与熟练应对的三种层次。德雷福斯在技能习得模型中揭示出不同于传统预设的表征意向性的运动意向性,以及不... 详细信息

德雷福斯通过批判笛卡尔主义式的人类智能解释传统模型,提出了基于熟练应对的技能习得模型。这一模型包括技能水平的五个发展阶段与熟练应对的三种层次。德雷福斯在技能习得模型中揭示出不同于传统预设的表征意向性的运动意向性,以及不同于意向行动的专注应对行为,并在与塞尔、麦克道尔的争论中逐步阐释了它们的关系:人与动物共享的运动意向性与专注应对行为,始终作为表征意向性和意向行动的背景基础,在此基础上深思熟虑的意向行动对专注应对行为的撤离,是我们学习新技能或达到更高层次技能水平的必要手段。这种观点需要一种不同于笛卡尔的心灵表征、个体主义的更为丰富的存在论,并更普遍地回应技术哲学领域的困境。

关键词：德雷福斯熟练应对技能习得模型表征意向性运动意向性

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冯塔纳“柏林小说姊妹篇”中的城市空间书写

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上海理工大学学报（社会科学版） 2024年第2期46卷 129-134页

作者：傅琪大连外国语大学德语学院辽宁大连116044

德国现实主义文学大师台奥多·冯塔纳的“柏林小说姊妹篇”是德语文学中极具代表性的柏林城市书写文本。作品巧妙地赋予德意志历史以空间维度,城市书写中隐含了生产方式、社会关系和阶级关系的发展与变化,变化中各种因素和力量的建构与... 详细信息

德国现实主义文学大师台奥多·冯塔纳的“柏林小说姊妹篇”是德语文学中极具代表性的柏林城市书写文本。作品巧妙地赋予德意志历史以空间维度,城市书写中隐含了生产方式、社会关系和阶级关系的发展与变化,变化中各种因素和力量的建构与解构过程动态揭示了城市物质性、精神性、社会性的三位一体本质和互动发展模式,也由此折射出德国由封建主义向资本主义过渡的划时代变迁。

关键词：台奥多·冯塔纳柏林过渡态空间话语

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冶金生产中智能自动化仪器仪表的设计研究

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仪器仪表用户 2024年第2期31卷 36-38页

作者：付奇中钢设备有限公司包头分公司

在现代工业领域，智能化和自动化已成为重要的发展趋势。其中，冶金行业是应用较为广泛的领域。为了提高冶金行业的生产效率和产品质量，须要采用先进的技术手段来实现自动化控制。因此，本文将从冶金生产中智能自动化仪器仪表的基础理... 详细信息

在现代工业领域，智能化和自动化已成为重要的发展趋势。其中，冶金行业是应用较为广泛的领域。为了提高冶金行业的生产效率和产品质量，须要采用先进的技术手段来实现自动化控制。因此，本文将从冶金生产中智能自动化仪器仪表的基础理论出发，对其硬件及软件进行设计，以期能够为实际生产提供有效的解决方案。

关键词：冶金生产智能自动化仪器仪表

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乡村水塘景观生态恢复设计——以武汉市新洲区仓埠镇丰乐村福乐庄园为例

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生态经济 2024年第6期40卷 201-207页

作者：杨中贵杨小雪付琪武汉工程大学艺术设计学院湖北武汉430205 武汉理工大学艺术与设计学院湖北武汉430070

针对乡村水塘因长期缺乏重视与保护,导致大量水塘被填平或废弃,失去原有的蓄洪调蓄功能,反而成为乡村建设中的负担的问题,论文基于低影响开发的雨水利用理念,构建了水塘景观生态网络,并优化了调控途径;采用新型水体生态治理技术,有效治... 详细信息

针对乡村水塘因长期缺乏重视与保护,导致大量水塘被填平或废弃,失去原有的蓄洪调蓄功能,反而成为乡村建设中的负担的问题,论文基于低影响开发的雨水利用理念,构建了水塘景观生态网络,并优化了调控途径;采用新型水体生态治理技术,有效治理污染水体,提高水塘的整体净化效果。同时,引植符合当地生境及具备艺术性的适生植被,共同营造集生态效益、经济效益、乡土特色、景观美感等多层次人工湿地生态景观。进而以武汉市新洲区仓埠镇丰乐村福乐庄园为例,详细阐述低影响开发的雨水利用理念的应用,得出针对乡村水塘的生境与植物群落景观营造需要协调内在关系的结论。这一研究不仅对区域水塘景观规划和生态保护具有重要意义,而且为我国乡村水塘治理提供了新的思路和方向。

关键词：低影响开发农村水环境水塘景观植物景观

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